Gene Page: VHL

Summary
GeneID  7428
Symbol  VHL
Synonyms  HRCA1|RCA1|VHL1
Description  von Hippel-Lindau tumor suppressor
See related  HGNC:12687|MIM:608537|Ensembl:ENSG00000134086|HPRD:01905|
Locus tag  -
Gene type  protein-coding
Map location  3p26-p25
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
NetworkShortest path distance of core genes in the Human protein-protein interaction networkContribution to shortest path in PPI network: 0.1204 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
AC009041.10.700.53
TRIM170.690.79
AC009041.30.660.50
CORT0.650.73
NPAS20.650.73
TTC220.650.69
TNK10.640.24
ANKRD550.630.77
FHOD10.630.54
APITD10.630.73
Top 10 negatively co-expressed genes
HEBP2-0.36-0.61
CSRP2-0.32-0.48
METRNL-0.31-0.47
COTL1-0.31-0.25
SNX7-0.31-0.26
RNF182-0.31-0.37
CBS-0.30-0.32
NEUROD6-0.30-0.17
SLA-0.30-0.11
KLHL1-0.30-0.10
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0008134transcription factor bindingTAS7660122 
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0000122negative regulation of transcription from RNA polymerase II promoterTAS7660122 
GO:0000902cell morphogenesisNAS12169691 
GO:0001525angiogenesisIEA-
GO:0006508proteolysisTAS10353251 
GO:0006511ubiquitin-dependent protein catabolic processIEA-
GO:0006950response to stressNAS12169691 
GO:0008285negative regulation of cell proliferationTAS7660130 
GO:0006916anti-apoptosisNAS12169691 
GO:0016567protein ubiquitinationIMP12169691 
GO:0050821protein stabilizationNAS12169691 
GO:0030163protein catabolic processIEA-
GO:0030198extracellular matrix organizationIEA-
GO:0045786negative regulation of cell cycleIEA-
GO:0043534blood vessel endothelial cell migrationIEA-
GO:0045597positive regulation of cell differentiationNAS12169691 
GO:0045449regulation of transcriptionIMP15824735 
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005829cytosolTAS7604013 
GO:0005634nucleusTAS7604013 
GO:0005737cytoplasmIEA-
GO:0005739mitochondrionNAS12169691 
GO:0005783endoplasmic reticulumNAS12169691 
GO:0016020membraneIEA-
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
APRTAMP | DKFZp686D13177 | MGC125856 | MGC125857 | MGC129961adenine phosphoribosyltransferaseAffinity Capture-MSBioGRID17353931 
ATXN2ATX2 | FLJ46772 | SCA2 | TNRC13ataxin 2Affinity Capture-MSBioGRID17353931 
CAB39CGI-66 | FLJ22682 | MO25calcium binding protein 39Affinity Capture-MSBioGRID17353931 
CCDC59BR22 | DKFZp686K1021 | FLJ10294 | HSPC128 | TAP26coiled-coil domain containing 59Affinity Capture-MSBioGRID17353931 
CCDC82FLJ23518 | HSPC048coiled-coil domain containing 82Affinity Capture-MSBioGRID17353931 
CDK2p33(CDK2)cyclin-dependent kinase 2Affinity Capture-MSBioGRID17353931 
CDO1-cysteine dioxygenase, type IAffinity Capture-MSBioGRID17353931 
CHMP2BCHMP2.5 | DKFZp564O123 | DMT1 | VPS2-2 | VPS2Bchromatin modifying protein 2BAffinity Capture-MSBioGRID17353931 
CNTFHCNTFciliary neurotrophic factorAffinity Capture-MSBioGRID17353931 
CSTBCST6 | EPM1 | PME | STFBcystatin B (stefin B)Affinity Capture-MSBioGRID17353931 
CSTF3CSTF-77 | MGC117398 | MGC43001 | MGC75122cleavage stimulation factor, 3' pre-RNA, subunit 3, 77kDaAffinity Capture-MSBioGRID17353931 
