Gene Page: PLD1

Summary ?
GeneID5337
SymbolPLD1
Synonyms-
Descriptionphospholipase D1
ReferenceMIM:602382|HGNC:HGNC:9067|Ensembl:ENSG00000075651|HPRD:03855|Vega:OTTHUMG00000156947
Gene typeprotein-coding
Map location3q26
Pascal p-value0.073
Fetal beta-1.302
SupportINTRACELLULAR SIGNAL TRANSDUCTION

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
CV:GWASdbGenome-wide Association StudiesGWASdb records for schizophrenia
CV:PGCnpGenome-wide Association StudyGWAS
PMID:cooccurHigh-throughput literature-searchSystematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
LiteratureHigh-throughput literature-searchCo-occurance with Schizophrenia keywords: schizophrenicClick to show details

Section I. Genetics and epigenetics annotation


Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

No co-expressed genes in brain regions


Section IV. Protein-protein interaction annotation

InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
ACTBPS1TP5BP1actin, beta-HPRD11373276 
AMPHAMPH1amphiphysinAffinity Capture-Western
Phenotypic Suppression
Reconstituted Complex		BioGRID10764771 
ARF1-ADP-ribosylation factor 1-HPRD,BioGRID9688545 
ARF6DKFZp564M0264ADP-ribosylation factor 6-HPRD,BioGRID12379803 
BIN1AMPH2 | AMPHL | DKFZp547F068 | MGC10367 | SH3P9bridging integrator 1Phenotypic Suppression
Reconstituted Complex		BioGRID10764771 
CDC42CDC42Hs | G25Kcell division cycle 42 (GTP binding protein, 25kDa)-HPRD,BioGRID10747870 
PEA15HMAT1 | HUMMAT1H | MAT1 | MAT1H | PEA-15 | PEDphosphoprotein enriched in astrocytes 15-HPRD,BioGRID10926929 
PIP5K1A-phosphatidylinositol-4-phosphate 5-kinase, type I, alpha-HPRD11032811 
PKN1DBK | MGC46204 | PAK1 | PKN | PKN-ALPHA | PRK1 | PRKCL1protein kinase N1-HPRD,BioGRID11259428 
PRKCAAAG6 | MGC129900 | MGC129901 | PKC-alpha | PKCA | PRKACAprotein kinase C, alpha-HPRD,BioGRID12839565 
RAC1MGC111543 | MIG5 | TC-25 | p21-Rac1ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)-HPRD11950936 
RALAMGC48949 | RALv-ral simian leukemia viral oncogene homolog A (ras related)-HPRD,BioGRID9207251 
RHOAARH12 | ARHA | RHO12 | RHOH12ras homolog gene family, member A-HPRD,BioGRID11311142 |12593858 
RHOGARHG | MGC125835 | MGC125836ras homolog gene family, member G (rho G)-HPRD12376551 
SNCAMGC110988 | NACP | PARK1 | PARK4 | PD1synuclein, alpha (non A4 component of amyloid precursor)-HPRD,BioGRID11821392 
SRCASV | SRC1 | c-SRC | p60-Srcv-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)Biochemical ActivityBioGRID12697812 


Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
KEGG GLYCEROPHOSPHOLIPID METABOLISM 7735All SZGR 2.0 genes in this pathway
KEGG ETHER LIPID METABOLISM 3315All SZGR 2.0 genes in this pathway
KEGG ENDOCYTOSIS 183132All SZGR 2.0 genes in this pathway
KEGG FC GAMMA R MEDIATED PHAGOCYTOSIS 9771All SZGR 2.0 genes in this pathway
KEGG GNRH SIGNALING PATHWAY 10177All SZGR 2.0 genes in this pathway
KEGG PATHWAYS IN CANCER 328259All SZGR 2.0 genes in this pathway
KEGG PANCREATIC CANCER 7056All SZGR 2.0 genes in this pathway
BIOCARTA RAC1 PATHWAY 2316All SZGR 2.0 genes in this pathway
BIOCARTA RAS PATHWAY 2320All SZGR 2.0 genes in this pathway
ST GA12 PATHWAY 2316All SZGR 2.0 genes in this pathway
ST GAQ PATHWAY 2822All SZGR 2.0 genes in this pathway
ST GA13 PATHWAY 3732All SZGR 2.0 genes in this pathway
PID RHOA PATHWAY 4533All SZGR 2.0 genes in this pathway
PID ARF6 TRAFFICKING PATHWAY 4934All SZGR 2.0 genes in this pathway
PID CDC42 PATHWAY 7051All SZGR 2.0 genes in this pathway
PID ARF6 DOWNSTREAM PATHWAY 1514All SZGR 2.0 genes in this pathway
PID MTOR 4PATHWAY 6955All SZGR 2.0 genes in this pathway
PID ERBB1 DOWNSTREAM PATHWAY 10578All SZGR 2.0 genes in this pathway
PID IL8 CXCR1 PATHWAY 2819All SZGR 2.0 genes in this pathway
PID ALPHA SYNUCLEIN PATHWAY 3325All SZGR 2.0 genes in this pathway
REACTOME PHOSPHOLIPID METABOLISM 198112All SZGR 2.0 genes in this pathway
REACTOME SYNTHESIS OF PA 2714All SZGR 2.0 genes in this pathway
REACTOME GLYCEROPHOSPHOLIPID BIOSYNTHESIS 8239All SZGR 2.0 genes in this pathway
REACTOME METABOLISM OF LIPIDS AND LIPOPROTEINS 478302All SZGR 2.0 genes in this pathway
PICCALUGA ANGIOIMMUNOBLASTIC LYMPHOMA UP 205140All SZGR 2.0 genes in this pathway
HUTTMANN B CLL POOR SURVIVAL UP 276187All SZGR 2.0 genes in this pathway
SENESE HDAC3 TARGETS UP 501327All SZGR 2.0 genes in this pathway
ZHOU INFLAMMATORY RESPONSE FIMA UP 544308All SZGR 2.0 genes in this pathway
GOZGIT ESR1 TARGETS UP 14984All SZGR 2.0 genes in this pathway
ENK UV RESPONSE EPIDERMIS DN 508354All SZGR 2.0 genes in this pathway
ENK UV RESPONSE KERATINOCYTE UP 530342All SZGR 2.0 genes in this pathway
LINDGREN BLADDER CANCER CLUSTER 1 UP 12171All SZGR 2.0 genes in this pathway
GRAESSMANN APOPTOSIS BY DOXORUBICIN DN 17811082All SZGR 2.0 genes in this pathway
MOHANKUMAR TLX1 TARGETS DN 193112All SZGR 2.0 genes in this pathway
YANG BREAST CANCER ESR1 LASER DN 5038All SZGR 2.0 genes in this pathway
NUYTTEN NIPP1 TARGETS UP 769437All SZGR 2.0 genes in this pathway
LOCKWOOD AMPLIFIED IN LUNG CANCER 214139All SZGR 2.0 genes in this pathway
LIAO METASTASIS 539324All SZGR 2.0 genes in this pathway
GOUYER TATI TARGETS UP 107All SZGR 2.0 genes in this pathway
BYSTROEM CORRELATED WITH IL5 DN 6447All SZGR 2.0 genes in this pathway
SASAKI ADULT T CELL LEUKEMIA 176122All SZGR 2.0 genes in this pathway
ABBUD LIF SIGNALING 1 UP 4629All SZGR 2.0 genes in this pathway
APPEL IMATINIB RESPONSE 3322All SZGR 2.0 genes in this pathway
CUI TCF21 TARGETS 2 DN 830547All SZGR 2.0 genes in this pathway
DURCHDEWALD SKIN CARCINOGENESIS DN 264168All SZGR 2.0 genes in this pathway
MONNIER POSTRADIATION TUMOR ESCAPE DN 373196All SZGR 2.0 genes in this pathway
CREIGHTON ENDOCRINE THERAPY RESISTANCE 3 720440All SZGR 2.0 genes in this pathway
STEARMAN LUNG CANCER EARLY VS LATE UP 12589All SZGR 2.0 genes in this pathway
MARTINEZ RB1 TARGETS UP 673430All SZGR 2.0 genes in this pathway
MARTINEZ TP53 TARGETS UP 602364All SZGR 2.0 genes in this pathway
MARTINEZ RB1 AND TP53 TARGETS UP 601369All SZGR 2.0 genes in this pathway
MASSARWEH TAMOXIFEN RESISTANCE UP 578341All SZGR 2.0 genes in this pathway
GRADE COLON AND RECTAL CANCER DN 10165All SZGR 2.0 genes in this pathway
WEST ADRENOCORTICAL TUMOR DN 546362All SZGR 2.0 genes in this pathway
BOYAULT LIVER CANCER SUBCLASS G56 DN 179All SZGR 2.0 genes in this pathway
HOSHIDA LIVER CANCER LATE RECURRENCE UP 6242All SZGR 2.0 genes in this pathway
DANG REGULATED BY MYC DN 253192All SZGR 2.0 genes in this pathway
MIKKELSEN NPC ICP WITH H3K4ME3 445257All SZGR 2.0 genes in this pathway
WANG RESPONSE TO GSK3 INHIBITOR SB216763 UP 397206All SZGR 2.0 genes in this pathway
GABRIELY MIR21 TARGETS 289187All SZGR 2.0 genes in this pathway
JOHNSTONE PARVB TARGETS 3 UP 430288All SZGR 2.0 genes in this pathway
KIM PTEN TARGETS UP 189All SZGR 2.0 genes in this pathway
LEE BMP2 TARGETS UP 745475All SZGR 2.0 genes in this pathway
KOINUMA TARGETS OF SMAD2 OR SMAD3 824528All SZGR 2.0 genes in this pathway
PEDERSEN METASTASIS BY ERBB2 ISOFORM 4 11066All SZGR 2.0 genes in this pathway
FOSTER KDM1A TARGETS UP 266142All SZGR 2.0 genes in this pathway
ZWANG TRANSIENTLY UP BY 1ST EGF PULSE ONLY 1839928All SZGR 2.0 genes in this pathway
ZWANG EGF INTERVAL DN 214124All SZGR 2.0 genes in this pathway