SZGR2

Summary ?

GeneID	5217
Symbol	PFN2
Synonyms	D3S1319E\|PFL
Description	profilin 2
Reference	MIM:176590\|HGNC:HGNC:8882\|Ensembl:ENSG00000070087\|HPRD:01451\|Vega:OTTHUMG00000159683
Gene type	protein-coding
Map location	3q25.1
Pascal p-value	0.566
Sherlock p-value	0.02
Fetal beta	0.278
Support	STRUCTURAL PLASTICITY CompositeSet

Gene in Data Sources

Gene set name	Method of gene set	Description	Info
Network	Shortest path distance of core genes in the Human protein-protein interaction network	Contribution to shortest path in PPI network: 0.0086

Section I. Genetics and epigenetics annotation

Section II. Transcriptome annotation

General gene expression (GTEx)

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

No co-expressed genes in brain regions

Section III. Gene Ontology annotation

Molecular function	GO term	Evidence	Neuro keywords	PubMed ID
GO:0003779	actin binding	NAS		-
GO:0005546	phosphatidylinositol-4,5-bisphosphate binding	NAS		-
GO:0005515	protein binding	IPI		15383276 \|16169070
Biological process	GO term	Evidence	Neuro keywords	PubMed ID
GO:0007010	cytoskeleton organization	IEA		-
GO:0008064	regulation of actin polymerization or depolymerization	NAS		-
GO:0030036	actin cytoskeleton organization	IEA		-
Cellular component	GO term	Evidence	Neuro keywords	PubMed ID
GO:0005737	cytoplasm	IEA		-
GO:0015629	actin cytoskeleton	NAS		-

