Gene Page: RIPK1

Summary ?
GeneID8737
SymbolRIPK1
SynonymsRIP|RIP-1|RIP1
Descriptionreceptor interacting serine/threonine kinase 1
ReferenceMIM:603453|HGNC:HGNC:10019|Ensembl:ENSG00000137275|HPRD:04583|Vega:OTTHUMG00000014134
Gene typeprotein-coding
Map location6p25.2
Pascal p-value0.053
Fetal beta0.457
DMG1 (# studies)
eGeneCerebellar Hemisphere
Cerebellum
Frontal Cortex BA9
Myers' cis & trans

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
CV:PGCnpGenome-wide Association StudyGWAS
DMG:Jaffe_2016Genome-wide DNA methylation analysisThis dataset includes 2,104 probes/CpGs associated with SZ patients (n=108) compared to 136 controls at Bonferroni-adjusted P < 0.05. 1
GSMA_IGenome scan meta-analysisPsr: 0.0159 

Section I. Genetics and epigenetics annotation

@Differentially methylated gene

ProbeChromosomePositionNearest geneP (dis)Beta (dis)FDR (dis)Study
cg1253477763064469RIPK12.56E-9-0.0111.88E-6DMG:Jaffe_2016

@eQTL annotation

SNP IDChromosomePositioneGeneGene Entrez IDpvalueqvalueTSS distanceeQTL type
rs9501885chr62741186RIPK187370.15cis
rs4864466chr454403975RIPK187370.16trans

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
GenePearson's Correlation Spearman's Correlation
C3orf490.770.77
PLEKHA10.740.74
MAPK100.740.70
MAN1C10.740.77
TBRG10.730.75
SMYD20.730.72
PIK3R10.730.75
IQWD10.730.72
SESN10.730.71
PIP4K2C0.720.73
Top 10 negatively co-expressed genes
GenePearson's Correlation Spearman's Correlation
RAB13-0.42-0.50
CLEC3B-0.40-0.51
AF347015.21-0.39-0.29
AF347015.18-0.37-0.27
IL32-0.37-0.33
BTBD17-0.37-0.43
GPR39-0.35-0.39
MPST-0.35-0.34
NME4-0.34-0.36
APOE-0.34-0.26

Section III. Gene Ontology annotation

Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0000166nucleotide bindingIEA-
GO:0005515protein bindingIPI10356400 
GO:0005524ATP bindingIEA-
GO:0004674protein serine/threonine kinase activityTAS8612133 
GO:0004713protein tyrosine kinase activityIEA-
GO:0016740transferase activityIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0006468protein amino acid phosphorylationIEA-
GO:0007165signal transductionTAS8612133 
GO:0008633activation of pro-apoptotic gene productsEXP14644197 
GO:0006915apoptosisTAS8612133 
GO:0043123positive regulation of I-kappaB kinase/NF-kappaB cascadeIEP12761501 
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005829cytosolEXP7758105 |12692549 |12887920 
|15064760 
GO:0005737cytoplasmIEA-

