Gene Page: PDYN

Summary ?
GeneID5173
SymbolPDYN
SynonymsADCA|PENKB|SCA23
Descriptionprodynorphin
ReferenceMIM:131340|HGNC:HGNC:8820|Ensembl:ENSG00000101327|HPRD:08838|Vega:OTTHUMG00000031683
Gene typeprotein-coding
Map location20p13
Pascal p-value0.188
Sherlock p-value0.663
DMG1 (# studies)
eGeneMyers' cis & trans
Meta
SupportNEUROTROPHIN SIGNALING

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
CV:PGCnpGenome-wide Association StudyGWAS
DMG:Wockner_2014Genome-wide DNA methylation analysisThis dataset includes 4641 differentially methylated probes corresponding to 2929 unique genes between schizophrenia patients (n=24) and controls (n=24). 1
PMID:cooccurHigh-throughput literature-searchSystematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
AssociationA combined odds ratio method (Sun et al. 2008), association studies1Link to SZGene
LiteratureHigh-throughput literature-searchCo-occurance with Schizophrenia keywords: schizophrenia,schizophrenic,schizophreniasClick to show details
GO_AnnotationMapping neuro-related keywords to Gene Ontology annotationsHits with neuro-related keywords: 2 

Section I. Genetics and epigenetics annotation

@Differentially methylated gene

ProbeChromosomePositionNearest geneP (dis)Beta (dis)FDR (dis)Study
cg24377694201975372PDYN1.551E-40.5180.032DMG:Wockner_2014

@eQTL annotation

SNP IDChromosomePositioneGeneGene Entrez IDpvalueqvalueTSS distanceeQTL type
rs6666937chr1170286842PDYN51730.16trans
rs636167chr1237402264PDYN51730.13trans
rs13396829chr2120222603PDYN51730.06trans
rs921163chr2205337399PDYN51730.03trans
rs13003798chr2205355767PDYN51730.03trans
rs6746267chr2205612604PDYN51730.16trans
rs16863576chr2223120977PDYN51730.1trans
rs9882574chr356944018PDYN51730.05trans
rs9862967chr356944181PDYN51730.05trans
rs9825359chr356944297PDYN51730.05trans
rs9828029chr356949706PDYN51730.01trans
rs1392700chr356952899PDYN51730.05trans
rs4362744chr387821108PDYN51730.01trans
rs16827037chr3117203284PDYN51730trans
rs16836473chr3131078626PDYN51730.19trans
rs16847375chr3137426961PDYN51730.17trans
rs17468523chr3137427751PDYN51730.17trans
rs16847377chr3137427893PDYN51730.17trans
rs17481423chr3137442185PDYN51730.17trans
rs6834153chr48606484PDYN51730.01trans
rs7688257chr468126424PDYN51730.13trans
rs6894161chr591098032PDYN51730.03trans
rs17109939chr5148694416PDYN51730.01trans
rs226963chr63724120PDYN51730.13trans
rs16885600chr622110853PDYN51730.1trans
snp_a-20466390PDYN51730.04trans
rs7749235chr630635592PDYN51730.08trans
rs16884095chr653470796PDYN51730.1trans
rs887719chr721184272PDYN51733.568E-4trans
rs320082chr729105404PDYN51732.379E-6trans
rs317720chr729110633PDYN51733.047E-4trans
rs317714chr729115553PDYN51732.17E-7trans
rs317724chr729120565PDYN51733.047E-4trans
rs6942437chr7146798442PDYN51730.09trans
rs7829733chr89691720PDYN51730.06trans
rs10099022chr824510800PDYN51730.02trans
rs4242415chr824597175PDYN51730.06trans
rs10504043chr841567870PDYN51730.08trans
rs16886605chr8115894398PDYN51730.04trans
rs7020469chr927338005PDYN51730.08trans
rs11203077chr1091097084PDYN51730.01trans
rs16933545chr117918293PDYN51730.1trans
rs10834670chr1125404015PDYN51730.12trans
rs11019015chr1190157517PDYN51730.01trans
rs12312877chr1279751818PDYN51730.07trans
rs11066476chr12113465366PDYN51730.01trans
rs2993290chr13113647189PDYN51730.01trans
rs13076870PDYN51730.06trans
rs11158850chr1470757171PDYN51730trans
rs2444983chr1533443919PDYN51730.12trans
rs16957838chr1682630295PDYN51730.1trans
rs12452652chr1772235560PDYN51737.708E-4trans
rs7230403chr1854982203PDYN51730.18trans
rs1230712chr1854992531PDYN51730.04trans
rs6039399chr209127493PDYN51730.16trans
rs6121844chr2060489981PDYN51730.06trans