Section IV. Protein-protein interaction annotation

Interactors	Aliases B	Official full name B	Experimental	Source	PubMed ID
ACTB	PS1TP5BP1	actin, beta	-	HPRD	10600384
ACTG1	ACT \| ACTG \| DFNA20 \| DFNA26	actin, gamma 1	Two-hybrid	BioGRID	16169070
CCDC113	DKFZp434N1418 \| FLJ23555 \| HSPC065	coiled-coil domain containing 113	Two-hybrid	BioGRID	16169070
DDX11	CHL1 \| CHLR1 \| KRG2 \| MGC133249 \| MGC9335	DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 11 (CHL1-like helicase homolog, S. cerevisiae)	Two-hybrid	BioGRID	16169070
DLST	DLTS	dihydrolipoamide S-succinyltransferase (E2 component of 2-oxo-glutarate complex)	Two-hybrid	BioGRID	16169070
DNM1	DNM	dynamin 1	-	HPRD	9463375
EEF1A1	CCS-3 \| CCS3 \| EEF-1 \| EEF1A \| EF-Tu \| EF1A \| FLJ25721 \| GRAF-1EF \| HNGC:16303 \| LENG7 \| MGC102687 \| MGC131894 \| MGC16224 \| PTI1 \| eEF1A-1	eukaryotic translation elongation factor 1 alpha 1	Two-hybrid	BioGRID	16169070
EVL	RNB6	Enah/Vasp-like	-	HPRD,BioGRID	10945997
FAM173A	C16orf24 \| MGC2494	family with sequence similarity 173, member A	Two-hybrid	BioGRID	16169070
FHOD1	FHOS	formin homology 2 domain containing 1	Two-hybrid	BioGRID	12677009
FHOD1	FHOS	formin homology 2 domain containing 1	PFN IIa interacts with FHOS.	BIND	12677009
FHOD1	FHOS	formin homology 2 domain containing 1	PFN IIa interacts with FHOS78.	BIND	12677009
FMNL1	C17orf1 \| C17orf1B \| FHOD4 \| FMNL \| KW-13 \| MGC133052 \| MGC1894 \| MGC21878	formin-like 1	Affinity Capture-Western Reconstituted Complex	BioGRID	10958683
GOLGB1	GCP \| GCP372 \| GIANTIN \| GOLIM1	golgin B1, golgi integral membrane protein	Two-hybrid	BioGRID	16169070
IK	CSA2 \| MGC59741 \| RED	IK cytokine, down-regulator of HLA II	Two-hybrid	BioGRID	16169070
IVNS1ABP	DKFZp686K06216 \| FLARA3 \| FLJ10069 \| FLJ10411 \| FLJ10962 \| FLJ35593 \| FLJ36593 \| HSPC068 \| KIAA0850 \| ND1 \| NS-1 \| NS1-BP \| NS1BP	influenza virus NS1A binding protein	Two-hybrid	BioGRID	16169070
LOC339344	-	hypothetical protein LOC339344	-	HPRD	15615774
NDUFB8	ASHI \| CI-ASHI	NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 8, 19kDa	Two-hybrid	BioGRID	16169070
PLAUR	CD87 \| UPAR \| URKR	plasminogen activator, urokinase receptor	Two-hybrid	BioGRID	16169070
PTPRS	PTPSIGMA	protein tyrosine phosphatase, receptor type, S	Two-hybrid	BioGRID	16169070
RAP1GAP	KIAA0474 \| RAP1GA1 \| Rap1GAP1 \| rap1GAPII	RAP1 GTPase activating protein	Two-hybrid	BioGRID	16169070
RNF146	DKFZp434O1427 \| RP3-351K20.1 \| dJ351K20.1	ring finger protein 146	Two-hybrid	BioGRID	16169070
ROCK1	MGC131603 \| MGC43611 \| P160ROCK \| PRO0435	Rho-associated, coiled-coil containing protein kinase 1	-	HPRD,BioGRID	14517206
RPS10	MGC88819	ribosomal protein S10	Two-hybrid	BioGRID	16169070
SEPT5	CDCREL \| CDCREL-1 \| CDCREL1 \| H5 \| PNUTL1	septin 5	Two-hybrid	BioGRID	16169070
SGTA	SGT \| alphaSGT \| hSGT	small glutamine-rich tetratricopeptide repeat (TPR)-containing, alpha	Two-hybrid	BioGRID	16169070
SIN3A	DKFZp434K2235 \| FLJ90319 \| KIAA0700	SIN3 homolog A, transcription regulator (yeast)	Affinity Capture-Western	BioGRID	12391155
SYN1	SYN1a \| SYN1b \| SYNI	synapsin I	-	HPRD	9463375
TERF1	FLJ41416 \| PIN2 \| TRBF1 \| TRF \| TRF1 \| hTRF1-AS \| t-TRF1	telomeric repeat binding factor (NIMA-interacting) 1	Two-hybrid	BioGRID	16169070
VASP	-	vasodilator-stimulated phosphoprotein	-	HPRD,BioGRID	7737110 \|10882740
WDR33	FLJ11294 \| WDC146	WD repeat domain 33	Two-hybrid	BioGRID	16169070

