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Association Linkage Expression Literature GO_Annotation Gene Network miRNA Targets

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Gene Page: PPP1CA

Summary

GeneID

5499

Symbol

PPP1CA

Synonyms

MGC15877|MGC1674|PP-1A|PPP1A

Description

protein phosphatase 1, catalytic subunit, alpha isoform

Locus tag

Gene type

protein-coding

Map location

11q13

Gene in Data Sources

Gene set name

Method of gene set

Evidence

Info

Network

Shortest path distance of core genes in the Human protein-protein interaction network

Contribution to shortest path in PPI network: 0.035

General Gene Expression (microarray) ?

Gene Expression in Brain Regions (new)

Top co-expressed genes in Brain Regions (new)

Gene

Pearson's Correlation

Spearman's Correlation

Top 10 positively co-expressed genes

PRMT1

0.97

0.96

DDX39

0.95

0.93

PAFAH1B3

0.95

0.94

SMARCB1

0.94

0.92

RALY

0.94

0.89

IP6K2

0.94

0.92

ERGIC3

0.94

0.96

C17orf49

0.94

0.96

WRAP53

0.94

0.93

NXT1

0.94

0.89

Top 10 negatively co-expressed genes

AF347015.27

-0.73

-0.86

AF347015.33

-0.71

-0.85

HLA-F

-0.71

-0.72

AF347015.31

-0.70

-0.81

MT-CO2

-0.70

-0.81

MT-CYB

-0.69

-0.84

AF347015.8

-0.68

-0.84

AF347015.15

-0.68

-0.84

C5orf53

-0.68

-0.69

AIFM3

-0.67

-0.69

Gene Ontology

Molecular function

GO term

Evidence

Neuro keywords

PubMed ID

GO:0005506

iron ion binding

IEA

GO:0005515

protein binding

IPI

17274640 |17511879

GO:0004722

protein serine/threonine phosphatase activity

TAS

8392016

GO:0004721

phosphoprotein phosphatase activity

IEA

GO:0016787

hydrolase activity

IEA

GO:0030145

manganese ion binding

IEA

GO:0046872

metal ion binding

IEA

Biological process

GO term

Evidence

Neuro keywords

PubMed ID

GO:0006470

protein amino acid dephosphorylation

IEA

GO:0006470

protein amino acid dephosphorylation

TAS

8392016

GO:0005977

glycogen metabolic process

IEA

GO:0005975

carbohydrate metabolic process

IEA

GO:0007049

cell cycle

IEA

GO:0048754

branching morphogenesis of a tube

IEA

GO:0051301

cell division

IEA

GO:0030324

lung development

IEA

Cellular component

GO term

Evidence

Neuro keywords

PubMed ID

GO:0005654

nucleoplasm

IEA

GO:0005737

cytoplasm

IEA

Protein-protein Interactions

Shown by network

Interactors	Aliases B	Official full name B	Experimental	Source	PubMed ID
ACTA1	ACTA \| ASMA \| CFTD \| CFTD1 \| CFTDM \| MPFD \| NEM1 \| NEM2 \| NEM3	actin, alpha 1, skeletal muscle	Affinity Capture-Western	BioGRID	15107502
AKAP1	AKAP \| AKAP121 \| AKAP149 \| AKAP84 \| D-AKAP1 \| MGC1807 \| PRKA1 \| SAKAP84	A kinase (PRKA) anchor protein 1	-	HPRD	10995432
AKAP11	AKAP220 \| DKFZp781I12161 \| FLJ11304 \| KIAA0629 \| PRKA11	A kinase (PRKA) anchor protein 11	Affinity Capture-Western Reconstituted Complex	BioGRID	10209101 \|12147701
AKAP9	AKAP350 \| AKAP450 \| CG-NAP \| HYPERION \| KIAA0803 \| MU-RMS-40.16A \| PRKA9 \| YOTIAO	A kinase (PRKA) anchor protein (yotiao) 9	-	HPRD	10358086
AURKA	AIK \| ARK1 \| AURA \| AURORA2 \| BTAK \| MGC34538 \| STK15 \| STK6 \| STK7	aurora kinase A	-	HPRD	11551964
BAD	BBC2 \| BCL2L8	BCL2-associated agonist of cell death	-	HPRD	10811615
BCL2	Bcl-2	B-cell CLL/lymphoma 2	-	HPRD	11390485
BCL2L1	BCL-XL/S \| BCL2L \| BCLX \| Bcl-X \| DKFZp781P2092 \| bcl-xL \| bcl-xS	BCL2-like 1	-	HPRD,BioGRID	12115603
BCL2L2	BCL-W \| BCLW \| KIAA0271	BCL2-like 2	Affinity Capture-Western Reconstituted Complex	BioGRID	12115603
BRCA1	BRCAI \| BRCC1 \| IRIS \| PSCP \| RNF53	breast cancer 1, early onset	Affinity Capture-Western Reconstituted Complex	BioGRID	12438214
CAV1	CAV \| MSTP085 \| VIP21	caveolin 1, caveolae protein, 22kDa	CAV1 interacts with PP1-C.	BIND	14645548
