Summary ?
GeneID5868
SymbolRAB5A
SynonymsRAB5
DescriptionRAB5A, member RAS oncogene family
ReferenceMIM:179512|HGNC:HGNC:9783|Ensembl:ENSG00000144566|HPRD:01542|Vega:OTTHUMG00000129889
Gene typeprotein-coding
Map location3p24.3
Pascal p-value0.027
Sherlock p-value0.248
SupportINTRACELLULAR TRAFFICKING
G2Cdb.human_BAYES-COLLINS-HUMAN-PSD-FULL
G2Cdb.humanPSD
G2Cdb.humanPSP

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
CV:PGCnpGenome-wide Association StudyGWAS
GSMA_IGenome scan meta-analysisPsr: 0.006 
NetworkShortest path distance of core genes in the Human protein-protein interaction networkContribution to shortest path in PPI network: 0.012 

Section I. Genetics and epigenetics annotation


Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
GenePearson's Correlation Spearman's Correlation
MAST20.950.93
ANKRD13B0.930.94
ZNF4460.930.94
AC145098.20.930.93
KIAA16020.930.93
SMPD40.930.95
GPR1730.930.92
CCDC1200.920.91
PPRC10.920.92
KIAA0895L0.920.93
Top 10 negatively co-expressed genes
GenePearson's Correlation Spearman's Correlation
AF347015.31-0.72-0.83
AF347015.27-0.71-0.82
C5orf53-0.70-0.73
MT-CO2-0.69-0.82
COPZ2-0.67-0.75
AF347015.33-0.67-0.77
AF347015.8-0.66-0.81
IFI27-0.66-0.75
MT-CYB-0.66-0.78
S100B-0.66-0.74

Section III. Gene Ontology annotation

Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0000166nucleotide bindingIEA-
GO:0003924GTPase activityTAS2501306 
GO:0005515protein bindingIPI9697774 |15016378 
GO:0005515protein bindingNAS14613930 
GO:0005525GTP bindingIEA-
GO:0019001guanyl nucleotide bindingIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0007264small GTPase mediated signal transductionIEA-
GO:0006897endocytosisTAS8521472 
GO:0015031protein transportIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0001726ruffleIEA-
GO:0005886plasma membraneIEA-
GO:0030139endocytic vesicleIEA-
GO:0042470melanosomeIEA-
GO:0031901early endosome membraneIEA-
GO:0045121membrane raftIEA-

