Gene Page: CFB

Summary
GeneID  629
Symbol  CFB
Synonyms  BF|BFD|CFAB|FB|FBI12|GBG|H2-Bf|PBF2
Description  complement factor B
See related  HGNC:1037|MIM:138470|Ensembl:ENSG00000204359|HPRD:00718|
Locus tag  DADB-122G4.5
Gene type  protein-coding
Map location  6p21.3
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
AssociationA combined odds ratio method (Sun et al. 2008), association studies2Link to SZGene
GSMA_Igenome scan meta-analysisPsr: 0.033 
LiteratureHigh-throughput literature-searchCo-occurance with Schizophrenia keywords: [schizophrenias, schizophrenia]Click to show detail
GO_AnnotationMapping neuro-related keywords to Gene Ontology annotationsHits with neuro-related keywords: 1 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
AIP0.740.66
ANAPC110.730.65
FAM96B0.730.65
C16orf130.720.67
DGCR6L0.720.66
NOSIP0.710.63
FAM128B0.700.59
NDUFS80.700.65
FUZ0.690.66
MRPL230.690.62
Top 10 negatively co-expressed genes
MT-ATP8-0.36-0.29
GIMAP8-0.32-0.29
C3orf64-0.31-0.26
COBLL1-0.31-0.25
AF347015.8-0.30-0.24
AP000758.2-0.30-0.25
AF347015.18-0.30-0.25
ITSN2-0.30-0.30
FLT1-0.30-0.26
LMBRD2-0.29-0.22
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0004252serine-type endopeptidase activityIEAglutamate (GO term level: 7)-
GO:0001848complement bindingTAS11367526 
GO:0008233peptidase activityIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0006508proteolysisIEA-
GO:0006957complement activation, alternative pathwayEXP162484 
GO:0006957complement activation, alternative pathwayNAS8225386 
GO:0006956complement activationIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005576extracellular regionEXP279011 |3052276 |15199963 
GO:0005576extracellular regionIEA-
GO:0005886plasma membraneEXP15199963 
 
