Gene Page: PRPSAP2
Summary ?
| GeneID | 5636 |
| Symbol | PRPSAP2 |
| Synonyms | PAP41 |
| Description | phosphoribosyl pyrophosphate synthetase-associated protein 2 |
| Reference | MIM:603762|HGNC:HGNC:9467|Ensembl:ENSG00000141127|HPRD:04789|Vega:OTTHUMG00000059406 |
| Gene type | protein-coding |
| Map location | 17p11.2-p12 |
| Pascal p-value | 0.002 |
| Sherlock p-value | 0.845 |
| Fetal beta | 1.973 |
| DMG | 1 (# studies) |
| eGene | Cerebellar Hemisphere Cerebellum Cortex Frontal Cortex BA9 Hippocampus Putamen basal ganglia Meta |
Gene in Data Sources
| Gene set name | Method of gene set | Description | Info |
|---|---|---|---|
| CV:PGCnp | Genome-wide Association Study | GWAS | |
| CV:PheWAS | Phenome-wide association studies (PheWAS) | 157 SNPs associated with schizophrenia | 1 |
| DMG:Jaffe_2016 | Genome-wide DNA methylation analysis | This dataset includes 2,104 probes/CpGs associated with SZ patients (n=108) compared to 136 controls at Bonferroni-adjusted P < 0.05. | 1 |
Section I. Genetics and epigenetics annotation
CV:PheWAS
| SNP ID | Chromosome | Position | Allele | P | Function | Gene | Up/Down Distance |
|---|---|---|---|---|---|---|---|
| rs4924935 | 17 | 18753870 | null | 1.506 | PRPSAP2 | null |
Differentially methylated gene
| Probe | Chromosome | Position | Nearest gene | P (dis) | Beta (dis) | FDR (dis) | Study |
|---|---|---|---|---|---|---|---|
| cg04747863 | 17 | 18761731 | PRPSAP2 | 7.39E-9 | -0.012 | 3.67E-6 | DMG:Jaffe_2016 |
eQTL annotation
| SNP ID | Chromosome | Position | eGene | Gene Entrez ID | pvalue | qvalue | TSS distance | eQTL type |
|---|---|---|---|---|---|---|---|---|
| rs7207570 | 17 | 18723995 | PRPSAP2 | ENSG00000141127.10 | 3.66E-6 | 0 | -19403 | gtex_brain_putamen_basal |
| rs58407466 | 17 | 18725266 | PRPSAP2 | ENSG00000141127.10 | 4.12E-6 | 0 | -18132 | gtex_brain_putamen_basal |
| rs28667787 | 17 | 18725527 | PRPSAP2 | ENSG00000141127.10 | 1.677E-6 | 0 | -17871 | gtex_brain_putamen_basal |
| rs138491805 | 17 | 18728325 | PRPSAP2 | ENSG00000141127.10 | 8.024E-7 | 0 | -15073 | gtex_brain_putamen_basal |
| rs35783872 | 17 | 18748820 | PRPSAP2 | ENSG00000141127.10 | 2.969E-7 | 0 | 5422 | gtex_brain_putamen_basal |
| rs7214585 | 17 | 18755300 | PRPSAP2 | ENSG00000141127.10 | 1.68E-6 | 0 | 11902 | gtex_brain_putamen_basal |
| rs4924936 | 17 | 18757213 | PRPSAP2 | ENSG00000141127.10 | 9.429E-7 | 0 | 13815 | gtex_brain_putamen_basal |
| rs7222187 | 17 | 18760826 | PRPSAP2 | ENSG00000141127.10 | 4.109E-7 | 0 | 17428 | gtex_brain_putamen_basal |
| rs8066636 | 17 | 18761109 | PRPSAP2 | ENSG00000141127.10 | 8.055E-8 | 0 | 17711 | gtex_brain_putamen_basal |
| rs59633160 | 17 | 18761396 | PRPSAP2 | ENSG00000141127.10 | 1.418E-7 | 0 | 17998 | gtex_brain_putamen_basal |
| rs11548434 | 17 | 18761508 | PRPSAP2 | ENSG00000141127.10 | 8.055E-8 | 0 | 18110 | gtex_brain_putamen_basal |
