Summary ?
GeneID51762
SymbolRAB8B
Synonyms-
DescriptionRAB8B, member RAS oncogene family
ReferenceMIM:613532|HGNC:HGNC:30273|Ensembl:ENSG00000166128|HPRD:11476|Vega:OTTHUMG00000132862
Gene typeprotein-coding
Map location15q22.2
Pascal p-value3.547E-5
SupportINTRACELLULAR TRAFFICKING

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
CV:PGCnpGenome-wide Association StudyGWAS

Section I. Genetics and epigenetics annotation


Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

No co-expressed genes in brain regions


Section IV. Protein-protein interaction annotation

InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
ACTBPS1TP5BP1actin, betaAffinity Capture-WesternBioGRID12639940 
CDH1Arc-1 | CD324 | CDHE | ECAD | LCAM | UVOcadherin 1, type 1, E-cadherin (epithelial)-HPRD,BioGRID12639940 
CDH2CD325 | CDHN | CDw325 | NCADcadherin 2, type 1, N-cadherin (neuronal)Affinity Capture-WesternBioGRID12639940 
CTNNB1CTNNB | DKFZp686D02253 | FLJ25606 | FLJ37923catenin (cadherin-associated protein), beta 1, 88kDaAffinity Capture-WesternBioGRID12639940 
ITGB1CD29 | FNRB | GPIIA | MDF2 | MSK12 | VLA-BETA | VLABintegrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)Affinity Capture-WesternBioGRID12639940 
JUPARVD12 | CTNNG | DP3 | DPIII | PDGB | PKGBjunction plakoglobinAffinity Capture-WesternBioGRID12639940 
OCLN-occludinAffinity Capture-WesternBioGRID12639940 
PXNFLJ16691paxillinAffinity Capture-WesternBioGRID12639940 
RAB3IPFLJ14660 | FLJ22548 | MGC71495 | RABIN3RAB3A interacting protein (rabin3)Rabin8, a Rab8-specific guanine nucleotide exchange factor, interacts with a GDP-bound Rab8 small GTPase, Rab8b. This interaction was modelled on a demonstrated interaction between Rabin8 from human and Rab8b from an unidentified species.BIND12221131 
RALAMGC48949 | RALv-ral simian leukemia viral oncogene homolog A (ras related)-HPRD10889189 
TESDKFZp586B2022 | MGC1146 | TESS | TESS-2testis derived transcript (3 LIM domains)Affinity Capture-WesternBioGRID12639940 
TJP1DKFZp686M05161 | MGC133289 | ZO-1tight junction protein 1 (zona occludens 1)Affinity Capture-WesternBioGRID12639940 
TUBA1AB-ALPHA-1 | FLJ25113 | LIS3 | TUBA3tubulin, alpha 1aAffinity Capture-WesternBioGRID12639940 
TUBA4AFLJ30169 | H2-ALPHA | TUBA1tubulin, alpha 4a-HPRD12639940 
TUBBM40 | MGC117247 | MGC16435 | OK/SW-cl.56 | TUBB1 | TUBB5tubulin, betaAffinity Capture-WesternBioGRID12639940 
TUBB2ATUBB | TUBB2 | dJ40E16.7tubulin, beta 2A-HPRD12639940 
TUBG1TUBG | TUBGCP1tubulin, gamma 1Affinity Capture-WesternBioGRID12639940 
VIMFLJ36605vimentin-HPRD,BioGRID12639940 


Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
CHARAFE BREAST CANCER LUMINAL VS MESENCHYMAL DN 460312All SZGR 2.0 genes in this pathway
RODRIGUES DCC TARGETS DN 12184All SZGR 2.0 genes in this pathway
GARGALOVIC RESPONSE TO OXIDIZED PHOSPHOLIPIDS YELLOW UP 3225All SZGR 2.0 genes in this pathway
SENESE HDAC1 TARGETS UP 457269All SZGR 2.0 genes in this pathway
SENESE HDAC2 TARGETS UP 11466All SZGR 2.0 genes in this pathway
SENESE HDAC3 TARGETS UP 501327All SZGR 2.0 genes in this pathway
MARKEY RB1 ACUTE LOF UP 215137All SZGR 2.0 genes in this pathway
KIM MYC AMPLIFICATION TARGETS UP 201127All SZGR 2.0 genes in this pathway
NUYTTEN EZH2 TARGETS UP 1037673All SZGR 2.0 genes in this pathway
BUYTAERT PHOTODYNAMIC THERAPY STRESS UP 811508All SZGR 2.0 genes in this pathway
GEORGES TARGETS OF MIR192 AND MIR215 893528All SZGR 2.0 genes in this pathway
RODWELL AGING KIDNEY UP 487303All SZGR 2.0 genes in this pathway
DOUGLAS BMI1 TARGETS DN 314188All SZGR 2.0 genes in this pathway
KRIGE RESPONSE TO TOSEDOSTAT 6HR UP 953554All SZGR 2.0 genes in this pathway
KRIGE RESPONSE TO TOSEDOSTAT 24HR UP 783442All SZGR 2.0 genes in this pathway
MONNIER POSTRADIATION TUMOR ESCAPE UP 393244All SZGR 2.0 genes in this pathway
ZHENG BOUND BY FOXP3 491310All SZGR 2.0 genes in this pathway
MARSON BOUND BY FOXP3 STIMULATED 1022619All SZGR 2.0 genes in this pathway
ZHENG FOXP3 TARGETS IN THYMUS UP 196137All SZGR 2.0 genes in this pathway
RUTELLA RESPONSE TO CSF2RB AND IL4 UP 338225All SZGR 2.0 genes in this pathway
RUTELLA RESPONSE TO HGF UP 418282All SZGR 2.0 genes in this pathway
RUTELLA RESPONSE TO HGF VS CSF2RB AND IL4 DN 245150All SZGR 2.0 genes in this pathway
HAN SATB1 TARGETS DN 442275All SZGR 2.0 genes in this pathway
CHEN METABOLIC SYNDROM NETWORK 1210725All SZGR 2.0 genes in this pathway
MILI PSEUDOPODIA HAPTOTAXIS UP 518299All SZGR 2.0 genes in this pathway
PILON KLF1 TARGETS DN 19721213All SZGR 2.0 genes in this pathway
FORTSCHEGGER PHF8 TARGETS DN 784464All SZGR 2.0 genes in this pathway
ZWANG CLASS 1 TRANSIENTLY INDUCED BY EGF 516308All SZGR 2.0 genes in this pathway