Gene Page: TDP2
Summary ?
| GeneID | 51567 |
| Symbol | TDP2 |
| Synonyms | AD022|EAP2|EAPII|TTRAP|dJ30M3.3|hTDP2 |
| Description | tyrosyl-DNA phosphodiesterase 2 |
| Reference | MIM:605764|HGNC:HGNC:17768|Ensembl:ENSG00000111802|HPRD:05771|Vega:OTTHUMG00000014360 |
| Gene type | protein-coding |
| Map location | 6p22.3-p22.1 |
| Pascal p-value | 0.007 |
| eGene | Myers' cis & trans |
Gene in Data Sources
| Gene set name | Method of gene set | Description | Info |
|---|---|---|---|
| CV:PGCnp | Genome-wide Association Study | GWAS |
Section I. Genetics and epigenetics annotation
eQTL annotation
| SNP ID | Chromosome | Position | eGene | Gene Entrez ID | pvalue | qvalue | TSS distance | eQTL type |
|---|---|---|---|---|---|---|---|---|
| rs9882137 | chr3 | 29494146 | TDP2 | 51567 | 0.11 | trans | ||
| rs4491879 | chr3 | 189373908 | TDP2 | 51567 | 0.18 | trans | ||
| rs4505678 | chr3 | 189374356 | TDP2 | 51567 | 0.12 | trans | ||
| rs17139868 | chr7 | 117079228 | TDP2 | 51567 | 0.01 | trans | ||
| rs1999514 | chr13 | 84147878 | TDP2 | 51567 | 0.12 | trans | ||
| rs12327665 | chr19 | 39622639 | TDP2 | 51567 | 0.05 | trans |
Section II. Transcriptome annotation
General gene expression (GTEx)
Gene expression of temporal and spatial changes (BrainSpan)
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
No co-expressed genes in brain regions
Section III. Gene Ontology annotation
| Molecular function | GO term | Evidence | Neuro keywords | PubMed ID |
|---|---|---|---|---|
| GO:0003714 | transcription corepressor activity | TAS | 10764746 | |
| Biological process | GO term | Evidence | Neuro keywords | PubMed ID |
| GO:0007166 | cell surface receptor linked signal transduction | TAS | 10764746 | |
| Cellular component | GO term | Evidence | Neuro keywords | PubMed ID |
| GO:0005634 | nucleus | IEA | - |
Section IV. Protein-protein interaction annotation
| Interactors | Aliases B | Official full name B | Experimental | Source | PubMed ID |
|---|---|---|---|---|---|
| CD40 | Bp50 | CDW40 | MGC9013 | TNFRSF5 | p50 | CD40 molecule, TNF receptor superfamily member 5 | - | HPRD,BioGRID | 10764746 |
| ETS1 | ETS-1 | EWSR2 | FLJ10768 | v-ets erythroblastosis virus E26 oncogene homolog 1 (avian) | EAPII interacts with ETS1. | BIND | 12743594 |
| ETS1 | ETS-1 | EWSR2 | FLJ10768 | v-ets erythroblastosis virus E26 oncogene homolog 1 (avian) | - | HPRD,BioGRID | 12743594 |
| ETS1 | ETS-1 | EWSR2 | FLJ10768 | v-ets erythroblastosis virus E26 oncogene homolog 1 (avian) | EAPII interacts with p42-ETS1. | BIND | 12743594 |
| ETS2 | ETS2IT1 | v-ets erythroblastosis virus E26 oncogene homolog 2 (avian) | ETS2 interacts with EAPII. | BIND | 12743594 |
| FLI1 | EWSR2 | SIC-1 | Friend leukemia virus integration 1 | FLI1 interacts with EAPII. | BIND | 12743594 |
| SUMO1 | DAP-1 | GMP1 | OFC10 | PIC1 | SENP2 | SMT3 | SMT3C | SMT3H3 | SUMO-1 | UBL1 | SMT3 suppressor of mif two 3 homolog 1 (S. cerevisiae) | SUMO-1 interacts with TTRAP. | BIND | 14609633 |