| rs28374894 | 17 | 18761659 | PRPSAP2 | ENSG00000141127.10 | 1.038E-7 | 0 | 18261 | gtex_brain_putamen_basal |
| rs28540773 | 17 | 18761754 | PRPSAP2 | ENSG00000141127.10 | 7.787E-8 | 0 | 18356 | gtex_brain_putamen_basal |
| rs8068683 | 17 | 18761827 | PRPSAP2 | ENSG00000141127.10 | 1.864E-7 | 0 | 18429 | gtex_brain_putamen_basal |
| rs397830161 | 17 | 18762169 | PRPSAP2 | ENSG00000141127.10 | 2.291E-6 | 0 | 18771 | gtex_brain_putamen_basal |
| rs8077111 | 17 | 18763260 | PRPSAP2 | ENSG00000141127.10 | 8.72E-7 | 0 | 19862 | gtex_brain_putamen_basal |
| rs1037037 | 17 | 18765021 | PRPSAP2 | ENSG00000141127.10 | 8.055E-8 | 0 | 21623 | gtex_brain_putamen_basal |
| rs8069826 | 17 | 18765490 | PRPSAP2 | ENSG00000141127.10 | 8.534E-7 | 0 | 22092 | gtex_brain_putamen_basal |
| rs57766245 | 17 | 18765779 | PRPSAP2 | ENSG00000141127.10 | 1.112E-7 | 0 | 22381 | gtex_brain_putamen_basal |
| rs72842306 | 17 | 18766115 | PRPSAP2 | ENSG00000141127.10 | 2.587E-7 | 0 | 22717 | gtex_brain_putamen_basal |
| rs9915343 | 17 | 18766494 | PRPSAP2 | ENSG00000141127.10 | 8.055E-8 | 0 | 23096 | gtex_brain_putamen_basal |
| rs12942794 | 17 | 18767217 | PRPSAP2 | ENSG00000141127.10 | 8.092E-8 | 0 | 23819 | gtex_brain_putamen_basal |
| rs7503663 | 17 | 18767446 | PRPSAP2 | ENSG00000141127.10 | 1.226E-7 | 0 | 24048 | gtex_brain_putamen_basal |
| rs12600851 | 17 | 18767518 | PRPSAP2 | ENSG00000141127.10 | 8.055E-8 | 0 | 24120 | gtex_brain_putamen_basal |
| rs3764443 | 17 | 18767756 | PRPSAP2 | ENSG00000141127.10 | 6.347E-7 | 0 | 24358 | gtex_brain_putamen_basal |
| rs3764445 | 17 | 18767923 | PRPSAP2 | ENSG00000141127.10 | 8.2E-8 | 0 | 24525 | gtex_brain_putamen_basal |
| rs3764447 | 17 | 18768372 | PRPSAP2 | ENSG00000141127.10 | 7.926E-8 | 0 | 24974 | gtex_brain_putamen_basal |
| rs3764448 | 17 | 18768437 | PRPSAP2 | ENSG00000141127.10 | 8.055E-8 | 0 | 25039 | gtex_brain_putamen_basal |
| rs9903574 | 17 | 18768582 | PRPSAP2 | ENSG00000141127.10 | 8.055E-8 | 0 | 25184 | gtex_brain_putamen_basal |
| rs2386404 | 17 | 18769349 | PRPSAP2 | ENSG00000141127.10 | 8.534E-7 | 0 | 25951 | gtex_brain_putamen_basal |
| rs2386403 | 17 | 18769600 | PRPSAP2 | ENSG00000141127.10 | 1.681E-6 | 0 | 26202 | gtex_brain_putamen_basal |
| rs6502672 | 17 | 18769750 | PRPSAP2 | ENSG00000141127.10 | 9.16E-7 | 0 | 26352 | gtex_brain_putamen_basal |
| rs11868500 | 17 | 18770254 | PRPSAP2 | ENSG00000141127.10 | 8.534E-7 | 0 | 26856 | gtex_brain_putamen_basal |
| rs12937933 | 17 | 18770283 | PRPSAP2 | ENSG00000141127.10 | 7.18E-8 | 0 | 26885 | gtex_brain_putamen_basal |
| rs11868520 | 17 | 18770367 | PRPSAP2 | ENSG00000141127.10 | 8.055E-8 | 0 | 26969 | gtex_brain_putamen_basal |
| rs2305064 | 17 | 18770733 | PRPSAP2 | ENSG00000141127.10 | 8.055E-8 | 0 | 27335 | gtex_brain_putamen_basal |
| rs9912713 | 17 | 18771145 | PRPSAP2 | ENSG00000141127.10 | 1.068E-6 | 0 | 27747 | gtex_brain_putamen_basal |
