SZGR2

Summary ?

GeneID	7534
Symbol	YWHAZ
Synonyms	14-3-3-zeta\|HEL-S-3\|HEL-S-93\|HEL4\|KCIP-1\|YWHAD
Description	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta
Reference	MIM:601288\|HGNC:HGNC:12855\|Ensembl:ENSG00000164924\|HPRD:03183\|Vega:OTTHUMG00000134291
Gene type	protein-coding
Map location	8q23.1
Pascal p-value	0.031
Sherlock p-value	0.209
Fetal beta	0.924
DMG	1 (# studies)
eGene	Anterior cingulate cortex BA24 Caudate basal ganglia Cerebellar Hemisphere Cerebellum Cortex Frontal Cortex BA9 Nucleus accumbens basal ganglia
Support	INTRACELLULAR SIGNAL TRANSDUCTION G2Cdb.human_mGluR5 G2Cdb.human_mitochondria G2Cdb.humanNRC G2Cdb.humanPSD G2Cdb.humanPSP CompositeSet Potential synaptic genes

Gene in Data Sources

Gene set name	Method of gene set	Description	Info
CV:PGCnp	Genome-wide Association Study	GWAS
DMG:Wockner_2014	Genome-wide DNA methylation analysis	This dataset includes 4641 differentially methylated probes corresponding to 2929 unique genes between schizophrenia patients (n=24) and controls (n=24).	2
DNM:Fromer_2014	Whole Exome Sequencing analysis	This study reported a WES study of 623 schizophrenia trios, reporting DNMs using genomic DNA.
PMID:cooccur	High-throughput literature-search	Systematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
Association	A combined odds ratio method (Sun et al. 2008), association studies	1	Link to SZGene
Literature	High-throughput literature-search	Co-occurance with Schizophrenia keywords: schizophrenia,schizophrenic,schizophrenias	Click to show details
Network	Shortest path distance of core genes in the Human protein-protein interaction network	Contribution to shortest path in PPI network: 11.6823

Section I. Genetics and epigenetics annotation

DNM table

Gene	Chromosome	Position	Ref	Alt	Transcript	AA change	Mutation type	Sift	CG46	Trait	Study
YWHAZ	chr8	101937218	T	C	NM_001135699 NM_001135700 NM_001135701 NM_001135702 NM_003406 NM_145690	p.115K>R p.115K>R p.115K>R p.115K>R p.115K>R p.115K>R	missense missense missense missense missense missense			Schizophrenia	DNM:Fromer_2014

Differentially methylated gene

Probe	Chromosome	Position	Nearest gene	P (dis)	Beta (dis)	FDR (dis)	Study
cg06776824	8	101962949	YWHAZ	1.84E-5	0.873	0.016	DMG:Wockner_2014
cg06692871	8	101964133	YWHAZ	5.67E-5	-0.524	0.022	DMG:Wockner_2014

eQTL annotation

SNP ID	Chromosome	Position	eGene	Gene Entrez ID	pvalue	qvalue	TSS distance	eQTL type
rs3105460	8	101937374	YWHAZ	ENSG00000164924.13	1.093E-6	0.01	28242	gtex_brain_ba24
rs34699406	8	101946380	YWHAZ	ENSG00000164924.13	1.095E-6	0.01	19236	gtex_brain_ba24
rs3134353	8	101947453	YWHAZ	ENSG00000164924.13	1.093E-6	0.01	18163	gtex_brain_ba24
rs1470764	8	101950038	YWHAZ	ENSG00000164924.13	1.093E-6	0.01	15578	gtex_brain_ba24
rs3134358	8	101958433	YWHAZ	ENSG00000164924.13	1.138E-6	0.01	7183	gtex_brain_ba24
rs983583	8	101961910	YWHAZ	ENSG00000164924.13	1.155E-6	0.01	3706	gtex_brain_ba24
rs71506350	8	101962901	YWHAZ	ENSG00000164924.13	1.057E-6	0.01	2715	gtex_brain_ba24
rs3100052	8	101967139	YWHAZ	ENSG00000164924.13	1.194E-6	0.01	-1523	gtex_brain_ba24
rs7817485	8	101969528	YWHAZ	ENSG00000164924.13	1.279E-6	0.01	-3912	gtex_brain_ba24
rs4734500	8	101970119	YWHAZ	ENSG00000164924.13	8.091E-7	0.01	-4503	gtex_brain_ba24
rs2386921	8	101975378	YWHAZ	ENSG00000164924.13	4.478E-7	0.01	-9762	gtex_brain_ba24
rs2386922	8	101975479	YWHAZ	ENSG00000164924.13	2.485E-7	0.01	-9863	gtex_brain_ba24
rs2923781	8	101976510	YWHAZ	ENSG00000164924.13	7.683E-7	0.01	-10894	gtex_brain_ba24
rs57408636	8	101980444	YWHAZ	ENSG00000164924.13	3.22E-7	0.01	-14828	gtex_brain_ba24

