SZGR2

Summary ?

GeneID	811
Symbol	CALR
Synonyms	CRT\|HEL-S-99n\|RO\|SSA\|cC1qR
Description	calreticulin
Reference	MIM:109091\|HGNC:HGNC:1455\|Ensembl:ENSG00000179218\|HPRD:00169\|Vega:OTTHUMG00000180574
Gene type	protein-coding
Map location	19p13.13
Pascal p-value	0.041
Sherlock p-value	0.055
Fetal beta	0.049
eGene	Myers' cis & trans
Support	INTRACELLULAR SIGNAL TRANSDUCTION

Gene in Data Sources

Gene set name	Method of gene set	Description	Info
CV:PGCnp	Genome-wide Association Study	GWAS
PMID:cooccur	High-throughput literature-search	Systematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
Literature	High-throughput literature-search	Co-occurance with Schizophrenia keywords: schizophrenia,schizophrenias	Click to show details

Section I. Genetics and epigenetics annotation

eQTL annotation

SNP ID	Chromosome	Position	eGene	Gene Entrez ID	pvalue	qvalue	TSS distance	eQTL type
rs2140065	chr1	241390757	CALR	811		0.06		trans

Section II. Transcriptome annotation

General gene expression (GTEx)

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
Gene	Pearson's Correlation	Spearman's Correlation
SYNPO	0.95	0.95
PACSIN1	0.95	0.93
CAMTA2	0.95	0.87
MICAL2	0.93	0.84
MFSD4	0.92	0.92
DGKZ	0.92	0.88
EXTL1	0.92	0.92
C8orf46	0.91	0.89
KCNAB2	0.91	0.90
SLC17A7	0.91	0.72

Top 10 negatively co-expressed genes
Gene	Pearson's Correlation	Spearman's Correlation
BCL7C	-0.60	-0.71
TRAF4	-0.54	-0.67
TUBB2B	-0.54	-0.63
KIAA1949	-0.54	-0.55
PDE9A	-0.53	-0.63
SH3BP2	-0.53	-0.63
SH2B2	-0.53	-0.63
DYNLT1	-0.53	-0.70
FADS2	-0.53	-0.53
PPP1R14B	-0.52	-0.69