| rs2166182 | 17 | 18772059 | PRPSAP2 | ENSG00000141127.10 | 7.523E-7 | 0 | 28661 | gtex_brain_putamen_basal |
| rs4290526 | 17 | 18772967 | PRPSAP2 | ENSG00000141127.10 | 2.668E-7 | 0 | 29569 | gtex_brain_putamen_basal |
| rs34417974 | 17 | 18773636 | PRPSAP2 | ENSG00000141127.10 | 9.392E-8 | 0 | 30238 | gtex_brain_putamen_basal |
| rs9797255 | 17 | 18774097 | PRPSAP2 | ENSG00000141127.10 | 8.231E-8 | 0 | 30699 | gtex_brain_putamen_basal |
| rs7212905 | 17 | 18774271 | PRPSAP2 | ENSG00000141127.10 | 8.088E-8 | 0 | 30873 | gtex_brain_putamen_basal |
| rs7214754 | 17 | 18774603 | PRPSAP2 | ENSG00000141127.10 | 8.082E-8 | 0 | 31205 | gtex_brain_putamen_basal |
| rs6502673 | 17 | 18775322 | PRPSAP2 | ENSG00000141127.10 | 1.035E-7 | 0 | 31924 | gtex_brain_putamen_basal |
| rs4393623 | 17 | 18775900 | PRPSAP2 | ENSG00000141127.10 | 8.055E-8 | 0 | 32502 | gtex_brain_putamen_basal |
| rs7503678 | 17 | 18776020 | PRPSAP2 | ENSG00000141127.10 | 8.055E-8 | 0 | 32622 | gtex_brain_putamen_basal |
| rs10852854 | 17 | 18776390 | PRPSAP2 | ENSG00000141127.10 | 9.606E-8 | 0 | 32992 | gtex_brain_putamen_basal |
| rs146888042 | 17 | 18776572 | PRPSAP2 | ENSG00000141127.10 | 9.792E-8 | 0 | 33174 | gtex_brain_putamen_basal |
| rs12451220 | 17 | 18778421 | PRPSAP2 | ENSG00000141127.10 | 8.055E-8 | 0 | 35023 | gtex_brain_putamen_basal |
| rs12451200 | 17 | 18778493 | PRPSAP2 | ENSG00000141127.10 | 8.055E-8 | 0 | 35095 | gtex_brain_putamen_basal |
| rs7220661 | 17 | 18779130 | PRPSAP2 | ENSG00000141127.10 | 6.697E-8 | 0 | 35732 | gtex_brain_putamen_basal |
| rs12452289 | 17 | 18781809 | PRPSAP2 | ENSG00000141127.10 | 7.854E-8 | 0 | 38411 | gtex_brain_putamen_basal |
| rs12449821 | 17 | 18781948 | PRPSAP2 | ENSG00000141127.10 | 1.657E-7 | 0 | 38550 | gtex_brain_putamen_basal |
| rs35911764 | 17 | 18782582 | PRPSAP2 | ENSG00000141127.10 | 7.854E-8 | 0 | 39184 | gtex_brain_putamen_basal |
| rs112429999 | 17 | 18782865 | PRPSAP2 | ENSG00000141127.10 | 8.198E-8 | 0 | 39467 | gtex_brain_putamen_basal |
| rs79897963 | 17 | 18783047 | PRPSAP2 | ENSG00000141127.10 | 1.19E-7 | 0 | 39649 | gtex_brain_putamen_basal |
| rs75520042 | 17 | 18783052 | PRPSAP2 | ENSG00000141127.10 | 2.213E-7 | 0 | 39654 | gtex_brain_putamen_basal |
| rs72834996 | 17 | 18783059 | PRPSAP2 | ENSG00000141127.10 | 7.515E-8 | 0 | 39661 | gtex_brain_putamen_basal |
| rs11650163 | 17 | 18784404 | PRPSAP2 | ENSG00000141127.10 | 1.407E-6 | 0 | 41006 | gtex_brain_putamen_basal |
| rs68046274 | 17 | 18785126 | PRPSAP2 | ENSG00000141127.10 | 7.864E-8 | 0 | 41728 | gtex_brain_putamen_basal |
| rs2892016 | 17 | 18786776 | PRPSAP2 | ENSG00000141127.10 | 8.883E-8 | 0 | 43378 | gtex_brain_putamen_basal |
| rs2892015 | 17 | 18786849 | PRPSAP2 | ENSG00000141127.10 | 7.864E-8 | 0 | 43451 | gtex_brain_putamen_basal |
| rs4334348 | 17 | 18787004 | PRPSAP2 | ENSG00000141127.10 | 7.864E-8 | 0 | 43606 | gtex_brain_putamen_basal |
