Summary ?
GeneID5518
SymbolPPP2R1A
SynonymsMRD36|PP2A-Aalpha|PP2AAALPHA|PR65A
Descriptionprotein phosphatase 2 regulatory subunit A, alpha
ReferenceMIM:605983|HGNC:HGNC:9302|HPRD:16184|
Gene typeprotein-coding
Map location19q13.41
Pascal p-value0.406
Sherlock p-value0.45
Fetal beta-0.659
SupportINTRACELLULAR SIGNAL TRANSDUCTION
G2Cdb.human_BAYES-COLLINS-HUMAN-PSD-CONSENSUS
G2Cdb.human_BAYES-COLLINS-HUMAN-PSD-FULL
G2Cdb.human_BAYES-COLLINS-MOUSE-PSD-CONSENSUS
G2Cdb.humanNRC
G2Cdb.humanPSD
G2Cdb.humanPSP
CompositeSet
Darnell FMRP targets
Potential synaptic genes

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
CV:GWASdbGenome-wide Association StudiesGWASdb records for schizophrenia
CV:PGCnpGenome-wide Association StudyGWAS
NetworkShortest path distance of core genes in the Human protein-protein interaction networkContribution to shortest path in PPI network: 0.4639 

Section I. Genetics and epigenetics annotation


Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
GenePearson's Correlation Spearman's Correlation
EIF4ENIF10.920.92
C6orf1680.920.92
TRPC4AP0.910.91
RTN10.910.90
CS0.910.91
KIFAP30.910.92
VPS26B0.900.91
EFTUD20.900.92
RUSC10.900.92
AP1M10.900.90
Top 10 negatively co-expressed genes
GenePearson's Correlation Spearman's Correlation
AF347015.31-0.84-0.86
MT-CO2-0.83-0.86
AF347015.8-0.82-0.87
AF347015.33-0.82-0.84
AF347015.27-0.81-0.85
MT-CYB-0.81-0.84
AF347015.15-0.79-0.84
AF347015.2-0.79-0.85
AF347015.26-0.78-0.85
FXYD1-0.78-0.83

Section III. Gene Ontology annotation

Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0003823antigen bindingIPI9847399 
GO:0005515protein bindingIEA-
GO:0005515protein bindingIPI9847399 
GO:0008601protein phosphatase type 2A regulator activityTAS11007961 
GO:0046982protein heterodimerization activityIPI9847399 
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0000188inactivation of MAPK activityNAS11007961 
GO:0008380RNA splicingNAS11007961 
GO:0006461protein complex assemblyTAS9989501 
GO:0006470protein amino acid dephosphorylationTAS11007961 
GO:0010033response to organic substanceNAS11007961 
GO:0006275regulation of DNA replicationNAS11007961 
GO:0006917induction of apoptosisTAS11007961 
GO:0006672ceramide metabolic processNAS11007961 
GO:0030111regulation of Wnt receptor signaling pathwayNAS11007961 
GO:0030155regulation of cell adhesionNAS11007961 
GO:0042518negative regulation of tyrosine phosphorylation of Stat3 proteinNAS11007961 
GO:0040008regulation of growthNAS11360189 
GO:0019932second-messenger-mediated signalingNAS11007961 
GO:0030308negative regulation of cell growthNAS11007961 
GO:0045595regulation of cell differentiationNAS11360189 
GO:0045449regulation of transcriptionNAS11007961 
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0000159protein phosphatase type 2A complexTAS11007961 
GO:0005829cytosolIEA-
GO:0005829cytosolTAS11007961 
GO:0005625soluble fractionNAS11007961 
GO:0005634nucleusNAS11007961 
GO:0005739mitochondrionNAS11007961 
GO:0016020membraneNAS11007961 
GO:0015630microtubule cytoskeletonNAS11007961 

