Gene Page: RAB8B
Summary ?
| GeneID | 51762 |
| Symbol | RAB8B |
| Synonyms | - |
| Description | RAB8B, member RAS oncogene family |
| Reference | MIM:613532|HGNC:HGNC:30273|Ensembl:ENSG00000166128|HPRD:11476|Vega:OTTHUMG00000132862 |
| Gene type | protein-coding |
| Map location | 15q22.2 |
| Pascal p-value | 3.547E-5 |
| Support | INTRACELLULAR TRAFFICKING |
Gene in Data Sources
| Gene set name | Method of gene set | Description | Info |
|---|---|---|---|
| CV:PGCnp | Genome-wide Association Study | GWAS |
Section I. Genetics and epigenetics annotation
Section II. Transcriptome annotation
General gene expression (GTEx)
Gene expression of temporal and spatial changes (BrainSpan)
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
No co-expressed genes in brain regions
Section IV. Protein-protein interaction annotation
| Interactors | Aliases B | Official full name B | Experimental | Source | PubMed ID |
|---|---|---|---|---|---|
| ACTB | PS1TP5BP1 | actin, beta | Affinity Capture-Western | BioGRID | 12639940 |
| CDH1 | Arc-1 | CD324 | CDHE | ECAD | LCAM | UVO | cadherin 1, type 1, E-cadherin (epithelial) | - | HPRD,BioGRID | 12639940 |
| CDH2 | CD325 | CDHN | CDw325 | NCAD | cadherin 2, type 1, N-cadherin (neuronal) | Affinity Capture-Western | BioGRID | 12639940 |
| CTNNB1 | CTNNB | DKFZp686D02253 | FLJ25606 | FLJ37923 | catenin (cadherin-associated protein), beta 1, 88kDa | Affinity Capture-Western | BioGRID | 12639940 |
| ITGB1 | CD29 | FNRB | GPIIA | MDF2 | MSK12 | VLA-BETA | VLAB | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | Affinity Capture-Western | BioGRID | 12639940 |
| JUP | ARVD12 | CTNNG | DP3 | DPIII | PDGB | PKGB | junction plakoglobin | Affinity Capture-Western | BioGRID | 12639940 |
| OCLN | - | occludin | Affinity Capture-Western | BioGRID | 12639940 |
| PXN | FLJ16691 | paxillin | Affinity Capture-Western | BioGRID | 12639940 |
| RAB3IP | FLJ14660 | FLJ22548 | MGC71495 | RABIN3 | RAB3A interacting protein (rabin3) | Rabin8, a Rab8-specific guanine nucleotide exchange factor, interacts with a GDP-bound Rab8 small GTPase, Rab8b. This interaction was modelled on a demonstrated interaction between Rabin8 from human and Rab8b from an unidentified species. | BIND | 12221131 |
| RALA | MGC48949 | RAL | v-ral simian leukemia viral oncogene homolog A (ras related) | - | HPRD | 10889189 |
| TES | DKFZp586B2022 | MGC1146 | TESS | TESS-2 | testis derived transcript (3 LIM domains) | Affinity Capture-Western | BioGRID | 12639940 |
| TJP1 | DKFZp686M05161 | MGC133289 | ZO-1 | tight junction protein 1 (zona occludens 1) | Affinity Capture-Western | BioGRID | 12639940 |
| TUBA1A | B-ALPHA-1 | FLJ25113 | LIS3 | TUBA3 | tubulin, alpha 1a | Affinity Capture-Western | BioGRID | 12639940 |
| TUBA4A | FLJ30169 | H2-ALPHA | TUBA1 | tubulin, alpha 4a | - | HPRD | 12639940 |
