Gene Page: CCL4
Summary ?
GeneID | 6351 |
Symbol | CCL4 |
Synonyms | ACT2|AT744.1|G-26|HC21|LAG-1|LAG1|MIP-1-beta|MIP1B|MIP1B1|SCYA2|SCYA4 |
Description | C-C motif chemokine ligand 4 |
Reference | MIM:182284|HGNC:HGNC:10630|HPRD:01657| |
Gene type | protein-coding |
Map location | 17q12 |
Pascal p-value | 0.489 |
Fetal beta | -0.135 |
eGene | Myers' cis & trans |
Gene in Data Sources
Gene set name | Method of gene set | Description | Info |
---|---|---|---|
CV:PGCnp | Genome-wide Association Study | GWAS | |
PMID:cooccur | High-throughput literature-search | Systematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included. | |
Literature | High-throughput literature-search | Co-occurance with Schizophrenia keywords: schizophrenia,schizophrenic,schizophrenias | Click to show details |
Section I. Genetics and epigenetics annotation
eQTL annotation
SNP ID | Chromosome | Position | eGene | Gene Entrez ID | pvalue | qvalue | TSS distance | eQTL type |
---|---|---|---|---|---|---|---|---|
rs10491115 | chr17 | 33969406 | CCL4 | 6351 | 0.18 | cis | ||
rs3760325 | chr17 | 34037419 | CCL4 | 6351 | 0.11 | cis | ||
rs6677917 | chr1 | 34406841 | CCL4 | 6351 | 0.2 | trans | ||
rs7545984 | chr1 | 45003892 | CCL4 | 6351 | 0.04 | trans | ||
rs7554123 | chr1 | 45004203 | CCL4 | 6351 | 0.04 | trans | ||
rs12059674 | chr1 | 57630277 | CCL4 | 6351 | 0.03 | trans | ||
rs17126801 | chr1 | 65098162 | CCL4 | 6351 | 0.15 | trans | ||
rs17474410 | chr1 | 68267242 | CCL4 | 6351 | 0 | trans | ||
rs7511937 | 0 | CCL4 | 6351 | 0.01 | trans | |||
rs2782784 | chr1 | 71195282 | CCL4 | 6351 | 0.03 | trans | ||
rs2257700 | chr1 | 71273516 | CCL4 | 6351 | 0.1 | trans | ||
rs7541092 | chr1 | 71362471 | CCL4 | 6351 | 0.16 | trans | ||
rs17689089 | chr1 | 77740105 | CCL4 | 6351 | 0.02 | trans | ||
rs17100231 | chr1 | 77761339 | CCL4 | 6351 | 0.06 | trans | ||
rs17100274 | chr1 | 77774412 | CCL4 | 6351 | 8.691E-4 | trans | ||
rs12034005 | chr1 | 79793034 | CCL4 | 6351 | 0.09 | trans | ||
rs3015033 | chr1 | 79847235 | CCL4 | 6351 | 0.08 | trans | ||
rs17098656 | chr1 | 80098386 | CCL4 | 6351 | 0.04 | trans | ||
rs6664544 | chr1 | 92524192 | CCL4 | 6351 | 0.02 | trans | ||
rs12403481 | chr1 | 109503655 | CCL4 | 6351 | 7.529E-5 | trans | ||
rs337294 | 0 | CCL4 | 6351 | 7.427E-4 | trans | |||
rs17029293 | chr1 | 112567844 | CCL4 | 6351 | 0 | trans | ||
rs16837984 | chr1 | 157042626 | CCL4 | 6351 | 0.04 | trans | ||
rs16837989 | chr1 | 157046286 | CCL4 | 6351 | 0.16 | trans | ||
rs16838012 | chr1 | 157048974 | CCL4 | 6351 | 0.04 | trans | ||
rs16838014 | 0 | CCL4 | 6351 | 0.04 | trans | |||
rs6666937 | chr1 | 170286842 | CCL4 | 6351 | 0.01 | trans | ||
rs12071422 | chr1 | 185573879 | CCL4 | 6351 | 0.08 | trans | ||
rs697455 | chr1 | 202512075 | CCL4 | 6351 | 0.09 | trans | ||
rs4457633 | chr1 | 204283819 | CCL4 | 6351 | 0.13 | trans | ||
rs3748669 | chr1 | 207077022 | CCL4 | 6351 | 0.1 | trans | ||
rs6673109 | chr1 | 207253132 | CCL4 | 6351 | 0 | trans | ||
rs1796829 | chr1 | 239661818 | CCL4 | 6351 | 0 | trans | ||
rs12034521 | chr1 | 239717679 | CCL4 | 6351 | 5.379E-4 | trans | ||
snp_a-1990354 | 0 | CCL4 | 6351 | 1.867E-5 | trans | |||
rs939217 | chr2 | 12730751 | CCL4 | 6351 | 0.11 | trans | ||
rs6432434 | chr2 | 14160930 | CCL4 | 6351 | 0.01 | trans | ||
rs6712107 | chr2 | 14178653 | CCL4 | 6351 | 0.16 | trans | ||
rs16861129 | chr2 | 14201738 | CCL4 | 6351 | 0.16 | trans | ||
rs16861131 | chr2 | 14202085 | CCL4 | 6351 | 0.16 | trans | ||
