Gene Page: PTS

Summary
GeneID  5805
Symbol  PTS
Synonyms  FLJ97081|PTPS
Description  6-pyruvoyltetrahydropterin synthase
See related  HGNC:9689|MIM:261640|Ensembl:ENSG00000150787|HPRD:11840|
Locus tag  -
Gene type  protein-coding
Map location  11q22.3-q23.3
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
GSMA_Igenome scan meta-analysisPsr: 0.006 
GO_AnnotationMapping neuro-related keywords to Gene Ontology annotationsHits with neuro-related keywords: 1 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
GPR37L10.870.95
ACSBG10.870.93
GRIN2C0.850.91
PRODH0.850.94
FAM151A0.850.90
HEPN10.840.92
SELENBP10.840.92
SLC7A100.840.89
C16orf890.840.88
SLC25A180.830.93
Top 10 negatively co-expressed genes
C6orf168-0.70-0.79
MLLT11-0.69-0.82
SPATS2-0.69-0.83
DUSP12-0.68-0.84
ATXN10-0.68-0.76
PARP6-0.68-0.80
ASNSD1-0.68-0.83
FARSB-0.67-0.73
RAE1-0.67-0.79
POLR3C-0.67-0.81
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:00038746-pyruvoyltetrahydropterin synthase activityTAS3308682 
GO:0016829lyase activityIEA-
GO:0008270zinc ion bindingIEA-
GO:0042802identical protein bindingIPI16169070 
GO:0046872metal ion bindingIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0007417central nervous system developmentTASBrain (GO term level: 6)3308682 
GO:0006520amino acid metabolic processTAS3308682 
GO:0006729tetrahydrobiopterin biosynthetic processTAS3308682 
GO:0006559L-phenylalanine catabolic processIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005737cytoplasmIDA11256614 
GO:0005739mitochondrionIDA11256614 
 
InteractionsShown by Network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
ATMAT1 | ATA | ATC | ATD | ATDC | ATE | DKFZp781A0353 | MGC74674 | TEL1 | TELO1ataxia telangiectasia mutatedProtein-peptideBioGRID10608806 
ATRFRP1 | MEC1 | SCKL | SCKL1ataxia telangiectasia and Rad3 relatedProtein-peptideBioGRID10608806 
FNDC5FRCP2fibronectin type III domain containing 5-HPRD11591653 
PBRM1BAF180 | MGC156155 | MGC156156 | PB1polybromo 1-HPRD11591653 
PRKDCDNA-PKcs | DNAPK | DNPK1 | HYRC | HYRC1 | XRCC7 | p350protein kinase, DNA-activated, catalytic polypeptideProtein-peptideBioGRID10608806 
PTSFLJ97081 | PTPS6-pyruvoyltetrahydropterin synthaseAffinity Capture-Western
Two-hybrid		BioGRID16169070 |16189514 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
KEGG_FOLATE_BIOSYNTHESIS 1110All SZGR genes in this pathway
REACTOME_TETRAHYDROBIOPTERIN_BH4_SYNTHESIS_RECYCLING_SALVAGE_AND_REGULATION 139All SZGR genes in this pathway
REACTOME_ENOS_ACTIVATION_AND_REGULATION 2014All SZGR genes in this pathway
FULCHER_INFLAMMATORY_RESPONSE_LECTIN_VS_LPS_UP 579346All SZGR genes in this pathway
WANG_LMO4_TARGETS_DN 352225All SZGR genes in this pathway
DITTMER_PTHLH_TARGETS_UP 11268All SZGR genes in this pathway
TIEN_INTESTINE_PROBIOTICS_6HR_DN 167100All SZGR genes in this pathway
TIEN_INTESTINE_PROBIOTICS_24HR_UP 557331All SZGR genes in this pathway
GRAESSMANN_APOPTOSIS_BY_DOXORUBICIN_DN 17811082All SZGR genes in this pathway
OUELLET_OVARIAN_CANCER_INVASIVE_VS_LMP_UP 11785All SZGR genes in this pathway
BERENJENO_TRANSFORMED_BY_RHOA_DN 394258All SZGR genes in this pathway
LASTOWSKA_NEUROBLASTOMA_COPY_NUMBER_DN 800473All SZGR genes in this pathway
WEI_MYCN_TARGETS_WITH_E_BOX 795478All SZGR genes in this pathway
SCHAEFFER_PROSTATE_DEVELOPMENT_48HR_UP 487286All SZGR genes in this pathway
BENPORATH_PROLIFERATION 14780All SZGR genes in this pathway
GEORGES_TARGETS_OF_MIR192_AND_MIR215 893528All SZGR genes in this pathway
BROWNE_HCMV_INFECTION_16HR_UP 225139All SZGR genes in this pathway
BLALOCK_ALZHEIMERS_DISEASE_DN 1237837All SZGR genes in this pathway
DOUGLAS_BMI1_TARGETS_UP 566371All SZGR genes in this pathway
DURCHDEWALD_SKIN_CARCINOGENESIS_UP 8847All SZGR genes in this pathway
LABBE_WNT3A_TARGETS_DN 9753All SZGR genes in this pathway
BRUECKNER_TARGETS_OF_MIRLET7A3_UP 11169All SZGR genes in this pathway
HOSHIDA_LIVER_CANCER_SUBCLASS_S3 266180All SZGR genes in this pathway
CAIRO_HEPATOBLASTOMA_DN 267160All SZGR genes in this pathway
KIM_ALL_DISORDERS_OLIGODENDROCYTE_NUMBER_CORR_UP 756494All SZGR genes in this pathway
KIM_BIPOLAR_DISORDER_OLIGODENDROCYTE_DENSITY_CORR_UP 682440All SZGR genes in this pathway
PILON_KLF1_TARGETS_DN 19721213All SZGR genes in this pathway
WAKABAYASHI_ADIPOGENESIS_PPARG_BOUND_8D 658397All SZGR genes in this pathway
FORTSCHEGGER_PHF8_TARGETS_DN 784464All SZGR genes in this pathway


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