Gene Page: S100A8

Summary ?
GeneID6279
SymbolS100A8
Synonyms60B8AG|CAGA|CFAG|CGLA|CP-10|L1Ag|MA387|MIF|MRP8|NIF|P8
DescriptionS100 calcium binding protein A8
ReferenceMIM:123885|HGNC:HGNC:10498|Ensembl:ENSG00000143546|HPRD:00471|Vega:OTTHUMG00000013124
Gene typeprotein-coding
Map location1q21
Sherlock p-value0.885
Fetal beta-2.241
eGeneMyers' cis & trans

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
PMID:cooccurHigh-throughput literature-searchSystematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
GSMA_IGenome scan meta-analysisPsr: 0.0235 
GSMA_IIAGenome scan meta-analysis (All samples)Psr: 0.00814 
LiteratureHigh-throughput literature-searchCo-occurance with Schizophrenia keywords: schizophrenia,schizophrenic,schizophreniasClick to show details

Section I. Genetics and epigenetics annotation

@eQTL annotation

SNP IDChromosomePositioneGeneGene Entrez IDpvalueqvalueTSS distanceeQTL type
rs16982680chr216885880S100A862790.13trans
rs1882577chr2227574206S100A862790.01trans
rs6762670chr3140756258S100A862790.15trans
rs11915229chr3140758709S100A862790.1trans
rs2916688chr86221560S100A862790.04trans
rs12547480chr813397698S100A862790.16trans
rs17111522chr1441634403S100A862790.19trans
rs11850244chr1482523917S100A862790.1trans

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

No co-expressed genes in brain regions


Section III. Gene Ontology annotation

Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0005509calcium ion bindingTAS2149559 
GO:0005515protein bindingIPI17353931 
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0006954inflammatory responseTAS3313057 

Section IV. Protein-protein interaction annotation

InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
ASB3ASB-3 | FLJ10123 | FLJ10421 | MGC12531 | MGC132002 | MGC996ankyrin repeat and SOCS box-containing 3Affinity Capture-MSBioGRID17353931 
C14orf1ERG28 | NET51chromosome 14 open reading frame 1Two-hybridBioGRID16169070 
C1orf103FLJ11269 | RIF1 | RP11-96K19.1chromosome 1 open reading frame 103Two-hybridBioGRID16169070 
CEACAM3CD66D | CEA | CGM1 | MGC119875 | W264 | W282carcinoembryonic antigen-related cell adhesion molecule 3-HPRD11708798 
CHGBSCG1chromogranin B (secretogranin 1)Two-hybridBioGRID16169070 
GDF9-growth differentiation factor 9Two-hybridBioGRID16169070 
IGSF21FLJ41177 | MGC15730immunoglobin superfamily, member 21Two-hybridBioGRID16169070 
LRRK1FLJ23119 | FLJ27465 | KIAA1790 | RIPK6 | Roco1leucine-rich repeat kinase 1Affinity Capture-MSBioGRID17353931 
MOBKL1BC2orf6 | FLJ10788 | FLJ11595 | MATS1 | MOB1 | MOBK1B | Mob4BMOB1, Mps One Binder kinase activator-like 1B (yeast)Affinity Capture-MSBioGRID17353931 
NUAK1ARK5 | KIAA0537NUAK family, SNF1-like kinase, 1Affinity Capture-MSBioGRID17353931 
PDCD11ALG-4 | ALG4 | KIAA0185 | NFBPprogrammed cell death 11Two-hybridBioGRID16169070 
PPIACYPA | CYPH | MGC117158 | MGC12404 | MGC23397peptidylprolyl isomerase A (cyclophilin A)Two-hybridBioGRID16169070 
PPM1BMGC21657 | PP2C-beta-X | PP2CB | PP2CBETA | PPC2BETAXprotein phosphatase 1B (formerly 2C), magnesium-dependent, beta isoformAffinity Capture-MSBioGRID17353931 
PRMT1ANM1 | HCP1 | HRMT1L2 | IR1B4protein arginine methyltransferase 1Two-hybridBioGRID16169070 
S100A860B8AG | CAGA | CFAG | CGLA | CP-10 | L1Ag | MA387 | MIF | MRP8 | NIF | P8S100 calcium binding protein A8-HPRD,BioGRID10771424 
S100A960B8AG | CAGB | CFAG | CGLB | L1AG | LIAG | MAC387 | MIF | MRP14 | NIF | P14S100 calcium binding protein A9-HPRD11867565 
TP53FLJ92943 | LFS1 | TRP53 | p53tumor protein p53Two-hybridBioGRID16169070 
UNC119HRG4unc-119 homolog (C. elegans)Two-hybridBioGRID16169070 
USF2FIP | bHLHb12upstream transcription factor 2, c-fos interactingAffinity Capture-MSBioGRID17353931 


Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
PID TOLL ENDOGENOUS PATHWAY 2519All SZGR 2.0 genes in this pathway
NAKAMURA TUMOR ZONE PERIPHERAL VS CENTRAL DN 634384All SZGR 2.0 genes in this pathway
SENGUPTA NASOPHARYNGEAL CARCINOMA WITH LMP1 DN 17582All SZGR 2.0 genes in this pathway
DIAZ CHRONIC MEYLOGENOUS LEUKEMIA DN 11679All SZGR 2.0 genes in this pathway
CHARAFE BREAST CANCER LUMINAL VS MESENCHYMAL UP 450256All SZGR 2.0 genes in this pathway
CHARAFE BREAST CANCER BASAL VS MESENCHYMAL UP 12145All SZGR 2.0 genes in this pathway
DOANE BREAST CANCER ESR1 DN 4828All SZGR 2.0 genes in this pathway
GAL LEUKEMIC STEM CELL DN 244153All SZGR 2.0 genes in this pathway
JAEGER METASTASIS DN 258141All SZGR 2.0 genes in this pathway
TAKEDA TARGETS OF NUP98 HOXA9 FUSION 3D DN 3119All SZGR 2.0 genes in this pathway
TAKEDA TARGETS OF NUP98 HOXA9 FUSION 8D DN 205127All SZGR 2.0 genes in this pathway
PEPPER CHRONIC LYMPHOCYTIC LEUKEMIA UP 3328All SZGR 2.0 genes in this pathway
RHEIN ALL GLUCOCORTICOID THERAPY UP 7841All SZGR 2.0 genes in this pathway
SABATES COLORECTAL ADENOMA UP 14175All SZGR 2.0 genes in this pathway
JAATINEN HEMATOPOIETIC STEM CELL DN 226132All SZGR 2.0 genes in this pathway
DODD NASOPHARYNGEAL CARCINOMA UP 1821933All SZGR 2.0 genes in this pathway
ENK UV RESPONSE EPIDERMIS UP 293179All SZGR 2.0 genes in this pathway
WANG BARRETTS ESOPHAGUS DN 2513All SZGR 2.0 genes in this pathway
MCBRYAN PUBERTAL BREAST 5 6WK UP 11668All SZGR 2.0 genes in this pathway
MCBRYAN PUBERTAL BREAST 6 7WK DN 7954All SZGR 2.0 genes in this pathway
DUNNE TARGETS OF AML1 MTG8 FUSION UP 5232All SZGR 2.0 genes in this pathway
HUMMERICH BENIGN SKIN TUMOR UP 188All SZGR 2.0 genes in this pathway
HUMMERICH MALIGNANT SKIN TUMOR UP 168All SZGR 2.0 genes in this pathway
DARWICHE SKIN TUMOR PROMOTER UP 14296All SZGR 2.0 genes in this pathway
DARWICHE PAPILLOMA RISK LOW UP 162104All SZGR 2.0 genes in this pathway
DARWICHE PAPILLOMA RISK HIGH UP 147101All SZGR 2.0 genes in this pathway
DARWICHE SQUAMOUS CELL CARCINOMA UP 146104All SZGR 2.0 genes in this pathway
OLSSON E2F3 TARGETS UP 2814All SZGR 2.0 genes in this pathway
RASHI RESPONSE TO IONIZING RADIATION 6 8454All SZGR 2.0 genes in this pathway
MATTIOLI MGUS VS PCL 11662All SZGR 2.0 genes in this pathway
FARMER BREAST CANCER APOCRINE VS LUMINAL 326213All SZGR 2.0 genes in this pathway