rs12329305 | chr2 | 19552912 | CCL4 | 6351 | 0.09 | trans | ||
rs12611832 | chr2 | 31196248 | CCL4 | 6351 | 0.04 | trans | ||
rs12614732 | chr2 | 31199913 | CCL4 | 6351 | 0.04 | trans | ||
rs7560081 | chr2 | 62793238 | CCL4 | 6351 | 0.02 | trans | ||
rs17029079 | chr2 | 64736071 | CCL4 | 6351 | 0.02 | trans | ||
rs17038084 | chr2 | 85192280 | CCL4 | 6351 | 4.581E-5 | trans | ||
rs17042517 | chr2 | 113639583 | CCL4 | 6351 | 0.05 | trans | ||
rs1840209 | chr2 | 125625401 | CCL4 | 6351 | 0.06 | trans | ||
rs6707117 | chr2 | 136855504 | CCL4 | 6351 | 3.09E-10 | trans | ||
rs10189091 | chr2 | 143471999 | CCL4 | 6351 | 0.01 | trans | ||
snp_a-2198363 | 0 | CCL4 | 6351 | 0.03 | trans | |||
rs16838911 | chr2 | 156087569 | CCL4 | 6351 | 0.01 | trans | ||
rs6729167 | chr2 | 174588057 | CCL4 | 6351 | 0.02 | trans | ||
rs7608942 | chr2 | 182820100 | CCL4 | 6351 | 0.12 | trans | ||
rs16848675 | chr2 | 213349996 | CCL4 | 6351 | 0.19 | trans | ||
rs16829292 | chr2 | 233447622 | CCL4 | 6351 | 0.04 | trans | ||
rs16829401 | chr2 | 233538391 | CCL4 | 6351 | 0.01 | trans | ||
rs17040622 | chr3 | 4440673 | CCL4 | 6351 | 0.11 | trans | ||
rs17684934 | chr3 | 4443547 | CCL4 | 6351 | 0.01 | trans | ||
rs17040633 | chr3 | 4446836 | CCL4 | 6351 | 0.01 | trans | ||
rs17756483 | chr3 | 4451309 | CCL4 | 6351 | 0.01 | trans | ||
rs17685441 | chr3 | 4465165 | CCL4 | 6351 | 0.01 | trans | ||
rs17015415 | chr3 | 24933888 | CCL4 | 6351 | 0.2 | trans | ||
rs12639503 | chr3 | 51860816 | CCL4 | 6351 | 0.17 | trans | ||
rs9863778 | chr3 | 55375950 | CCL4 | 6351 | 0.04 | trans | ||
rs997245 | chr3 | 61844600 | CCL4 | 6351 | 0.01 | trans | ||
rs2875492 | chr3 | 86006209 | CCL4 | 6351 | 0.04 | trans | ||
rs16843128 | chr3 | 100713413 | CCL4 | 6351 | 0.01 | trans | ||
rs1381835 | chr3 | 110600595 | CCL4 | 6351 | 0.02 | trans | ||
rs1403709 | chr3 | 187472811 | CCL4 | 6351 | 0.01 | trans | ||
rs16839796 | chr4 | 7188348 | CCL4 | 6351 | 0 | trans | ||
rs7684087 | chr4 | 21673380 | CCL4 | 6351 | 0.03 | trans | ||
rs16989064 | chr4 | 33639397 | CCL4 | 6351 | 0.05 | trans | ||
rs11096966 | chr4 | 38961258 | CCL4 | 6351 | 0.01 | trans | ||
rs4469113 | chr4 | 41461062 | CCL4 | 6351 | 0 | trans | ||
rs2643038 | chr4 | 62313218 | CCL4 | 6351 | 0.09 | trans | ||
rs6817626 | chr4 | 78005836 | CCL4 | 6351 | 0.19 | trans | ||
rs1604153 | chr4 | 78472744 | CCL4 | 6351 | 0.13 | trans | ||
rs6827713 | chr4 | 79936877 | CCL4 | 6351 | 0.11 | trans | ||
rs17005000 | chr4 | 81826551 | CCL4 | 6351 | 0.1 | trans | ||
rs6847620 | chr4 | 90426429 | CCL4 | 6351 | 0.11 | trans | ||
rs10011751 | chr4 | 93984994 | CCL4 | 6351 | 0.06 | trans | ||
rs6881821 | chr5 | 8578465 | CCL4 | 6351 | 0 | trans | ||
rs9312843 | chr5 | 13802997 | CCL4 | 6351 | 0.08 | trans | ||
rs1697073 | chr5 | 30907267 | CCL4 | 6351 | 0.14 | trans | ||
rs2115110 | chr5 | 38193428 | CCL4 | 6351 | 4.888E-4 | trans | ||
rs16873956 | chr5 | 44312488 | CCL4 | 6351 | 0.01 | trans | ||
rs10040715 | chr5 | 57594207 | CCL4 | 6351 | 1.573E-9 | trans | ||
rs16894149 | chr5 | 61013724 | CCL4 | 6351 | 0 | trans | ||
snp_a-4217300 | 0 | CCL4 | 6351 | 9.65E-10 | trans | |||
rs1862599 | chr5 | 82095088 | CCL4 | 6351 | 0.05 | trans | ||
rs163953 | chr5 | 92289536 | CCL4 | 6351 | 0.05 | trans | ||
rs17134275 | chr5 | 100634998 | CCL4 | 6351 | 0.04 | trans | ||
rs10063272 | chr5 | 103540974 | CCL4 | 6351 | 0.07 | trans | ||
rs2963232 | chr5 | 103713882 | CCL4 | 6351 | 0.16 | trans | ||
rs250323 | chr5 | 115646995 | CCL4 | 6351 | 0.11 | trans | ||