Section IV. Protein-protein interaction annotation

InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
ARIH2ARI2 | FLJ10938 | FLJ33921 | TRIAD1ariadne homolog 2 (Drosophila)Two-hybridBioGRID16169070 
CTNNBIP1ICAT | MGC15093catenin, beta interacting protein 1Affinity Capture-MSBioGRID17353931 
CTTNBP2C7orf8 | CORTBP2 | FLJ34229 | KIAA1758 | MGC104579 | Orf4cortactin binding protein 2Affinity Capture-MSBioGRID18782753 
CTTNBP2NLDKFZp547A023 | FLJ13278CTTNBP2 N-terminal likeAffinity Capture-MS
Affinity Capture-Western
BioGRID18782753 
FAM40AFLJ14743 | KIAA1761 | MGC148091 | RP4-773N10.1family with sequence similarity 40, member AAffinity Capture-MS
Affinity Capture-Western
BioGRID18782753 
GNA12MGC104623 | MGC99644 | NNX3 | RMP | gepguanine nucleotide binding protein (G protein) alpha 12Galpha12 interacts with Aalpha. This interaction was modelled on a demonstrated interaction between mouse Galpha12 and human Aalpha.BIND15525651 
GRIN1NMDA1 | NMDAR1 | NR1glutamate receptor, ionotropic, N-methyl D-aspartate 1-HPRD10862698 
GRIN2DEB11 | NMDAR2Dglutamate receptor, ionotropic, N-methyl D-aspartate 2D-HPRD10862698 
HSF2MGC117376 | MGC156196 | MGC75048heat shock transcription factor 2-HPRD10224043 
IKBKEIKK-i | IKKE | IKKI | KIAA0151 | MGC125294 | MGC125295 | MGC125297inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilonAffinity Capture-MSBioGRID17353931 
IPO9DKFZp761M1547 | FLJ10402 | Imp9importin 9-HPRD12670497 
MAP3K3MAPKKK3 | MEKK3mitogen-activated protein kinase kinase kinase 3-HPRD14743216 
MCCDKFZp762O1615 | FLJ38893 | FLJ46755 | MCC1mutated in colorectal cancersAffinity Capture-MSBioGRID17353931 
MOBKL32C4D | CGI-95 | MGC12264 | MOB1 | MOB3 | PREI3MOB1, Mps One Binder kinase activator-like 3 (yeast)Affinity Capture-MSBioGRID18782753 
NFKB2LYT-10 | LYT10nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)-HPRD14743216 
PDCD10CCM3 | MGC1212 | MGC24477 | TFAR15programmed cell death 10Affinity Capture-MSBioGRID18782753 
PPFIA1FLJ41337 | FLJ42630 | FLJ43474 | LIP.1 | LIP1 | LIPRIN | MGC26800protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1Affinity Capture-MSBioGRID18782753 
PPFIA2FLJ41378 | MGC132572protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 2Affinity Capture-MSBioGRID18782753 
PPME1FLJ22226 | PME-1protein phosphatase methylesterase 1Affinity Capture-MSBioGRID18782753 
PPP2CAPP2Ac | PP2CA | RP-Cprotein phosphatase 2 (formerly 2A), catalytic subunit, alpha isoformAffinity Capture-MS
Affinity Capture-Western
Reconstituted Complex
BioGRID12370081 |18782753 
PPP2CAPP2Ac | PP2CA | RP-Cprotein phosphatase 2 (formerly 2A), catalytic subunit, alpha isoformA-alpha subunit interacts with C-alpha subunit of PP2A.BIND12370081 