Section V. Pathway annotation

Pathway name	Pathway size	# SZGR 2.0 genes in pathway	Info
KEGG REGULATION OF ACTIN CYTOSKELETON	216	144	All SZGR 2.0 genes in this pathway
SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES	35	25	All SZGR 2.0 genes in this pathway
ST FAS SIGNALING PATHWAY	65	54	All SZGR 2.0 genes in this pathway
REACTOME DEVELOPMENTAL BIOLOGY	396	292	All SZGR 2.0 genes in this pathway
REACTOME AXON GUIDANCE	251	188	All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY ROBO RECEPTOR	30	26	All SZGR 2.0 genes in this pathway
WATANABE RECTAL CANCER RADIOTHERAPY RESPONSIVE DN	92	51	All SZGR 2.0 genes in this pathway
ONKEN UVEAL MELANOMA UP	783	507	All SZGR 2.0 genes in this pathway
GOZGIT ESR1 TARGETS DN	781	465	All SZGR 2.0 genes in this pathway
PROVENZANI METASTASIS DN	136	94	All SZGR 2.0 genes in this pathway
CHIARADONNA NEOPLASTIC TRANSFORMATION CDC25 UP	120	73	All SZGR 2.0 genes in this pathway
CHEBOTAEV GR TARGETS DN	120	73	All SZGR 2.0 genes in this pathway
GRAESSMANN APOPTOSIS BY SERUM DEPRIVATION DN	234	147	All SZGR 2.0 genes in this pathway
GRAESSMANN APOPTOSIS BY DOXORUBICIN UP	1142	669	All SZGR 2.0 genes in this pathway
GRAESSMANN RESPONSE TO MC AND DOXORUBICIN UP	612	367	All SZGR 2.0 genes in this pathway
MCBRYAN PUBERTAL BREAST 4 5WK UP	271	175	All SZGR 2.0 genes in this pathway
MCBRYAN PUBERTAL TGFB1 TARGETS DN	62	44	All SZGR 2.0 genes in this pathway
HU ANGIOGENESIS DN	37	25	All SZGR 2.0 genes in this pathway
LI AMPLIFIED IN LUNG CANCER	178	108	All SZGR 2.0 genes in this pathway
GROSS HYPOXIA VIA ELK3 UP	209	139	All SZGR 2.0 genes in this pathway
TARTE PLASMA CELL VS PLASMABLAST UP	398	262	All SZGR 2.0 genes in this pathway
FLECHNER BIOPSY KIDNEY TRANSPLANT REJECTED VS OK DN	546	351	All SZGR 2.0 genes in this pathway
FLECHNER BIOPSY KIDNEY TRANSPLANT OK VS DONOR UP	555	346	All SZGR 2.0 genes in this pathway
MATSUDA NATURAL KILLER DIFFERENTIATION	475	313	All SZGR 2.0 genes in this pathway
TAVOR CEBPA TARGETS DN	30	21	All SZGR 2.0 genes in this pathway
PETROVA ENDOTHELIUM LYMPHATIC VS BLOOD DN	162	102	All SZGR 2.0 genes in this pathway
FAELT B CLL WITH VH REARRANGEMENTS DN	48	26	All SZGR 2.0 genes in this pathway
SESTO RESPONSE TO UV C8	72	56	All SZGR 2.0 genes in this pathway
BLALOCK ALZHEIMERS DISEASE DN	1237	837	All SZGR 2.0 genes in this pathway
BAELDE DIABETIC NEPHROPATHY DN	434	302	All SZGR 2.0 genes in this pathway
CREIGHTON ENDOCRINE THERAPY RESISTANCE 2	473	224	All SZGR 2.0 genes in this pathway
RIGGINS TAMOXIFEN RESISTANCE UP	66	44	All SZGR 2.0 genes in this pathway
HELLER HDAC TARGETS UP	317	208	All SZGR 2.0 genes in this pathway
HELLER HDAC TARGETS SILENCED BY METHYLATION UP	461	298	All SZGR 2.0 genes in this pathway
AMUNDSON POOR SURVIVAL AFTER GAMMA RADIATION 8G	95	62	All SZGR 2.0 genes in this pathway