Section II. Transcriptome annotation

General gene expression (GTEx)

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

No co-expressed genes in brain regions

Section III. Gene Ontology annotation

Molecular function	GO term	Evidence	Neuro keywords	PubMed ID
GO:0008134	transcription factor binding	IPI		16114898
GO:0019904	protein domain specific binding	IEA		-
Biological process	GO term	Evidence	Neuro keywords	PubMed ID
GO:0007165	signal transduction	TAS		16130169
GO:0006916	anti-apoptosis	TAS		16130169
Cellular component	GO term	Evidence	Neuro keywords	PubMed ID
GO:0005737	cytoplasm	TAS		16130169
GO:0042470	melanosome	IEA		-

Section IV. Protein-protein interaction annotation

Interactors	Aliases B	Official full name B	Experimental	Source	PubMed ID
AANAT	AA-NAT \| SNAT	arylalkylamine N-acetyltransferase	-	HPRD,BioGRID	11336675
AANAT	AA-NAT \| SNAT	arylalkylamine N-acetyltransferase	AANAT interacts with 14-3-3-zeta isoform. This interaction was modeled on a demonstrated interaction between sheep AANAT and human 14-3-3-zeta.	BIND	8024705 \|11336675 \|11427721
ADAM22	MDC2 \| MGC149832	ADAM metallopeptidase domain 22	-	HPRD	12589811
ADRA2A	ADRA2 \| ADRA2R \| ADRAR \| ALPHA2AAR \| ZNF32	adrenergic, alpha-2A-, receptor	-	HPRD	10224112
ADRA2B	ADRA2L1 \| ADRA2RL1 \| ADRARL1 \| ALPHA2BAR	adrenergic, alpha-2B-, receptor	-	HPRD	10224112
ADRA2C	ADRA2L2 \| ADRA2RL2 \| ADRARL2 \| ALPHA2CAR	adrenergic, alpha-2C-, receptor	-	HPRD	10224112
AKT1	AKT \| MGC99656 \| PKB \| PKB-ALPHA \| PRKBA \| RAC \| RAC-ALPHA	v-akt murine thymoma viral oncogene homolog 1	-	HPRD,BioGRID	11956222
AKT1	AKT \| MGC99656 \| PKB \| PKB-ALPHA \| PRKBA \| RAC \| RAC-ALPHA	v-akt murine thymoma viral oncogene homolog 1	Akt interaction with and phosphorylation of 14-3-3 zeta at the same residue as MAPKAPK2.	BIND	11956222
ARHGEF2	DKFZp547L106 \| DKFZp547P1516 \| GEF \| GEF-H1 \| GEFH1 \| KIAA0651 \| LFP40 \| P40	rho/rac guanine nucleotide exchange factor (GEF) 2	-	HPRD	14970201
BAD	BBC2 \| BCL2L8	BCL2-associated agonist of cell death	-	HPRD,BioGRID	11410287
BCAR1	CAS \| CAS1 \| CASS1 \| CRKAS \| P130Cas	breast cancer anti-estrogen resistance 1	-	HPRD,BioGRID	10026197
BCR	ALL \| BCR-ABL1 \| BCR1 \| CML \| D22S11 \| D22S662 \| FLJ16453 \| PHL	breakpoint cluster region	-	HPRD	7939633
BRAF	B-RAF1 \| BRAF1 \| FLJ95109 \| MGC126806 \| MGC138284 \| RAFB1	v-raf murine sarcoma viral oncogene homolog B1	Affinity Capture-MS	BioGRID	17353931
BRAF	B-RAF1 \| BRAF1 \| FLJ95109 \| MGC126806 \| MGC138284 \| RAFB1	v-raf murine sarcoma viral oncogene homolog B1	-	HPRD	8668348
BSPRY	FLJ20150	B-box and SPRY domain containing	-	HPRD	12615066
C22orf9	-	chromosome 22 open reading frame 9	Affinity Capture-MS	BioGRID	17353931
CBL	C-CBL \| CBL2 \| RNF55	Cas-Br-M (murine) ecotropic retroviral transforming sequence	Two-hybrid	BioGRID	9367879
CBL	C-CBL \| CBL2 \| RNF55	Cas-Br-M (murine) ecotropic retroviral transforming sequence	c-Cbl interacts with 14-3-3-zeta.	BIND	9367879
CDC25A	CDC25A2	cell division cycle 25 homolog A (S. pombe)	-	HPRD,BioGRID	11912208
CDC25B	-	cell division cycle 25 homolog B (S. pombe)	-	HPRD,BioGRID	10713667
CDC25B	-	cell division cycle 25 homolog B (S. pombe)	14-3-3-zeta interacts with phosphorylated CDC25B.	BIND	15629715
CDC25C	CDC25	cell division cycle 25 homolog C (S. pombe)	-	HPRD,BioGRID	10864927
CLIC4	CLIC4L \| DKFZp566G223 \| FLJ38640 \| H1 \| MTCLIC \| huH1 \| p64H1	chloride intracellular channel 4	-	HPRD	11563969