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
GenePearson's Correlation Spearman's Correlation
FRMPD40.720.69
THRB0.720.71
RIMBP20.710.69
ADAM220.700.69
STXBP50.700.67
KIF5C0.700.65
CSMD10.690.69
DLG20.690.67
CYTH30.690.68
POU6F20.690.64
Top 10 negatively co-expressed genes
GenePearson's Correlation Spearman's Correlation
C1orf61-0.44-0.50
SERF2-0.44-0.50
WBP1-0.44-0.44
ENHO-0.43-0.42
RPS27L-0.43-0.47
DBI-0.41-0.43
RFXANK-0.41-0.46
IFI27L2-0.40-0.47
H2AFJ-0.40-0.47
TMEM219-0.40-0.40

Section III. Gene Ontology annotation

Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0001515opioid peptide activityIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0007268synaptic transmissionIEAneuron, Synap, Neurotransmitter (GO term level: 6)-
GO:0007218neuropeptide signaling pathwayIEANeurotransmitter (GO term level: 8)-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005576extracellular regionIEA-
GO:0005886plasma membraneIDA9047294 

Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
REACTOME SIGNALING BY GPCR 920449All SZGR 2.0 genes in this pathway
REACTOME PEPTIDE LIGAND BINDING RECEPTORS 188108All SZGR 2.0 genes in this pathway
REACTOME CLASS A1 RHODOPSIN LIKE RECEPTORS 305177All SZGR 2.0 genes in this pathway
REACTOME OPIOID SIGNALLING 7856All SZGR 2.0 genes in this pathway
REACTOME G PROTEIN ACTIVATION 2715All SZGR 2.0 genes in this pathway
REACTOME GPCR DOWNSTREAM SIGNALING 805368All SZGR 2.0 genes in this pathway
REACTOME G ALPHA I SIGNALLING EVENTS 195114All SZGR 2.0 genes in this pathway
REACTOME GPCR LIGAND BINDING 408246All SZGR 2.0 genes in this pathway
FERREIRA EWINGS SARCOMA UNSTABLE VS STABLE UP 16792All SZGR 2.0 genes in this pathway
WEIGEL OXIDATIVE STRESS BY HNE AND H2O2 3929All SZGR 2.0 genes in this pathway
MCCLUNG CREB1 TARGETS DN 5739All SZGR 2.0 genes in this pathway
SATO SILENCED BY METHYLATION IN PANCREATIC CANCER 2 5034All SZGR 2.0 genes in this pathway
BROWNE HCMV INFECTION 6HR UP 7148All SZGR 2.0 genes in this pathway
SATO SILENCED BY METHYLATION IN PANCREATIC CANCER 1 419273All SZGR 2.0 genes in this pathway
BROWNE HCMV INFECTION 24HR UP 14896All SZGR 2.0 genes in this pathway
RIZKI TUMOR INVASIVENESS 2D UP 6946All SZGR 2.0 genes in this pathway
MIKKELSEN MCV6 ICP WITH H3K27ME3 7446All SZGR 2.0 genes in this pathway
MIKKELSEN MEF ICP WITH H3K27ME3 206108All SZGR 2.0 genes in this pathway
MIKKELSEN IPS ICP WITH H3K4ME3 AND H327ME3 12683All SZGR 2.0 genes in this pathway
MIKKELSEN ES ICP WITH H3K4ME3 AND H3K27ME3 13785All SZGR 2.0 genes in this pathway
BROWNE HCMV INFECTION 30MIN UP 5638All SZGR 2.0 genes in this pathway