| rs4319824 | 17 | 18787418 | PRPSAP2 | ENSG00000141127.10 | 7.907E-8 | 0 | 44020 | gtex_brain_putamen_basal |
| rs9914914 | 17 | 18787780 | PRPSAP2 | ENSG00000141127.10 | 7.864E-8 | 0 | 44382 | gtex_brain_putamen_basal |
| rs7222748 | 17 | 18787976 | PRPSAP2 | ENSG00000141127.10 | 7.864E-8 | 0 | 44578 | gtex_brain_putamen_basal |
| rs4924938 | 17 | 18788559 | PRPSAP2 | ENSG00000141127.10 | 7.866E-8 | 0 | 45161 | gtex_brain_putamen_basal |
| rs12600722 | 17 | 18788987 | PRPSAP2 | ENSG00000141127.10 | 1.724E-7 | 0 | 45589 | gtex_brain_putamen_basal |
| rs9748173 | 17 | 18789671 | PRPSAP2 | ENSG00000141127.10 | 1.321E-7 | 0 | 46273 | gtex_brain_putamen_basal |
| rs9748183 | 17 | 18789724 | PRPSAP2 | ENSG00000141127.10 | 7.719E-8 | 0 | 46326 | gtex_brain_putamen_basal |
| rs8071147 | 17 | 18790678 | PRPSAP2 | ENSG00000141127.10 | 8.541E-8 | 0 | 47280 | gtex_brain_putamen_basal |
| rs8071458 | 17 | 18790840 | PRPSAP2 | ENSG00000141127.10 | 7.866E-8 | 0 | 47442 | gtex_brain_putamen_basal |
| rs9912568 | 17 | 18792719 | PRPSAP2 | ENSG00000141127.10 | 7.869E-8 | 0 | 49321 | gtex_brain_putamen_basal |
| rs3803835 | 17 | 18793061 | PRPSAP2 | ENSG00000141127.10 | 7.869E-8 | 0 | 49663 | gtex_brain_putamen_basal |
| rs3826380 | 17 | 18793225 | PRPSAP2 | ENSG00000141127.10 | 7.869E-8 | 0 | 49827 | gtex_brain_putamen_basal |
| rs11650153 | 17 | 18793573 | PRPSAP2 | ENSG00000141127.10 | 4.372E-8 | 0 | 50175 | gtex_brain_putamen_basal |
| rs9898426 | 17 | 18794071 | PRPSAP2 | ENSG00000141127.10 | 7.869E-8 | 0 | 50673 | gtex_brain_putamen_basal |
| rs71862188 | 17 | 18794107 | PRPSAP2 | ENSG00000141127.10 | 7.869E-8 | 0 | 50709 | gtex_brain_putamen_basal |
| rs4924774 | 17 | 18794920 | PRPSAP2 | ENSG00000141127.10 | 7.869E-8 | 0 | 51522 | gtex_brain_putamen_basal |
| rs9906799 | 17 | 18795317 | PRPSAP2 | ENSG00000141127.10 | 7.869E-8 | 0 | 51919 | gtex_brain_putamen_basal |
| rs8078993 | 17 | 18797126 | PRPSAP2 | ENSG00000141127.10 | 7.872E-8 | 0 | 53728 | gtex_brain_putamen_basal |
| rs57035178 | 17 | 18797767 | PRPSAP2 | ENSG00000141127.10 | 7.872E-8 | 0 | 54369 | gtex_brain_putamen_basal |
| rs4322727 | 17 | 18798573 | PRPSAP2 | ENSG00000141127.10 | 2.692E-6 | 0 | 55175 | gtex_brain_putamen_basal |
| rs7209853 | 17 | 18798600 | PRPSAP2 | ENSG00000141127.10 | 7.909E-8 | 0 | 55202 | gtex_brain_putamen_basal |
| rs4510081 | 17 | 18798846 | PRPSAP2 | ENSG00000141127.10 | 7.872E-8 | 0 | 55448 | gtex_brain_putamen_basal |
| rs4924940 | 17 | 18800092 | PRPSAP2 | ENSG00000141127.10 | 8.683E-8 | 0 | 56694 | gtex_brain_putamen_basal |
| rs8074020 | 17 | 18801380 | PRPSAP2 | ENSG00000141127.10 | 8.393E-7 | 0 | 57982 | gtex_brain_putamen_basal |
| rs8073436 | 17 | 18801841 | PRPSAP2 | ENSG00000141127.10 | 7.878E-8 | 0 | 58443 | gtex_brain_putamen_basal |
| rs6502676 | 17 | 18803459 | PRPSAP2 | ENSG00000141127.10 | 9.488E-8 | 0 | 60061 | gtex_brain_putamen_basal |
| rs11078422 | 17 | 18804413 | PRPSAP2 | ENSG00000141127.10 | 2.17E-7 | 0 | 61015 | gtex_brain_putamen_basal |
