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Association Linkage Expression Literature GO_Annotation Gene Network miRNA Targets

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Association Linkage Expression Literature GO_Annotation Gene Network miRNA Targets Datasets Gene Ranking

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Gene Page: BCR

Summary

GeneID

613

Symbol

BCR

Synonyms

ALL|BCR-ABL1|BCR1|CML|D22S11|D22S662|FLJ16453|PHL

Description

breakpoint cluster region

Locus tag

Gene type

protein-coding

Map location

22q11|22q11.23

Gene in Data Sources

Gene set name

Method of gene set

Evidence

Info

GSMA_I

genome scan meta-analysis

Psr: 0.031

GO_Annotation

Mapping neuro-related keywords to Gene Ontology annotations

Hits with neuro-related keywords: 1

Network

Shortest path distance of core genes in the Human protein-protein interaction network

Contribution to shortest path in PPI network: 0.1296

General Gene Expression (microarray) ?

Gene Expression in Brain Regions (new)

Top co-expressed genes in Brain Regions (new)

Gene

Pearson's Correlation

Spearman's Correlation

Top 10 positively co-expressed genes

Top 10 negatively co-expressed genes

Gene Ontology

Molecular function

GO term

Evidence

Neuro keywords

PubMed ID

GO:0005089

Rho guanyl-nucleotide exchange factor activity

IEA

GO:0005085

guanyl-nucleotide exchange factor activity

IEA

GO:0005096

GTPase activator activity

NAS

GO:0005096

GTPase activator activity

TAS

1903516

GO:0004674

protein serine/threonine kinase activity

NAS

GO:0004674

protein serine/threonine kinase activity

TAS

1657398

GO:0016740

transferase activity

IEA

GO:0016301

kinase activity

IEA

Biological process

GO term

Evidence

Neuro keywords

PubMed ID

GO:0007420

brain development

IEA

Brain (GO term level: 7)

