SZGR2

Summary ?

GeneID	7088
Symbol	TLE1
Synonyms	ESG\|ESG1\|GRG1
Description	transducin like enhancer of split 1
Reference	MIM:600189\|HGNC:HGNC:11837\|Ensembl:ENSG00000196781\|HPRD:02557\|Vega:OTTHUMG00000021008
Gene type	protein-coding
Map location	9q21.32
Pascal p-value	4.704E-4
Sherlock p-value	0.813
Fetal beta	0.211
DMG	1 (# studies)
Support	Ascano FMRP targets

Gene in Data Sources

Gene set name	Method of gene set	Description	Info
CV:PGCnp	Genome-wide Association Study	GWAS
DMG:Wockner_2014	Genome-wide DNA methylation analysis	This dataset includes 4641 differentially methylated probes corresponding to 2929 unique genes between schizophrenia patients (n=24) and controls (n=24).	1
PMID:cooccur	High-throughput literature-search	Systematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
Literature	High-throughput literature-search	Co-occurance with Schizophrenia keywords: schizophrenia,schizophrenics,schizophrenias	Click to show details

Section I. Genetics and epigenetics annotation

Differentially methylated gene

Probe	Chromosome	Position	Nearest gene	P (dis)	Beta (dis)	FDR (dis)	Study
cg14095100	9	84303413	TLE1	2.775E-4	0.665	0.039	DMG:Wockner_2014

Section II. Transcriptome annotation

General gene expression (GTEx)