AMUNDSON POOR SURVIVAL AFTER GAMMA RADIATION 2G	171	96	All SZGR 2.0 genes in this pathway
MARTINEZ RB1 TARGETS DN	543	317	All SZGR 2.0 genes in this pathway
MARTINEZ TP53 TARGETS DN	593	372	All SZGR 2.0 genes in this pathway
MARTINEZ RB1 AND TP53 TARGETS DN	591	366	All SZGR 2.0 genes in this pathway
POS RESPONSE TO HISTAMINE UP	13	10	All SZGR 2.0 genes in this pathway
POS HISTAMINE RESPONSE NETWORK	32	22	All SZGR 2.0 genes in this pathway
SMID BREAST CANCER BASAL UP	648	398	All SZGR 2.0 genes in this pathway
TOYOTA TARGETS OF MIR34B AND MIR34C	463	262	All SZGR 2.0 genes in this pathway
ZHANG BREAST CANCER PROGENITORS UP	425	253	All SZGR 2.0 genes in this pathway
CROMER TUMORIGENESIS UP	63	36	All SZGR 2.0 genes in this pathway
SHEDDEN LUNG CANCER POOR SURVIVAL A6	456	285	All SZGR 2.0 genes in this pathway
COLINA TARGETS OF 4EBP1 AND 4EBP2	356	214	All SZGR 2.0 genes in this pathway
MILI PSEUDOPODIA HAPTOTAXIS UP	518	299	All SZGR 2.0 genes in this pathway
JISON SICKLE CELL DISEASE DN	181	97	All SZGR 2.0 genes in this pathway
BOYAULT LIVER CANCER SUBCLASS G3 UP	188	121	All SZGR 2.0 genes in this pathway
WOO LIVER CANCER RECURRENCE UP	105	75	All SZGR 2.0 genes in this pathway
CAIRO LIVER DEVELOPMENT UP	166	105	All SZGR 2.0 genes in this pathway
WONG ADULT TISSUE STEM MODULE	721	492	All SZGR 2.0 genes in this pathway
YAO TEMPORAL RESPONSE TO PROGESTERONE CLUSTER 16	79	47	All SZGR 2.0 genes in this pathway
KIM ALL DISORDERS OLIGODENDROCYTE NUMBER CORR UP	756	494	All SZGR 2.0 genes in this pathway
KIM BIPOLAR DISORDER OLIGODENDROCYTE DENSITY CORR UP	682	440	All SZGR 2.0 genes in this pathway
KIM ALL DISORDERS CALB1 CORR UP	548	370	All SZGR 2.0 genes in this pathway
VERHAAK GLIOBLASTOMA PRONEURAL	177	132	All SZGR 2.0 genes in this pathway
FIGUEROA AML METHYLATION CLUSTER 1 UP	125	61	All SZGR 2.0 genes in this pathway
FIGUEROA AML METHYLATION CLUSTER 2 UP	54	31	All SZGR 2.0 genes in this pathway
FIGUEROA AML METHYLATION CLUSTER 3 UP	170	97	All SZGR 2.0 genes in this pathway
FIGUEROA AML METHYLATION CLUSTER 4 UP	112	64	All SZGR 2.0 genes in this pathway
FIGUEROA AML METHYLATION CLUSTER 6 UP	140	81	All SZGR 2.0 genes in this pathway
FIGUEROA AML METHYLATION CLUSTER 7 UP	118	68	All SZGR 2.0 genes in this pathway
CARD MIR302A TARGETS	77	62	All SZGR 2.0 genes in this pathway
JOHNSTONE PARVB TARGETS 2 DN	336	211	All SZGR 2.0 genes in this pathway
DELPUECH FOXO3 TARGETS DN	41	27	All SZGR 2.0 genes in this pathway
LEE BMP2 TARGETS DN	882	538	All SZGR 2.0 genes in this pathway
PURBEY TARGETS OF CTBP1 NOT SATB1 UP	344	215	All SZGR 2.0 genes in this pathway
GOBERT OLIGODENDROCYTE DIFFERENTIATION DN	1080	713	All SZGR 2.0 genes in this pathway
KRIEG KDM3A TARGETS NOT HYPOXIA	208	107	All SZGR 2.0 genes in this pathway