GO:0006468

protein amino acid phosphorylation

TAS

1657398

GO:0007242

intracellular signaling cascade

IEA

GO:0007242

intracellular signaling cascade

NAS

GO:0035023

regulation of Rho protein signal transduction

IEA

GO:0051726

regulation of cell cycle

IEA

Cellular component

GO term

Evidence

Neuro keywords

PubMed ID

GO:0005575

cellular_component

GO:0005622

intracellular

IEA

Protein-protein Interactions

Shown by network

Interactors	Aliases B	Official full name B	Experimental	Source	PubMed ID
ABL1	ABL \| JTK7 \| bcr/abl \| c-ABL \| p150 \| v-abl	c-abl oncogene 1, receptor tyrosine kinase	BCR interacts with c-Abl. This interaction was modeled on a demonstrated interaction between BCR from an unspecified source and human c-Abl.	BIND	1383690
			-	HPRD	11780146
			Affinity Capture-Western Reconstituted Complex	BioGRID	1712671 \|8112292 \|12543778
ABL2	ABLL \| ARG \| FLJ22224 \| FLJ31718 \| FLJ41441	v-abl Abelson murine leukemia viral oncogene homolog 2 (arg, Abelson-related gene)	BCR interacts with ARG. This interaction was modeled on a demonstrated interaction between BCR from an unspecified source and human ARG.	BIND	1383690
BCR	ALL \| BCR-ABL1 \| BCR1 \| CML \| D22S11 \| D22S662 \| FLJ16453 \| PHL	breakpoint cluster region	-	HPRD	11780146
BCR		breakpoint cluster region	p210 Bcr-Abl phosphorylates p160 Bcr.	BIND	8112292
BLK	MGC10442	B lymphoid tyrosine kinase	-	HPRD	8756631
CBL	C-CBL \| CBL2 \| RNF55	Cas-Br-M (murine) ecotropic retroviral transforming sequence	Co-purification	BioGRID	8641358
CRKL	-	v-crk sarcoma virus CT10 oncogene homolog (avian)-like	Affinity Capture-Western Far Western Two-hybrid	BioGRID	8978305 \|9747873 \|10194128 \|15143164
ERCC3	BTF2 \| GTF2H \| RAD25 \| TFIIH \| XPB	excision repair cross-complementing rodent repair deficiency, complementation group 3 (xeroderma pigmentosum group B complementing)	-	HPRD,BioGRID	9874796
FES	FPS	feline sarcoma oncogene	-	HPRD,BioGRID	7529874
GAB2	KIAA0571	GRB2-associated binding protein 2	Affinity Capture-Western	BioGRID	15143164
GRB10	GRB-IR \| Grb-10 \| IRBP \| KIAA0207 \| MEG1 \| RSS	growth factor receptor-bound protein 10	-	HPRD,BioGRID	9747873
GRB2	ASH \| EGFRBP-GRB2 \| Grb3-3 \| MST084 \| MSTP084	growth factor receptor-bound protein 2	Grb2 interacts with Bcr-Abl.	BIND	9872323
			-	HPRD,BioGRID	8112292 \|9178913
			Tyrosine phosphorylated Bcr-Abl interacts with Grb2.	BIND	8112292
HCK	JTK9	hemopoietic cell kinase	Affinity Capture-Western	BioGRID	10849448 \|12592324
HOXA9	ABD-B \| HOX1 \| HOX1.7 \| HOX1G \| MGC1934	homeobox A9	Phenotypic Enhancement	BioGRID	12393433
IGSF21	FLJ41177 \| MGC15730	immunoglobin superfamily, member 21	Two-hybrid	BioGRID	16169070
JAK2	JTK10	Janus kinase 2 (a protein tyrosine kinase)	-	HPRD,BioGRID	12023981 \|12370803
KIT	C-Kit \| CD117 \| PBT \| SCFR	v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog	Affinity Capture-Western	BioGRID	8757502
MAP4K5	GCKR \| KHS \| KHS1 \| MAPKKKK5	mitogen-activated protein kinase kinase kinase kinase 5	-	HPRD	9949177
MLLT4	AF-6 \| AF6 \| AFADIN \| FLJ34371 \| RP3-431P23.3	myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4	-	HPRD,BioGRID	12808105
NCK2	GRB4 \| NCKbeta	NCK adaptor protein 2	-	HPRD	10887126
PIK3CG	PI3CG \| PI3K \| PI3Kgamma \| PIK3	phosphoinositide-3-kinase, catalytic, gamma polypeptide	Affinity Capture-Western Co-purification Two-hybrid	BioGRID	7606002 \|8641358 \|9747873
PLCG1	PLC-II \| PLC1 \| PLC148 \| PLCgamma1	phospholipase C, gamma 1	BCR interacts with PLCgamma1. This interaction was modeled on a demonstrated interaction between BCR from an unspecified source and bovine PLCgamma1.	BIND	1383690
PTPN11	BPTP3 \| CFC \| MGC14433 \| NS1 \| PTP-1D \| PTP2C \| SH-PTP2 \| SH-PTP3 \| SHP2	protein tyrosine phosphatase, non-receptor type 11	Phosphorylated p210bcr-abl interacts with phosphorylated Syp. This interaction was modeled on a demonstrated interaction between human p210bcr-abl and mouse Syp.	BIND	8195176
PTPN11		protein tyrosine phosphatase, non-receptor type 11	-	HPRD	12115002
PTPN6	HCP \| HCPH \| HPTP1C \| PTP-1C \| SH-PTP1 \| SHP-1 \| SHP-1L \| SHP1	protein tyrosine phosphatase, non-receptor type 6	-	HPRD,BioGRID	9211920
PXN	FLJ16691	paxillin	Affinity Capture-Western Co-purification	BioGRID	7534286 \|8641358
RASA1	CM-AVM \| CMAVM \| DKFZp434N071 \| GAP \| PKWS \| RASA \| RASGAP \| p120GAP \| p120RASGAP	RAS p21 protein activator (GTPase activating protein) 1	BCR interacts with GAP. This interaction was modeled on a demonstrated interaction between BCR from an unspecified source and human GAP.	BIND	1383690
RB1	OSRC \| RB \| p105-Rb \| pRb \| pp110	retinoblastoma 1	Affinity Capture-Western	BioGRID	9071815
SH2B1	DKFZp547G1110 \| FLJ30542 \| KIAA1299 \| SH2-B \| SH2B	SH2B adaptor protein 1	Affinity Capture-Western	BioGRID	12370803
SHC1	FLJ26504 \| SHC \| SHCA	SHC (Src homology 2 domain containing) transforming protein 1	-	HPRD,BioGRID	9209414
SOS1	GF1 \| GGF1 \| GINGF \| HGF \| NS4	son of sevenless homolog 1 (Drosophila)	Affinity Capture-Western	BioGRID	8112292
SRC	ASV \| SRC1 \| c-SRC \| p60-Src	v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)	BCR interacts with Src. This interaction was modeled on a demonstrated interaction between BCR from an unspecified source and Src from Rous Sarcoma virus.	BIND	1383690
TLN1	ILWEQ \| KIAA1027 \| TLN	talin 1	Co-purification	BioGRID	8641358
TP53	FLJ92943 \| LFS1 \| TRP53 \| p53	tumor protein p53	Two-hybrid	BioGRID	16169070
UNC119	HRG4	unc-119 homolog (C. elegans)	Two-hybrid	BioGRID	16169070
VAV1	VAV	vav 1 guanine nucleotide exchange factor	-	HPRD	11790798
YWHAZ	KCIP-1 \| MGC111427 \| MGC126532 \| MGC138156	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide	-	HPRD	7939633