| TUBB | M40 | MGC117247 | MGC16435 | OK/SW-cl.56 | TUBB1 | TUBB5 | tubulin, beta | Affinity Capture-Western | BioGRID | 12639940 |
| TUBB2A | TUBB | TUBB2 | dJ40E16.7 | tubulin, beta 2A | - | HPRD | 12639940 |
| TUBG1 | TUBG | TUBGCP1 | tubulin, gamma 1 | Affinity Capture-Western | BioGRID | 12639940 |
| VIM | FLJ36605 | vimentin | - | HPRD,BioGRID | 12639940 |
Section V. Pathway annotation
| Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
|---|---|---|---|
| CHARAFE BREAST CANCER LUMINAL VS MESENCHYMAL DN | 460 | 312 | All SZGR 2.0 genes in this pathway |
| RODRIGUES DCC TARGETS DN | 121 | 84 | All SZGR 2.0 genes in this pathway |
| GARGALOVIC RESPONSE TO OXIDIZED PHOSPHOLIPIDS YELLOW UP | 32 | 25 | All SZGR 2.0 genes in this pathway |
| SENESE HDAC1 TARGETS UP | 457 | 269 | All SZGR 2.0 genes in this pathway |
| SENESE HDAC2 TARGETS UP | 114 | 66 | All SZGR 2.0 genes in this pathway |
| SENESE HDAC3 TARGETS UP | 501 | 327 | All SZGR 2.0 genes in this pathway |
| MARKEY RB1 ACUTE LOF UP | 215 | 137 | All SZGR 2.0 genes in this pathway |
| KIM MYC AMPLIFICATION TARGETS UP | 201 | 127 | All SZGR 2.0 genes in this pathway |
| NUYTTEN EZH2 TARGETS UP | 1037 | 673 | All SZGR 2.0 genes in this pathway |
| BUYTAERT PHOTODYNAMIC THERAPY STRESS UP | 811 | 508 | All SZGR 2.0 genes in this pathway |
| GEORGES TARGETS OF MIR192 AND MIR215 | 893 | 528 | All SZGR 2.0 genes in this pathway |
| RODWELL AGING KIDNEY UP | 487 | 303 | All SZGR 2.0 genes in this pathway |
| DOUGLAS BMI1 TARGETS DN | 314 | 188 | All SZGR 2.0 genes in this pathway |
| KRIGE RESPONSE TO TOSEDOSTAT 6HR UP | 953 | 554 | All SZGR 2.0 genes in this pathway |
| KRIGE RESPONSE TO TOSEDOSTAT 24HR UP | 783 | 442 | All SZGR 2.0 genes in this pathway |
| MONNIER POSTRADIATION TUMOR ESCAPE UP | 393 | 244 | All SZGR 2.0 genes in this pathway |
| ZHENG BOUND BY FOXP3 | 491 | 310 | All SZGR 2.0 genes in this pathway |
| MARSON BOUND BY FOXP3 STIMULATED | 1022 | 619 | All SZGR 2.0 genes in this pathway |
| ZHENG FOXP3 TARGETS IN THYMUS UP | 196 | 137 | All SZGR 2.0 genes in this pathway |
| RUTELLA RESPONSE TO CSF2RB AND IL4 UP | 338 | 225 | All SZGR 2.0 genes in this pathway |
| RUTELLA RESPONSE TO HGF UP | 418 | 282 | All SZGR 2.0 genes in this pathway |
| RUTELLA RESPONSE TO HGF VS CSF2RB AND IL4 DN | 245 | 150 | All SZGR 2.0 genes in this pathway |
| HAN SATB1 TARGETS DN | 442 | 275 | All SZGR 2.0 genes in this pathway |
| CHEN METABOLIC SYNDROM NETWORK | 1210 | 725 | All SZGR 2.0 genes in this pathway |
| MILI PSEUDOPODIA HAPTOTAXIS UP | 518 | 299 | All SZGR 2.0 genes in this pathway |
| PILON KLF1 TARGETS DN | 1972 | 1213 | All SZGR 2.0 genes in this pathway |
| FORTSCHEGGER PHF8 TARGETS DN | 784 | 464 | All SZGR 2.0 genes in this pathway |
| ZWANG CLASS 1 TRANSIENTLY INDUCED BY EGF | 516 | 308 | All SZGR 2.0 genes in this pathway |