CSF2RB	CD131 \| CDw131 \| IL3RB \| IL5RB	colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage)	-	HPRD,BioGRID	8278375 \|10477722
DFFA	DFF-45 \| DFF1 \| ICAD	DNA fragmentation factor, 45kDa, alpha polypeptide	Affinity Capture-MS	BioGRID	17353931
EDC3	FLJ21128 \| FLJ31777 \| LSM16 \| YJDC \| YJEFN2	enhancer of mRNA decapping 3 homolog (S. cerevisiae)	Affinity Capture-MS	BioGRID	17353931
EGFR	ERBB \| ERBB1 \| HER1 \| PIG61 \| mENA	epidermal growth factor receptor (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian)	EGFR interacts with 14-3-3-zeta.	BIND	15225635
EPB41L3	4.1B \| DAL-1 \| DAL1 \| FLJ37633 \| KIAA0987	erythrocyte membrane protein band 4.1-like 3	Affinity Capture-MS	BioGRID	17353931
FOXO1	FKH1 \| FKHR \| FOXO1A	forkhead box O1	-	HPRD,BioGRID	11237865
FOXO3	AF6q21 \| DKFZp781A0677 \| FKHRL1 \| FKHRL1P2 \| FOXO2 \| FOXO3A \| MGC12739 \| MGC31925	forkhead box O3	-	HPRD,BioGRID	10102273
GP1BA	BSS \| CD42B \| CD42b-alpha \| GP1B \| MGC34595	glycoprotein Ib (platelet), alpha polypeptide	-	HPRD,BioGRID	8631758 \|9454760 \|10627461\|9454760
GP1BB	CD42c	glycoprotein Ib (platelet), beta polypeptide	-	HPRD	8034572 \|10627461
GP1BB	CD42c	glycoprotein Ib (platelet), beta polypeptide	in vitro in vivo Two-hybrid	BioGRID	8034572 \|9454760 \|10627461
HDAC4	HA6116 \| HD4 \| HDAC-A \| HDACA \| KIAA0288	histone deacetylase 4	Reconstituted Complex	BioGRID	11504882
HDAC4	HA6116 \| HD4 \| HDAC-A \| HDACA \| KIAA0288	histone deacetylase 4	-	HPRD	11486037
HMGN1	FLJ27265 \| FLJ31471 \| HMG14 \| MGC104230 \| MGC117425	high-mobility group nucleosome binding domain 1	-	HPRD,BioGRID	12215538
HNRNPL	FLJ35509 \| HNRPL \| P/OKcl.14 \| hnRNP-L	heterogeneous nuclear ribonucleoprotein L	Affinity Capture-MS	BioGRID	17353931
IGF1R	CD221 \| IGFIR \| JTK13 \| MGC142170 \| MGC142172 \| MGC18216	insulin-like growth factor 1 receptor	-	HPRD	9581554
IGF1R	CD221 \| IGFIR \| JTK13 \| MGC142170 \| MGC142172 \| MGC18216	insulin-like growth factor 1 receptor	IGFIR interacts with 14-3-3-zeta isoform.	BIND	9581554
IL9R	CD129	interleukin 9 receptor	-	HPRD,BioGRID	10642536
INPP5A	5PTASE \| DKFZp434A1721 \| MGC116947 \| MGC116949	inositol polyphosphate-5-phosphatase, 40kDa	-	HPRD,BioGRID	9398266
IRS1	HIRS-1	insulin receptor substrate 1	-	HPRD,BioGRID	9312143
IRS2	-	insulin receptor substrate 2	-	HPRD,BioGRID	9312143
KIAA1377	-	KIAA1377	Two-hybrid	BioGRID	16169070
KIF1C	KIAA0706 \| LTXS1	kinesin family member 1C	-	HPRD	10559254
KIF5B	KINH \| KNS \| KNS1 \| UKHC	kinesin family member 5B	Affinity Capture-MS	BioGRID	17353931
KLC1	KLC \| KNS2 \| KNS2A \| MGC15245	kinesin light chain 1	Affinity Capture-MS	BioGRID	17353931
KLC4	KNSL8 \| MGC111777 \| bA387M24.3	kinesin light chain 4	Affinity Capture-MS	BioGRID	17353931
KRT18	CYK18 \| K18	keratin 18	-	HPRD	9524113 \|11917136
LARP1	KIAA0731 \| LARP \| MGC19556	La ribonucleoprotein domain family, member 1	Affinity Capture-MS	BioGRID	17353931
LIMK1	LIMK	LIM domain kinase 1	-	HPRD,BioGRID	12323073
LYST	CHS \| CHS1	lysosomal trafficking regulator	Reconstituted Complex	BioGRID	11984006
MAP3K2	MEKK2 \| MEKK2B	mitogen-activated protein kinase kinase kinase 2	-	HPRD	9452471
MAP3K3	MAPKKK3 \| MEKK3	mitogen-activated protein kinase kinase kinase 3	-	HPRD	9452471
MAP3K5	ASK1 \| MAPKKK5 \| MEKK5	mitogen-activated protein kinase kinase kinase 5	-	HPRD,BioGRID	10411906\|11336675