rs1350578 | chr5 | 116310282 | CCL4 | 6351 | 0.06 | trans | ||
rs11955842 | chr5 | 118066618 | CCL4 | 6351 | 0.17 | trans | ||
rs2141482 | chr5 | 136760477 | CCL4 | 6351 | 8.555E-4 | trans | ||
rs2189803 | chr5 | 137684661 | CCL4 | 6351 | 6.536E-7 | trans | ||
rs1549236 | chr5 | 159688545 | CCL4 | 6351 | 0.02 | trans | ||
rs9313842 | chr5 | 159690030 | CCL4 | 6351 | 0.01 | trans | ||
rs17063216 | chr5 | 163777647 | CCL4 | 6351 | 1.602E-5 | trans | ||
rs17063224 | chr5 | 163780687 | CCL4 | 6351 | 1.602E-5 | trans | ||
rs259913 | chr5 | 169370782 | CCL4 | 6351 | 6.645E-4 | trans | ||
rs2116811 | chr5 | 171820051 | CCL4 | 6351 | 0 | trans | ||
rs258875 | chr5 | 173046554 | CCL4 | 6351 | 0.05 | trans | ||
rs10484635 | chr6 | 20538664 | CCL4 | 6351 | 0.15 | trans | ||
rs195429 | chr6 | 37354434 | CCL4 | 6351 | 0.04 | trans | ||
rs12528414 | chr6 | 38404800 | CCL4 | 6351 | 0.19 | trans | ||
rs7771164 | chr6 | 40442772 | CCL4 | 6351 | 0 | trans | ||
rs9320694 | chr6 | 119865840 | CCL4 | 6351 | 0.1 | trans | ||
rs4289676 | chr6 | 123999302 | CCL4 | 6351 | 0.01 | trans | ||
rs17055235 | chr6 | 128355263 | CCL4 | 6351 | 3.355E-4 | trans | ||
rs2030024 | chr6 | 131014624 | CCL4 | 6351 | 0.03 | trans | ||
rs10485094 | chr6 | 131071433 | CCL4 | 6351 | 0.01 | trans | ||
rs17059517 | chr6 | 131076254 | CCL4 | 6351 | 0.03 | trans | ||
rs9402280 | chr6 | 131102770 | CCL4 | 6351 | 0.06 | trans | ||
rs7767456 | chr6 | 134356119 | CCL4 | 6351 | 0.06 | trans | ||
rs12176346 | chr6 | 136732663 | CCL4 | 6351 | 0.14 | trans | ||
rs2237264 | chr6 | 136919977 | CCL4 | 6351 | 0.14 | trans | ||
rs17080121 | chr6 | 151009189 | CCL4 | 6351 | 0.04 | trans | ||
rs12529269 | chr6 | 153543829 | CCL4 | 6351 | 0.01 | trans | ||
rs10872699 | chr6 | 153544252 | CCL4 | 6351 | 4.356E-4 | trans | ||
rs1321606 | chr6 | 153545278 | CCL4 | 6351 | 0.01 | trans | ||
rs10945911 | chr6 | 164047509 | CCL4 | 6351 | 4.246E-4 | trans | ||
rs17136841 | chr7 | 16963043 | CCL4 | 6351 | 0.02 | trans | ||
rs12540348 | chr7 | 25802146 | CCL4 | 6351 | 0.01 | trans | ||
rs4719825 | chr7 | 25813917 | CCL4 | 6351 | 0 | trans | ||
rs6461881 | chr7 | 25837688 | CCL4 | 6351 | 0.19 | trans | ||
rs13239699 | chr7 | 26377619 | CCL4 | 6351 | 0.13 | trans | ||
rs6462054 | chr7 | 27886170 | CCL4 | 6351 | 0.08 | trans | ||
rs17156078 | chr7 | 27988688 | CCL4 | 6351 | 0.06 | trans | ||
rs12701006 | chr7 | 30147298 | CCL4 | 6351 | 2.256E-5 | trans | ||
rs17815964 | chr7 | 52540908 | CCL4 | 6351 | 0.15 | trans | ||
rs17621151 | chr7 | 53572911 | CCL4 | 6351 | 0 | trans | ||
rs10245449 | chr7 | 80935100 | CCL4 | 6351 | 0.05 | trans | ||
rs10487383 | chr7 | 117671737 | CCL4 | 6351 | 0.03 | trans | ||
rs1562835 | chr7 | 131832157 | CCL4 | 6351 | 0.05 | trans | ||
rs6958821 | chr7 | 153253566 | CCL4 | 6351 | 0.01 | trans | ||
rs11779237 | chr8 | 1227664 | CCL4 | 6351 | 0 | trans | ||
rs1358128 | chr8 | 5268072 | CCL4 | 6351 | 0.02 | trans | ||
rs12682256 | chr8 | 5306138 | CCL4 | 6351 | 0.06 | trans | ||
rs10109456 | chr8 | 19565941 | CCL4 | 6351 | 0.18 | trans | ||
rs1457044 | chr8 | 59257567 | CCL4 | 6351 | 3.629E-5 | trans | ||
rs1457032 | chr8 | 59290536 | CCL4 | 6351 | 0 | trans | ||
rs2680903 | chr8 | 59512333 | CCL4 | 6351 | 0.11 | trans | ||
rs2634533 | chr8 | 59535621 | CCL4 | 6351 | 0.17 | trans | ||
rs7465259 | 0 | CCL4 | 6351 | 0.02 | trans | |||
rs10104622 | chr8 | 63333773 | CCL4 | 6351 | 0.02 | trans | ||
rs2218911 | chr8 | 63371015 | CCL4 | 6351 | 0.02 | trans | ||