CDC5L	CEF1 \| KIAA0432 \| PCDC5RP \| dJ319D22.1 \| hCDC5	CDC5 cell division cycle 5-like (S. pombe)	-	HPRD	10827081
EED	HEED \| WAIT1	embryonic ectoderm development	Reconstituted Complex	BioGRID	12788942
EIF2AK2	EIF2AK1 \| MGC126524 \| PKR \| PRKR	eukaryotic translation initiation factor 2-alpha kinase 2	-	HPRD,BioGRID	12138106
FXYD1	MGC44983 \| PLM	FXYD domain containing ion transport regulator 1	-	HPRD,BioGRID	10087003
GSK3B	-	glycogen synthase kinase 3 beta	Affinity Capture-Western	BioGRID	12147701
HCFC1	CFF \| HCF-1 \| HCF1 \| HFC1 \| MGC70925 \| VCAF	host cell factor C1 (VP16-accessory protein)	Affinity Capture-Western Reconstituted Complex	BioGRID	10637318
HSPA8	HSC54 \| HSC70 \| HSC71 \| HSP71 \| HSP73 \| HSPA10 \| LAP1 \| MGC131511 \| MGC29929 \| NIP71	heat shock 70kDa protein 8	Affinity Capture-Western	BioGRID	9269769
KCNQ1	ATFB1 \| FLJ26167 \| JLNS1 \| KCNA8 \| KCNA9 \| KVLQT1 \| Kv1.9 \| Kv7.1 \| LQT \| LQT1 \| RWS \| SQT2 \| WRS	potassium voltage-gated channel, KQT-like subfamily, member 1	Affinity Capture-Western Reconstituted Complex	BioGRID	11799244
LMTK2	AATYK2 \| BREK \| KIAA1079 \| KPI-2 \| KPI2 \| LMR2 \| cprk	lemur tyrosine kinase 2	Affinity Capture-Western Biochemical Activity Reconstituted Complex Two-hybrid	BioGRID	12393858
MAP3K3	MAPKKK3 \| MEKK3	mitogen-activated protein kinase kinase kinase 3	-	HPRD	14743216
MYO16	KIAA0865 \| MYR8 \| Myo16b	myosin XVI	-	HPRD	11588169
NOC2L	DKFZp564C186 \| FLJ35172 \| NIR	nucleolar complex associated 2 homolog (S. cerevisiae)	Reconstituted Complex	BioGRID	10637318
PHACTR1	KIAA1733 \| MGC126575 \| MGC126577 \| RPEL \| RPEL1 \| dJ257A7.2	phosphatase and actin regulator 1	Affinity Capture-Western Two-hybrid	BioGRID	15107502
PHACTR3	C20orf101 \| H17739 \| MGC117178 \| SCAPIN1 \| SCAPININ	phosphatase and actin regulator 3	-	HPRD,BioGRID	12925532
PPP1R10	CAT53 \| FB19 \| PNUTS \| PP1R10	protein phosphatase 1, regulatory (inhibitor) subunit 10	Reconstituted Complex	BioGRID	10637318
PPP1R15A	GADD34	protein phosphatase 1, regulatory (inhibitor) subunit 15A	Affinity Capture-Western Phenotypic Suppression	BioGRID	11564868 \|12016208 \|12724406
PPP1R2	IPP2 \| MGC87148	protein phosphatase 1, regulatory (inhibitor) subunit 2	-	HPRD,BioGRID	10807923
PPP1R8	ARD-1 \| ARD1 \| NIPP-1 \| NIPP1 \| PRO2047	protein phosphatase 1, regulatory (inhibitor) subunit 8	Reconstituted Complex	BioGRID	10637318 \|12788942
PPP1R9A	FLJ20068 \| KIAA1222 \| NRB1 \| NRBI \| Neurabin-I	protein phosphatase 1, regulatory (inhibitor) subunit 9A	-	HPRD	10504266 \|12052877
PPP1R9B	FLJ30345 \| PPP1R6 \| PPP1R9 \| SPINO \| Spn	protein phosphatase 1, regulatory (inhibitor) subunit 9B	Affinity Capture-Western Reconstituted Complex	BioGRID	10194355
RRP1B	KIAA0179 \| NNP1L \| Nnp1 \| RRP1	ribosomal RNA processing 1 homolog B (S. cerevisiae)	Reconstituted Complex	BioGRID	10637318
RYR2	ARVC2 \| ARVD2 \| VTSIP	ryanodine receptor 2 (cardiac)	Co-fractionation	BioGRID	10830164
SMARCB1	BAF47 \| INI1 \| RDT \| SNF5 \| SNF5L1 \| Sfh1p \| Snr1 \| hSNFS	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1	Affinity Capture-Western Phenotypic Enhancement Reconstituted Complex	BioGRID	12016208
TGFBR1	AAT5 \| ACVRLK4 \| ALK-5 \| ALK5 \| LDS1A \| LDS2A \| SKR4 \| TGFR-1	transforming growth factor, beta receptor 1	T-beta-RI interacts with an unspecific isoform of PPP1C. This interaction was modeled on a demonstrated interaction between human T-beta-RI and mouse PPP1C.	BIND	15761153
TGFBR2	AAT3 \| FAA3 \| LDS1B \| LDS2B \| MFS2 \| RIIC \| TAAD2 \| TGFR-2 \| TGFbeta-RII	transforming growth factor, beta receptor II (70/80kDa)	T-beta-RII interacts with an unspecific isoform of PPP1C. This interaction was modeled on a demonstrated interaction between human T-beta-RII and mouse PPP1C.	BIND	15761153