Section IV. Protein-protein interaction annotation

Interactors	Aliases B	Official full name B	Experimental	Source	PubMed ID
APOB	FLDB	apolipoprotein B (including Ag(x) antigen)	-	HPRD,BioGRID	10513896 \|12397072
APP	AAA \| ABETA \| ABPP \| AD1 \| APPI \| CTFgamma \| CVAP \| PN2	amyloid beta (A4) precursor protein	-	HPRD,BioGRID	11378243
AR	AIS \| DHTR \| HUMARA \| KD \| NR3C4 \| SBMA \| SMAX1 \| TFM	androgen receptor	-	HPRD,BioGRID	8107809
B2M	-	beta-2-microglobulin	-	HPRD	8769474
CALR	CRT \| FLJ26680 \| RO \| SSA \| cC1qR	calreticulin	CRT interacts with itself to form a dimer.	BIND	15383281
CANX	CNX \| FLJ26570 \| IP90 \| P90	calnexin	Affinity Capture-Western	BioGRID	10436013
CD1D	CD1A \| MGC34622 \| R3	CD1d molecule	-	HPRD,BioGRID	12239218
CD40	Bp50 \| CDW40 \| MGC9013 \| TNFRSF5 \| p50	CD40 molecule, TNF receptor superfamily member 5	Affinity Capture-MS	BioGRID	17353931
CD93	C1QR1 \| C1qR(P) \| C1qRP \| CDw93 \| MXRA4 \| dJ737E23.1	CD93 molecule	-	HPRD	8062452
ELF3	EPR-1 \| ERT \| ESE-1 \| ESX	E74-like factor 3 (ets domain transcription factor, epithelial-specific )	Affinity Capture-MS	BioGRID	17353931
EPB41	4.1R \| EL1 \| HE	erythrocyte membrane protein band 4.1 (elliptocytosis 1, RH-linked)	Affinity Capture-MS	BioGRID	17353931
F5	FVL \| PCCF	coagulation factor V (proaccelerin, labile factor)	Affinity Capture-Western	BioGRID	9525969
F8	AHF \| DXS1253E \| F8B \| F8C \| FVIII \| HEMA	coagulation factor VIII, procoagulant component	-	HPRD	9525969
FBN1	FBN \| MASS \| MFS1 \| OCTD \| SGS \| WMS	fibrillin 1	-	HPRD	10547375
FGB	MGC104327 \| MGC120405	fibrinogen beta chain	-	HPRD,BioGRID	7592883
HLA-A	HLAA	major histocompatibility complex, class I, A	CRT interacts with HLA-A2. This interaction was modeled on a demonstrated interaction between rabbit CRT and human HLA-A2.	BIND	15383281
HLA-C	D6S204 \| FLJ27082 \| HLA-Cw \| HLA-Cw12 \| HLA-JY3 \| HLC-C \| PSORS1	major histocompatibility complex, class I, C	-	HPRD	8769474
ITGA2B	CD41 \| CD41B \| GP2B \| GPIIb \| GTA \| HPA3	integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41)	-	HPRD	7559457
ITGA3	CD49C \| FLJ34631 \| FLJ34704 \| GAP-B3 \| GAPB3 \| MSK18 \| VCA-2 \| VL3A \| VLA3a	integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)	-	HPRD	8006073\|11327697
ITGA3	CD49C \| FLJ34631 \| FLJ34704 \| GAP-B3 \| GAPB3 \| MSK18 \| VCA-2 \| VL3A \| VLA3a	integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)	-	HPRD	11327697
LRP1	A2MR \| APOER \| APR \| CD91 \| FLJ16451 \| IGFBP3R \| LRP \| MGC88725 \| TGFBR5	low density lipoprotein-related protein 1 (alpha-2-macroglobulin receptor)	-	HPRD,BioGRID	12821648 \|14980518
MBL2	COLEC1 \| HSMBPC \| MBL \| MBP \| MBP1 \| MGC116832 \| MGC116833	mannose-binding lectin (protein C) 2, soluble (opsonic defect)	-	HPRD,BioGRID	8062452
NKX2-1	BCH \| BHC \| NK-2 \| NKX2.1 \| NKX2A \| TEBP \| TITF1 \| TTF-1 \| TTF1	NK2 homeobox 1	-	HPRD,BioGRID	9988700
NR3C1	GCCR \| GCR \| GR \| GRL	nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)	-	HPRD,BioGRID	8107808 \|9089287
PDIA3	ER60 \| ERp57 \| ERp60 \| ERp61 \| GRP57 \| GRP58 \| HsT17083 \| P58 \| PI-PLC	protein disulfide isomerase family A, member 3	-	HPRD,BioGRID	10436013
PDIA3	ER60 \| ERp57 \| ERp60 \| ERp61 \| GRP57 \| GRP58 \| HsT17083 \| P58 \| PI-PLC	protein disulfide isomerase family A, member 3	ERp57 interacts with CRT. This interaction was modeled on a demonstrated interaction between ERp57 from an unspecified source and rabbit CRT.	BIND	12052826
PLAT	DKFZp686I03148 \| T-PA \| TPA	plasminogen activator, tissue	-	HPRD,BioGRID	9359841
PRF1	FLH2 \| HPLH2 \| MGC65093 \| P1 \| PFN1 \| PFP	perforin 1 (pore forming protein)	-	HPRD,BioGRID	9671507
PRKCSH	AGE-R2 \| G19P1 \| PCLD \| PLD1	protein kinase C substrate 80K-H	-	HPRD	8910335
SEC14L2	C22orf6 \| KIAA1186 \| KIAA1658 \| MGC65053 \| SPF \| TAP \| TAP1	SEC14-like 2 (S. cerevisiae)	-	HPRD	9036970
SLC2A1	DYT17 \| DYT18 \| GLUT \| GLUT1 \| MGC141895 \| MGC141896 \| PED	solute carrier family 2 (facilitated glucose transporter), member 1	Reconstituted Complex	BioGRID	8662691
SLC6A4	5-HTT \| 5HTT \| HTT \| OCD1 \| SERT \| hSERT	solute carrier family 6 (neurotransmitter transporter, serotonin), member 4	Reconstituted Complex	BioGRID	10364189
TAPBP	NGS17 \| TAPA \| TPN \| TPSN \| tapasin	TAP binding protein (tapasin)	-	HPRD,BioGRID	8769474
TF	DKFZp781D0156 \| PRO1557 \| PRO2086	transferrin	-	HPRD,BioGRID	9312001
TSHR	CHNG1 \| LGR3 \| MGC75129 \| hTSHR-I	thyroid stimulating hormone receptor	-	HPRD	12383251
TSHR	CHNG1 \| LGR3 \| MGC75129 \| hTSHR-I	thyroid stimulating hormone receptor	TSHR interacts with the molecular chaperone protein calreticulin. This interaction was modeled on a demonstrated interaction between human TSHR and rabbit calreticulin.	BIND	12383251
VWF	F8VWF \| VWD	von Willebrand factor	Affinity Capture-Western	BioGRID	10887119

