Gene Page: RRN3

Summary ?
GeneID54700
SymbolRRN3
SynonymsA-270G1.2|TIFIA
DescriptionRRN3 homolog, RNA polymerase I transcription factor
ReferenceMIM:605121|HGNC:HGNC:30346|Ensembl:ENSG00000085721|HPRD:12004|Vega:OTTHUMG00000129847
Gene typeprotein-coding
Map location16p12
Pascal p-value1.961E-5
Sherlock p-value0.689
eGeneMyers' cis & trans
Meta

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
CV:PGCnpGenome-wide Association StudyGWAS
GSMA_IIEGenome scan meta-analysis (European-ancestry samples)Psr: 0.01775 

Section I. Genetics and epigenetics annotation

@eQTL annotation

SNP IDChromosomePositioneGeneGene Entrez IDpvalueqvalueTSS distanceeQTL type
rs7404450chr1614450653RRN3547000.08cis
rs8014005chr1448182689RRN3547000.11trans

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

No co-expressed genes in brain regions


Section III. Gene Ontology annotation

Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0003701RNA polymerase I transcription factor activityTAS10758157 
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0006360transcription from RNA polymerase I promoterTAS10758157 

Section IV. Protein-protein interaction annotation

InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
ACTBPS1TP5BP1actin, betaTIF-IA interacts with actin.BIND15558034 
CCNE1CCNEcyclin E1Reconstituted ComplexBioGRID15004009 
CDK2p33(CDK2)cyclin-dependent kinase 2Reconstituted ComplexBioGRID15004009 
EIF3EIPEIF3S11 | EIF3S6IP | HSPC021 | HSPC025 | MSTP005eukaryotic translation initiation factor 3, subunit E interacting proteinTIF-IA interacts with PAF67. This interaction was modeled on a demonstrated interaction between human TIF-IA and PAF67 from an unspecified species.BIND12393749 
MYO1CFLJ23903 | MMI-beta | MMIb | NMI | myr2myosin ICNMI interacts with TIF-IA.BIND15558034 
POLR1ADKFZp586M0122 | FLJ21915 | MGC87965 | RPA1 | RPO1-4polymerase (RNA) I polypeptide A, 194kDa-HPRD,BioGRID11250903 
POLR1ADKFZp586M0122 | FLJ21915 | MGC87965 | RPA1 | RPO1-4polymerase (RNA) I polypeptide A, 194kDaTIF-IA interacts with RPA43. This interaction was modeled on a demonstrated interaction between human TIF-IA and mouse RPA43.BIND12393749 
POLR1BFLJ10816 | FLJ21921 | MGC131780 | RPA135 | RPA2 | Rpo1-2polymerase (RNA) I polypeptide B, 128kDaPol I interacts with TIF-IA.BIND15558034 
POLR1BFLJ10816 | FLJ21921 | MGC131780 | RPA135 | RPA2 | Rpo1-2polymerase (RNA) I polypeptide B, 128kDa-HPRD11250903 
PPP2R2AB55-ALPHA | B55A | FLJ26613 | MGC52248 | PR52A | PR55Aprotein phosphatase 2 (formerly 2A), regulatory subunit B, alpha isoformReconstituted ComplexBioGRID15004009 
RIBIN-rRNA promoter binding proteinTIF-IA interacts with rDNA.BIND15558034 
TAF1AMGC:17061 | RAFI48 | SL1 | TAFI48TATA box binding protein (TBP)-associated factor, RNA polymerase I, A, 48kDa-HPRD,BioGRID11250903 
TAF1BMGC:9349 | RAF1B | RAFI63 | SL1 | TAFI63TATA box binding protein (TBP)-associated factor, RNA polymerase I, B, 63kDa-HPRD,BioGRID11250903 
TAF1BMGC:9349 | RAF1B | RAFI63 | SL1 | TAFI63TATA box binding protein (TBP)-associated factor, RNA polymerase I, B, 63kDaTIF-IA interacts with TAFI68. This interaction was modeled on a demonstrated interaction between human TIF-IA and TAFI68 from an unspecified species.BIND12393749 
TAF1CMGC:39976 | SL1 | TAFI110 | TAFI95TATA box binding protein (TBP)-associated factor, RNA polymerase I, C, 110kDa-HPRD,BioGRID11250903 
TAF1CMGC:39976 | SL1 | TAFI110 | TAFI95TATA box binding protein (TBP)-associated factor, RNA polymerase I, C, 110kDaTIF-IA interacts with TAFI95. This interaction was modeled on a demonstrated interaction between human TIF-IA and TAFI95 from an unspecified species.BIND12393749 
TBPGTF2D | GTF2D1 | MGC117320 | MGC126054 | MGC126055 | SCA17 | TFIIDTATA box binding proteinAffinity Capture-WesternBioGRID11250903 
UBTFNOR-90 | UBFupstream binding transcription factor, RNA polymerase IAffinity Capture-WesternBioGRID11250903 


Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
PID MTOR 4PATHWAY 6955All SZGR 2.0 genes in this pathway
REACTOME RNA POL I TRANSCRIPTION 8964All SZGR 2.0 genes in this pathway
REACTOME TRANSCRIPTION 210127All SZGR 2.0 genes in this pathway
REACTOME RNA POL I RNA POL III AND MITOCHONDRIAL TRANSCRIPTION 12280All SZGR 2.0 genes in this pathway
REACTOME RNA POL I TRANSCRIPTION INITIATION 2514All SZGR 2.0 genes in this pathway
ONKEN UVEAL MELANOMA UP 783507All SZGR 2.0 genes in this pathway
BIDUS METASTASIS UP 214134All SZGR 2.0 genes in this pathway
DODD NASOPHARYNGEAL CARCINOMA DN 1375806All SZGR 2.0 genes in this pathway
CONCANNON APOPTOSIS BY EPOXOMICIN UP 239157All SZGR 2.0 genes in this pathway
BERENJENO TRANSFORMED BY RHOA UP 536340All SZGR 2.0 genes in this pathway
PUJANA BRCA1 PCC NETWORK 16521023All SZGR 2.0 genes in this pathway
PUJANA ATM PCC NETWORK 1442892All SZGR 2.0 genes in this pathway
BENPORATH NANOG TARGETS 988594All SZGR 2.0 genes in this pathway
BENPORATH SOX2 TARGETS 734436All SZGR 2.0 genes in this pathway
BYSTRYKH HEMATOPOIESIS STEM CELL QTL TRANS 882572All SZGR 2.0 genes in this pathway
RAMALHO STEMNESS UP 206118All SZGR 2.0 genes in this pathway
MARTINEZ RB1 TARGETS DN 543317All SZGR 2.0 genes in this pathway
MARTINEZ TP53 TARGETS UP 602364All SZGR 2.0 genes in this pathway
MARTINEZ RB1 AND TP53 TARGETS DN 591366All SZGR 2.0 genes in this pathway
LIN NPAS4 TARGETS UP 163100All SZGR 2.0 genes in this pathway
LEE BMP2 TARGETS DN 882538All SZGR 2.0 genes in this pathway