PPP2CBPP2CBprotein phosphatase 2 (formerly 2A), catalytic subunit, beta isoformAffinity Capture-MS
Affinity Capture-Western
Reconstituted Complex
BioGRID12370081 |18782753 
PPP2R1BMGC26454 | PR65Bprotein phosphatase 2 (formerly 2A), regulatory subunit A, beta isoformAffinity Capture-MSBioGRID18782753 
PPP2R2AB55-ALPHA | B55A | FLJ26613 | MGC52248 | PR52A | PR55Aprotein phosphatase 2 (formerly 2A), regulatory subunit B, alpha isoformAffinity Capture-MS
Affinity Capture-Western
Reconstituted Complex
BioGRID12370081 |18782753 
PPP2R2CB55-GAMMA | IMYPNO | IMYPNO1 | MGC33570 | PR52 | PR55Gprotein phosphatase 2 (formerly 2A), regulatory subunit B, gamma isoformAffinity Capture-MSBioGRID18782753 
PPP2R2DMDS026protein phosphatase 2, regulatory subunit B, delta isoformAffinity Capture-MSBioGRID18782753 
PPP2R3BNY-REN-8 | PPP2R3L | PPP2R3LY | PR48protein phosphatase 2 (formerly 2A), regulatory subunit B'', betaAffinity Capture-MS
Affinity Capture-Western
Reconstituted Complex
BioGRID12370081 |18782753 
PPP2R5AB56A | MGC131915 | PR61Aprotein phosphatase 2, regulatory subunit B', alpha isoformAffinity Capture-MS
Affinity Capture-Western
Reconstituted Complex
BioGRID12370081 |18782753 
PPP2R5CB56G | MGC23064 | PR61Gprotein phosphatase 2, regulatory subunit B', gamma isoformAffinity Capture-MSBioGRID18782753 
PPP2R5DB56D | MGC2134 | MGC8949protein phosphatase 2, regulatory subunit B', delta isoformAffinity Capture-MSBioGRID18782753 
PPP2R5E-protein phosphatase 2, regulatory subunit B', epsilon isoformAffinity Capture-MSBioGRID18782753 
PPP4CPP4 | PPH3 | PPXprotein phosphatase 4 (formerly X), catalytic subunitAffinity Capture-MSBioGRID17353931 |18715871 
PPP5CFLJ36922 | PP5 | PPP5protein phosphatase 5, catalytic subunit-HPRD11504734 
RP5-1000E10.4DKFZp686A0768 | FLJ21168 | SIKEsuppressor of IKK epsilonAffinity Capture-MSBioGRID18782753 
RP6-213H19.1MASK | MST4serine/threonine protein kinase MST4Affinity Capture-MSBioGRID18782753 
STK24MST-3 | MST3 | MST3B | STE20 | STK3serine/threonine kinase 24 (STE20 homolog, yeast)Affinity Capture-MSBioGRID17353931 |18782753 
STK25DKFZp686J1430 | SOK1 | YSK1serine/threonine kinase 25 (STE20 homolog, yeast)Affinity Capture-MSBioGRID18782753 
STRNMGC125642 | SG2NAstriatin, calmodulin binding proteinAffinity Capture-MSBioGRID18782753 
STRN3SG2NAstriatin, calmodulin binding protein 3Affinity Capture-MSBioGRID18782753 
STRN4FLJ35594 | ZIN | zinedinstriatin, calmodulin binding protein 4Affinity Capture-MSBioGRID18782753 
TRAF3IP3DJ434O14.3 | FLJ44151 | MGC117354 | MGC163289 | T3JAMTRAF3 interacting protein 3Affinity Capture-MSBioGRID18782753 


Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
KEGG OOCYTE MEIOSIS 11479All SZGR 2.0 genes in this pathway
KEGG WNT SIGNALING PATHWAY 151112All SZGR 2.0 genes in this pathway
KEGG TGF BETA SIGNALING PATHWAY 8664All SZGR 2.0 genes in this pathway
KEGG TIGHT JUNCTION 13486All SZGR 2.0 genes in this pathway
KEGG LONG TERM DEPRESSION 7053All SZGR 2.0 genes in this pathway
BIOCARTA CHREBP2 PATHWAY 4235All SZGR 2.0 genes in this pathway
WNT SIGNALING 8971All SZGR 2.0 genes in this pathway
PID ATR PATHWAY 3925All SZGR 2.0 genes in this pathway
PID PLK1 PATHWAY 4625All SZGR 2.0 genes in this pathway
PID ERBB1 DOWNSTREAM PATHWAY 10578All SZGR 2.0 genes in this pathway
PID PDGFRB PATHWAY 129103All SZGR 2.0 genes in this pathway
PID IL8 CXCR2 PATHWAY 3426All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY WNT 6541All SZGR 2.0 genes in this pathway
REACTOME SIGNALLING BY NGF 217167All SZGR 2.0 genes in this pathway
REACTOME CTNNB1 PHOSPHORYLATION CASCADE 1611All SZGR 2.0 genes in this pathway
REACTOME SPRY REGULATION OF FGF SIGNALING 149All SZGR 2.0 genes in this pathway
REACTOME TRIF MEDIATED TLR3 SIGNALING 7454All SZGR 2.0 genes in this pathway
REACTOME NEGATIVE REGULATION OF FGFR SIGNALING 3724All SZGR 2.0 genes in this pathway
REACTOME CELL CYCLE 421253All SZGR 2.0 genes in this pathway
REACTOME NGF SIGNALLING VIA TRKA FROM THE PLASMA MEMBRANE 137105All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY FGFR IN DISEASE 12788All SZGR 2.0 genes in this pathway
REACTOME NUCLEAR EVENTS KINASE AND TRANSCRIPTION FACTOR ACTIVATION 2420All SZGR 2.0 genes in this pathway
REACTOME ERKS ARE INACTIVATED 129All SZGR 2.0 genes in this pathway
REACTOME ERK MAPK TARGETS 2117All SZGR 2.0 genes in this pathway
REACTOME GLYCOLYSIS 2918All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY GPCR 920449All SZGR 2.0 genes in this pathway
REACTOME INTEGRATION OF ENERGY METABOLISM 12084All SZGR 2.0 genes in this pathway
REACTOME CELL CYCLE MITOTIC 325185All SZGR 2.0 genes in this pathway
REACTOME OPIOID SIGNALLING 7856All SZGR 2.0 genes in this pathway
REACTOME RECRUITMENT OF MITOTIC CENTROSOME PROTEINS AND COMPLEXES 6643All SZGR 2.0 genes in this pathway
REACTOME DARPP 32 EVENTS 2520All SZGR 2.0 genes in this pathway
REACTOME LOSS OF NLP FROM MITOTIC CENTROSOMES 5938All SZGR 2.0 genes in this pathway
REACTOME G1 PHASE 3823All SZGR 2.0 genes in this pathway
REACTOME G1 S TRANSITION 11263All SZGR 2.0 genes in this pathway
REACTOME COSTIMULATION BY THE CD28 FAMILY 6348All SZGR 2.0 genes in this pathway
REACTOME CTLA4 INHIBITORY SIGNALING 2115All SZGR 2.0 genes in this pathway
REACTOME METABOLISM OF MRNA 284128All SZGR 2.0 genes in this pathway
REACTOME METABOLISM OF RNA 330155All SZGR 2.0 genes in this pathway
REACTOME MITOTIC G1 G1 S PHASES 13779All SZGR 2.0 genes in this pathway
REACTOME MITOTIC M M G1 PHASES 17298All SZGR 2.0 genes in this pathway
REACTOME MAP KINASE ACTIVATION IN TLR CASCADE 5037All SZGR 2.0 genes in this pathway
REACTOME MAPK TARGETS NUCLEAR EVENTS MEDIATED BY MAP KINASES 3024All SZGR 2.0 genes in this pathway
REACTOME MITOTIC G2 G2 M PHASES 8150All SZGR 2.0 genes in this pathway
REACTOME PLATELET HOMEOSTASIS 7849All SZGR 2.0 genes in this pathway
REACTOME PLATELET SENSITIZATION BY LDL 169All SZGR 2.0 genes in this pathway
REACTOME TRAF6 MEDIATED INDUCTION OF NFKB AND MAP KINASES UPON TLR7 8 OR 9 ACTIVATION 7757All SZGR 2.0 genes in this pathway
REACTOME NFKB AND MAP KINASES ACTIVATION MEDIATED BY TLR4 SIGNALING REPERTOIRE 7253All SZGR 2.0 genes in this pathway
REACTOME INHIBITION OF REPLICATION INITIATION OF DAMAGED DNA BY RB1 E2F1 136All SZGR 2.0 genes in this pathway
REACTOME DNA REPLICATION 192110All SZGR 2.0 genes in this pathway
REACTOME E2F MEDIATED REGULATION OF DNA REPLICATION 3517All SZGR 2.0 genes in this pathway