| SUMO1 | DAP-1 | GMP1 | OFC10 | PIC1 | SENP2 | SMT3 | SMT3C | SMT3H3 | SUMO-1 | UBL1 | SMT3 suppressor of mif two 3 homolog 1 (S. cerevisiae) | Two-hybrid | BioGRID | 14609633 |
| TNFRSF1B | CD120b | TBPII | TNF-R-II | TNF-R75 | TNFBR | TNFR1B | TNFR2 | TNFR80 | p75 | p75TNFR | tumor necrosis factor receptor superfamily, member 1B | - | HPRD,BioGRID | 10764746 |
| TNFRSF8 | CD30 | D1S166E | KI-1 | tumor necrosis factor receptor superfamily, member 8 | - | HPRD,BioGRID | 10764746 |
| TRAF2 | MGC:45012 | TRAP | TRAP3 | TNF receptor-associated factor 2 | - | HPRD,BioGRID | 10764746 |
| TRAF3 | CAP-1 | CD40bp | CRAF1 | LAP1 | TNF receptor-associated factor 3 | Affinity Capture-Western | BioGRID | 10764746 |
| TRAF5 | MGC:39780 | RNF84 | TNF receptor-associated factor 5 | - | HPRD,BioGRID | 10764746 |
| TRAF6 | MGC:3310 | RNF85 | TNF receptor-associated factor 6 | - | HPRD,BioGRID | 10764746 |
| UBE2I | C358B7.1 | P18 | UBC9 | ubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast) | Two-hybrid | BioGRID | 14609633 |
| UBE2I | C358B7.1 | P18 | UBC9 | ubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast) | Ubc9 interacts with TTRAP. | BIND | 14609633 |
Section V. Pathway annotation
| Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
|---|---|---|---|
| PID CD40 PATHWAY | 31 | 26 | All SZGR 2.0 genes in this pathway |
| HORIUCHI WTAP TARGETS DN | 310 | 188 | All SZGR 2.0 genes in this pathway |
| PAPASPYRIDONOS UNSTABLE ATEROSCLEROTIC PLAQUE UP | 52 | 36 | All SZGR 2.0 genes in this pathway |
| BERENJENO TRANSFORMED BY RHOA UP | 536 | 340 | All SZGR 2.0 genes in this pathway |
| GRASEMANN RETINOBLASTOMA WITH 6P AMPLIFICATION | 14 | 14 | All SZGR 2.0 genes in this pathway |
| SCHLOSSER SERUM RESPONSE DN | 712 | 443 | All SZGR 2.0 genes in this pathway |
| PATIL LIVER CANCER | 747 | 453 | All SZGR 2.0 genes in this pathway |
| NUYTTEN NIPP1 TARGETS DN | 848 | 527 | All SZGR 2.0 genes in this pathway |
| SHEN SMARCA2 TARGETS UP | 424 | 268 | All SZGR 2.0 genes in this pathway |
| MOREAUX B LYMPHOCYTE MATURATION BY TACI DN | 73 | 45 | All SZGR 2.0 genes in this pathway |
| MOREAUX MULTIPLE MYELOMA BY TACI DN | 172 | 107 | All SZGR 2.0 genes in this pathway |
| BLALOCK ALZHEIMERS DISEASE DN | 1237 | 837 | All SZGR 2.0 genes in this pathway |
| BONOME OVARIAN CANCER SURVIVAL OPTIMAL DEBULKING | 246 | 152 | All SZGR 2.0 genes in this pathway |
| MUELLER PLURINET | 299 | 189 | All SZGR 2.0 genes in this pathway |
| KIM ALL DISORDERS CALB1 CORR UP | 548 | 370 | All SZGR 2.0 genes in this pathway |
| PILON KLF1 TARGETS DN | 1972 | 1213 | All SZGR 2.0 genes in this pathway |
| JOHNSTONE PARVB TARGETS 2 DN | 336 | 211 | All SZGR 2.0 genes in this pathway |
| GOBERT OLIGODENDROCYTE DIFFERENTIATION UP | 570 | 339 | All SZGR 2.0 genes in this pathway |