Section V. Pathway annotation

Pathway name	Pathway size	# SZGR 2.0 genes in pathway	Info
KEGG ANTIGEN PROCESSING AND PRESENTATION	89	65	All SZGR 2.0 genes in this pathway
BIOCARTA NFAT PATHWAY	56	45	All SZGR 2.0 genes in this pathway
REACTOME ANTIGEN PROCESSING CROSS PRESENTATION	76	48	All SZGR 2.0 genes in this pathway
REACTOME ER PHAGOSOME PATHWAY	61	40	All SZGR 2.0 genes in this pathway
REACTOME DIABETES PATHWAYS	133	91	All SZGR 2.0 genes in this pathway
REACTOME METABOLISM OF PROTEINS	518	242	All SZGR 2.0 genes in this pathway
REACTOME ACTIVATION OF CHAPERONES BY ATF6 ALPHA	13	9	All SZGR 2.0 genes in this pathway
REACTOME UNFOLDED PROTEIN RESPONSE	80	51	All SZGR 2.0 genes in this pathway
REACTOME ACTIVATION OF CHAPERONE GENES BY ATF6 ALPHA	11	8	All SZGR 2.0 genes in this pathway
REACTOME POST TRANSLATIONAL PROTEIN MODIFICATION	188	116	All SZGR 2.0 genes in this pathway
REACTOME ASPARAGINE N LINKED GLYCOSYLATION	81	54	All SZGR 2.0 genes in this pathway
REACTOME CALNEXIN CALRETICULIN CYCLE	11	7	All SZGR 2.0 genes in this pathway
REACTOME N GLYCAN TRIMMING IN THE ER AND CALNEXIN CALRETICULIN CYCLE	13	9	All SZGR 2.0 genes in this pathway
REACTOME INFLUENZA LIFE CYCLE	203	72	All SZGR 2.0 genes in this pathway
REACTOME IMMUNE SYSTEM	933	616	All SZGR 2.0 genes in this pathway
REACTOME ADAPTIVE IMMUNE SYSTEM	539	350	All SZGR 2.0 genes in this pathway
REACTOME ANTIGEN PRESENTATION FOLDING ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC	21	17	All SZGR 2.0 genes in this pathway
REACTOME CLASS I MHC MEDIATED ANTIGEN PROCESSING PRESENTATION	251	156	All SZGR 2.0 genes in this pathway
LIU PROSTATE CANCER UP	96	57	All SZGR 2.0 genes in this pathway
ONKEN UVEAL MELANOMA UP	783	507	All SZGR 2.0 genes in this pathway
GAZDA DIAMOND BLACKFAN ANEMIA ERYTHROID DN	493	298	All SZGR 2.0 genes in this pathway
FULCHER INFLAMMATORY RESPONSE LECTIN VS LPS DN	463	290	All SZGR 2.0 genes in this pathway
GARY CD5 TARGETS UP	473	314	All SZGR 2.0 genes in this pathway
DOANE RESPONSE TO ANDROGEN UP	184	125	All SZGR 2.0 genes in this pathway
WANG LMO4 TARGETS UP	372	227	All SZGR 2.0 genes in this pathway
WANG CLIM2 TARGETS UP	269	146	All SZGR 2.0 genes in this pathway
OSMAN BLADDER CANCER UP	404	246	All SZGR 2.0 genes in this pathway
GINESTIER BREAST CANCER ZNF217 AMPLIFIED DN	335	193	All SZGR 2.0 genes in this pathway
OSWALD HEMATOPOIETIC STEM CELL IN COLLAGEN GEL UP	233	161	All SZGR 2.0 genes in this pathway
TIEN INTESTINE PROBIOTICS 6HR UP	55	34	All SZGR 2.0 genes in this pathway
TIEN INTESTINE PROBIOTICS 24HR DN	214	133	All SZGR 2.0 genes in this pathway
HWANG PROSTATE CANCER MARKERS	28	19	All SZGR 2.0 genes in this pathway
LI LUNG CANCER	41	30	All SZGR 2.0 genes in this pathway
LI AMPLIFIED IN LUNG CANCER	178	108	All SZGR 2.0 genes in this pathway
PATIL LIVER CANCER	747	453	All SZGR 2.0 genes in this pathway
MOHANKUMAR TLX1 TARGETS UP	414	287	All SZGR 2.0 genes in this pathway
SPIELMAN LYMPHOBLAST EUROPEAN VS ASIAN UP	479	299	All SZGR 2.0 genes in this pathway
PUJANA BRCA1 PCC NETWORK	1652	1023	All SZGR 2.0 genes in this pathway
WEI MYCN TARGETS WITH E BOX	795	478	All SZGR 2.0 genes in this pathway
SCHAEFFER PROSTATE DEVELOPMENT 6HR DN	514	330	All SZGR 2.0 genes in this pathway
SCHAEFFER PROSTATE DEVELOPMENT AND CANCER BOX1 DN	10	7	All SZGR 2.0 genes in this pathway
