Gene Page: TTPA

Summary ?
GeneID7274
SymbolTTPA
SynonymsATTP|AVED|TTP1|alphaTTP
Descriptiontocopherol (alpha) transfer protein
ReferenceMIM:600415|HGNC:HGNC:12404|Ensembl:ENSG00000137561|HPRD:02685|Vega:OTTHUMG00000164367
Gene typeprotein-coding
Map location8q12.3
Pascal p-value0.349
TADA p-value0.008
Fetal beta-1.648
DMG1 (# studies)
SupportCompositeSet

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
CV:PGCnpGenome-wide Association StudyGWAS
DMG:Jaffe_2016Genome-wide DNA methylation analysisThis dataset includes 2,104 probes/CpGs associated with SZ patients (n=108) compared to 136 controls at Bonferroni-adjusted P < 0.05. 1
DNM:Fromer_2014Whole Exome Sequencing analysisThis study reported a WES study of 623 schizophrenia trios, reporting DNMs using genomic DNA.

Section I. Genetics and epigenetics annotation

@DNM table

GeneChromosomePositionRefAltTranscriptAA changeMutation typeSiftCG46TraitStudy
TTPAchr863978636ACNM_000370p.127F>VmissenseSchizophreniaDNM:Fromer_2014

@Differentially methylated gene

ProbeChromosomePositionNearest geneP (dis)Beta (dis)FDR (dis)Study
cg16231500863998736TTPA6.06E-9-0.0183.22E-6DMG:Jaffe_2016


Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
GenePearson's Correlation Spearman's Correlation
AP1M10.950.95
ZNF5740.950.96
FAM40A0.950.96
TUBGCP20.940.97
EDC40.940.94
TRO0.940.95
RUSC10.940.95
VPS16A0.940.96
RIC8A0.940.94
MAGED10.940.96
Top 10 negatively co-expressed genes
GenePearson's Correlation Spearman's Correlation
AF347015.31-0.80-0.88
MT-CO2-0.80-0.89
AF347015.27-0.79-0.88
AF347015.33-0.78-0.87
AF347015.8-0.77-0.88
MT-CYB-0.76-0.85
AF347015.21-0.75-0.92
FXYD1-0.74-0.83
S100B-0.73-0.82
AF347015.15-0.73-0.84

Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
MCBRYAN PUBERTAL BREAST 4 5WK UP 271175All SZGR 2.0 genes in this pathway
BENPORATH EED TARGETS 1062725All SZGR 2.0 genes in this pathway
BENPORATH ES WITH H3K27ME3 1118744All SZGR 2.0 genes in this pathway
GEORGES TARGETS OF MIR192 AND MIR215 893528All SZGR 2.0 genes in this pathway
NIKOLSKY BREAST CANCER 8Q12 Q22 AMPLICON 13282All SZGR 2.0 genes in this pathway
YAGI AML SURVIVAL 12987All SZGR 2.0 genes in this pathway
IVANOVA HEMATOPOIESIS STEM CELL AND PROGENITOR 681420All SZGR 2.0 genes in this pathway
LEE LIVER CANCER SURVIVAL UP 185112All SZGR 2.0 genes in this pathway
YOSHIMURA MAPK8 TARGETS UP 1305895All SZGR 2.0 genes in this pathway
ZHANG TLX TARGETS 36HR DN 185116All SZGR 2.0 genes in this pathway
ZHANG TLX TARGETS 60HR DN 277166All SZGR 2.0 genes in this pathway
ZHANG TLX TARGETS DN 8950All SZGR 2.0 genes in this pathway
CHIANG LIVER CANCER SUBCLASS CTNNB1 UP 176110All SZGR 2.0 genes in this pathway
CHIANG LIVER CANCER SUBCLASS PROLIFERATION DN 17997All SZGR 2.0 genes in this pathway
WOO LIVER CANCER RECURRENCE DN 8054All SZGR 2.0 genes in this pathway
CAIRO LIVER DEVELOPMENT DN 222141All SZGR 2.0 genes in this pathway
WONG ADULT TISSUE STEM MODULE 721492All SZGR 2.0 genes in this pathway
VERHAAK GLIOBLASTOMA NEURAL 12985All SZGR 2.0 genes in this pathway
CHYLA CBFA2T3 TARGETS UP 387225All SZGR 2.0 genes in this pathway
VANDESLUIS COMMD1 TARGETS GROUP 4 DN 1611All SZGR 2.0 genes in this pathway
MADAN DPPA4 TARGETS 4626All SZGR 2.0 genes in this pathway