rs1551199 | chr8 | 63388117 | CCL4 | 6351 | 0.02 | trans | ||
rs1733950 | chr8 | 90062516 | CCL4 | 6351 | 2.459E-9 | trans | ||
rs1240028 | chr8 | 90093357 | CCL4 | 6351 | 5.654E-4 | trans | ||
rs1240087 | chr8 | 90113945 | CCL4 | 6351 | 0 | trans | ||
rs318307 | chr8 | 90185459 | CCL4 | 6351 | 4.698E-4 | trans | ||
rs1483373 | chr8 | 90186442 | CCL4 | 6351 | 0.07 | trans | ||
rs11776005 | chr8 | 90187416 | CCL4 | 6351 | 0.01 | trans | ||
rs1159499 | chr8 | 90196948 | CCL4 | 6351 | 0.03 | trans | ||
rs1355060 | chr8 | 118717710 | CCL4 | 6351 | 0.02 | trans | ||
rs2280828 | chr8 | 118762435 | CCL4 | 6351 | 0.01 | trans | ||
rs2514602 | chr8 | 119650549 | CCL4 | 6351 | 0.17 | trans | ||
rs17683401 | chr8 | 119671834 | CCL4 | 6351 | 7.051E-4 | trans | ||
rs4976941 | chr8 | 142744439 | CCL4 | 6351 | 6.721E-4 | trans | ||
rs9298651 | chr9 | 10076275 | CCL4 | 6351 | 1.655E-4 | trans | ||
rs16931013 | chr9 | 10076859 | CCL4 | 6351 | 1.655E-4 | trans | ||
rs16931018 | chr9 | 10077048 | CCL4 | 6351 | 1.655E-4 | trans | ||
rs1467547 | chr9 | 17630726 | CCL4 | 6351 | 0.17 | trans | ||
rs2210327 | chr9 | 18109234 | CCL4 | 6351 | 0.04 | trans | ||
rs6476383 | chr9 | 32865568 | CCL4 | 6351 | 0.08 | trans | ||
rs11143622 | chr9 | 71370050 | CCL4 | 6351 | 0.05 | trans | ||
rs11791891 | chr9 | 87512411 | CCL4 | 6351 | 0.02 | trans | ||
rs2165893 | chr9 | 87531423 | CCL4 | 6351 | 0.01 | trans | ||
rs10992752 | chr9 | 96240578 | CCL4 | 6351 | 0.09 | trans | ||
rs2807706 | chr9 | 121744331 | CCL4 | 6351 | 0.01 | trans | ||
rs2818297 | chr9 | 121757015 | CCL4 | 6351 | 0.09 | trans | ||
rs10739527 | chr9 | 121772512 | CCL4 | 6351 | 0.1 | trans | ||
rs6537944 | chr9 | 137312827 | CCL4 | 6351 | 0.11 | trans | ||
rs11103132 | chr9 | 138575901 | CCL4 | 6351 | 0.18 | trans | ||
rs11252514 | chr10 | 499572 | CCL4 | 6351 | 0.03 | trans | ||
rs11014370 | chr10 | 25352798 | CCL4 | 6351 | 0.05 | trans | ||
rs772394 | chr10 | 35980024 | CCL4 | 6351 | 0.06 | trans | ||
rs17432714 | chr10 | 43526022 | CCL4 | 6351 | 0.13 | trans | ||
rs2853836 | chr10 | 48431948 | CCL4 | 6351 | 0.05 | trans | ||
rs1908351 | chr10 | 57877117 | CCL4 | 6351 | 0.03 | trans | ||
rs3104871 | chr10 | 57878502 | CCL4 | 6351 | 7.468E-4 | trans | ||
rs901309 | chr10 | 72571899 | CCL4 | 6351 | 0.04 | trans | ||
rs17271314 | chr10 | 86662514 | CCL4 | 6351 | 0.02 | trans | ||
rs17094517 | chr10 | 104021108 | CCL4 | 6351 | 0.01 | trans | ||
rs485305 | chr10 | 116048044 | CCL4 | 6351 | 0 | trans | ||
rs17540632 | chr10 | 118774194 | CCL4 | 6351 | 0.2 | trans | ||
rs4750827 | chr10 | 132547183 | CCL4 | 6351 | 0.12 | trans | ||
rs4750829 | chr10 | 132547260 | CCL4 | 6351 | 0.12 | trans | ||
rs11021918 | chr11 | 2269189 | CCL4 | 6351 | 0.12 | trans | ||
rs862785 | chr11 | 20175604 | CCL4 | 6351 | 0.01 | trans | ||
rs16911034 | chr11 | 23302320 | CCL4 | 6351 | 0.05 | trans | ||
rs17142688 | chr11 | 81319064 | CCL4 | 6351 | 0.12 | trans | ||
rs11232976 | 0 | CCL4 | 6351 | 0.12 | trans | |||
rs1789300 | chr11 | 95463631 | CCL4 | 6351 | 5.263E-5 | trans | ||
rs1727152 | chr11 | 95467435 | CCL4 | 6351 | 0 | trans | ||
rs1255149 | chr11 | 95484493 | CCL4 | 6351 | 0.01 | trans | ||
rs3748251 | chr11 | 95519156 | CCL4 | 6351 | 0.01 | trans | ||
rs16922543 | chr11 | 95526116 | CCL4 | 6351 | 0.01 | trans | ||
rs16922622 | chr11 | 95567387 | CCL4 | 6351 | 0.01 | trans | ||
rs3181323 | chr11 | 104878386 | CCL4 | 6351 | 0.04 | trans | ||
rs11219092 | chr11 | 123130750 | CCL4 | 6351 | 0.01 | trans | ||