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

No co-expressed genes in brain regions

Section IV. Protein-protein interaction annotation

Interactors	Aliases B	Official full name B	Experimental	Source	PubMed ID
AES	AES-1 \| AES-2 \| ESP1 \| GRG \| GRG5 \| TLE5	amino-terminal enhancer of split	Affinity Capture-MS	BioGRID	17353931
ARL3	ARFL3	ADP-ribosylation factor-like 3	Two-hybrid	BioGRID	16169070
ARL4D	ARF4L \| ARL6	ADP-ribosylation factor-like 4D	Two-hybrid	BioGRID	16169070
ATN1	B37 \| D12S755E \| DRPLA \| NOD	atrophin 1	Two-hybrid	BioGRID	16169070
BTBD2	-	BTB (POZ) domain containing 2	Two-hybrid	BioGRID	16169070
CCL18	AMAC-1 \| AMAC1 \| CKb7 \| DC-CK1 \| DCCK1 \| MIP-4 \| PARC \| SCYA18	chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated)	Two-hybrid	BioGRID	16169070
CCNB1	CCNB	cyclin B1	-	HPRD	12397081
CDC2	CDC28A \| CDK1 \| DKFZp686L20222 \| MGC111195	cell division cycle 2, G1 to S and G2 to M	-	HPRD	12397081
CDKN2C	INK4C \| p18 \| p18-INK4C	cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)	Two-hybrid	BioGRID	16169070
CRCT1	C1orf42 \| NICE-1	cysteine-rich C-terminal 1	Two-hybrid	BioGRID	16169070
DLEU1	BCMS \| DLB1 \| DLEU2 \| LEU1 \| LEU2 \| MGC22430 \| NCRNA00021 \| XTP6	deleted in lymphocytic leukemia 1 (non-protein coding)	Two-hybrid	BioGRID	16169070
EIF2S2	DKFZp686L18198 \| EIF2 \| EIF2B \| EIF2beta \| MGC8508	eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa	Two-hybrid	BioGRID	16169070
ERH	DROER \| FLJ27340	enhancer of rudimentary homolog (Drosophila)	Two-hybrid	BioGRID	16169070
FOXA2	HNF3B \| MGC19807 \| TCF3B	forkhead box A2	-	HPRD,BioGRID	10748198
FOXG1	BF1 \| BF2 \| FHKL3 \| FKH2 \| FKHL1 \| FKHL2 \| FKHL3 \| FKHL4 \| FOXG1A \| FOXG1B \| FOXG1C \| HBF-1 \| HBF-2 \| HBF-3 \| HBF-G2 \| HBF2 \| HFK1 \| HFK2 \| HFK3 \| KHL2 \| QIN	forkhead box G1	-	HPRD	11238932
FUBP1	FBP \| FUBP	far upstream element (FUSE) binding protein 1	Two-hybrid	BioGRID	16169070
FXYD6	-	FXYD domain containing ion transport regulator 6	Two-hybrid	BioGRID	16169070
GSTM4	GSTM4-4 \| GTM4 \| MGC131945 \| MGC9247	glutathione S-transferase mu 4	Two-hybrid	BioGRID	16169070
HES1	FLJ20408 \| HES-1 \| HHL \| HRY \| bHLHb39	hairy and enhancer of split 1, (Drosophila)	-	HPRD	8687460
HES6	bHLHc23	hairy and enhancer of split 6 (Drosophila)	-	HPRD,BioGRID	11551980
HHEX	HEX \| HMPH \| HOX11L-PEN \| PRH \| PRHX	hematopoietically expressed homeobox	HHEX (PRH) interacts with TLE1.	BIND	15187083
HLA-DQA1	CD \| CELIAC1 \| DQ-A1 \| FLJ27088 \| FLJ27328 \| GSE \| HLA-DQA \| MGC149527	major histocompatibility complex, class II, DQ alpha 1	Two-hybrid	BioGRID	16169070
HMGB1	DKFZp686A04236 \| HMG1 \| HMG3 \| SBP-1	high-mobility group box 1	-	HPRD,BioGRID	11748221
HNF1A	HNF1 \| LFB1 \| MODY3 \| TCF1	HNF1 homeobox A	-	HPRD,BioGRID	10209158
HSPE1	CPN10 \| GROES \| HSP10	heat shock 10kDa protein 1 (chaperonin 10)	Two-hybrid	BioGRID	16169070
IL6ST	CD130 \| CDw130 \| GP130 \| GP130-RAPS \| IL6R-beta	interleukin 6 signal transducer (gp130, oncostatin M receptor)	-	HPRD,BioGRID	12030375
LEF1	DKFZp586H0919 \| TCF1ALPHA	lymphoid enhancer-binding factor 1	-	HPRD,BioGRID	9751710
LEF1	DKFZp586H0919 \| TCF1ALPHA	lymphoid enhancer-binding factor 1	LEF-1 interacts with TLE1. This interaction was modeled on a demonstrated interaction between LEF-1 from an unspecified species and human TLE1.	BIND	9751710
MPHOSPH6	MPP \| MPP-6 \| MPP6	M-phase phosphoprotein 6	Two-hybrid	BioGRID	16169070
PAFAH1B3	-	platelet-activating factor acetylhydrolase, isoform Ib, gamma subunit 29kDa	Two-hybrid	BioGRID	16169070