Pathway annotation

Pathway name	Pathway size	# SZGR genes in pathway	Info
KEGG_OOCYTE_MEIOSIS	114	79	All SZGR genes in this pathway
KEGG_VASCULAR_SMOOTH_MUSCLE_CONTRACTION	115	81	All SZGR genes in this pathway
KEGG_FOCAL_ADHESION	201	138	All SZGR genes in this pathway
KEGG_LONG_TERM_POTENTIATION	70	57	All SZGR genes in this pathway
KEGG_REGULATION_OF_ACTIN_CYTOSKELETON	216	144	All SZGR genes in this pathway
KEGG_INSULIN_SIGNALING_PATHWAY	137	103	All SZGR genes in this pathway
BIOCARTA_AKAP95_PATHWAY	12	9	All SZGR genes in this pathway
BIOCARTA_AKAPCENTROSOME_PATHWAY	15	14	All SZGR genes in this pathway
BIOCARTA_CK1_PATHWAY	17	17	All SZGR genes in this pathway
BIOCARTA_EIF2_PATHWAY	11	8	All SZGR genes in this pathway
PID_BMP_PATHWAY	42	31	All SZGR genes in this pathway
PID_ALK1_PATHWAY	26	21	All SZGR genes in this pathway
PID_TGFBR_PATHWAY	55	38	All SZGR genes in this pathway
REACTOME_DOWNREGULATION_OF_TGF_BETA_RECEPTOR_SIGNALING	23	13	All SZGR genes in this pathway
REACTOME_TGF_BETA_RECEPTOR_SIGNALING_ACTIVATES_SMADS	26	16	All SZGR genes in this pathway
REACTOME_SIGNALING_BY_GPCR	920	449	All SZGR genes in this pathway
REACTOME_OPIOID_SIGNALLING	78	56	All SZGR genes in this pathway
REACTOME_DARPP_32_EVENTS	25	20	All SZGR genes in this pathway
REACTOME_METABOLISM_OF_LIPIDS_AND_LIPOPROTEINS	478	302	All SZGR genes in this pathway
REACTOME_HORMONE_SENSITIVE_LIPASE_HSL_MEDIATED_TRIACYLGLYCEROL_HYDROLYSIS	13	11	All SZGR genes in this pathway
REACTOME_LIPID_DIGESTION_MOBILIZATION_AND_TRANSPORT	46	37	All SZGR genes in this pathway
REACTOME_SIGNALING_BY_TGF_BETA_RECEPTOR_COMPLEX	63	42	All SZGR genes in this pathway
HOLLMANN_APOPTOSIS_VIA_CD40_DN	267	178	All SZGR genes in this pathway
CHOW_RASSF1_TARGETS_DN	29	19	All SZGR genes in this pathway
ENK_UV_RESPONSE_KERATINOCYTE_UP	530	342	All SZGR genes in this pathway
LASTOWSKA_NEUROBLASTOMA_COPY_NUMBER_DN	800	473	All SZGR genes in this pathway
DACOSTA_UV_RESPONSE_VIA_ERCC3_UP	309	199	All SZGR genes in this pathway
LOPEZ_MBD_TARGETS	957	597	All SZGR genes in this pathway