Pathway annotation

Pathway name	Pathway size	# SZGR genes in pathway	Info
KEGG_PATHWAYS_IN_CANCER	328	259	All SZGR genes in this pathway
KEGG_CHRONIC_MYELOID_LEUKEMIA	73	59	All SZGR genes in this pathway
BIOCARTA_GLEEVEC_PATHWAY	23	17	All SZGR genes in this pathway
BIOCARTA_INTEGRIN_PATHWAY	38	29	All SZGR genes in this pathway
SA_B_CELL_RECEPTOR_COMPLEXES	24	20	All SZGR genes in this pathway
SIG_PIP3_SIGNALING_IN_B_LYMPHOCYTES	36	31	All SZGR genes in this pathway
SIG_BCR_SIGNALING_PATHWAY	46	38	All SZGR genes in this pathway
ST_B_CELL_ANTIGEN_RECEPTOR	40	32	All SZGR genes in this pathway
PID_RHOA_REG_PATHWAY	46	30	All SZGR genes in this pathway
PID_RAC1_REG_PATHWAY	38	25	All SZGR genes in this pathway
REACTOME_SIGNALING_BY_RHO_GTPASES	113	81	All SZGR genes in this pathway
REACTOME_SIGNALING_BY_FGFR_IN_DISEASE	127	88	All SZGR genes in this pathway
REACTOME_SIGNALING_BY_FGFR1_MUTANTS	30	20	All SZGR genes in this pathway
REACTOME_SIGNALING_BY_FGFR1_FUSION_MUTANTS	19	12	All SZGR genes in this pathway
REACTOME_SIGNALING_BY_FGFR_MUTANTS	44	29	All SZGR genes in this pathway
NAKAMURA_TUMOR_ZONE_PERIPHERAL_VS_CENTRAL_DN	634	384	All SZGR genes in this pathway
HOLLMANN_APOPTOSIS_VIA_CD40_DN	267	178	All SZGR genes in this pathway
DIAZ_CHRONIC_MEYLOGENOUS_LEUKEMIA_DN	116	79	All SZGR genes in this pathway
LIU_CMYB_TARGETS_UP	165	106	All SZGR genes in this pathway
LIU_VMYB_TARGETS_UP	127	78	All SZGR genes in this pathway
CHARAFE_BREAST_CANCER_LUMINAL_VS_MESENCHYMAL_UP	450	256	All SZGR genes in this pathway
MULLIGHAN_MLL_SIGNATURE_1_DN	242	165	All SZGR genes in this pathway
MULLIGHAN_MLL_SIGNATURE_2_DN	281	186	All SZGR genes in this pathway
RODRIGUES_THYROID_CARCINOMA_POORLY_DIFFERENTIATED_DN	805	505	All SZGR genes in this pathway
GRAESSMANN_APOPTOSIS_BY_SERUM_DEPRIVATION_UP	552	347	All SZGR genes in this pathway
GRAESSMANN_RESPONSE_TO_MC_AND_SERUM_DEPRIVATION_UP	211	136	All SZGR genes in this pathway
GRAESSMANN_APOPTOSIS_BY_DOXORUBICIN_DN	1781	1082	All SZGR genes in this pathway
BARRIER_CANCER_RELAPSE_NORMAL_SAMPLE_DN	31	19	All SZGR genes in this pathway
MYLLYKANGAS_AMPLIFICATION_HOT_SPOT_22	13	9	All SZGR genes in this pathway
SCHLOSSER_SERUM_RESPONSE_AUGMENTED_BY_MYC	108	74	All SZGR genes in this pathway
RICKMAN_METASTASIS_DN	261	155	All SZGR genes in this pathway
TARTE_PLASMA_CELL_VS_PLASMABLAST_UP	398	262	All SZGR genes in this pathway
FAELT_B_CLL_WITH_VH3_21_UP	44	30	All SZGR genes in this pathway
KRIGE_RESPONSE_TO_TOSEDOSTAT_6HR_DN	911	527	All SZGR genes in this pathway
KRIGE_RESPONSE_TO_TOSEDOSTAT_24HR_DN	1011	592	All SZGR genes in this pathway
MARTINEZ_RB1_TARGETS_DN	543	317	All SZGR genes in this pathway
MARTINEZ_TP53_TARGETS_DN	593	372	All SZGR genes in this pathway
MARTINEZ_RB1_AND_TP53_TARGETS_DN	591	366	All SZGR genes in this pathway
RIZKI_TUMOR_INVASIVENESS_3D_UP	210	124	All SZGR genes in this pathway
GRESHOCK_CANCER_COPY_NUMBER_UP	323	240	All SZGR genes in this pathway
NUTT_GBM_VS_AO_GLIOMA_DN	45	22	All SZGR genes in this pathway
AGUIRRE_PANCREATIC_CANCER_COPY_NUMBER_DN	238	145	All SZGR genes in this pathway
ZHAN_VARIABLE_EARLY_DIFFERENTIATION_GENES_UP	15	9	All SZGR genes in this pathway
YAGI_AML_WITH_T_8_21_TRANSLOCATION	368	247	All SZGR genes in this pathway
CHYLA_CBFA2T3_TARGETS_UP	387	225	All SZGR genes in this pathway
PILON_KLF1_TARGETS_DN	1972	1213	All SZGR genes in this pathway
BRUINS_UVC_RESPONSE_LATE	1137	655	All SZGR genes in this pathway
LINSLEY_MIR16_TARGETS	206	127	All SZGR genes in this pathway
FEVR_CTNNB1_TARGETS_UP	682	433	All SZGR genes in this pathway
TORCHIA_TARGETS_OF_EWSR1_FLI1_FUSION_DN	321	200	All SZGR genes in this pathway
KOINUMA_TARGETS_OF_SMAD2_OR_SMAD3	824	528	All SZGR genes in this pathway
HOLLEMAN_ASPARAGINASE_RESISTANCE_B_ALL_UP	26	15	All SZGR genes in this pathway
HOLLEMAN_ASPARAGINASE_RESISTANCE_ALL_UP	22	14	All SZGR genes in this pathway