REACTOME METABOLISM OF CARBOHYDRATES 247154All SZGR 2.0 genes in this pathway
REACTOME HEMOSTASIS 466331All SZGR 2.0 genes in this pathway
REACTOME MYD88 MAL CASCADE INITIATED ON PLASMA MEMBRANE 8363All SZGR 2.0 genes in this pathway
REACTOME INNATE IMMUNE SYSTEM 279178All SZGR 2.0 genes in this pathway
REACTOME MITOTIC PROMETAPHASE 8751All SZGR 2.0 genes in this pathway
REACTOME ACTIVATED TLR4 SIGNALLING 9369All SZGR 2.0 genes in this pathway
REACTOME IMMUNE SYSTEM 933616All SZGR 2.0 genes in this pathway
REACTOME TOLL RECEPTOR CASCADES 11884All SZGR 2.0 genes in this pathway
REACTOME GLUCOSE METABOLISM 6942All SZGR 2.0 genes in this pathway
REACTOME ADAPTIVE IMMUNE SYSTEM 539350All SZGR 2.0 genes in this pathway
REACTOME NONSENSE MEDIATED DECAY ENHANCED BY THE EXON JUNCTION COMPLEX 17657All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY FGFR 11280All SZGR 2.0 genes in this pathway
DIAZ CHRONIC MEYLOGENOUS LEUKEMIA UP 1382904All SZGR 2.0 genes in this pathway
ENK UV RESPONSE KERATINOCYTE UP 530342All SZGR 2.0 genes in this pathway
CREIGHTON AKT1 SIGNALING VIA MTOR DN 2316All SZGR 2.0 genes in this pathway
SCHLOSSER SERUM RESPONSE AUGMENTED BY MYC 10874All SZGR 2.0 genes in this pathway
MOHANKUMAR TLX1 TARGETS UP 414287All SZGR 2.0 genes in this pathway
GRUETZMANN PANCREATIC CANCER UP 358245All SZGR 2.0 genes in this pathway
LOPEZ MBD TARGETS 957597All SZGR 2.0 genes in this pathway
BENPORATH NANOG TARGETS 988594All SZGR 2.0 genes in this pathway
BENPORATH SOX2 TARGETS 734436All SZGR 2.0 genes in this pathway
KAUFFMANN DNA REPLICATION GENES 14787All SZGR 2.0 genes in this pathway
FLECHNER BIOPSY KIDNEY TRANSPLANT REJECTED VS OK DN 546351All SZGR 2.0 genes in this pathway
PEART HDAC PROLIFERATION CLUSTER DN 7657All SZGR 2.0 genes in this pathway
FLECHNER BIOPSY KIDNEY TRANSPLANT OK VS DONOR UP 555346All SZGR 2.0 genes in this pathway
JIANG AGING HYPOTHALAMUS DN 4031All SZGR 2.0 genes in this pathway
KIM GASTRIC CANCER CHEMOSENSITIVITY 10364All SZGR 2.0 genes in this pathway
DAZARD RESPONSE TO UV NHEK UP 244151All SZGR 2.0 genes in this pathway
DAZARD UV RESPONSE CLUSTER G4 2115All SZGR 2.0 genes in this pathway
ZHOU TNF SIGNALING 30MIN 5436All SZGR 2.0 genes in this pathway
ZAMORA NOS2 TARGETS DN 9671All SZGR 2.0 genes in this pathway
URS ADIPOCYTE DIFFERENTIATION DN 3020All SZGR 2.0 genes in this pathway
MARSON BOUND BY FOXP3 STIMULATED 1022619All SZGR 2.0 genes in this pathway
LEE METASTASIS AND ALTERNATIVE SPLICING UP 7451All SZGR 2.0 genes in this pathway
ZHANG BREAST CANCER PROGENITORS UP 425253All SZGR 2.0 genes in this pathway
GRADE METASTASIS DN 4531All SZGR 2.0 genes in this pathway
GRADE COLON CANCER UP 871505All SZGR 2.0 genes in this pathway
YOSHIMURA MAPK8 TARGETS UP 1305895All SZGR 2.0 genes in this pathway
HOSHIDA LIVER CANCER SUBCLASS S2 11574All SZGR 2.0 genes in this pathway
SASSON RESPONSE TO GONADOTROPHINS UP 9159All SZGR 2.0 genes in this pathway
SASSON RESPONSE TO FORSKOLIN UP 9058All SZGR 2.0 genes in this pathway
KIM ALL DISORDERS OLIGODENDROCYTE NUMBER CORR UP 756494All SZGR 2.0 genes in this pathway
KIM BIPOLAR DISORDER OLIGODENDROCYTE DENSITY CORR UP 682440All SZGR 2.0 genes in this pathway
KIM ALL DISORDERS CALB1 CORR UP 548370All SZGR 2.0 genes in this pathway
PILON KLF1 TARGETS DN 19721213All SZGR 2.0 genes in this pathway
PURBEY TARGETS OF CTBP1 NOT SATB1 DN 448282All SZGR 2.0 genes in this pathway

Section VI. microRNA annotation

miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-15/16/195/424/497290296m8hsa-miR-15abrainUAGCAGCACAUAAUGGUUUGUG
hsa-miR-16brainUAGCAGCACGUAAAUAUUGGCG
hsa-miR-15bbrainUAGCAGCACAUCAUGGUUUACA
hsa-miR-195SZUAGCAGCACAGAAAUAUUGGC
hsa-miR-424CAGCAGCAAUUCAUGUUUUGAA
hsa-miR-497CAGCAGCACACUGUGGUUUGU
miR-338171Ahsa-miR-338brainUCCAGCAUCAGUGAUUUUGUUGA