Gene Page: CARD11

Summary
GeneID  84433
Symbol  CARD11
Synonyms  BIMP3|CARMA1|MGC133069
Description  caspase recruitment domain family, member 11
See related  HGNC:16393|MIM:607210|Ensembl:ENSG00000198286|HPRD:06234|
Locus tag  -
Gene type  protein-coding
Map location  7p22
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
GO_AnnotationMapping neuro-related keywords to Gene Ontology annotationsHits with neuro-related keywords: 1 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
Top 10 negatively co-expressed genes
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0005515protein bindingIPI16809782 
GO:0004385guanylate kinase activityNAS11278692 
GO:0050700CARD domain bindingIPI11278692 
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0001819positive regulation of cytokine productionIMP12154360 
GO:0007165signal transductionIEA-
GO:0042981regulation of apoptosisIEA-
GO:0051092positive regulation of NF-kappaB transcription factor activityIMP12154360 
GO:0042102positive regulation of T cell proliferationIEA-
GO:0030890positive regulation of B cell proliferationIEA-
GO:0043123positive regulation of I-kappaB kinase/NF-kappaB cascadeIEA-
GO:0045577regulation of B cell differentiationIEA-
GO:0045580regulation of T cell differentiationIEA-
GO:0050776regulation of immune responseIEA-
GO:0045086positive regulation of interleukin-2 biosynthetic processIEA-
GO:0045061thymic T cell selectionIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0042101T cell receptor complexIDASynap (GO term level: 8)12154360 
GO:0005829cytosolEXP15122200 |15125833 |15541657 
|17468049 
GO:0005622intracellularIEA-
GO:0005737cytoplasmIDA12154360 
GO:0005886plasma membraneIDA12154360 
GO:0045121membrane raftIDA12154360 
 
InteractionsShown by Network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
BCL10CARMEN | CIPER | CLAP | c-E10 | mE10B-cell CLL/lymphoma 10-HPRD,BioGRID11278692 
CARD11 interacts with BCL10.BIND11278692 
PDPK1MGC20087 | MGC35290 | PDK1 | PRO04613-phosphoinositide dependent protein kinase-1PDK1 interacts with CARD11.BIND15802604 
PRKCQMGC126514 | MGC141919 | PRKCT | nPKC-thetaprotein kinase C, thetaPRKCQ (PKC-theta) interacts with CARD11 (CARMA1).BIND14673152 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
KEGG_T_CELL_RECEPTOR_SIGNALING_PATHWAY 10889All SZGR genes in this pathway
KEGG_B_CELL_RECEPTOR_SIGNALING_PATHWAY 7556All SZGR genes in this pathway
PID_BCR_5PATHWAY 6550All SZGR genes in this pathway
PID_TCR_PATHWAY 6651All SZGR genes in this pathway
PID_CD8_TCR_PATHWAY 5342All SZGR genes in this pathway
REACTOME_DOWNSTREAM_SIGNALING_EVENTS_OF_B_CELL_RECEPTOR_BCR 9766All SZGR genes in this pathway
REACTOME_ACTIVATION_OF_NF_KAPPAB_IN_B_CELLS 6443All SZGR genes in this pathway
REACTOME_SIGNALING_BY_THE_B_CELL_RECEPTOR_BCR 12690All SZGR genes in this pathway
REACTOME_TCR_SIGNALING 5446All SZGR genes in this pathway
REACTOME_DOWNSTREAM_TCR_SIGNALING 3732All SZGR genes in this pathway
REACTOME_IMMUNE_SYSTEM 933616All SZGR genes in this pathway
REACTOME_ADAPTIVE_IMMUNE_SYSTEM 539350All SZGR genes in this pathway
SCHEIDEREIT_IKK_INTERACTING_PROTEINS 5845All SZGR genes in this pathway
SANSOM_APC_MYC_TARGETS 217138All SZGR genes in this pathway
QI_PLASMACYTOMA_UP 259185All SZGR genes in this pathway
VILIMAS_NOTCH1_TARGETS_UP 5241All SZGR genes in this pathway
CHEN_METABOLIC_SYNDROM_NETWORK 1210725All SZGR genes in this pathway
BRUINS_UVC_RESPONSE_VIA_TP53_GROUP_D 280158All SZGR genes in this pathway
FEVR_CTNNB1_TARGETS_DN 553343All SZGR genes in this pathway
JUBAN_TARGETS_OF_SPI1_AND_FLI1_DN 9260All SZGR genes in this pathway
PEDRIOLI_MIR31_TARGETS_DN 418245All SZGR genes in this pathway
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-1554724781Ahsa-miR-155UUAAUGCUAAUCGUGAUAGGGG
miR-1813193261A,m8hsa-miR-181abrainAACAUUCAACGCUGUCGGUGAGU
hsa-miR-181bSZAACAUUCAUUGCUGUCGGUGGG
hsa-miR-181cbrainAACAUUCAACCUGUCGGUGAGU
hsa-miR-181dbrainAACAUUCAUUGUUGUCGGUGGGUU
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


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