miRNA Targets ?

miRNA family	Target position			miRNA ID	miRNA seq
miRNA family	UTR start	UTR end	Match method	miRNA ID	miRNA seq
miR-145	2008	2015	1A,m8	hsa-miR-145	GUCCAGUUUUCCCAGGAAUCCCUU
miR-15/16/195/424/497	419	425	m8	hsa-miR-15a^brain	UAGCAGCACAUAAUGGUUUGUG
				hsa-miR-16^brain	UAGCAGCACGUAAAUAUUGGCG
				hsa-miR-15b^brain	UAGCAGCACAUCAUGGUUUACA
				hsa-miR-195^SZ	UAGCAGCACAGAAAUAUUGGC
				hsa-miR-424	CAGCAGCAAUUCAUGUUUUGAA
				hsa-miR-497	CAGCAGCACACUGUGGUUUGU
miR-181	1059	1065	1A	hsa-miR-181a^brain	AACAUUCAACGCUGUCGGUGAGU
				hsa-miR-181b^SZ	AACAUUCAUUGCUGUCGGUGGG
				hsa-miR-181c^brain	AACAUUCAACCUGUCGGUGAGU
				hsa-miR-181d^brain	AACAUUCAUUGUUGUCGGUGGGUU
miR-26	983	990	1A,m8	hsa-miR-26a^brain	UUCAAGUAAUCCAGGAUAGGC
miR-26	983	990	1A,m8	hsa-miR-26b^SZ	UUCAAGUAAUUCAGGAUAGGUU
miR-96	2034	2040	m8	hsa-miR-96^brain	UUUGGCACUAGCACAUUUUUGC

SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.