MAPKAPK2	MK2	mitogen-activated protein kinase-activated protein kinase 2	MAPKAPK2 interacts with and phosphorylates 14-3-3-zeta.	BIND	12861023
MAPT	DDPAC \| FLJ31424 \| FTDP-17 \| MAPTL \| MGC138549 \| MSTD \| MTBT1 \| MTBT2 \| PPND \| TAU	microtubule-associated protein tau	Tau interacts with 14-3-3-zeta.	BIND	12176984
MAPT	DDPAC \| FLJ31424 \| FTDP-17 \| MAPTL \| MGC138549 \| MSTD \| MTBT1 \| MTBT2 \| PPND \| TAU	microtubule-associated protein tau	-	HPRD,BioGRID	10840038
MLF1	-	myeloid leukemia factor 1	-	HPRD	12176995
NADK	FLJ13052 \| FLJ37724 \| dJ283E3.1	NAD kinase	Affinity Capture-MS	BioGRID	17353931
NCKAP1	FLJ11291 \| HEM2 \| KIAA0587 \| MGC8981 \| NAP1 \| NAP125	NCK-associated protein 1	Affinity Capture-MS	BioGRID	17353931
NFATC2	KIAA0611 \| NFAT1 \| NFATP	nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2	-	HPRD,BioGRID	10611249
NFATC4	NF-ATc4 \| NFAT3	nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4	-	HPRD,BioGRID	10611249
NOLC1	KIAA0035 \| NOPP130 \| NOPP140 \| NS5ATP13 \| P130	nucleolar and coiled-body phosphoprotein 1	Affinity Capture-MS	BioGRID	17353931
PABPC4	APP-1 \| APP1 \| FLJ43938 \| PABP4 \| iPABP	poly(A) binding protein, cytoplasmic 4 (inducible form)	Affinity Capture-MS	BioGRID	17353931
PAK4	-	p21 protein (Cdc42/Rac)-activated kinase 4	Affinity Capture-MS	BioGRID	17353931
PCTK1	FLJ16665 \| PCTAIRE \| PCTAIRE1 \| PCTGAIRE	PCTAIRE protein kinase 1	-	HPRD,BioGRID	9197417
PDC	MEKA \| PHD \| PhLOP \| PhLP	phosducin	-	HPRD	11287646 \|11331285
PFKFB2	DKFZp781D2217 \| MGC138308 \| MGC138310 \| PFK-2/FBPase-2	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2	-	HPRD	12853467
PRKCA	AAG6 \| MGC129900 \| MGC129901 \| PKC-alpha \| PKCA \| PRKACA	protein kinase C, alpha	-	HPRD,BioGRID	11950841
PRKCD	MAY1 \| MGC49908 \| PKCD \| nPKC-delta	protein kinase C, delta	Affinity Capture-Western	BioGRID	11950841
PRKCE	MGC125656 \| MGC125657 \| PKCE \| nPKC-epsilon	protein kinase C, epsilon	Affinity Capture-Western	BioGRID	11950841
PRKCI	DXS1179E \| MGC26534 \| PKCI \| nPKC-iota	protein kinase C, iota	Reconstituted Complex	BioGRID	12893243
PRKCZ	PKC-ZETA \| PKC2	protein kinase C, zeta	Biochemical Activity Reconstituted Complex	BioGRID	10620507 \|12893243
PRKD1	PKC-MU \| PKCM \| PKD \| PRKCM	protein kinase D1	Reconstituted Complex	BioGRID	12893243
PTPN13	DKFZp686J1497 \| FAP-1 \| PNP1 \| PTP-BAS \| PTP-BL \| PTP1E \| PTPL1 \| PTPLE	protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase)	-	HPRD	9305890
RAF1	CRAF \| NS5 \| Raf-1 \| c-Raf	v-raf-1 murine leukemia viral oncogene homolog 1	Raf-1 interacts with 14-3-3 zeta. This interaction was modelled on a demonstrated interaction between human Raf-1 and murine 14-3-3-zeta.	BIND	7559537
RAF1	CRAF \| NS5 \| Raf-1 \| c-Raf	v-raf-1 murine leukemia viral oncogene homolog 1	Affinity Capture-Western Reconstituted Complex	BioGRID	7628630 \|9261098 \|10620507 \|10887173
RAF1	CRAF \| NS5 \| Raf-1 \| c-Raf	v-raf-1 murine leukemia viral oncogene homolog 1	-	HPRD	7628630 \|7939632
RAI14	DKFZp564G013 \| KIAA1334 \| NORPEG \| RAI13	retinoic acid induced 14	Affinity Capture-MS	BioGRID	17353931
RALGPS2	FLJ10244 \| FLJ25604 \| KIAA0351 \| dJ595C2.1	Ral GEF with PH domain and SH3 binding motif 2	Affinity Capture-MS	BioGRID	17353931
REM1	GD:REM \| GES \| MGC48669 \| REM	RAS (RAD and GEM)-like GTP-binding 1	-	HPRD,BioGRID	10441394
RGS3	C2PA \| FLJ20370 \| FLJ31516 \| FLJ90496 \| PDZ-RGS3 \| RGP3	regulator of G-protein signaling 3	-	HPRD,BioGRID	11985497
