Gene Page: TCAP
Summary ?
GeneID | 8557 |
Symbol | TCAP |
Synonyms | CMD1N|CMH25|LGMD2G|T-cap|TELE|telethonin |
Description | titin-cap |
Reference | MIM:604488|HGNC:HGNC:11610|HPRD:05133| |
Gene type | protein-coding |
Map location | 17q12 |
Pascal p-value | 0.004 |
eGene | Myers' cis & trans |
Gene in Data Sources
Gene set name | Method of gene set | Description | Info |
---|---|---|---|
CV:PGCnp | Genome-wide Association Study | GWAS | |
Network | Shortest path distance of core genes in the Human protein-protein interaction network | Contribution to shortest path in PPI network: 0.0033 |
Section I. Genetics and epigenetics annotation
eQTL annotation
SNP ID | Chromosome | Position | eGene | Gene Entrez ID | pvalue | qvalue | TSS distance | eQTL type |
---|---|---|---|---|---|---|---|---|
rs10026915 | chr4 | 57857770 | TCAP | 8557 | 0.16 | trans |
Section II. Transcriptome annotation
General gene expression (GTEx)

Gene expression of temporal and spatial changes (BrainSpan)
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
Top co-expressed genes in brain regions
Top 10 positively co-expressed genes | ||
Gene | Pearson's Correlation | Spearman's Correlation |
PHLDB2 | 0.47 | 0.47 |
ABCA9 | 0.44 | 0.46 |
APC | 0.42 | 0.35 |
NOV | 0.42 | 0.34 |
LAMC3 | 0.41 | 0.38 |
SLC6A20 | 0.40 | 0.38 |
PCDH20 | 0.40 | 0.34 |
GLT8D2 | 0.40 | 0.29 |
RECK | 0.40 | 0.37 |
APOB | 0.39 | 0.35 |
Top 10 negatively co-expressed genes | ||
Gene | Pearson's Correlation | Spearman's Correlation |
SSR4 | -0.25 | -0.26 |
RPS21 | -0.24 | -0.28 |
POLR2J | -0.24 | -0.26 |
MRPL53 | -0.24 | -0.25 |
RPL23A | -0.24 | -0.22 |
LSM2 | -0.23 | -0.24 |
NUDT8 | -0.23 | -0.25 |
AP003068.3 | -0.23 | -0.24 |
C22orf32 | -0.23 | -0.23 |
UXT | -0.23 | -0.25 |
Section III. Gene Ontology annotation
Molecular function | GO term | Evidence | Neuro keywords | PubMed ID |
---|---|---|---|---|
GO:0005515 | protein binding | IPI | 10984498 |11842093 | |
GO:0008307 | structural constituent of muscle | TAS | 9350988 | |
Biological process | GO term | Evidence | Neuro keywords | PubMed ID |
GO:0006461 | protein complex assembly | TAS | 9817758 | |
GO:0006950 | response to stress | TAS | 17921333 | |
GO:0050982 | detection of mechanical stimulus | TAS | 17921333 | |
GO:0045214 | sarcomere organization | TAS | 17921333 | |
Cellular component | GO term | Evidence | Neuro keywords | PubMed ID |
GO:0005737 | cytoplasm | IEA | - | |
GO:0030018 | Z disc | IDA | 17921333 |
Section V. Pathway annotation
Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
---|---|---|---|
REACTOME STRIATED MUSCLE CONTRACTION | 27 | 12 | All SZGR 2.0 genes in this pathway |
REACTOME MUSCLE CONTRACTION | 48 | 24 | All SZGR 2.0 genes in this pathway |
HUMMERICH SKIN CANCER PROGRESSION DN | 100 | 64 | All SZGR 2.0 genes in this pathway |
SCHLOSSER SERUM RESPONSE DN | 712 | 443 | All SZGR 2.0 genes in this pathway |
NIKOLSKY BREAST CANCER 17Q11 Q21 AMPLICON | 133 | 78 | All SZGR 2.0 genes in this pathway |
SANSOM APC TARGETS DN | 366 | 238 | All SZGR 2.0 genes in this pathway |
NGUYEN NOTCH1 TARGETS UP | 29 | 23 | All SZGR 2.0 genes in this pathway |
THEILGAARD NEUTROPHIL AT SKIN WOUND DN | 225 | 163 | All SZGR 2.0 genes in this pathway |
CHEN LVAD SUPPORT OF FAILING HEART UP | 103 | 69 | All SZGR 2.0 genes in this pathway |
SCHLINGEMANN SKIN CARCINOGENESIS TPA DN | 29 | 15 | All SZGR 2.0 genes in this pathway |
MARTINEZ RB1 TARGETS UP | 673 | 430 | All SZGR 2.0 genes in this pathway |
MARTINEZ TP53 TARGETS UP | 602 | 364 | All SZGR 2.0 genes in this pathway |
MARTINEZ RB1 AND TP53 TARGETS UP | 601 | 369 | All SZGR 2.0 genes in this pathway |
BRUINS UVC RESPONSE VIA TP53 GROUP A | 898 | 516 | All SZGR 2.0 genes in this pathway |