Gene Page: MYO5C

Summary ?
GeneID55930
SymbolMYO5C
Synonyms-
Descriptionmyosin VC
ReferenceMIM:610022|HGNC:HGNC:7604|Ensembl:ENSG00000128833|HPRD:11380|Vega:OTTHUMG00000172630
Gene typeprotein-coding
Map location15q21
Pascal p-value0.146
Sherlock p-value0.016
eGeneMyers' cis & trans

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
CV:PGCnpGenome-wide Association StudyGWAS
DMG:Wockner_2014Genome-wide DNA methylation analysisThis dataset includes 4641 differentially methylated probes corresponding to 2929 unique genes between schizophrenia patients (n=24) and controls (n=24). 1

Section I. Genetics and epigenetics annotation

@Differentially methylated gene

ProbeChromosomePositionNearest geneP (dis)Beta (dis)FDR (dis)Study
cg075676791552570612MIR1266;MYO5C2.621E-40.5610.038DMG:Wockner_2014

@eQTL annotation

SNP IDChromosomePositioneGeneGene Entrez IDpvalueqvalueTSS distanceeQTL type
rs17572651chr1218943612MYO5C559300.13trans
rs16829545chr2151977407MYO5C559305.986E-12trans
rs3845734chr2171125572MYO5C559300trans
rs7584986chr2184111432MYO5C559302.536E-7trans
rs2183142chr4159232695MYO5C559300.15trans
rs17762315chr576807576MYO5C559300trans
rs3118341chr925185518MYO5C559300.03trans
rs17176921chr1050580874MYO5C559300.15trans
rs2393316chr1059333070MYO5C559300.05trans
rs16955618chr1529937543MYO5C559302.293E-17trans
rs12914345chr1577670400MYO5C559300.17trans
rs1041786chr2122617710MYO5C559300trans
rs16986332chrX10958354MYO5C559300.04trans

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
GenePearson's Correlation Spearman's Correlation
C7orf570.980.45
SPATA180.980.45
YSK40.980.48
ARMC30.980.56
SPAG60.970.62
RGS220.970.53
CCDC1080.970.53
VWA3B0.970.50
ARMC40.970.46
TEKT10.970.44
Top 10 negatively co-expressed genes
GenePearson's Correlation Spearman's Correlation
IER5L-0.13-0.19
CIDEA-0.12-0.12
NDRG1-0.12-0.03
EMX1-0.11-0.20
SLC26A4-0.11-0.09
GPR22-0.10-0.15
GPR21-0.10-0.07
MPPED1-0.10-0.14
MEF2C-0.10-0.05
DUSP1-0.100.02

Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
KIM RESPONSE TO TSA AND DECITABINE UP 12973All SZGR 2.0 genes in this pathway
HUTTMANN B CLL POOR SURVIVAL UP 276187All SZGR 2.0 genes in this pathway
DIAZ CHRONIC MEYLOGENOUS LEUKEMIA DN 11679All SZGR 2.0 genes in this pathway
CHARAFE BREAST CANCER LUMINAL VS MESENCHYMAL UP 450256All SZGR 2.0 genes in this pathway
RHEIN ALL GLUCOCORTICOID THERAPY DN 362238All SZGR 2.0 genes in this pathway
MULLIGHAN MLL SIGNATURE 1 DN 242165All SZGR 2.0 genes in this pathway
MULLIGHAN MLL SIGNATURE 2 DN 281186All SZGR 2.0 genes in this pathway
JAATINEN HEMATOPOIETIC STEM CELL UP 316190All SZGR 2.0 genes in this pathway
GRAHAM CML DIVIDING VS NORMAL QUIESCENT DN 9557All SZGR 2.0 genes in this pathway
FARMER BREAST CANCER BASAL VS LULMINAL 330215All SZGR 2.0 genes in this pathway
AIYAR COBRA1 TARGETS DN 2918All SZGR 2.0 genes in this pathway
PATIL LIVER CANCER 747453All SZGR 2.0 genes in this pathway
LIEN BREAST CARCINOMA METAPLASTIC VS DUCTAL DN 11458All SZGR 2.0 genes in this pathway
YANG BREAST CANCER ESR1 BULK UP 2715All SZGR 2.0 genes in this pathway
ONDER CDH1 TARGETS 2 DN 464276All SZGR 2.0 genes in this pathway
ONDER CDH1 TARGETS 1 DN 169102All SZGR 2.0 genes in this pathway
ONDER CDH1 TARGETS 3 DN 5932All SZGR 2.0 genes in this pathway
LEE LIVER CANCER CIPROFIBRATE UP 6042All SZGR 2.0 genes in this pathway
IVANOVA HEMATOPOIESIS STEM CELL LONG TERM 302191All SZGR 2.0 genes in this pathway
BLALOCK ALZHEIMERS DISEASE UP 16911088All SZGR 2.0 genes in this pathway
ACEVEDO LIVER TUMOR VS NORMAL ADJACENT TISSUE UP 863514All SZGR 2.0 genes in this pathway
BOQUEST STEM CELL DN 216143All SZGR 2.0 genes in this pathway
HUPER BREAST BASAL VS LUMINAL DN 5944All SZGR 2.0 genes in this pathway
BEIER GLIOMA STEM CELL UP 3917All SZGR 2.0 genes in this pathway
ROSS LEUKEMIA WITH MLL FUSIONS 7849All SZGR 2.0 genes in this pathway
VANTVEER BREAST CANCER ESR1 UP 16799All SZGR 2.0 genes in this pathway
MEISSNER NPC HCP WITH H3 UNMETHYLATED 536296All SZGR 2.0 genes in this pathway
VALK AML CLUSTER 11 3624All SZGR 2.0 genes in this pathway
BOYAULT LIVER CANCER SUBCLASS G1 UP 11370All SZGR 2.0 genes in this pathway
MEISSNER BRAIN HCP WITH H3K4ME2 1711All SZGR 2.0 genes in this pathway
PYEON CANCER HEAD AND NECK VS CERVICAL UP 19395All SZGR 2.0 genes in this pathway
WONG ADULT TISSUE STEM MODULE 721492All SZGR 2.0 genes in this pathway
MIKKELSEN MEF HCP WITH H3K27ME3 590403All SZGR 2.0 genes in this pathway
VERHAAK GLIOBLASTOMA CLASSICAL 162122All SZGR 2.0 genes in this pathway
BRUINS UVC RESPONSE VIA TP53 GROUP A 898516All SZGR 2.0 genes in this pathway
BRUINS UVC RESPONSE LATE 1137655All SZGR 2.0 genes in this pathway
VANDESLUIS NORMAL EMBRYOS DN 2513All SZGR 2.0 genes in this pathway
RATTENBACHER BOUND BY CELF1 467251All SZGR 2.0 genes in this pathway
LIM MAMMARY STEM CELL DN 428246All SZGR 2.0 genes in this pathway