| rs7223173 | 17 | 18805887 | PRPSAP2 | ENSG00000141127.10 | 4.882E-7 | 0 | 62489 | gtex_brain_putamen_basal |
| rs4924943 | 17 | 18806025 | PRPSAP2 | ENSG00000141127.10 | 8.055E-8 | 0 | 62627 | gtex_brain_putamen_basal |
| rs8067882 | 17 | 18807131 | PRPSAP2 | ENSG00000141127.10 | 8.071E-8 | 0 | 63733 | gtex_brain_putamen_basal |
| rs8072860 | 17 | 18807884 | PRPSAP2 | ENSG00000141127.10 | 8.055E-8 | 0 | 64486 | gtex_brain_putamen_basal |
| rs8071783 | 17 | 18807939 | PRPSAP2 | ENSG00000141127.10 | 8.055E-8 | 0 | 64541 | gtex_brain_putamen_basal |
| rs8077775 | 17 | 18809543 | PRPSAP2 | ENSG00000141127.10 | 8.055E-8 | 0 | 66145 | gtex_brain_putamen_basal |
| rs4924944 | 17 | 18810002 | PRPSAP2 | ENSG00000141127.10 | 8.055E-8 | 0 | 66604 | gtex_brain_putamen_basal |
| rs7222893 | 17 | 18811702 | PRPSAP2 | ENSG00000141127.10 | 8.055E-8 | 0 | 68304 | gtex_brain_putamen_basal |
| rs35137608 | 17 | 18812102 | PRPSAP2 | ENSG00000141127.10 | 8.055E-8 | 0 | 68704 | gtex_brain_putamen_basal |
| rs4924945 | 17 | 18813160 | PRPSAP2 | ENSG00000141127.10 | 8.521E-7 | 0 | 69762 | gtex_brain_putamen_basal |
| rs9906795 | 17 | 18816740 | PRPSAP2 | ENSG00000141127.10 | 2.555E-6 | 0 | 73342 | gtex_brain_putamen_basal |
Section II. Transcriptome annotation
General gene expression (GTEx)
Gene expression during devlopment (BrainCloud)
Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.
Gene expression of temporal and spatial changes (BrainSpan)
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
No co-expressed genes in brain regions
Section V. Pathway annotation
| Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
|---|---|---|---|
| HOLLMANN APOPTOSIS VIA CD40 UP | 201 | 125 | All SZGR 2.0 genes in this pathway |
| CHEMNITZ RESPONSE TO PROSTAGLANDIN E2 DN | 391 | 222 | All SZGR 2.0 genes in this pathway |
| DIAZ CHRONIC MEYLOGENOUS LEUKEMIA UP | 1382 | 904 | All SZGR 2.0 genes in this pathway |
| BORCZUK MALIGNANT MESOTHELIOMA UP | 305 | 185 | All SZGR 2.0 genes in this pathway |
| OSMAN BLADDER CANCER DN | 406 | 230 | All SZGR 2.0 genes in this pathway |
| SCHLOSSER SERUM RESPONSE DN | 712 | 443 | All SZGR 2.0 genes in this pathway |
| PUJANA BRCA1 PCC NETWORK | 1652 | 1023 | All SZGR 2.0 genes in this pathway |
| PUJANA ATM PCC NETWORK | 1442 | 892 | All SZGR 2.0 genes in this pathway |
| PUJANA CHEK2 PCC NETWORK | 779 | 480 | All SZGR 2.0 genes in this pathway |
| FLECHNER BIOPSY KIDNEY TRANSPLANT REJECTED VS OK DN | 546 | 351 | All SZGR 2.0 genes in this pathway |
| STEARMAN LUNG CANCER EARLY VS LATE UP | 125 | 89 | All SZGR 2.0 genes in this pathway |
| YOSHIMURA MAPK8 TARGETS UP | 1305 | 895 | All SZGR 2.0 genes in this pathway |
| YAO TEMPORAL RESPONSE TO PROGESTERONE CLUSTER 13 | 172 | 107 | All SZGR 2.0 genes in this pathway |
| VERHAAK GLIOBLASTOMA NEURAL | 129 | 85 | All SZGR 2.0 genes in this pathway |