Gene Page: REL

Summary ?
GeneID5966
SymbolREL
SynonymsC-Rel
Descriptionv-rel avian reticuloendotheliosis viral oncogene homolog
ReferenceMIM:164910|HGNC:HGNC:9954|HPRD:01286|
Gene typeprotein-coding
Map location2p13-p12
Pascal p-value0.434
Fetal beta0.308

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
CV:GWASdbGenome-wide Association StudiesGWASdb records for schizophrenia
CV:PGCnpGenome-wide Association StudyGWAS
CV:PheWASPhenome-wide association studies (PheWAS)157 SNPs associated with schizophrenia 3
PMID:cooccurHigh-throughput literature-searchSystematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
LiteratureHigh-throughput literature-searchCo-occurance with Schizophrenia keywords: schizophrenia,schizophrenic,schizophreniasClick to show details
NetworkShortest path distance of core genes in the Human protein-protein interaction networkContribution to shortest path in PPI network: 0.0024 

Section I. Genetics and epigenetics annotation

@CV:PheWAS

SNP IDChromosomePositionAllelePFunctionGeneUp/Down Distance
rs702873260935046null0.5759RELnull
rs13031237261136129null0.6549RELnull
rs13017599261164331null0.6607RELnull


Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
GenePearson's Correlation Spearman's Correlation
TTC39A0.910.61
NTNG10.900.55
RGS160.900.63
CHRNA30.880.49
PTPN30.860.36
FAM19A40.860.41
GRID2IP0.860.34
GALM0.850.57
SLC17A60.850.46
SUSD20.840.29
Top 10 negatively co-expressed genes
GenePearson's Correlation Spearman's Correlation
SLC26A4-0.25-0.18
TMOD1-0.24-0.13
GPR22-0.23-0.24
FAM81A-0.23-0.13
GPM6A-0.23-0.21
MEF2C-0.22-0.18
DPP4-0.22-0.18
IER5L-0.22-0.13
MPPED1-0.21-0.17
EMID1-0.21-0.23

Section III. Gene Ontology annotation

Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0003700transcription factor activityIEA-
GO:0003700transcription factor activityNAS8423996 
GO:0005515protein bindingIPI10498867 |15799966 
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0001816cytokine productionIEA-
GO:0006355regulation of transcription, DNA-dependentIEA-
GO:0043123positive regulation of I-kappaB kinase/NF-kappaB cascadeIEP12761501 
GO:0045893positive regulation of transcription, DNA-dependentIEA-
GO:0045084positive regulation of interleukin-12 biosynthetic processIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005634nucleusIEA-

Section IV. Protein-protein interaction annotation

InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
CCNE1CCNEcyclin E1-HPRD9731206 
CDK2p33(CDK2)cyclin-dependent kinase 2Affinity Capture-WesternBioGRID9731206 
ELF1-E74-like factor 1 (ets domain transcription factor)Reconstituted ComplexBioGRID7862168 
GTF2BTF2B | TFIIBgeneral transcription factor IIBReconstituted ComplexBioGRID8413269 
HSPA8HSC54 | HSC70 | HSC71 | HSP71 | HSP73 | HSPA10 | LAP1 | MGC131511 | MGC29929 | NIP71heat shock 70kDa protein 8-HPRD2155506 
MAP3K8COT | EST | ESTF | FLJ10486 | TPL2 | Tpl-2 | c-COTmitogen-activated protein kinase kinase kinase 8Affinity Capture-MSBioGRID14743216 
MAPK8JNK | JNK1 | JNK1A2 | JNK21B1/2 | PRKM8 | SAPK1mitogen-activated protein kinase 8-HPRD,BioGRID8621542 
MTPNFLJ31098 | FLJ99857 | GCDP | V-1myotrophinAffinity Capture-Western
Reconstituted Complex		BioGRID11971907 
NFKB1DKFZp686C01211 | EBP-1 | KBF1 | MGC54151 | NF-kappa-B | NFKB-p105 | NFKB-p50 | p105nuclear factor of kappa light polypeptide gene enhancer in B-cells 1Affinity Capture-MSBioGRID14743216 
NFKB2LYT-10 | LYT10nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)-HPRD,BioGRID8413211 
NFKBIAIKBA | MAD-3 | NFKBInuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alphaAffinity Capture-WesternBioGRID10706725 
NFKBIBIKBB | TRIP9nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, betaAffinity Capture-WesternBioGRID10706725 
NFKBIEIKBEnuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilonAffinity Capture-Western
Reconstituted Complex		BioGRID8415639 |9315679 
|10706725 
NFKBIEIKBEnuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon-HPRD8139561 |8415639 
|10706725 
NKRFITBA4 | NRFNFKB repressing factorReconstituted ComplexBioGRID10562553 
PAPOLAMGC5378 | PAPpoly(A) polymerase alphaAffinity Capture-MSBioGRID14743216 
PPP4CPP4 | PPH3 | PPXprotein phosphatase 4 (formerly X), catalytic subunit-HPRD,BioGRID9837938 
RELAMGC131774 | NFKB3 | p65v-rel reticuloendotheliosis viral oncogene homolog A (avian)-HPRD7886940 |11967310 
RELAMGC131774 | NFKB3 | p65v-rel reticuloendotheliosis viral oncogene homolog A (avian)Affinity Capture-MS
Affinity Capture-Western
Reconstituted Complex
Two-hybrid		BioGRID8139561 |11967310 
|14743216 
SP1-Sp1 transcription factor-HPRD,BioGRID7933095 
SRFMCM1serum response factor (c-fos serum response element-binding transcription factor)Reconstituted ComplexBioGRID8670842 
TBK1FLJ11330 | NAK | T2KTANK-binding kinase 1Affinity Capture-MSBioGRID14743216 
TBPGTF2D | GTF2D1 | MGC117320 | MGC126054 | MGC126055 | SCA17 | TFIIDTATA box binding protein-HPRD,BioGRID8413269 
TNIP2ABIN-2 | ABIN2 | FLIP1 | KLIP | MGC4289TNFAIP3 interacting protein 2Affinity Capture-MSBioGRID14743216 


Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
PID NFKAPPAB ATYPICAL PATHWAY 1715All SZGR 2.0 genes in this pathway
PID AR TF PATHWAY 5338All SZGR 2.0 genes in this pathway
REACTOME DOWNSTREAM SIGNALING EVENTS OF B CELL RECEPTOR BCR 9766All SZGR 2.0 genes in this pathway
REACTOME ACTIVATION OF NF KAPPAB IN B CELLS 6443All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY THE B CELL RECEPTOR BCR 12690All SZGR 2.0 genes in this pathway
REACTOME IMMUNE SYSTEM 933616All SZGR 2.0 genes in this pathway
REACTOME ADAPTIVE IMMUNE SYSTEM 539350All SZGR 2.0 genes in this pathway
PICCALUGA ANGIOIMMUNOBLASTIC LYMPHOMA DN 13686All SZGR 2.0 genes in this pathway
FULCHER INFLAMMATORY RESPONSE LECTIN VS LPS UP 579346All SZGR 2.0 genes in this pathway
ZHOU INFLAMMATORY RESPONSE LIVE UP 485293All SZGR 2.0 genes in this pathway
ZHOU INFLAMMATORY RESPONSE FIMA UP 544308All SZGR 2.0 genes in this pathway
ZHOU INFLAMMATORY RESPONSE LPS UP 431237All SZGR 2.0 genes in this pathway
NAGASHIMA NRG1 SIGNALING UP 176123All SZGR 2.0 genes in this pathway
CHASSOT SKIN WOUND 109All SZGR 2.0 genes in this pathway
GILMORE CORE NFKB PATHWAY 1410All SZGR 2.0 genes in this pathway
PUJANA BRCA1 PCC NETWORK 16521023All SZGR 2.0 genes in this pathway
PUJANA ATM PCC NETWORK 1442892All SZGR 2.0 genes in this pathway
SHIN B CELL LYMPHOMA CLUSTER 9 1913All SZGR 2.0 genes in this pathway
TARTE PLASMA CELL VS B LYMPHOCYTE DN 3825All SZGR 2.0 genes in this pathway
OKUMURA INFLAMMATORY RESPONSE LPS 183115All SZGR 2.0 genes in this pathway
IIZUKA LIVER CANCER EARLY RECURRENCE 1110All SZGR 2.0 genes in this pathway
HOFMANN CELL LYMPHOMA UP 5035All SZGR 2.0 genes in this pathway
MOREAUX MULTIPLE MYELOMA BY TACI UP 412249All SZGR 2.0 genes in this pathway
XU RESPONSE TO TRETINOIN UP 1610All SZGR 2.0 genes in this pathway
BROWNE HCMV INFECTION 20HR UP 240152All SZGR 2.0 genes in this pathway
BROWNE HCMV INFECTION 16HR UP 225139All SZGR 2.0 genes in this pathway
RAMASWAMY METASTASIS DN 6147All SZGR 2.0 genes in this pathway
WEIGEL OXIDATIVE STRESS BY HNE AND TBH 6042All SZGR 2.0 genes in this pathway
BROWNE HCMV INFECTION 12HR UP 11168All SZGR 2.0 genes in this pathway
XU GH1 AUTOCRINE TARGETS DN 14294All SZGR 2.0 genes in this pathway
MARSON BOUND BY FOXP3 STIMULATED 1022619All SZGR 2.0 genes in this pathway
FOSTER TOLERANT MACROPHAGE DN 409268All SZGR 2.0 genes in this pathway
HELLER SILENCED BY METHYLATION UP 282183All SZGR 2.0 genes in this pathway
BOQUEST STEM CELL CULTURED VS FRESH UP 425298All SZGR 2.0 genes in this pathway
GRESHOCK CANCER COPY NUMBER UP 323240All SZGR 2.0 genes in this pathway
SEKI INFLAMMATORY RESPONSE LPS UP 7756All SZGR 2.0 genes in this pathway
LINDSTEDT DENDRITIC CELL MATURATION B 5336All SZGR 2.0 genes in this pathway
SHEDDEN LUNG CANCER GOOD SURVIVAL A4 196124All SZGR 2.0 genes in this pathway
ZHAN EARLY DIFFERENTIATION GENES DN 4229All SZGR 2.0 genes in this pathway
YAGI AML WITH T 8 21 TRANSLOCATION 368247All SZGR 2.0 genes in this pathway
TIAN TNF SIGNALING VIA NFKB 2821All SZGR 2.0 genes in this pathway
PHONG TNF TARGETS UP 6343All SZGR 2.0 genes in this pathway
PHONG TNF RESPONSE VIA P38 PARTIAL 160106All SZGR 2.0 genes in this pathway
RAO BOUND BY SALL4 ISOFORM B 517302All SZGR 2.0 genes in this pathway
ZWANG TRANSIENTLY UP BY 1ST EGF PULSE ONLY 1839928All SZGR 2.0 genes in this pathway