InteractionsShown by Network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
C3ARMD9 | ASP | CPAMD1complement component 3-HPRD,BioGRID8648130 |10610782 
|11367533 
C4BC4A | C4A13 | C4A91 | C4B1 | C4B12 | C4B2 | C4B3 | C4B5 | C4F | CH | CO4 | CPAMD3 | FLJ60561 | MGC164979complement component 4B (Childo blood group)-HPRD11341920 
CFPBFD | PFC | PFD | PROPERDINcomplement factor properdin-HPRD,BioGRID3140783 |10861231 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
KEGG_COMPLEMENT_AND_COAGULATION_CASCADES 6949All SZGR genes in this pathway
BIOCARTA_COMP_PATHWAY 1915All SZGR genes in this pathway
ST_WNT_CA2_CYCLIC_GMP_PATHWAY 2014All SZGR genes in this pathway
ST_GA12_PATHWAY 2316All SZGR genes in this pathway
ST_G_ALPHA_S_PATHWAY 1611All SZGR genes in this pathway
ST_G_ALPHA_I_PATHWAY 3529All SZGR genes in this pathway
ST_ADRENERGIC 3629All SZGR genes in this pathway
ST_GAQ_PATHWAY 2822All SZGR genes in this pathway
ST_GA13_PATHWAY 3732All SZGR genes in this pathway
ST_MYOCYTE_AD_PATHWAY 2725All SZGR genes in this pathway
REACTOME_REGULATION_OF_COMPLEMENT_CASCADE 1412All SZGR genes in this pathway
REACTOME_INNATE_IMMUNE_SYSTEM 279178All SZGR genes in this pathway
REACTOME_IMMUNE_SYSTEM 933616All SZGR genes in this pathway
REACTOME_COMPLEMENT_CASCADE 3222All SZGR genes in this pathway
REACTOME_INITIAL_TRIGGERING_OF_COMPLEMENT 1610All SZGR genes in this pathway
PICCALUGA_ANGIOIMMUNOBLASTIC_LYMPHOMA_UP 205140All SZGR genes in this pathway
SENGUPTA_NASOPHARYNGEAL_CARCINOMA_DN 349157All SZGR genes in this pathway
SENGUPTA_NASOPHARYNGEAL_CARCINOMA_WITH_LMP1_DN 17582All SZGR genes in this pathway
FULCHER_INFLAMMATORY_RESPONSE_LECTIN_VS_LPS_DN 463290All SZGR genes in this pathway
THUM_SYSTOLIC_HEART_FAILURE_UP 423283All SZGR genes in this pathway
CHARAFE_BREAST_CANCER_LUMINAL_VS_BASAL_DN 455304All SZGR genes in this pathway
DOANE_BREAST_CANCER_ESR1_UP 11272All SZGR genes in this pathway
HORIUCHI_WTAP_TARGETS_UP 306188All SZGR genes in this pathway
GOZGIT_ESR1_TARGETS_DN 781465All SZGR genes in this pathway
DELYS_THYROID_CANCER_UP 443294All SZGR genes in this pathway
GRAESSMANN_APOPTOSIS_BY_SERUM_DEPRIVATION_UP 552347All SZGR genes in this pathway
GRAESSMANN_RESPONSE_TO_MC_AND_SERUM_DEPRIVATION_UP 211136All SZGR genes in this pathway
PEREZ_TP63_TARGETS 355243All SZGR genes in this pathway
TSUNODA_CISPLATIN_RESISTANCE_DN 5138All SZGR genes in this pathway
YAN_ESCAPE_FROM_ANOIKIS 2419All SZGR genes in this pathway
KIM_MYC_AMPLIFICATION_TARGETS_DN 9751All SZGR genes in this pathway
CERVERA_SDHB_TARGETS_2 11476All SZGR genes in this pathway
SHEPARD_BMYB_MORPHOLINO_DN 200112All SZGR genes in this pathway
TARTE_PLASMA_CELL_VS_PLASMABLAST_UP 398262All SZGR genes in this pathway
HSIAO_LIVER_SPECIFIC_GENES 244154All SZGR genes in this pathway
LINDVALL_IMMORTALIZED_BY_TERT_DN 8056All SZGR genes in this pathway
MCLACHLAN_DENTAL_CARIES_DN 245144All SZGR genes in this pathway
RODWELL_AGING_KIDNEY_NO_BLOOD_UP 222139All SZGR genes in this pathway
RODWELL_AGING_KIDNEY_UP 487303All SZGR genes in this pathway
WANG_CISPLATIN_RESPONSE_AND_XPC_UP 202115All SZGR genes in this pathway
MCLACHLAN_DENTAL_CARIES_UP 253147All SZGR genes in this pathway
ZHONG_SECRETOME_OF_LUNG_CANCER_AND_MACROPHAGE 7750All SZGR genes in this pathway
ZHONG_SECRETOME_OF_LUNG_CANCER_AND_ENDOTHELIUM 6647All SZGR genes in this pathway
ZHONG_SECRETOME_OF_LUNG_CANCER_AND_FIBROBLAST 13293All SZGR genes in this pathway
CREIGHTON_ENDOCRINE_THERAPY_RESISTANCE_3 720440All SZGR genes in this pathway
HELLER_SILENCED_BY_METHYLATION_UP 282183All SZGR genes in this pathway
SARRIO_EPITHELIAL_MESENCHYMAL_TRANSITION_DN 154101All SZGR genes in this pathway
FUJII_YBX1_TARGETS_UP 4328All SZGR genes in this pathway
SMID_BREAST_CANCER_RELAPSE_IN_LIVER_DN 109All SZGR genes in this pathway
SMID_BREAST_CANCER_BASAL_DN 701446All SZGR genes in this pathway
BONOME_OVARIAN_CANCER_SURVIVAL_OPTIMAL_DEBULKING 246152All SZGR genes in this pathway
IZADPANAH_STEM_CELL_ADIPOSE_VS_BONE_DN 10868All SZGR genes in this pathway
ZHENG_IL22_SIGNALING_UP 5636All SZGR genes in this pathway
GRADE_COLON_AND_RECTAL_CANCER_UP 285167All SZGR genes in this pathway
BOQUEST_STEM_CELL_UP 260174All SZGR genes in this pathway
LABBE_TARGETS_OF_TGFB1_AND_WNT3A_DN 10868All SZGR genes in this pathway
RAY_TUMORIGENESIS_BY_ERBB2_CDC25A_DN 159105All SZGR genes in this pathway
TSAI_RESPONSE_TO_RADIATION_THERAPY 3220All SZGR genes in this pathway
YOSHIMURA_MAPK8_TARGETS_UP 1305895All SZGR genes in this pathway
CHANG_CORE_SERUM_RESPONSE_DN 209137All SZGR genes in this pathway
HAN_SATB1_TARGETS_UP 395249All SZGR genes in this pathway
SHEDDEN_LUNG_CANCER_GOOD_SURVIVAL_A12 317177All SZGR genes in this pathway
HOSHIDA_LIVER_CANCER_SUBCLASS_S3 266180All SZGR genes in this pathway
DANG_REGULATED_BY_MYC_DN 253192All SZGR genes in this pathway
NAKAYAMA_SOFT_TISSUE_TUMORS_PCA1_UP 7646All SZGR genes in this pathway
MARTENS_TRETINOIN_RESPONSE_DN 841431All SZGR genes in this pathway
ZWANG_TRANSIENTLY_UP_BY_1ST_EGF_PULSE_ONLY 1839928All SZGR genes in this pathway


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