rs7119608 | chr11 | 134922824 | CCL4 | 6351 | 0.19 | trans | ||
rs733593 | chr12 | 6636391 | CCL4 | 6351 | 0.06 | trans | ||
rs374484 | chr12 | 27627159 | CCL4 | 6351 | 0.01 | trans | ||
rs10783318 | chr12 | 39070575 | CCL4 | 6351 | 0.01 | trans | ||
rs180424 | chr12 | 47171757 | CCL4 | 6351 | 0.13 | trans | ||
rs11183673 | chr12 | 47351412 | CCL4 | 6351 | 0.02 | trans | ||
rs17097455 | chr12 | 47398974 | CCL4 | 6351 | 0.11 | trans | ||
rs17097566 | chr12 | 47460199 | CCL4 | 6351 | 0.19 | trans | ||
rs8490 | chr12 | 51453904 | CCL4 | 6351 | 1.414E-5 | trans | ||
rs1344796 | chr12 | 76397104 | CCL4 | 6351 | 0.01 | trans | ||
rs10850201 | chr12 | 109903061 | CCL4 | 6351 | 0.03 | trans | ||
rs11833075 | chr12 | 122114592 | CCL4 | 6351 | 0 | trans | ||
rs3803214 | chr13 | 25740255 | CCL4 | 6351 | 0.05 | trans | ||
rs1041050 | chr13 | 26585121 | CCL4 | 6351 | 0.13 | trans | ||
rs9581602 | chr13 | 26834548 | CCL4 | 6351 | 0.14 | trans | ||
rs17084271 | chr13 | 27089799 | CCL4 | 6351 | 0.16 | trans | ||
rs17084280 | chr13 | 27090872 | CCL4 | 6351 | 0.16 | trans | ||
rs7982110 | chr13 | 59723428 | CCL4 | 6351 | 0 | trans | ||
rs9528250 | chr13 | 61410190 | CCL4 | 6351 | 0.02 | trans | ||
rs7330331 | chr13 | 67403122 | CCL4 | 6351 | 0 | trans | ||
rs7327697 | chr13 | 83227456 | CCL4 | 6351 | 8.701E-4 | trans | ||
rs17667894 | chr13 | 92014308 | CCL4 | 6351 | 0.04 | trans | ||
rs1111763 | chr14 | 25591536 | CCL4 | 6351 | 0.11 | trans | ||
rs7156088 | chr14 | 27821865 | CCL4 | 6351 | 0.01 | trans | ||
rs7147321 | chr14 | 45877904 | CCL4 | 6351 | 0.08 | trans | ||
rs1952728 | chr14 | 45893091 | CCL4 | 6351 | 0.08 | trans | ||
rs17116137 | chr14 | 45940865 | CCL4 | 6351 | 0.08 | trans | ||
rs7151829 | chr14 | 45971281 | CCL4 | 6351 | 0.08 | trans | ||
rs4898690 | chr14 | 51848710 | CCL4 | 6351 | 0.11 | trans | ||
rs8022005 | chr14 | 61345380 | CCL4 | 6351 | 0.01 | trans | ||
rs10148418 | chr14 | 67003872 | CCL4 | 6351 | 4.771E-4 | trans | ||
rs149642 | chr14 | 72653498 | CCL4 | 6351 | 0.09 | trans | ||
rs3861624 | chr14 | 78416193 | CCL4 | 6351 | 0.17 | trans | ||
rs4905035 | chr14 | 93489262 | CCL4 | 6351 | 0 | trans | ||
rs941539 | chr14 | 93561214 | CCL4 | 6351 | 4.742E-5 | trans | ||
rs1885073 | chr14 | 104357181 | CCL4 | 6351 | 9.905E-5 | trans | ||
rs16973929 | chr15 | 47395709 | CCL4 | 6351 | 0.09 | trans | ||
rs10518936 | chr15 | 58090522 | CCL4 | 6351 | 0.19 | trans | ||
rs2414703 | chr15 | 61904602 | CCL4 | 6351 | 0.12 | trans | ||
rs289171 | chr15 | 62576053 | CCL4 | 6351 | 0 | trans | ||
rs289161 | chr15 | 62589888 | CCL4 | 6351 | 0.01 | trans | ||
rs939043 | chr15 | 70236428 | CCL4 | 6351 | 0.16 | trans | ||
rs2957037 | chr15 | 76485535 | CCL4 | 6351 | 0.12 | trans | ||
rs11858762 | chr15 | 81386594 | CCL4 | 6351 | 0.14 | trans | ||
rs9635390 | chr15 | 90809632 | CCL4 | 6351 | 8.401E-4 | trans | ||
rs7174562 | chr15 | 93811530 | CCL4 | 6351 | 0.19 | trans | ||
rs16948359 | chr15 | 94233206 | CCL4 | 6351 | 0.14 | trans | ||
rs16948375 | chr15 | 94236354 | CCL4 | 6351 | 0.02 | trans | ||
rs6500824 | chr16 | 6820959 | CCL4 | 6351 | 0.14 | trans | ||
rs8047151 | chr16 | 17209696 | CCL4 | 6351 | 9.752E-6 | trans | ||
rs4271578 | chr16 | 17213886 | CCL4 | 6351 | 1.356E-4 | trans | ||
rs7200513 | chr16 | 17219474 | CCL4 | 6351 | 0.08 | trans | ||
rs3829495 | chr16 | 17221986 | CCL4 | 6351 | 0.01 | trans | ||
rs7193763 | chr16 | 17225534 | CCL4 | 6351 | 0 | trans | ||
rs11861635 | chr16 | 82543377 | CCL4 | 6351 | 0.06 | trans | ||