BENPORATH NANOG TARGETS	988	594	All SZGR 2.0 genes in this pathway
BENPORATH SOX2 TARGETS	734	436	All SZGR 2.0 genes in this pathway
BENPORATH MYC MAX TARGETS	775	494	All SZGR 2.0 genes in this pathway
BENPORATH ES CORE NINE CORRELATED	100	68	All SZGR 2.0 genes in this pathway
SUNG METASTASIS STROMA UP	110	70	All SZGR 2.0 genes in this pathway
ROSS AML WITH PML RARA FUSION	77	62	All SZGR 2.0 genes in this pathway
PENG LEUCINE DEPRIVATION DN	187	122	All SZGR 2.0 genes in this pathway
RADAEVA RESPONSE TO IFNA1 UP	52	40	All SZGR 2.0 genes in this pathway
PENG GLUTAMINE DEPRIVATION DN	337	230	All SZGR 2.0 genes in this pathway
BROWN MYELOID CELL DEVELOPMENT DN	129	86	All SZGR 2.0 genes in this pathway
MA MYELOID DIFFERENTIATION UP	39	29	All SZGR 2.0 genes in this pathway
MUNSHI MULTIPLE MYELOMA UP	81	52	All SZGR 2.0 genes in this pathway
FAELT B CLL WITH VH3 21 UP	44	30	All SZGR 2.0 genes in this pathway
BLALOCK ALZHEIMERS DISEASE DN	1237	837	All SZGR 2.0 genes in this pathway
KAAB HEART ATRIUM VS VENTRICLE UP	249	170	All SZGR 2.0 genes in this pathway
BROWNE HCMV INFECTION 48HR DN	504	323	All SZGR 2.0 genes in this pathway
IVANOVA HEMATOPOIESIS STEM CELL AND PROGENITOR	681	420	All SZGR 2.0 genes in this pathway
MARCHINI TRABECTEDIN RESISTANCE DN	49	34	All SZGR 2.0 genes in this pathway
KRIGE RESPONSE TO TOSEDOSTAT 6HR DN	911	527	All SZGR 2.0 genes in this pathway
KRIGE RESPONSE TO TOSEDOSTAT 24HR DN	1011	592	All SZGR 2.0 genes in this pathway
ZHONG SECRETOME OF LUNG CANCER AND FIBROBLAST	132	93	All SZGR 2.0 genes in this pathway
PELLICCIOTTA HDAC IN ANTIGEN PRESENTATION UP	64	40	All SZGR 2.0 genes in this pathway
HELLER HDAC TARGETS DN	292	189	All SZGR 2.0 genes in this pathway
MARTINEZ RB1 TARGETS DN	543	317	All SZGR 2.0 genes in this pathway
MARTINEZ TP53 TARGETS DN	593	372	All SZGR 2.0 genes in this pathway
MARTINEZ RB1 AND TP53 TARGETS DN	591	366	All SZGR 2.0 genes in this pathway
SMID BREAST CANCER BASAL UP	648	398	All SZGR 2.0 genes in this pathway
HONMA DOCETAXEL RESISTANCE	34	23	All SZGR 2.0 genes in this pathway
GRADE COLON CANCER UP	871	505	All SZGR 2.0 genes in this pathway
BHATI G2M ARREST BY 2METHOXYESTRADIOL UP	125	68	All SZGR 2.0 genes in this pathway
CUI GLUCOSE DEPRIVATION	60	44	All SZGR 2.0 genes in this pathway
JIANG TIP30 TARGETS DN	24	14	All SZGR 2.0 genes in this pathway
VART KSHV INFECTION ANGIOGENIC MARKERS UP	165	118	All SZGR 2.0 genes in this pathway
VART KSHV INFECTION ANGIOGENIC MARKERS DN	138	92	All SZGR 2.0 genes in this pathway
CHEN METABOLIC SYNDROM NETWORK	1210	725	All SZGR 2.0 genes in this pathway
VALK AML CLUSTER 12	30	20	All SZGR 2.0 genes in this pathway
JISON SICKLE CELL DISEASE UP	181	106	All SZGR 2.0 genes in this pathway
YAGI AML WITH T 8 21 TRANSLOCATION	368	247	All SZGR 2.0 genes in this pathway
DANG BOUND BY MYC	1103	714	All SZGR 2.0 genes in this pathway
MARTENS TRETINOIN RESPONSE DN	841	431	All SZGR 2.0 genes in this pathway
CHICAS RB1 TARGETS SENESCENT	572	352	All SZGR 2.0 genes in this pathway
CHYLA CBFA2T3 TARGETS UP	387	225	All SZGR 2.0 genes in this pathway
JOHNSTONE PARVB TARGETS 2 UP	140	94	All SZGR 2.0 genes in this pathway
DELACROIX RARG BOUND MEF	367	231	All SZGR 2.0 genes in this pathway
DELACROIX RAR BOUND ES	462	273	All SZGR 2.0 genes in this pathway

Gene Page: CALR