LOCKWOOD_AMPLIFIED_IN_LUNG_CANCER	214	139	All SZGR genes in this pathway
SCHAEFFER_PROSTATE_DEVELOPMENT_6HR_DN	514	330	All SZGR genes in this pathway
STARK_PREFRONTAL_CORTEX_22Q11_DELETION_DN	517	309	All SZGR genes in this pathway
GEORGES_CELL_CYCLE_MIR192_TARGETS	62	46	All SZGR genes in this pathway
GEORGES_TARGETS_OF_MIR192_AND_MIR215	893	528	All SZGR genes in this pathway
NIKOLSKY_BREAST_CANCER_11Q12_Q14_AMPLICON	158	93	All SZGR genes in this pathway
SASAKI_ADULT_T_CELL_LEUKEMIA	176	122	All SZGR genes in this pathway
THEILGAARD_NEUTROPHIL_AT_SKIN_WOUND_DN	225	163	All SZGR genes in this pathway
YIH_RESPONSE_TO_ARSENITE_C2	18	15	All SZGR genes in this pathway
WEIGEL_OXIDATIVE_STRESS_BY_HNE_AND_TBH	60	42	All SZGR genes in this pathway
ZAMORA_NOS2_TARGETS_DN	96	71	All SZGR genes in this pathway
KYNG_RESPONSE_TO_H2O2	71	42	All SZGR genes in this pathway
ACEVEDO_LIVER_TUMOR_VS_NORMAL_ADJACENT_TISSUE_UP	863	514	All SZGR genes in this pathway
YOSHIMURA_MAPK8_TARGETS_UP	1305	895	All SZGR genes in this pathway
HOFFMANN_PRE_BI_TO_LARGE_PRE_BII_LYMPHOCYTE_UP	36	24	All SZGR genes in this pathway
HOFFMANN_LARGE_TO_SMALL_PRE_BII_LYMPHOCYTE_UP	163	102	All SZGR genes in this pathway
YAGI_AML_WITH_11Q23_REARRANGED	351	238	All SZGR genes in this pathway
MOOTHA_GLYCOGEN_METABOLISM	21	16	All SZGR genes in this pathway
NAKAMURA_ADIPOGENESIS_EARLY_UP	66	44	All SZGR genes in this pathway
NAKAMURA_ADIPOGENESIS_LATE_UP	104	67	All SZGR genes in this pathway
KIM_ALL_DISORDERS_OLIGODENDROCYTE_NUMBER_CORR_UP	756	494	All SZGR genes in this pathway
PURBEY_TARGETS_OF_CTBP1_AND_SATB1_UP	87	52	All SZGR genes in this pathway

miRNA Targets ?

miRNA family	Target position			miRNA ID	miRNA seq
miRNA family	UTR start	UTR end	Match method	miRNA ID	miRNA seq
miR-125/351	236	242	m8	hsa-miR-125b^brain	UCCCUGAGACCCUAACUUGUGA
miR-125/351	236	242	m8	hsa-miR-125a^brain	UCCCUGAGACCCUUUAACCUGUG
miR-192/215	334	340	1A	hsa-miR-192	CUGACCUAUGAAUUGACAGCC
miR-192/215	334	340	1A	hsa-miR-215	AUGACCUAUGAAUUGACAGAC
miR-335	323	329	1A	hsa-miR-335^brain	UCAAGAGCAAUAACGAAAAAUGU

SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.