CUL2MGC131970cullin 2Affinity Capture-MS
Affinity Capture-Western
Reconstituted Complex		BioGRID10587522 |11384984 
|17353931 
CUL5VACM-1 | VACM1cullin 5Reconstituted ComplexBioGRID11384984 
EPAS1ECYT4 | HIF2A | HLF | MOP2 | PASD2endothelial PAS domain protein 1The von Hippel-Lindau tumor suppressor protein (pVHL) interacts with Hypoxia inducible factor-2-alpha (HIF-2 alpha)BIND10823831 
FLNAABP-280 | ABPX | DKFZp434P031 | FLN | FLN1 | FMD | MNS | NHBP | OPD | OPD1 | OPD2filamin A, alpha (actin binding protein 280)The von Hippel-Lindau tumor suppressor protein (pVHL) interacts with FLNA .BIND12169691 
-HPRD,BioGRID8674032 |12169691 
FN1CIG | DKFZp686F10164 | DKFZp686H0342 | DKFZp686I1370 | DKFZp686O13149 | ED-B | FINC | FN | FNZ | GFND | GFND2 | LETS | MSFfibronectin 1pVHL interacts with fibronectin 1BIND10823831 
-HPRD,BioGRID9651579 
FSCN1FLJ38511 | SNL | p55fascin homolog 1, actin-bundling protein (Strongylocentrotus purpuratus)Affinity Capture-MSBioGRID17353931 
HAS1HAShyaluronan synthase 1Affinity Capture-MSBioGRID17353931 
HDAC1DKFZp686H12203 | GON-10 | HD1 | RPD3 | RPD3L1histone deacetylase 1Reconstituted ComplexBioGRID11641274 
HDAC2RPD3 | YAF1histone deacetylase 2Reconstituted ComplexBioGRID11641274 
HDAC3HD3 | RPD3 | RPD3-2histone deacetylase 3Reconstituted ComplexBioGRID11641274 
HIF1AHIF-1alpha | HIF1 | HIF1-ALPHA | MOP1 | PASD8hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)Hydroxylated HIF-1 alpha interacts with VHL. This interaction was modeled on a demonstrated interaction between human hydroxylated HIF-1 alpha and an unspecified isoform of VHL from an unspecified species.BIND15721254 
The von Hippel-Lindau tumor suppressor protein (pVHL) interacts with Hypoxia inducible factor-alpha (HIF-1 alpha)BIND10823831 
-HPRD11504942 
HIF1A (HIF-1alpha) interacts with VHL.BIND15750626 
-HPRD,BioGRID10944113 
HIF1ANDKFZp762F1811 | FIH1 | FLJ20615 | FLJ22027hypoxia-inducible factor 1, alpha subunit inhibitorReconstituted ComplexBioGRID11641274 
HIF3AHIF-3A | HIF-3A2 | HIF-3A4 | IPAS | MOP7 | PASD7 | bHLHe17hypoxia inducible factor 3, alpha subunit-HPRD12538644 
HIST1H2BCH2B.1 | H2B/l | H2BFL | MGC104246 | dJ221C16.3histone cluster 1, H2bcAffinity Capture-MSBioGRID17353931 
HNRNPA2B1DKFZp779B0244 | FLJ22720 | HNRNPA2 | HNRNPB1 | HNRPA2 | HNRPA2B1 | HNRPB1 | RNPA2 | SNRPB1heterogeneous nuclear ribonucleoprotein A2/B1-HPRD,BioGRID11517223 
IARSFLJ20736 | IARS1 | ILRS | PRO0785isoleucyl-tRNA synthetaseAffinity Capture-MSBioGRID17353931 
IMPDH2IMPD2 | IMPDH-IIIMP (inosine monophosphate) dehydrogenase 2Affinity Capture-MSBioGRID17353931 
JMJD1CDKFZp761F0118 | FLJ14374 | KIAA1380 | RP11-10C13.2 | TRIP8jumonji domain containing 1CAffinity Capture-MSBioGRID17353931 
KNTC1FLJ36151 | KIAA0166 | RODkinetochore associated 1Affinity Capture-MSBioGRID17353931 
MCCDKFZp762O1615 | FLJ38893 | FLJ46755 | MCC1mutated in colorectal cancersAffinity Capture-MSBioGRID17353931 
MOBKL32C4D | CGI-95 | MGC12264 | MOB1 | MOB3 | PREI3MOB1, Mps One Binder kinase activator-like 3 (yeast)Affinity Capture-MSBioGRID17353931 
MRCL3MLCB | MRLC3myosin regulatory light chain MRCL3Affinity Capture-MSBioGRID17353931 