RIN1	-	Ras and Rab interactor 1	-	HPRD	9144171
RPL31	MGC88191	ribosomal protein L31	Affinity Capture-MS	BioGRID	17353931
RRAD	RAD \| RAD1 \| REM3	Ras-related associated with diabetes	Affinity Capture-Western	BioGRID	10441394
SAMD4B	FLJ10211 \| MGC99832 \| SMGB	sterile alpha motif domain containing 4B	Affinity Capture-MS	BioGRID	17353931
SF3B1	PRP10 \| PRPF10 \| SAP155 \| SF3b155	splicing factor 3b, subunit 1, 155kDa	Affinity Capture-MS	BioGRID	17353931
SFRS10	DKFZp686F18120 \| Htra2-beta \| SRFS10 \| TRA2-BETA \| TRA2B \| TRAN2B	splicing factor, arginine/serine-rich 10 (transformer 2 homolog, Drosophila)	Affinity Capture-MS	BioGRID	17353931
SSH1	FLJ38102 \| KIAA1298 \| SSH-1	slingshot homolog 1 (Drosophila)	SSH-1S interacts with 14-3-3-zeta.	BIND	15660133
SSH1	FLJ38102 \| KIAA1298 \| SSH-1	slingshot homolog 1 (Drosophila)	SSH-1L interacts with 14-3-3-zeta.	BIND	15660133
SSH2	KIAA1725 \| MGC78588 \| SSH-2	slingshot homolog 2 (Drosophila)	SSH-2S interacts with 14-3-3-zeta.	BIND	15660133
SSH3	FLJ10928 \| FLJ20515 \| SSH-3	slingshot homolog 3 (Drosophila)	SSH-3S interacts with 14-3-3-zeta.	BIND	15660133
SYN2	SYNII \| SYNIIa \| SYNIIb	synapsin II	Two-hybrid	BioGRID	10358015
TERT	EST2 \| TCS1 \| TP2 \| TRT \| hEST2	telomerase reverse transcriptase	Two-hybrid	BioGRID	10835362
TH	TYH	tyrosine hydroxylase	-	HPRD	11359875
TJP2	MGC26306 \| X104 \| ZO-2 \| ZO2	tight junction protein 2 (zona occludens 2)	Affinity Capture-MS	BioGRID	17353931
TNFAIP3	A20 \| MGC104522 \| MGC138687 \| MGC138688 \| OTUD7C \| TNFA1P2	tumor necrosis factor, alpha-induced protein 3	-	HPRD,BioGRID	9299557
TP53	FLJ92943 \| LFS1 \| TRP53 \| p53	tumor protein p53	-	HPRD,BioGRID	9620776
TPH1	MGC119994 \| TPH \| TPRH	tryptophan hydroxylase 1	-	HPRD,BioGRID	8101440
TSC1	KIAA0243 \| LAM \| MGC86987 \| TSC	tuberous sclerosis 1	-	HPRD,BioGRID	12176984
TSC2	FLJ43106 \| LAM \| TSC4	tuberous sclerosis 2	-	HPRD	12176984 \|12438239 \|12468542
TSC2	FLJ43106 \| LAM \| TSC4	tuberous sclerosis 2	-	HPRD,BioGRID	12176984
TSC2	FLJ43106 \| LAM \| TSC4	tuberous sclerosis 2	Tumor suppressor protein tuberin interacts with 14-3-3-zeta isoform.	BIND	11533041 \|12176984
UCP2	BMIQ4 \| SLC25A8 \| UCPH	uncoupling protein 2 (mitochondrial, proton carrier)	UCP2 interacts with 14.3.3-zeta.	BIND	10785390
UCP2	BMIQ4 \| SLC25A8 \| UCPH	uncoupling protein 2 (mitochondrial, proton carrier)	-	HPRD,BioGRID	10785390
UCP3	SLC25A9	uncoupling protein 3 (mitochondrial, proton carrier)	UCP3 interacts with 14.3.3-zeta.	BIND	10785390
UCP3	SLC25A9	uncoupling protein 3 (mitochondrial, proton carrier)	-	HPRD,BioGRID	10785390
USP8	FLJ34456 \| HumORF8 \| KIAA0055 \| MGC129718 \| UBPY	ubiquitin specific peptidase 8	Affinity Capture-MS	BioGRID	17353931
VIM	FLJ36605	vimentin	-	HPRD,BioGRID	10887173
XRCC6	CTC75 \| CTCBF \| G22P1 \| KU70 \| ML8 \| TLAA	X-ray repair complementing defective repair in Chinese hamster cells 6	Two-hybrid	BioGRID	16169070
YWHAZ	KCIP-1 \| MGC111427 \| MGC126532 \| MGC138156	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide	Affinity Capture-Western Reconstituted Complex	BioGRID	10887173
YWHAZ	KCIP-1 \| MGC111427 \| MGC126532 \| MGC138156	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide	-	HPRD	11336675
YWHAZ	KCIP-1 \| MGC111427 \| MGC126532 \| MGC138156	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide	14-3-3zeta homodimerizes.	BIND	12861023