AIYAR COBRA1 TARGETS UP 3925All SZGR 2.0 genes in this pathway
GROSS HYPOXIA VIA ELK3 DN 156106All SZGR 2.0 genes in this pathway
RICKMAN TUMOR DIFFERENTIATED WELL VS POORLY DN 382224All SZGR 2.0 genes in this pathway
GOTZMANN EPITHELIAL TO MESENCHYMAL TRANSITION DN 206136All SZGR 2.0 genes in this pathway
SHIN B CELL LYMPHOMA CLUSTER 6 119All SZGR 2.0 genes in this pathway
ONDER CDH1 TARGETS 2 DN 464276All SZGR 2.0 genes in this pathway
KENNY CTNNB1 TARGETS UP 5030All SZGR 2.0 genes in this pathway
ROSS AML WITH CBFB MYH11 FUSION 5232All SZGR 2.0 genes in this pathway
JECHLINGER EPITHELIAL TO MESENCHYMAL TRANSITION UP 7151All SZGR 2.0 genes in this pathway
NING CHRONIC OBSTRUCTIVE PULMONARY DISEASE DN 12179All SZGR 2.0 genes in this pathway
TARTE PLASMA CELL VS PLASMABLAST UP 398262All SZGR 2.0 genes in this pathway
FLECHNER BIOPSY KIDNEY TRANSPLANT REJECTED VS OK UP 8758All SZGR 2.0 genes in this pathway
CHEOK RESPONSE TO HD MTX UP 2313All SZGR 2.0 genes in this pathway
LEI MYB TARGETS 318215All SZGR 2.0 genes in this pathway
LENAOUR DENDRITIC CELL MATURATION DN 12890All SZGR 2.0 genes in this pathway
GERY CEBP TARGETS 12690All SZGR 2.0 genes in this pathway
BENNETT SYSTEMIC LUPUS ERYTHEMATOSUS 3121All SZGR 2.0 genes in this pathway
HADDAD T LYMPHOCYTE AND NK PROGENITOR DN 6341All SZGR 2.0 genes in this pathway
SCHLINGEMANN SKIN CARCINOGENESIS TPA UP 4224All SZGR 2.0 genes in this pathway
CHEN LVAD SUPPORT OF FAILING HEART DN 4232All SZGR 2.0 genes in this pathway
MCDOWELL ACUTE LUNG INJURY UP 4529All SZGR 2.0 genes in this pathway
WANG SMARCE1 TARGETS DN 371218All SZGR 2.0 genes in this pathway
BURTON ADIPOGENESIS PEAK AT 24HR 4330All SZGR 2.0 genes in this pathway
MCLACHLAN DENTAL CARIES DN 245144All SZGR 2.0 genes in this pathway
MCLACHLAN DENTAL CARIES UP 253147All SZGR 2.0 genes in this pathway
BURTON ADIPOGENESIS 6 189112All SZGR 2.0 genes in this pathway
KRIGE RESPONSE TO TOSEDOSTAT 6HR UP 953554All SZGR 2.0 genes in this pathway
KRIGE RESPONSE TO TOSEDOSTAT 6HR DN 911527All SZGR 2.0 genes in this pathway
KRIGE RESPONSE TO TOSEDOSTAT 24HR UP 783442All SZGR 2.0 genes in this pathway
RIGGINS TAMOXIFEN RESISTANCE DN 220147All SZGR 2.0 genes in this pathway
MARTINEZ RB1 TARGETS DN 543317All SZGR 2.0 genes in this pathway
MARTINEZ TP53 TARGETS UP 602364All SZGR 2.0 genes in this pathway