PCDHA4	CNR1 \| CNRN1 \| CRNR1 \| MGC138307 \| MGC142169 \| PCDH-ALPHA4	protocadherin alpha 4	Two-hybrid	BioGRID	16169070
PFN1	-	profilin 1	Two-hybrid	BioGRID	16169070
POLB	MGC125976	polymerase (DNA directed), beta	Two-hybrid	BioGRID	16169070
POLE2	DPE2	polymerase (DNA directed), epsilon 2 (p59 subunit)	Two-hybrid	BioGRID	16169070
PRDM1	BLIMP1 \| MGC118922 \| MGC118923 \| MGC118924 \| MGC118925 \| PRDI-BF1	PR domain containing 1, with ZNF domain	-	HPRD,BioGRID	9887105
PSMD11	MGC3844 \| Rpn6 \| S9 \| p44.5	proteasome (prosome, macropain) 26S subunit, non-ATPase, 11	Two-hybrid	BioGRID	16169070
PXMP3	PAF-1 \| PAF1 \| PEX2 \| PMP3 \| PMP35 \| RNF72	peroxisomal membrane protein 3, 35kDa	Two-hybrid	BioGRID	16169070
RELA	MGC131774 \| NFKB3 \| p65	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	TLE1 interacts with p65.	BIND	10660609
RELA	MGC131774 \| NFKB3 \| p65	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	Affinity Capture-Western	BioGRID	10660609
RNF10	KIAA0262 \| MGC126758 \| MGC126764 \| RIE2	ring finger protein 10	Two-hybrid	BioGRID	16169070
RPA2	REPA2 \| RPA32	replication protein A2, 32kDa	Two-hybrid	BioGRID	16169070
RUNX1	AML1 \| AML1-EVI-1 \| AMLCR1 \| CBFA2 \| EVI-1 \| PEBP2aB	runt-related transcription factor 1	AML1a interacts with TLE1.	BIND	9751710
RUNX1	AML1 \| AML1-EVI-1 \| AMLCR1 \| CBFA2 \| EVI-1 \| PEBP2aB	runt-related transcription factor 1	-	HPRD,BioGRID	9751710
RUNX1	AML1 \| AML1-EVI-1 \| AMLCR1 \| CBFA2 \| EVI-1 \| PEBP2aB	runt-related transcription factor 1	AML1b interacts with TLE1.	BIND	9751710
RUNX3	AML2 \| CBFA3 \| FLJ34510 \| MGC16070 \| PEBP2aC	runt-related transcription factor 3	AML2 interacts with TLE1.	BIND	9751710
RUNX3	AML2 \| CBFA3 \| FLJ34510 \| MGC16070 \| PEBP2aC	runt-related transcription factor 3	-	HPRD,BioGRID	9751710
SAT1	DC21 \| KFSD \| SAT \| SSAT \| SSAT-1	spermidine/spermine N1-acetyltransferase 1	Two-hybrid	BioGRID	16169070
SERPINB9	CAP-3 \| CAP3 \| PI9	serpin peptidase inhibitor, clade B (ovalbumin), member 9	Two-hybrid	BioGRID	16169070
SIX1	BOS3 \| DFNA23 \| TIP39	SIX homeobox 1	SIX1 interacts with TLE1.	BIND	12441302
SIX2	-	SIX homeobox 2	SIX2 interacts with TLE1. This interaction was modeled on a demonstrated interaction between mouse Six2 and human TLE1.	BIND	12441302
SIX3	HPE2	SIX homeobox 3	SIX3 interacts with TLE1.	BIND	12441302
SIX3	HPE2	SIX homeobox 3	-	HPRD,BioGRID	12441302
SIX4	AREC3 \| MGC119450 \| MGC119452 \| MGC119453	SIX homeobox 4	SIX4 interacts with TLE1. This interaction was modeled on a demonstrated interaction between mouse Six4 and human TLE1.	BIND	12441302
SIX6	MCOPCT2 \| OPTX2 \| Six9	SIX homeobox 6	SIX6 interacts with TLE1.	BIND	12441302
SIX6	MCOPCT2 \| OPTX2 \| Six9	SIX homeobox 6	Reconstituted Complex Two-hybrid	BioGRID	12441302
SNRPG	MGC117317 \| SMG	small nuclear ribonucleoprotein polypeptide G	Two-hybrid	BioGRID	16169070
TK1	TK2	thymidine kinase 1, soluble	Two-hybrid	BioGRID	16169070
TLE2	ESG \| ESG2 \| FLJ41188 \| GRG2	transducin-like enhancer of split 2 (E(sp1) homolog, Drosophila)	-	HPRD,BioGRID	9874198
TNRC4	BRUNOL1 \| CAGH4 \| CELF3 \| ERDA4 \| MGC57297	trinucleotide repeat containing 4	Two-hybrid	BioGRID	16169070
UTX	DKFZp686A03225 \| MGC141941 \| bA386N14.2	ubiquitously transcribed tetratricopeptide repeat, X chromosome	-	HPRD,BioGRID	9854018
UTY	DKFZp686L12190 \| UTY1	ubiquitously transcribed tetratricopeptide repeat gene, Y-linked	-	HPRD,BioGRID	9854018
ZFP64	MGC940 \| ZNF338	zinc finger protein 64 homolog (mouse)	Two-hybrid	BioGRID	16169070