Section V. Pathway annotation

Pathway name	Pathway size	# SZGR 2.0 genes in pathway	Info
KEGG CELL CYCLE	128	84	All SZGR 2.0 genes in this pathway
KEGG OOCYTE MEIOSIS	114	79	All SZGR 2.0 genes in this pathway
KEGG NEUROTROPHIN SIGNALING PATHWAY	126	103	All SZGR 2.0 genes in this pathway
KEGG PATHOGENIC ESCHERICHIA COLI INFECTION	59	36	All SZGR 2.0 genes in this pathway
BIOCARTA CHREBP2 PATHWAY	42	35	All SZGR 2.0 genes in this pathway
SIG PIP3 SIGNALING IN CARDIAC MYOCTES	67	54	All SZGR 2.0 genes in this pathway
SIG INSULIN RECEPTOR PATHWAY IN CARDIAC MYOCYTES	51	41	All SZGR 2.0 genes in this pathway
ST PHOSPHOINOSITIDE 3 KINASE PATHWAY	37	29	All SZGR 2.0 genes in this pathway
PID GMCSF PATHWAY	37	31	All SZGR 2.0 genes in this pathway
PID ATR PATHWAY	39	25	All SZGR 2.0 genes in this pathway
PID LKB1 PATHWAY	47	37	All SZGR 2.0 genes in this pathway
PID NFAT 3PATHWAY	54	47	All SZGR 2.0 genes in this pathway
PID MTOR 4PATHWAY	69	55	All SZGR 2.0 genes in this pathway
PID IGF1 PATHWAY	30	23	All SZGR 2.0 genes in this pathway
PID FOXO PATHWAY	49	43	All SZGR 2.0 genes in this pathway
PID ERBB1 DOWNSTREAM PATHWAY	105	78	All SZGR 2.0 genes in this pathway
PID IL3 PATHWAY	27	19	All SZGR 2.0 genes in this pathway
PID PDGFRB PATHWAY	129	103	All SZGR 2.0 genes in this pathway
PID P38 MK2 PATHWAY	21	19	All SZGR 2.0 genes in this pathway
PID BETA CATENIN NUC PATHWAY	80	60	All SZGR 2.0 genes in this pathway
PID A6B1 A6B4 INTEGRIN PATHWAY	46	35	All SZGR 2.0 genes in this pathway
PID INSULIN GLUCOSE PATHWAY	26	24	All SZGR 2.0 genes in this pathway
PID PI3KCI AKT PATHWAY	35	30	All SZGR 2.0 genes in this pathway
PID PI3K PLC TRK PATHWAY	36	31	All SZGR 2.0 genes in this pathway
PID INTEGRIN A4B1 PATHWAY	33	24	All SZGR 2.0 genes in this pathway
REACTOME METABOLISM OF MRNA	284	128	All SZGR 2.0 genes in this pathway
REACTOME METABOLISM OF RNA	330	155	All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY ILS	107	86	All SZGR 2.0 genes in this pathway
REACTOME IL 3 5 AND GM CSF SIGNALING	43	34	All SZGR 2.0 genes in this pathway
REACTOME RAP1 SIGNALLING	17	12	All SZGR 2.0 genes in this pathway
REACTOME REGULATION OF MRNA STABILITY BY PROTEINS THAT BIND AU RICH ELEMENTS	84	50	All SZGR 2.0 genes in this pathway
REACTOME DESTABILIZATION OF MRNA BY KSRP	17	9	All SZGR 2.0 genes in this pathway
REACTOME HEMOSTASIS	466	331	All SZGR 2.0 genes in this pathway
REACTOME IMMUNE SYSTEM	933	616	All SZGR 2.0 genes in this pathway
REACTOME ADAPTIVE IMMUNE SYSTEM	539	350	All SZGR 2.0 genes in this pathway
REACTOME CYTOKINE SIGNALING IN IMMUNE SYSTEM	270	204	All SZGR 2.0 genes in this pathway
REACTOME PLATELET ACTIVATION SIGNALING AND AGGREGATION	208	138	All SZGR 2.0 genes in this pathway
ONKEN UVEAL MELANOMA UP	783	507	All SZGR 2.0 genes in this pathway
FRASOR TAMOXIFEN RESPONSE UP	51	36	All SZGR 2.0 genes in this pathway
THUM SYSTOLIC HEART FAILURE UP	423	283	All SZGR 2.0 genes in this pathway
DIAZ CHRONIC MEYLOGENOUS LEUKEMIA UP	1382	904	All SZGR 2.0 genes in this pathway
BORCZUK MALIGNANT MESOTHELIOMA UP	305	185	All SZGR 2.0 genes in this pathway
SENESE HDAC1 TARGETS UP	457	269	All SZGR 2.0 genes in this pathway
SENESE HDAC3 TARGETS UP	501	327	All SZGR 2.0 genes in this pathway
RODRIGUES THYROID CARCINOMA POORLY DIFFERENTIATED UP	633	376	All SZGR 2.0 genes in this pathway
RODRIGUES THYROID CARCINOMA ANAPLASTIC UP	722	443	All SZGR 2.0 genes in this pathway
HAHTOLA MYCOSIS FUNGOIDES SKIN UP	177	113	All SZGR 2.0 genes in this pathway
ENK UV RESPONSE KERATINOCYTE UP	530	342	All SZGR 2.0 genes in this pathway