NEDD8FLJ43224 | MGC104393 | MGC125896 | MGC125897 | Nedd-8neural precursor cell expressed, developmentally down-regulated 8Affinity Capture-MSBioGRID17353931 
PAPSS2ATPSK2 | SK23'-phosphoadenosine 5'-phosphosulfate synthase 2Affinity Capture-MSBioGRID17353931 
PCMT1-protein-L-isoaspartate (D-aspartate) O-methyltransferaseAffinity Capture-MSBioGRID17353931 
PFASFGAMS | FGARAT | KIAA0361 | PURLphosphoribosylformylglycinamidine synthaseAffinity Capture-MSBioGRID17353931 
PHF17FLJ22479 | JADE1 | KIAA1807PHD finger protein 17The von Hippel-Lindau tumor suppressor protein (pVHL) interacts with Jade-1BIND12169691 
-HPRD,BioGRID12169691 
PIN1DOD | UBL5peptidylprolyl cis/trans isomerase, NIMA-interacting 1Affinity Capture-MSBioGRID17353931 
PKD1L3-polycystic kidney disease 1-like 3Affinity Capture-MSBioGRID17353931 
PPIBCYP-S1 | CYPB | MGC14109 | MGC2224 | SCYLPpeptidylprolyl isomerase B (cyclophilin B)Affinity Capture-MSBioGRID17353931 
PSMB1FLJ25321 | HC5 | KIAA1838 | PMSB1 | PSC5proteasome (prosome, macropain) subunit, beta type, 1Affinity Capture-MSBioGRID17353931 
PSMB3HC10-II | MGC4147proteasome (prosome, macropain) subunit, beta type, 3Affinity Capture-MSBioGRID17353931 
PSMC3MGC8487 | TBP1proteasome (prosome, macropain) 26S subunit, ATPase, 3-HPRD,BioGRID14556007 
PSMD13HSPC027 | Rpn9 | S11 | p40.5proteasome (prosome, macropain) 26S subunit, non-ATPase, 13Affinity Capture-MSBioGRID17353931 
RAB1B-RAB1B, member RAS oncogene familyAffinity Capture-MSBioGRID17353931 
RASGRP1CALDAG-GEFI | CALDAG-GEFII | MGC129998 | MGC129999 | RASGRP | V | hRasGRP1RAS guanyl releasing protein 1 (calcium and DAG-regulated)Affinity Capture-MSBioGRID17353931 
RBX1BA554C12.1 | MGC13357 | MGC1481 | RNF75 | ROC1ring-box 1Affinity Capture-MSBioGRID17353931 
RHOCARH9 | ARHC | H9 | MGC1448 | MGC61427 | RHOH9ras homolog gene family, member CAffinity Capture-MSBioGRID17353931 
RNF139HRCA1 | MGC31961 | RCA1 | TRC8ring finger protein 139-HPRD12032852 
RPA3REPA3replication protein A3, 14kDaAffinity Capture-MSBioGRID17353931 
RPS9-ribosomal protein S9Affinity Capture-MSBioGRID17353931 
STK16FLJ39635 | KRCT | MPSK | PKL12 | TSF1serine/threonine kinase 16Affinity Capture-MSBioGRID17353931 
TAGLN2HA1756 | KIAA0120transgelin 2Affinity Capture-MSBioGRID17353931 
TARSMGC9344 | ThrRSthreonyl-tRNA synthetaseAffinity Capture-MSBioGRID17353931 
TCEB1SIIItranscription elongation factor B (SIII), polypeptide 1 (15kDa, elongin C)Affinity Capture-MS
Co-crystal Structure
Reconstituted Complex
Two-hybrid		BioGRID8674032 |10587522 
|11739384 |12004076 
|17353931 
-HPRD7660130 |10449727 
|12004076 
TCEB2ELOB | SIIItranscription elongation factor B (SIII), polypeptide 2 (18kDa, elongin B)Affinity Capture-MS
Affinity Capture-Western
Co-crystal Structure
Reconstituted Complex		BioGRID10587522 |12004076 
|17353931 
TGFB1I1ARA55 | HIC-5 | HIC5 | TSC-5transforming growth factor beta 1 induced transcript 1Affinity Capture-MSBioGRID17353931 
TPT1FLJ27337 | HRF | TCTP | p02tumor protein, translationally-controlled 1Affinity Capture-MSBioGRID17353931 
TRIM28FLJ29029 | KAP1 | RNF96 | TF1B | TIF1Btripartite motif-containing 28Reconstituted ComplexBioGRID12682018 