rs276966 | chr16 | 86233753 | CCL4 | 6351 | 0.12 | trans | ||
rs1867231 | chr17 | 13678834 | CCL4 | 6351 | 0.03 | trans | ||
rs757075 | chr17 | 31372017 | CCL4 | 6351 | 0.06 | trans | ||
rs9903086 | chr17 | 39949515 | CCL4 | 6351 | 0.19 | trans | ||
rs7219986 | chr17 | 53263206 | CCL4 | 6351 | 0.02 | trans | ||
rs17817797 | chr17 | 53332496 | CCL4 | 6351 | 0.01 | trans | ||
rs9907100 | chr17 | 53576709 | CCL4 | 6351 | 0.09 | trans | ||
rs16951770 | chr18 | 7444826 | CCL4 | 6351 | 0.03 | trans | ||
rs7244394 | chr18 | 32223105 | CCL4 | 6351 | 0.07 | trans | ||
snp_a-4248697 | 0 | CCL4 | 6351 | 0.14 | trans | |||
rs9950823 | chr18 | 47526879 | CCL4 | 6351 | 0.01 | trans | ||
rs16951384 | chr18 | 47527116 | CCL4 | 6351 | 0 | trans | ||
rs10502924 | chr18 | 49172178 | CCL4 | 6351 | 0.05 | trans | ||
rs8095378 | chr18 | 49283781 | CCL4 | 6351 | 0.09 | trans | ||
rs6508086 | chr18 | 49297572 | CCL4 | 6351 | 0.1 | trans | ||
rs17064695 | chr18 | 55956427 | CCL4 | 6351 | 0.09 | trans | ||
rs17074993 | chr18 | 63260128 | CCL4 | 6351 | 0.04 | trans | ||
snp_a-1821751 | 0 | CCL4 | 6351 | 0.01 | trans | |||
rs1942461 | chr18 | 70509159 | CCL4 | 6351 | 0.07 | trans | ||
rs1942462 | chr18 | 70509823 | CCL4 | 6351 | 0.07 | trans | ||
rs1942463 | chr18 | 70509841 | CCL4 | 6351 | 0.07 | trans | ||
rs1942464 | chr18 | 70509877 | CCL4 | 6351 | 0.01 | trans | ||
rs1942466 | chr18 | 70517154 | CCL4 | 6351 | 0.07 | trans | ||
rs2156494 | chr18 | 70518084 | CCL4 | 6351 | 0.07 | trans | ||
rs17056922 | chr18 | 73086804 | CCL4 | 6351 | 0.03 | trans | ||
rs1540051 | chr18 | 75049934 | CCL4 | 6351 | 0.06 | trans | ||
rs6603096 | chr19 | 7415722 | CCL4 | 6351 | 0.13 | trans | ||
rs16980096 | chr19 | 15000921 | CCL4 | 6351 | 0.16 | trans | ||
snp_a-2138575 | 0 | CCL4 | 6351 | 0.01 | trans | |||
rs16997215 | chr20 | 16101890 | CCL4 | 6351 | 0.12 | trans | ||
snp_a-4254460 | 0 | CCL4 | 6351 | 0.11 | trans | |||
rs1797040 | chr20 | 23907743 | CCL4 | 6351 | 0.05 | trans | ||
rs2424603 | 0 | CCL4 | 6351 | 0.05 | trans | |||
rs6102879 | chr20 | 41138766 | CCL4 | 6351 | 0.13 | trans | ||
rs6026122 | chr20 | 56769083 | CCL4 | 6351 | 0.01 | trans | ||
rs259991 | chr20 | 57728347 | CCL4 | 6351 | 0.14 | trans | ||
rs6015452 | chr20 | 57782312 | CCL4 | 6351 | 0.1 | trans | ||
rs4812237 | chr20 | 59518040 | CCL4 | 6351 | 0.09 | trans | ||
rs2847443 | chr21 | 14595263 | CCL4 | 6351 | 0.19 | trans | ||
rs2834872 | chr21 | 36634845 | CCL4 | 6351 | 0.03 | trans | ||
rs2834874 | chr21 | 36641270 | CCL4 | 6351 | 0.12 | trans | ||
rs2834875 | chr21 | 36656119 | CCL4 | 6351 | 0.02 | trans | ||
rs877910 | chr21 | 36658376 | CCL4 | 6351 | 0.04 | trans | ||
rs369613 | chr22 | 22380717 | CCL4 | 6351 | 0.17 | trans | ||
rs410285 | chr22 | 22381767 | CCL4 | 6351 | 0.17 | trans | ||
rs134028 | chr22 | 28048448 | CCL4 | 6351 | 2.171E-4 | trans | ||
rs5762317 | chr22 | 28094988 | CCL4 | 6351 | 0.01 | trans | ||
rs5768165 | chr22 | 48318197 | CCL4 | 6351 | 0.02 | trans | ||
rs5768168 | chr22 | 48319334 | CCL4 | 6351 | 0.02 | trans | ||
rs5768173 | chr22 | 48321475 | CCL4 | 6351 | 0.02 | trans | ||
rs12006821 | chrX | 50424687 | CCL4 | 6351 | 0.1 | trans | ||
rs5977652 | chrX | 131315199 | CCL4 | 6351 | 0.12 | trans | ||
rs5977655 | chrX | 131333069 | CCL4 | 6351 | 0.07 | trans | ||
rs4824295 | chrX | 146496881 | CCL4 | 6351 | 0.14 | trans |
Section II. Transcriptome annotation
General gene expression (GTEx)
Gene expression during devlopment (BrainCloud)
Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.