GRAESSMANN APOPTOSIS BY DOXORUBICIN DN	1781	1082	All SZGR 2.0 genes in this pathway
GRAESSMANN RESPONSE TO MC AND DOXORUBICIN DN	770	415	All SZGR 2.0 genes in this pathway
GAUSSMANN MLL AF4 FUSION TARGETS C UP	170	114	All SZGR 2.0 genes in this pathway
OUELLET OVARIAN CANCER INVASIVE VS LMP UP	117	85	All SZGR 2.0 genes in this pathway
LUI THYROID CANCER PAX8 PPARG DN	45	29	All SZGR 2.0 genes in this pathway
LI LUNG CANCER	41	30	All SZGR 2.0 genes in this pathway
LINDGREN BLADDER CANCER CLUSTER 2B	392	251	All SZGR 2.0 genes in this pathway
PATIL LIVER CANCER	747	453	All SZGR 2.0 genes in this pathway
GRUETZMANN PANCREATIC CANCER UP	358	245	All SZGR 2.0 genes in this pathway
SPIELMAN LYMPHOBLAST EUROPEAN VS ASIAN DN	584	395	All SZGR 2.0 genes in this pathway
NUYTTEN NIPP1 TARGETS UP	769	437	All SZGR 2.0 genes in this pathway
NUYTTEN EZH2 TARGETS UP	1037	673	All SZGR 2.0 genes in this pathway
SCHAEFFER PROSTATE DEVELOPMENT 6HR DN	514	330	All SZGR 2.0 genes in this pathway
SCHAEFFER SOX9 TARGETS IN PROSTATE DEVELOPMENT DN	45	33	All SZGR 2.0 genes in this pathway
GOTZMANN EPITHELIAL TO MESENCHYMAL TRANSITION DN	206	136	All SZGR 2.0 genes in this pathway
DEN INTERACT WITH LCA5	26	21	All SZGR 2.0 genes in this pathway
NIKOLSKY BREAST CANCER 8Q12 Q22 AMPLICON	132	82	All SZGR 2.0 genes in this pathway
FLECHNER PBL KIDNEY TRANSPLANT OK VS DONOR UP	151	100	All SZGR 2.0 genes in this pathway
WANG TARGETS OF MLL CBP FUSION UP	44	26	All SZGR 2.0 genes in this pathway
LI WILMS TUMOR VS FETAL KIDNEY 1 DN	163	115	All SZGR 2.0 genes in this pathway
KAAB FAILED HEART ATRIUM DN	141	99	All SZGR 2.0 genes in this pathway
LU AGING BRAIN DN	153	120	All SZGR 2.0 genes in this pathway
BLALOCK ALZHEIMERS DISEASE DN	1237	837	All SZGR 2.0 genes in this pathway
JI RESPONSE TO FSH DN	58	43	All SZGR 2.0 genes in this pathway
DAZARD RESPONSE TO UV SCC UP	123	75	All SZGR 2.0 genes in this pathway
JIANG HYPOXIA NORMAL	311	205	All SZGR 2.0 genes in this pathway
BAELDE DIABETIC NEPHROPATHY DN	434	302	All SZGR 2.0 genes in this pathway
DURCHDEWALD SKIN CARCINOGENESIS DN	264	168	All SZGR 2.0 genes in this pathway
ZHONG SECRETOME OF LUNG CANCER AND MACROPHAGE	77	50	All SZGR 2.0 genes in this pathway
ZHONG SECRETOME OF LUNG CANCER AND ENDOTHELIUM	66	47	All SZGR 2.0 genes in this pathway
ZHONG SECRETOME OF LUNG CANCER AND FIBROBLAST	132	93	All SZGR 2.0 genes in this pathway
MARSON BOUND BY FOXP3 UNSTIMULATED	1229	713	All SZGR 2.0 genes in this pathway
SMID BREAST CANCER RELAPSE IN BONE DN	315	197	All SZGR 2.0 genes in this pathway
SMID BREAST CANCER BASAL UP	648	398	All SZGR 2.0 genes in this pathway
TOYOTA TARGETS OF MIR34B AND MIR34C	463	262	All SZGR 2.0 genes in this pathway
WANG TUMOR INVASIVENESS DN	210	128	All SZGR 2.0 genes in this pathway
YOSHIMURA MAPK8 TARGETS DN	366	257	All SZGR 2.0 genes in this pathway
HSIAO HOUSEKEEPING GENES	389	245	All SZGR 2.0 genes in this pathway
YAMASHITA LIVER CANCER STEM CELL UP	47	38	All SZGR 2.0 genes in this pathway
CAIRO HEPATOBLASTOMA CLASSES UP	605	377	All SZGR 2.0 genes in this pathway
GUTIERREZ MULTIPLE MYELOMA UP	35	24	All SZGR 2.0 genes in this pathway
FEVR CTNNB1 TARGETS DN	553	343	All SZGR 2.0 genes in this pathway
KOINUMA TARGETS OF SMAD2 OR SMAD3	824	528	All SZGR 2.0 genes in this pathway
IKEDA MIR1 TARGETS UP	53	39	All SZGR 2.0 genes in this pathway
IKEDA MIR30 TARGETS UP	116	87	All SZGR 2.0 genes in this pathway
GUILLAUMOND KLF10 TARGETS UP	51	39	All SZGR 2.0 genes in this pathway