Section V. Pathway annotation

Pathway name	Pathway size	# SZGR 2.0 genes in pathway	Info
BIOCARTA WNT PATHWAY	26	24	All SZGR 2.0 genes in this pathway
WNT SIGNALING	89	71	All SZGR 2.0 genes in this pathway
PID PS1 PATHWAY	46	39	All SZGR 2.0 genes in this pathway
PID BETA CATENIN NUC PATHWAY	80	60	All SZGR 2.0 genes in this pathway
PID HES HEY PATHWAY	48	39	All SZGR 2.0 genes in this pathway
REACTOME NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION	46	28	All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY NOTCH1	70	46	All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY NOTCH	103	64	All SZGR 2.0 genes in this pathway
HOLLMANN APOPTOSIS VIA CD40 DN	267	178	All SZGR 2.0 genes in this pathway
LIU SOX4 TARGETS UP	137	94	All SZGR 2.0 genes in this pathway
HUTTMANN B CLL POOR SURVIVAL UP	276	187	All SZGR 2.0 genes in this pathway
DODD NASOPHARYNGEAL CARCINOMA DN	1375	806	All SZGR 2.0 genes in this pathway
GOZGIT ESR1 TARGETS DN	781	465	All SZGR 2.0 genes in this pathway
DELYS THYROID CANCER DN	232	154	All SZGR 2.0 genes in this pathway
PEREZ TP63 TARGETS	355	243	All SZGR 2.0 genes in this pathway
FARMER BREAST CANCER APOCRINE VS LUMINAL	326	213	All SZGR 2.0 genes in this pathway
DACOSTA UV RESPONSE VIA ERCC3 DN	855	609	All SZGR 2.0 genes in this pathway
DACOSTA UV RESPONSE VIA ERCC3 COMMON DN	483	336	All SZGR 2.0 genes in this pathway
WANG RESPONSE TO PACLITAXEL VIA MAPK8 UP	14	9	All SZGR 2.0 genes in this pathway
BUYTAERT PHOTODYNAMIC THERAPY STRESS UP	811	508	All SZGR 2.0 genes in this pathway
LIU COMMON CANCER GENES	79	47	All SZGR 2.0 genes in this pathway
SCHAEFFER PROSTATE DEVELOPMENT 6HR UP	176	115	All SZGR 2.0 genes in this pathway
SCHAEFFER PROSTATE DEVELOPMENT 12HR UP	116	79	All SZGR 2.0 genes in this pathway
SCHAEFFER PROSTATE DEVELOPMENT 48HR UP	487	286	All SZGR 2.0 genes in this pathway
SCHAEFFER PROSTATE DEVELOPMENT AND CANCER BOX1 UP	15	10	All SZGR 2.0 genes in this pathway
SCHAEFFER PROSTATE DEVELOPMENT AND CANCER BOX2 DN	7	6	All SZGR 2.0 genes in this pathway
SCHAEFFER PROSTATE DEVELOPMENT AND CANCER BOX5 DN	8	5	All SZGR 2.0 genes in this pathway
SCHAEFFER SOX9 TARGETS IN PROSTATE DEVELOPMENT UP	21	19	All SZGR 2.0 genes in this pathway
GOTZMANN EPITHELIAL TO MESENCHYMAL TRANSITION DN	206	136	All SZGR 2.0 genes in this pathway
BENPORATH SOX2 TARGETS	734	436	All SZGR 2.0 genes in this pathway
BENPORATH ES CORE NINE CORRELATED	100	68	All SZGR 2.0 genes in this pathway