Gene expression of temporal and spatial changes (BrainSpan)
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
Top co-expressed genes in brain regions
Top 10 positively co-expressed genes | ||
Gene | Pearson's Correlation | Spearman's Correlation |
NID1 | 0.81 | 0.57 |
AL137026.3 | 0.81 | 0.76 |
COL1A1 | 0.79 | 0.59 |
PCOLCE | 0.78 | 0.51 |
COL6A2 | 0.78 | 0.59 |
COL3A1 | 0.78 | 0.54 |
OLFML3 | 0.77 | 0.60 |
COL1A2 | 0.77 | 0.70 |
IGF2 | 0.76 | 0.65 |
FN1 | 0.75 | 0.63 |
Top 10 negatively co-expressed genes | ||
Gene | Pearson's Correlation | Spearman's Correlation |
MT1G | -0.29 | -0.17 |
FXYD1 | -0.28 | -0.15 |
AC098691.2 | -0.27 | -0.27 |
AF347015.33 | -0.27 | -0.15 |
S100A13 | -0.27 | -0.16 |
S100A1 | -0.26 | -0.09 |
SEPT4 | -0.26 | -0.17 |
MT-CO2 | -0.26 | -0.17 |
AF347015.21 | -0.26 | -0.16 |
C5orf53 | -0.26 | -0.12 |
Section V. Pathway annotation
Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
---|---|---|---|
KEGG CYTOKINE CYTOKINE RECEPTOR INTERACTION | 267 | 161 | All SZGR 2.0 genes in this pathway |
KEGG CHEMOKINE SIGNALING PATHWAY | 190 | 128 | All SZGR 2.0 genes in this pathway |
KEGG TOLL LIKE RECEPTOR SIGNALING PATHWAY | 102 | 88 | All SZGR 2.0 genes in this pathway |
KEGG CYTOSOLIC DNA SENSING PATHWAY | 56 | 44 | All SZGR 2.0 genes in this pathway |
BIOCARTA CCR5 PATHWAY | 20 | 16 | All SZGR 2.0 genes in this pathway |
BIOCARTA NKT PATHWAY | 29 | 21 | All SZGR 2.0 genes in this pathway |
PID IL12 2PATHWAY | 63 | 54 | All SZGR 2.0 genes in this pathway |
REACTOME SIGNALING BY GPCR | 920 | 449 | All SZGR 2.0 genes in this pathway |
REACTOME PEPTIDE LIGAND BINDING RECEPTORS | 188 | 108 | All SZGR 2.0 genes in this pathway |
REACTOME CLASS A1 RHODOPSIN LIKE RECEPTORS | 305 | 177 | All SZGR 2.0 genes in this pathway |
REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES | 57 | 27 | All SZGR 2.0 genes in this pathway |
REACTOME GPCR LIGAND BINDING | 408 | 246 | All SZGR 2.0 genes in this pathway |
DAVICIONI TARGETS OF PAX FOXO1 FUSIONS DN | 68 | 49 | All SZGR 2.0 genes in this pathway |
GARY CD5 TARGETS UP | 473 | 314 | All SZGR 2.0 genes in this pathway |
ZHOU INFLAMMATORY RESPONSE LIVE UP | 485 | 293 | All SZGR 2.0 genes in this pathway |
THUM SYSTOLIC HEART FAILURE UP | 423 | 283 | All SZGR 2.0 genes in this pathway |
DEURIG T CELL PROLYMPHOCYTIC LEUKEMIA DN | 320 | 184 | All SZGR 2.0 genes in this pathway |
GAL LEUKEMIC STEM CELL DN | 244 | 153 | All SZGR 2.0 genes in this pathway |
OSWALD HEMATOPOIETIC STEM CELL IN COLLAGEN GEL UP | 233 | 161 | All SZGR 2.0 genes in this pathway |
TAKEDA TARGETS OF NUP98 HOXA9 FUSION 6HR DN | 41 | 29 | All SZGR 2.0 genes in this pathway |
TAKEDA TARGETS OF NUP98 HOXA9 FUSION 10D DN | 142 | 90 | All SZGR 2.0 genes in this pathway |
ZHOU INFLAMMATORY RESPONSE FIMA UP | 544 | 308 | All SZGR 2.0 genes in this pathway |
ZHOU INFLAMMATORY RESPONSE LPS UP | 431 | 237 | All SZGR 2.0 genes in this pathway |
JAATINEN HEMATOPOIETIC STEM CELL DN | 226 | 132 | All SZGR 2.0 genes in this pathway |
DODD NASOPHARYNGEAL CARCINOMA DN | 1375 | 806 | All SZGR 2.0 genes in this pathway |
