Gene Page: CARD11

Summary ?
GeneID84433
SymbolCARD11
SynonymsBENTA|BIMP3|CARMA1|IMD11|PPBL
Descriptioncaspase recruitment domain family member 11
ReferenceMIM:607210|HGNC:HGNC:16393|Ensembl:ENSG00000198286|HPRD:06234|Vega:OTTHUMG00000023023
Gene typeprotein-coding
Map location7p22
Pascal p-value0.013
eGeneMeta

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
CV:PGCnpGenome-wide Association StudyGWAS
GO_AnnotationMapping neuro-related keywords to Gene Ontology annotationsHits with neuro-related keywords: 1 

Section I. Genetics and epigenetics annotation


Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

No co-expressed genes in brain regions


Section III. Gene Ontology annotation

Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0005515protein bindingIPI16809782 
GO:0004385guanylate kinase activityNAS11278692 
GO:0050700CARD domain bindingIPI11278692 
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0001819positive regulation of cytokine productionIMP12154360 
GO:0007165signal transductionIEA-
GO:0042981regulation of apoptosisIEA-
GO:0051092positive regulation of NF-kappaB transcription factor activityIMP12154360 
GO:0042102positive regulation of T cell proliferationIEA-
GO:0030890positive regulation of B cell proliferationIEA-
GO:0043123positive regulation of I-kappaB kinase/NF-kappaB cascadeIEA-
GO:0045577regulation of B cell differentiationIEA-
GO:0045580regulation of T cell differentiationIEA-
GO:0050776regulation of immune responseIEA-
GO:0045086positive regulation of interleukin-2 biosynthetic processIEA-
GO:0045061thymic T cell selectionIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0042101T cell receptor complexIDASynap (GO term level: 8)12154360 
GO:0005829cytosolEXP15122200 |15125833 |15541657 
|17468049 
GO:0005622intracellularIEA-
GO:0005737cytoplasmIDA12154360 
GO:0005886plasma membraneIDA12154360 
GO:0045121membrane raftIDA12154360 

Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
KEGG T CELL RECEPTOR SIGNALING PATHWAY 10889All SZGR 2.0 genes in this pathway
KEGG B CELL RECEPTOR SIGNALING PATHWAY 7556All SZGR 2.0 genes in this pathway
PID BCR 5PATHWAY 6550All SZGR 2.0 genes in this pathway
PID TCR PATHWAY 6651All SZGR 2.0 genes in this pathway
PID CD8 TCR PATHWAY 5342All SZGR 2.0 genes in this pathway
REACTOME DOWNSTREAM SIGNALING EVENTS OF B CELL RECEPTOR BCR 9766All SZGR 2.0 genes in this pathway
REACTOME ACTIVATION OF NF KAPPAB IN B CELLS 6443All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY THE B CELL RECEPTOR BCR 12690All SZGR 2.0 genes in this pathway
REACTOME TCR SIGNALING 5446All SZGR 2.0 genes in this pathway
REACTOME DOWNSTREAM TCR SIGNALING 3732All SZGR 2.0 genes in this pathway
REACTOME IMMUNE SYSTEM 933616All SZGR 2.0 genes in this pathway
REACTOME ADAPTIVE IMMUNE SYSTEM 539350All SZGR 2.0 genes in this pathway
SCHEIDEREIT IKK INTERACTING PROTEINS 5845All SZGR 2.0 genes in this pathway
SANSOM APC MYC TARGETS 217138All SZGR 2.0 genes in this pathway
QI PLASMACYTOMA UP 259185All SZGR 2.0 genes in this pathway
VILIMAS NOTCH1 TARGETS UP 5241All SZGR 2.0 genes in this pathway
CHEN METABOLIC SYNDROM NETWORK 1210725All SZGR 2.0 genes in this pathway
BRUINS UVC RESPONSE VIA TP53 GROUP D 280158All SZGR 2.0 genes in this pathway
FEVR CTNNB1 TARGETS DN 553343All SZGR 2.0 genes in this pathway
JUBAN TARGETS OF SPI1 AND FLI1 DN 9260All SZGR 2.0 genes in this pathway
PEDRIOLI MIR31 TARGETS DN 418245All SZGR 2.0 genes in this pathway

Section VI. microRNA annotation

miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-1554724781Ahsa-miR-155UUAAUGCUAAUCGUGAUAGGGG
miR-1813193261A,m8hsa-miR-181abrainAACAUUCAACGCUGUCGGUGAGU
hsa-miR-181bSZAACAUUCAUUGCUGUCGGUGGG
hsa-miR-181cbrainAACAUUCAACCUGUCGGUGAGU
hsa-miR-181dbrainAACAUUCAUUGUUGUCGGUGGGUU