Section IV. Protein-protein interaction annotation

InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
AGTR1AG2S | AGTR1A | AGTR1B | AT1 | AT1B | AT1R | AT2R1 | AT2R1A | AT2R1B | HAT1Rangiotensin II receptor, type 1-HPRD,BioGRID11682489 
ALS2CLDKFZp686P238 | MGC129698 | RN49018ALS2 C-terminal like-HPRD,BioGRID15388334 
AP1G1ADTG | CLAPG1 | MGC18255adaptor-related protein complex 1, gamma 1 subunitTwo-hybridBioGRID14665628 
AP1G2G2ADadaptor-related protein complex 1, gamma 2 subunitTwo-hybridBioGRID14665628 
CHMDXS540 | FLJ38564 | GGTA | HSD-32 | MGC102710 | REP-1 | TCDchoroideremia (Rab escort protein 1)Reconstituted ComplexBioGRID8294464 
CHMLFLJ10071 | FLJ13361 | REP2choroideremia-like (Rab escort protein 2)-HPRD,BioGRID8294464 |9730828 
EEA1MST105 | MSTP105 | ZFYVE2early endosome antigen 1Rab5 interacts with EEA.1.BIND15782196 
EEA1MST105 | MSTP105 | ZFYVE2early endosome antigen 1-HPRD10491193 |14600265 
EEA1MST105 | MSTP105 | ZFYVE2early endosome antigen 1FRET
Reconstituted Complex
Two-hybrid
BioGRID11493665 |11718716 
|14600265 
GDI2FLJ16452 | FLJ37352 | RABGDIBGDP dissociation inhibitor 2-HPRD,BioGRID10512627 
GGA1-golgi associated, gamma adaptin ear containing, ARF binding protein 1Two-hybridBioGRID14665628 
GGA2FLJ20966 | KIAA1080 | VEARgolgi associated, gamma adaptin ear containing, ARF binding protein 2Two-hybridBioGRID14665628 
GGA3KIAA0154golgi associated, gamma adaptin ear containing, ARF binding protein 3Two-hybridBioGRID14665628 
KIF3BHH0048 | KIAA0359kinesin family member 3BAffinity Capture-WesternBioGRID12832475 
RAB37FLJ30284 | FLJ32507RAB37, member RAS oncogene family-HPRD,BioGRID10722846 
RAB4AHRES-1/RAB4 | RAB4RAB4A, member RAS oncogene familyCo-purificationBioGRID9524117 
RAB5ARAB5RAB5A, member RAS oncogene familyRab5 interacts with a second Rab5 molecule.BIND15782196 
RAB7AFLJ20819 | PRO2706 | RAB7RAB7A, member RAS oncogene familyTwo-hybridBioGRID10329441 
RABAC1PRA1 | PRAF1 | YIP3Rab acceptor 1 (prenylated)-HPRD10329441 
RABEP1RAB5EP | RABPT5rabaptin, RAB GTPase binding effector protein 1Co-purification
Reconstituted Complex
Two-hybrid
BioGRID8521472 |9045618 
|9524117 |11718716 
RABEP1RAB5EP | RABPT5rabaptin, RAB GTPase binding effector protein 1-HPRD8521472|9045618 
RASA1CM-AVM | CMAVM | DKFZp434N071 | GAP | PKWS | RASA | RASGAP | p120GAP | p120RASGAPRAS p21 protein activator (GTPase activating protein) 1-HPRD11536198 
RIN1-Ras and Rab interactor 1-HPRD,BioGRID11703925 
RIN2RASSF4Ras and Rab interactor 2-HPRD12972505 
RIN2RASSF4Ras and Rab interactor 2Two-hybridBioGRID11733506 
RIN3DKFZp762H1613 | FLJ11700 | FLJ22439Ras and Rab interactor 3Two-hybridBioGRID12972505 
RIT2RIBA | RIN | ROC2Ras-like without CAAX 2Biochemical ActivityBioGRID11703925 
SDCBPMDA-9 | ST1 | SYCL | TACIP18syndecan binding protein (syntenin)Affinity Capture-Western
Two-hybrid
BioGRID15014045 
STX4STX4A | p35-2syntaxin 4-HPRD,BioGRID11884531 
TBC1D3TBC1D3A | TRE17TBC1 domain family, member 3-HPRD12612085 
TBC1D3CFLJ78248 | MGC44903TBC1 domain family, member 3C-HPRD12359748 
TSC2FLJ43106 | LAM | TSC4tuberous sclerosis 2-HPRD9045618 
TSC2FLJ43106 | LAM | TSC4tuberous sclerosis 2Co-purificationBioGRID12147258 
VPS45H1 | H1VPS45 | VPS45A | VPS45B | VPS54A | VSP45 | VSP45Avacuolar protein sorting 45 homolog (S. cerevisiae)Affinity Capture-MSBioGRID11062261 
ZFYVE20FLJ34993 | MGC126210 | Rabenosyn-5zinc finger, FYVE domain containing 20-HPRD,BioGRID11062261 


Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
KEGG ENDOCYTOSIS 183132All SZGR 2.0 genes in this pathway
KEGG VASOPRESSIN REGULATED WATER REABSORPTION 4430All SZGR 2.0 genes in this pathway
KEGG AMYOTROPHIC LATERAL SCLEROSIS ALS 5343All SZGR 2.0 genes in this pathway
BIOCARTA PTDINS PATHWAY 2316All SZGR 2.0 genes in this pathway
BIOCARTA RAB PATHWAY 128All SZGR 2.0 genes in this pathway
PID MET PATHWAY 8060All SZGR 2.0 genes in this pathway
PID AJDISS 2PATHWAY 4838All SZGR 2.0 genes in this pathway
PID ERBB1 DOWNSTREAM PATHWAY 10578All SZGR 2.0 genes in this pathway
PID PDGFRB PATHWAY 129103All SZGR 2.0 genes in this pathway
PID IL8 CXCR2 PATHWAY 3426All SZGR 2.0 genes in this pathway
PID ERBB1 INTERNALIZATION PATHWAY 4135All SZGR 2.0 genes in this pathway
PID P38 ALPHA BETA DOWNSTREAM PATHWAY 3829All SZGR 2.0 genes in this pathway
PID IL8 CXCR1 PATHWAY 2819All SZGR 2.0 genes in this pathway
REACTOME FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION 132101All SZGR 2.0 genes in this pathway
REACTOME HEMOSTASIS 466331All SZGR 2.0 genes in this pathway
THUM SYSTOLIC HEART FAILURE UP 423283All SZGR 2.0 genes in this pathway
SENESE HDAC2 TARGETS UP 11466All SZGR 2.0 genes in this pathway
ENK UV RESPONSE EPIDERMIS DN 508354All SZGR 2.0 genes in this pathway
ENK UV RESPONSE KERATINOCYTE UP 530342All SZGR 2.0 genes in this pathway
LASTOWSKA NEUROBLASTOMA COPY NUMBER DN 800473All SZGR 2.0 genes in this pathway
SCHLOSSER SERUM RESPONSE DN 712443All SZGR 2.0 genes in this pathway
BUYTAERT PHOTODYNAMIC THERAPY STRESS UP 811508All SZGR 2.0 genes in this pathway
CAFFAREL RESPONSE TO THC UP 3320All SZGR 2.0 genes in this pathway
CAFFAREL RESPONSE TO THC 24HR 5 UP 3423All SZGR 2.0 genes in this pathway
BENPORATH NANOG TARGETS 988594All SZGR 2.0 genes in this pathway
BENPORATH OCT4 TARGETS 290172All SZGR 2.0 genes in this pathway
BENPORATH SOX2 TARGETS 734436All SZGR 2.0 genes in this pathway
BENPORATH NOS TARGETS 179105All SZGR 2.0 genes in this pathway
PENG GLUCOSE DEPRIVATION DN 169112All SZGR 2.0 genes in this pathway
BROWNE HCMV INFECTION 20HR UP 240152All SZGR 2.0 genes in this pathway
BROWNE HCMV INFECTION 16HR UP 225139All SZGR 2.0 genes in this pathway
DEBIASI APOPTOSIS BY REOVIRUS INFECTION UP 314201All SZGR 2.0 genes in this pathway
LU AGING BRAIN DN 153120All SZGR 2.0 genes in this pathway
BROWNE HCMV INFECTION 8HR UP 10573All SZGR 2.0 genes in this pathway
YIH RESPONSE TO ARSENITE C2 1815All SZGR 2.0 genes in this pathway
MARTINEZ RESPONSE TO TRABECTEDIN DN 271175All SZGR 2.0 genes in this pathway
ACEVEDO NORMAL TISSUE ADJACENT TO LIVER TUMOR DN 354216All SZGR 2.0 genes in this pathway
BLUM RESPONSE TO SALIRASIB UP 245159All SZGR 2.0 genes in this pathway
LINDSTEDT DENDRITIC CELL MATURATION A 6752All SZGR 2.0 genes in this pathway
MILI PSEUDOPODIA HAPTOTAXIS UP 518299All SZGR 2.0 genes in this pathway
ROME INSULIN TARGETS IN MUSCLE UP 442263All SZGR 2.0 genes in this pathway
SASSON RESPONSE TO GONADOTROPHINS UP 9159All SZGR 2.0 genes in this pathway
SASSON RESPONSE TO FORSKOLIN DN 8868All SZGR 2.0 genes in this pathway
PILON KLF1 TARGETS DN 19721213All SZGR 2.0 genes in this pathway
AZARE NEOPLASTIC TRANSFORMATION BY STAT3 UP 12170All SZGR 2.0 genes in this pathway

Section VI. microRNA annotation

miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-1018848911A,m8hsa-miR-101UACAGUACUGUGAUAACUGAAG
miR-130/301116211691A,m8hsa-miR-130abrainCAGUGCAAUGUUAAAAGGGCAU
hsa-miR-301CAGUGCAAUAGUAUUGUCAAAGC
hsa-miR-130bbrainCAGUGCAAUGAUGAAAGGGCAU
hsa-miR-454-3pUAGUGCAAUAUUGCUUAUAGGGUUU
hsa-miR-130abrainCAGUGCAAUGUUAAAAGGGCAU
hsa-miR-301CAGUGCAAUAGUAUUGUCAAAGC
hsa-miR-130bbrainCAGUGCAAUGAUGAAAGGGCAU
hsa-miR-454-3pUAGUGCAAUAUUGCUUAUAGGGUUU
miR-1448858911Ahsa-miR-144UACAGUAUAGAUGAUGUACUAG