ROSS AML WITH PML RARA FUSION	77	62	All SZGR 2.0 genes in this pathway
SHIPP DLBCL CURED VS FATAL DN	45	30	All SZGR 2.0 genes in this pathway
WILLERT WNT SIGNALING	24	13	All SZGR 2.0 genes in this pathway
UEDA PERIFERAL CLOCK	169	111	All SZGR 2.0 genes in this pathway
OKUMURA INFLAMMATORY RESPONSE LPS	183	115	All SZGR 2.0 genes in this pathway
MANALO HYPOXIA UP	207	145	All SZGR 2.0 genes in this pathway
HASLINGER B CLL WITH MUTATED VH GENES	18	14	All SZGR 2.0 genes in this pathway
MATSUDA NATURAL KILLER DIFFERENTIATION	475	313	All SZGR 2.0 genes in this pathway
HADDAD B LYMPHOCYTE PROGENITOR	293	193	All SZGR 2.0 genes in this pathway
LEE CALORIE RESTRICTION NEOCORTEX UP	83	66	All SZGR 2.0 genes in this pathway
BROWNE HCMV INFECTION 48HR UP	180	125	All SZGR 2.0 genes in this pathway
BURTON ADIPOGENESIS 2	72	52	All SZGR 2.0 genes in this pathway
GENTILE UV RESPONSE CLUSTER D7	40	21	All SZGR 2.0 genes in this pathway
GENTILE UV HIGH DOSE DN	312	203	All SZGR 2.0 genes in this pathway
KYNG DNA DAMAGE BY 4NQO OR UV	63	44	All SZGR 2.0 genes in this pathway
KYNG DNA DAMAGE DN	195	135	All SZGR 2.0 genes in this pathway
WALLACE PROSTATE CANCER RACE DN	88	42	All SZGR 2.0 genes in this pathway
RIZKI TUMOR INVASIVENESS 3D UP	210	124	All SZGR 2.0 genes in this pathway
IZADPANAH STEM CELL ADIPOSE VS BONE DN	108	68	All SZGR 2.0 genes in this pathway
ZHENG GLIOBLASTOMA PLASTICITY UP	250	168	All SZGR 2.0 genes in this pathway
GRADE METASTASIS DN	45	31	All SZGR 2.0 genes in this pathway
BEIER GLIOMA STEM CELL UP	39	17	All SZGR 2.0 genes in this pathway
SETLUR PROSTATE CANCER TMPRSS2 ERG FUSION UP	67	48	All SZGR 2.0 genes in this pathway
WONG ADULT TISSUE STEM MODULE	721	492	All SZGR 2.0 genes in this pathway
NAKAYAMA SOFT TISSUE TUMORS PCA1 DN	74	47	All SZGR 2.0 genes in this pathway
GREGORY SYNTHETIC LETHAL WITH IMATINIB	145	83	All SZGR 2.0 genes in this pathway
DUTERTRE ESTRADIOL RESPONSE 24HR DN	505	328	All SZGR 2.0 genes in this pathway
BHAT ESR1 TARGETS NOT VIA AKT1 DN	88	61	All SZGR 2.0 genes in this pathway
BHAT ESR1 TARGETS VIA AKT1 DN	82	51	All SZGR 2.0 genes in this pathway
BRUINS UVC RESPONSE MIDDLE	98	56	All SZGR 2.0 genes in this pathway
MIYAGAWA TARGETS OF EWSR1 ETS FUSIONS DN	229	135	All SZGR 2.0 genes in this pathway
KOINUMA TARGETS OF SMAD2 OR SMAD3	824	528	All SZGR 2.0 genes in this pathway
WAKABAYASHI ADIPOGENESIS PPARG RXRA BOUND 8D	882	506	All SZGR 2.0 genes in this pathway
RATTENBACHER BOUND BY CELF1	467	251	All SZGR 2.0 genes in this pathway

Gene Page: TLE1