Section VI. microRNA annotation

miRNA family	Target position			miRNA ID	miRNA seq
miRNA family	UTR start	UTR end	Match method	miRNA ID	miRNA seq
miR-133	866	872	1A	hsa-miR-133a	UUGGUCCCCUUCAACCAGCUGU
miR-133	866	872	1A	hsa-miR-133b	UUGGUCCCCUUCAACCAGCUA
miR-138	767	773	m8	hsa-miR-138^brain	AGCUGGUGUUGUGAAUC
miR-150	401	407	m8	hsa-miR-150	UCUCCCAACCCUUGUACCAGUG
miR-17-5p/20/93.mr/106/519.d	350	356	m8	hsa-miR-17-5p	CAAAGUGCUUACAGUGCAGGUAGU
				hsa-miR-20a^brain	UAAAGUGCUUAUAGUGCAGGUAG
				hsa-miR-106a	AAAAGUGCUUACAGUGCAGGUAGC
				hsa-miR-106b^SZ	UAAAGUGCUGACAGUGCAGAU
				hsa-miR-20b^SZ	CAAAGUGCUCAUAGUGCAGGUAG
				hsa-miR-519d	CAAAGUGCCUCCCUUUAGAGUGU
				hsa-miR-17-5p	CAAAGUGCUUACAGUGCAGGUAGU
				hsa-miR-20a^brain	UAAAGUGCUUAUAGUGCAGGUAG
				hsa-miR-106a	AAAAGUGCUUACAGUGCAGGUAGC
				hsa-miR-106b^SZ	UAAAGUGCUGACAGUGCAGAU
				hsa-miR-20b^SZ	CAAAGUGCUCAUAGUGCAGGUAG
				hsa-miR-519d	CAAAGUGCCUCCCUUUAGAGUGU
miR-183	959	966	1A,m8	hsa-miR-183	UAUGGCACUGGUAGAAUUCACUG
miR-183	959	966	1A,m8	hsa-miR-183	UAUGGCACUGGUAGAAUUCACUG
miR-19	761	768	1A,m8	hsa-miR-19a	UGUGCAAAUCUAUGCAAAACUGA
miR-19	761	768	1A,m8	hsa-miR-19b	UGUGCAAAUCCAUGCAAAACUGA
miR-194	1151	1157	1A	hsa-miR-194	UGUAACAGCAACUCCAUGUGGA
miR-218	192	198	1A	hsa-miR-218^brain	UUGUGCUUGAUCUAACCAUGU
miR-30-5p	1226	1233	1A,m8	hsa-miR-30a-5p	UGUAAACAUCCUCGACUGGAAG
				hsa-miR-30c^brain	UGUAAACAUCCUACACUCUCAGC
				hsa-miR-30d^SZ	UGUAAACAUCCCCGACUGGAAG
				hsa-miR-30b^SZ	UGUAAACAUCCUACACUCAGCU
				hsa-miR-30e-5p	UGUAAACAUCCUUGACUGGA
miR-342	993	999	1A	hsa-miR-342^brain	UCUCACACAGAAAUCGCACCCGUC
miR-409-5p	692	698	1A	hsa-miR-409-5p	AGGUUACCCGAGCAACUUUGCA
miR-448	1188	1194	m8	hsa-miR-448	UUGCAUAUGUAGGAUGUCCCAU
miR-488	836	842	1A	hsa-miR-488	CCCAGAUAAUGGCACUCUCAA
miR-488	836	842	1A	hsa-miR-488	CCCAGAUAAUGGCACUCUCAA
miR-493-5p	1093	1099	m8	hsa-miR-493-5p	UUGUACAUGGUAGGCUUUCAUU
miR-495	1149	1155	1A	hsa-miR-495^brain	AAACAAACAUGGUGCACUUCUUU
miR-7	379	385	m8	hsa-miR-7^SZ	UGGAAGACUAGUGAUUUUGUUG
miR-93.hd/291-3p/294/295/302/372/373/520	349	355	m8	hsa-miR-93^brain	AAAGUGCUGUUCGUGCAGGUAG
				hsa-miR-302a	UAAGUGCUUCCAUGUUUUGGUGA
				hsa-miR-302b	UAAGUGCUUCCAUGUUUUAGUAG
				hsa-miR-302c	UAAGUGCUUCCAUGUUUCAGUGG
				hsa-miR-302d	UAAGUGCUUCCAUGUUUGAGUGU
				hsa-miR-372	AAAGUGCUGCGACAUUUGAGCGU
				hsa-miR-373	GAAGUGCUUCGAUUUUGGGGUGU
				hsa-miR-520e	AAAGUGCUUCCUUUUUGAGGG
				hsa-miR-520a	AAAGUGCUUCCCUUUGGACUGU
				hsa-miR-520b	AAAGUGCUUCCUUUUAGAGGG
				hsa-miR-520c	AAAGUGCUUCCUUUUAGAGGGUU
				hsa-miR-520d	AAAGUGCUUCUCUUUGGUGGGUU

SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.

Gene Page: PFN2