TXNDKFZp686B1993 | MGC61975 | TRX | TRX1thioredoxinAffinity Capture-MSBioGRID17353931 
USP33KIAA1097 | MGC16868 | VDU1ubiquitin specific peptidase 33pVHL interacts with VDU1-type II.BIND11739384 
-HPRD,BioGRID11739384 
VBP1PFD3 | PFDN3 | VBP-1von Hippel-Lindau binding protein 1Affinity Capture-Western
Two-hybrid		BioGRID8674032 |12169691 
The von Hippel-Lindau tumor suppressor protein (pVHL) interacts with VBP1.BIND12169691 
ZNF197D3S1363E | P18 | VHLaK | ZKSCAN9 | ZNF166 | ZNF20zinc finger protein 197Affinity Capture-Western
Reconstituted Complex
Two-hybrid		BioGRID12682018 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
KEGG_UBIQUITIN_MEDIATED_PROTEOLYSIS 13898All SZGR genes in this pathway
KEGG_PATHWAYS_IN_CANCER 328259All SZGR genes in this pathway
KEGG_RENAL_CELL_CARCINOMA 7060All SZGR genes in this pathway
BIOCARTA_HIF_PATHWAY 1512All SZGR genes in this pathway
BIOCARTA_VEGF_PATHWAY 2918All SZGR genes in this pathway
PID_HIF2PATHWAY 3429All SZGR genes in this pathway
PID_HIF1A_PATHWAY 1912All SZGR genes in this pathway
REACTOME_REGULATION_OF_HYPOXIA_INDUCIBLE_FACTOR_HIF_BY_OXYGEN 2517All SZGR genes in this pathway
REACTOME_OXYGEN_DEPENDENT_PROLINE_HYDROXYLATION_OF_HYPOXIA_INDUCIBLE_FACTOR_ALPHA 1812All SZGR genes in this pathway
REACTOME_IMMUNE_SYSTEM 933616All SZGR genes in this pathway
REACTOME_ADAPTIVE_IMMUNE_SYSTEM 539350All SZGR genes in this pathway
REACTOME_CLASS_I_MHC_MEDIATED_ANTIGEN_PROCESSING_PRESENTATION 251156All SZGR genes in this pathway
REACTOME_ANTIGEN_PROCESSING_UBIQUITINATION_PROTEASOME_DEGRADATION 212129All SZGR genes in this pathway
NOJIMA_SFRP2_TARGETS_UP 3123All SZGR genes in this pathway
DARWICHE_SKIN_TUMOR_PROMOTER_DN 185115All SZGR genes in this pathway
DARWICHE_PAPILLOMA_RISK_LOW_DN 165107All SZGR genes in this pathway
DARWICHE_PAPILLOMA_RISK_HIGH_UP 147101All SZGR genes in this pathway
DARWICHE_SQUAMOUS_CELL_CARCINOMA_UP 146104All SZGR genes in this pathway
LASTOWSKA_NEUROBLASTOMA_COPY_NUMBER_DN 800473All SZGR genes in this pathway
RASHI_RESPONSE_TO_IONIZING_RADIATION_5 14789All SZGR genes in this pathway
HERNANDEZ_ABERRANT_MITOSIS_BY_DOCETACEL_2NM_UP 8157All SZGR genes in this pathway
DARWICHE_PAPILLOMA_RISK_HIGH_VS_LOW_UP 66All SZGR genes in this pathway
PUJANA_BRCA1_PCC_NETWORK 16521023All SZGR genes in this pathway
PUJANA_ATM_PCC_NETWORK 1442892All SZGR genes in this pathway
GROSS_HYPOXIA_VIA_HIF1A_DN 11078All SZGR genes in this pathway
GROSS_HYPOXIA_VIA_ELK3_AND_HIF1A_UP 142104All SZGR genes in this pathway
LOPEZ_MBD_TARGETS 957597All SZGR genes in this pathway
RICKMAN_METASTASIS_UP 344180All SZGR genes in this pathway
BENPORATH_MYC_TARGETS_WITH_EBOX 230156All SZGR genes in this pathway
FERNANDEZ_BOUND_BY_MYC 182116All SZGR genes in this pathway
DORSAM_HOXA9_TARGETS_DN 3222All SZGR genes in this pathway
GRESHOCK_CANCER_COPY_NUMBER_UP 323240All SZGR genes in this pathway
DANG_REGULATED_BY_MYC_DN 253192All SZGR genes in this pathway
DANG_MYC_TARGETS_DN 3125All SZGR genes in this pathway
DANG_BOUND_BY_MYC 1103714All SZGR genes in this pathway
QI_HYPOXIA 14096All SZGR genes in this pathway


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