HAHTOLA SEZARY SYNDROM DN | 42 | 26 | All SZGR 2.0 genes in this pathway |
HAHTOLA MYCOSIS FUNGOIDES CD4 UP | 64 | 46 | All SZGR 2.0 genes in this pathway |
MARKEY RB1 ACUTE LOF UP | 215 | 137 | All SZGR 2.0 genes in this pathway |
WANG ESOPHAGUS CANCER VS NORMAL UP | 121 | 72 | All SZGR 2.0 genes in this pathway |
DIRMEIER LMP1 RESPONSE EARLY | 66 | 48 | All SZGR 2.0 genes in this pathway |
TSAI RESPONSE TO IONIZING RADIATION | 149 | 101 | All SZGR 2.0 genes in this pathway |
KAUFFMANN DNA REPLICATION GENES | 147 | 87 | All SZGR 2.0 genes in this pathway |
NIKOLSKY BREAST CANCER 17Q11 Q21 AMPLICON | 133 | 78 | All SZGR 2.0 genes in this pathway |
LU IL4 SIGNALING | 94 | 56 | All SZGR 2.0 genes in this pathway |
BYSTRYKH HEMATOPOIESIS STEM CELL QTL TRANS | 882 | 572 | All SZGR 2.0 genes in this pathway |
NAKAJIMA EOSINOPHIL | 30 | 20 | All SZGR 2.0 genes in this pathway |
GALINDO IMMUNE RESPONSE TO ENTEROTOXIN | 85 | 67 | All SZGR 2.0 genes in this pathway |
MATSUDA NATURAL KILLER DIFFERENTIATION | 475 | 313 | All SZGR 2.0 genes in this pathway |
VERHAAK AML WITH NPM1 MUTATED UP | 183 | 111 | All SZGR 2.0 genes in this pathway |
BASSO CD40 SIGNALING UP | 101 | 76 | All SZGR 2.0 genes in this pathway |
GEISS RESPONSE TO DSRNA UP | 38 | 29 | All SZGR 2.0 genes in this pathway |
ZHANG ANTIVIRAL RESPONSE TO RIBAVIRIN DN | 51 | 32 | All SZGR 2.0 genes in this pathway |
SATO SILENCED BY METHYLATION IN PANCREATIC CANCER 1 | 419 | 273 | All SZGR 2.0 genes in this pathway |
WALLACE PROSTATE CANCER RACE UP | 299 | 167 | All SZGR 2.0 genes in this pathway |
WORSCHECH TUMOR REJECTION UP | 56 | 32 | All SZGR 2.0 genes in this pathway |
QI PLASMACYTOMA UP | 259 | 185 | All SZGR 2.0 genes in this pathway |
GOLDRATH ANTIGEN RESPONSE | 346 | 192 | All SZGR 2.0 genes in this pathway |
ICHIBA GRAFT VERSUS HOST DISEASE 35D UP | 131 | 79 | All SZGR 2.0 genes in this pathway |
LINDSTEDT DENDRITIC CELL MATURATION A | 67 | 52 | All SZGR 2.0 genes in this pathway |
YOSHIMURA MAPK8 TARGETS DN | 366 | 257 | All SZGR 2.0 genes in this pathway |
CHEN METABOLIC SYNDROM NETWORK | 1210 | 725 | All SZGR 2.0 genes in this pathway |
CROONQUIST STROMAL STIMULATION UP | 60 | 42 | All SZGR 2.0 genes in this pathway |
CROONQUIST NRAS SIGNALING UP | 41 | 24 | All SZGR 2.0 genes in this pathway |
ROME INSULIN TARGETS IN MUSCLE DN | 204 | 114 | All SZGR 2.0 genes in this pathway |
POOLA INVASIVE BREAST CANCER UP | 288 | 168 | All SZGR 2.0 genes in this pathway |
WORSCHECH TUMOR EVASION AND TOLEROGENICITY UP | 30 | 19 | All SZGR 2.0 genes in this pathway |
LI INDUCED T TO NATURAL KILLER UP | 307 | 182 | All SZGR 2.0 genes in this pathway |
ALTEMEIER RESPONSE TO LPS WITH MECHANICAL VENTILATION | 128 | 81 | All SZGR 2.0 genes in this pathway |
SMIRNOV RESPONSE TO IR 6HR DN | 114 | 69 | All SZGR 2.0 genes in this pathway |
NABA SECRETED FACTORS | 344 | 197 | All SZGR 2.0 genes in this pathway |
NABA MATRISOME ASSOCIATED | 753 | 411 | All SZGR 2.0 genes in this pathway |
NABA MATRISOME | 1028 | 559 | All SZGR 2.0 genes in this pathway |