Section VI. microRNA annotation

miRNA family	Target position			miRNA ID	miRNA seq
miRNA family	UTR start	UTR end	Match method	miRNA ID	miRNA seq
miR-1/206	590	597	1A,m8	hsa-miR-1	UGGAAUGUAAAGAAGUAUGUA
				hsa-miR-206^SZ	UGGAAUGUAAGGAAGUGUGUGG
				hsa-miR-613	AGGAAUGUUCCUUCUUUGCC
miR-149	172	178	m8	hsa-miR-149^brain	UCUGGCUCCGUGUCUUCACUCC
miR-155	1353	1360	1A,m8	hsa-miR-155	UUAAUGCUAAUCGUGAUAGGGG
miR-193	296	302	m8	hsa-miR-193a	AACUGGCCUACAAAGUCCCAG
miR-193	296	302	m8	hsa-miR-193b	AACUGGCCCUCAAAGUCCCGCUUU
miR-214	613	619	m8	hsa-miR-214^brain	ACAGCAGGCACAGACAGGCAG
miR-30-5p	85	91	m8	hsa-miR-30a-5p	UGUAAACAUCCUCGACUGGAAG
				hsa-miR-30c^brain	UGUAAACAUCCUACACUCUCAGC
				hsa-miR-30d^SZ	UGUAAACAUCCCCGACUGGAAG
				hsa-miR-30b^SZ	UGUAAACAUCCUACACUCAGCU
				hsa-miR-30e-5p	UGUAAACAUCCUUGACUGGA
miR-328	294	300	m8	hsa-miR-328^brain	CUGGCCCUCUCUGCCCUUCCGU
miR-34b	334	341	1A,m8	hsa-miR-34b	UAGGCAGUGUCAUUAGCUGAUUG
miR-433-3p	916	922	1A	hsa-miR-433^brain	AUCAUGAUGGGCUCCUCGGUGU
miR-451	582	588	m8	hsa-miR-451^brain	AAACCGUUACCAUUACUGAGUUU
miR-544	577	583	1A	hsa-miR-544	AUUCUGCAUUUUUAGCAAGU
miR-93.hd/291-3p/294/295/302/372/373/520	426	433	1A,m8	hsa-miR-93^brain	AAAGUGCUGUUCGUGCAGGUAG
				hsa-miR-302a	UAAGUGCUUCCAUGUUUUGGUGA
				hsa-miR-302b	UAAGUGCUUCCAUGUUUUAGUAG
				hsa-miR-302c	UAAGUGCUUCCAUGUUUCAGUGG
				hsa-miR-302d	UAAGUGCUUCCAUGUUUGAGUGU
				hsa-miR-372	AAAGUGCUGCGACAUUUGAGCGU
				hsa-miR-373	GAAGUGCUUCGAUUUUGGGGUGU
				hsa-miR-520e	AAAGUGCUUCCUUUUUGAGGG
				hsa-miR-520a	AAAGUGCUUCCCUUUGGACUGU
				hsa-miR-520b	AAAGUGCUUCCUUUUAGAGGG
				hsa-miR-520c	AAAGUGCUUCCUUUUAGAGGGUU
				hsa-miR-520d	AAAGUGCUUCUCUUUGGUGGGUU

SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.

Gene Page: YWHAZ