MARTINEZ RB1 AND TP53 TARGETS UP 601369All SZGR 2.0 genes in this pathway
SARRIO EPITHELIAL MESENCHYMAL TRANSITION DN 154101All SZGR 2.0 genes in this pathway
YAMASHITA METHYLATED IN PROSTATE CANCER 5729All SZGR 2.0 genes in this pathway
SMID BREAST CANCER RELAPSE IN BONE DN 315197All SZGR 2.0 genes in this pathway
SMID BREAST CANCER LUMINAL B DN 564326All SZGR 2.0 genes in this pathway
SMID BREAST CANCER ERBB2 UP 14783All SZGR 2.0 genes in this pathway
SMID BREAST CANCER BASAL UP 648398All SZGR 2.0 genes in this pathway
ZHENG IL22 SIGNALING UP 5636All SZGR 2.0 genes in this pathway
HUPER BREAST BASAL VS LUMINAL UP 5429All SZGR 2.0 genes in this pathway
DAVIES MULTIPLE MYELOMA VS MGUS DN 2818All SZGR 2.0 genes in this pathway
BOYLAN MULTIPLE MYELOMA C D DN 252155All SZGR 2.0 genes in this pathway
ICHIBA GRAFT VERSUS HOST DISEASE 35D UP 13179All SZGR 2.0 genes in this pathway
SWEET LUNG CANCER KRAS DN 435289All SZGR 2.0 genes in this pathway
CHEN METABOLIC SYNDROM NETWORK 1210725All SZGR 2.0 genes in this pathway
BOYLAN MULTIPLE MYELOMA PCA1 UP 10166All SZGR 2.0 genes in this pathway
CAIRO LIVER DEVELOPMENT DN 222141All SZGR 2.0 genes in this pathway
GUTIERREZ WALDENSTROEMS MACROGLOBULINEMIA 1 DN 97All SZGR 2.0 genes in this pathway
CHANDRAN METASTASIS UP 221135All SZGR 2.0 genes in this pathway
KAMIKUBO MYELOID CEBPA NETWORK 2819All SZGR 2.0 genes in this pathway
MARTENS TRETINOIN RESPONSE UP 857456All SZGR 2.0 genes in this pathway
KIM BIPOLAR DISORDER OLIGODENDROCYTE DENSITY CORR DN 8859All SZGR 2.0 genes in this pathway
KIM ALL DISORDERS CALB1 CORR DN 3720All SZGR 2.0 genes in this pathway
CHYLA CBFA2T3 TARGETS DN 242146All SZGR 2.0 genes in this pathway
AZARE NEOPLASTIC TRANSFORMATION BY STAT3 UP 12170All SZGR 2.0 genes in this pathway
LEE BMP2 TARGETS DN 882538All SZGR 2.0 genes in this pathway
DELACROIX RARG BOUND MEF 367231All SZGR 2.0 genes in this pathway
KUMAR PATHOGEN LOAD BY MACROPHAGES 275155All SZGR 2.0 genes in this pathway
LIM MAMMARY LUMINAL PROGENITOR UP 5830All SZGR 2.0 genes in this pathway
ZWANG TRANSIENTLY UP BY 1ST EGF PULSE ONLY 1839928All SZGR 2.0 genes in this pathway
NABA SECRETED FACTORS 344197All SZGR 2.0 genes in this pathway
NABA MATRISOME ASSOCIATED 753411All SZGR 2.0 genes in this pathway
NABA MATRISOME 1028559All SZGR 2.0 genes in this pathway