Section IV. Protein-protein interaction annotation

InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
CASP10ALPS2 | FLICE2 | MCH4caspase 10, apoptosis-related cysteine peptidaseAffinity Capture-WesternBioGRID11002417 
CASP8ALPS2B | CAP4 | FLICE | FLJ17672 | MACH | MCH5 | MGC78473caspase 8, apoptosis-related cysteine peptidase-HPRD,BioGRID11002417 
CFLARCASH | CASP8AP1 | CLARP | Casper | FLAME | FLAME-1 | FLAME1 | FLIP | I-FLICE | MRIT | c-FLIP | c-FLIPL | c-FLIPR | c-FLIPSCASP8 and FADD-like apoptosis regulator-HPRD,BioGRID10837247 
CRADDMGC9163 | RAIDDCASP2 and RIPK1 domain containing adaptor with death domain-HPRD,BioGRID8985253 |9044836 
EGFRERBB | ERBB1 | HER1 | PIG61 | mENAepidermal growth factor receptor (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian)-HPRD,BioGRID11116146 
FADDGIG3 | MGC8528 | MORT1Fas (TNFRSF6)-associated via death domainTwo-hybridBioGRID11854271 
FADDGIG3 | MGC8528 | MORT1Fas (TNFRSF6)-associated via death domain-HPRD11002422 
FASALPS1A | APO-1 | APT1 | CD95 | FAS1 | FASTM | TNFRSF6Fas (TNF receptor superfamily, member 6)-HPRD,BioGRID7538908 |9740801 
HSP90AA1FLJ31884 | HSP86 | HSP89A | HSP90A | HSP90N | HSPC1 | HSPCA | HSPCAL1 | HSPCAL4 | HSPN | Hsp89 | Hsp90 | LAP2heat shock protein 90kDa alpha (cytosolic), class A member 1-HPRD10744744 
HSPA8HSC54 | HSC70 | HSC71 | HSP71 | HSP73 | HSPA10 | LAP1 | MGC131511 | MGC29929 | NIP71heat shock 70kDa protein 8-HPRD14743216 
IKBKGAMCBX1 | FIP-3 | FIP3 | Fip3p | IKK-gamma | IP | IP1 | IP2 | IPD2 | NEMOinhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma-HPRD,BioGRID10880512 
MAP3K14FTDCR1B | HS | HSNIK | NIKmitogen-activated protein kinase kinase kinase 14-HPRD,BioGRID11116146 
MAP3K3MAPKKK3 | MEKK3mitogen-activated protein kinase kinase kinase 3-HPRD,BioGRID11429546 
PTK2FADK | FAK | FAK1 | pp125FAKPTK2 protein tyrosine kinase 2FAK interacts with RIP.BIND15121855 
RIPK3RIP3receptor-interacting serine-threonine kinase 3-HPRD,BioGRID10339433 
RNF216TRIAD3 | U7I1 | UBCE7IP1 | ZINring finger protein 216-HPRD,BioGRID11854271 
SQSTM1A170 | OSIL | PDB3 | ZIP3 | p60 | p62 | p62Bsequestosome 1-HPRD,BioGRID10356400 
TICAM1MGC35334 | PRVTIRB | TICAM-1 | TRIFtoll-like receptor adaptor molecule 1Affinity Capture-WesternBioGRID15064760 
TNFAIP3A20 | MGC104522 | MGC138687 | MGC138688 | OTUD7C | TNFA1P2tumor necrosis factor, alpha-induced protein 3A20 ubiquitinates and de-ubiquitinates RIP.BIND15258597 
TNFRSF10AAPO2 | CD261 | DR4 | MGC9365 | TRAILR-1 | TRAILR1tumor necrosis factor receptor superfamily, member 10a-HPRD9430227 
TNFRSF10BCD262 | DR5 | KILLER | KILLER/DR5 | TRAIL-R2 | TRAILR2 | TRICK2 | TRICK2A | TRICK2B | TRICKB | ZTNFR9tumor necrosis factor receptor superfamily, member 10b-HPRD,BioGRID9430227 
TNFRSF1ACD120a | FPF | MGC19588 | TBP1 | TNF-R | TNF-R-I | TNF-R55 | TNFAR | TNFR1 | TNFR55 | TNFR60 | p55 | p55-R | p60tumor necrosis factor receptor superfamily, member 1A-HPRD,BioGRID8612133 
TRADDHs.89862 | MGC11078TNFRSF1A-associated via death domain-HPRD,BioGRID8612133 
TRAF1EBI6 | MGC:10353TNF receptor-associated factor 1-HPRD,BioGRID8612133 
TRAF2MGC:45012 | TRAP | TRAP3TNF receptor-associated factor 2-HPRD,BioGRID8612133 |8702708 
TRAF2MGC:45012 | TRAP | TRAP3TNF receptor-associated factor 2TRAF2 ubiquitinates RIP.BIND15258597 
TRAF2MGC:45012 | TRAP | TRAP3TNF receptor-associated factor 2TRAF2 interacts with RIP.BIND8702708 
TRAF3CAP-1 | CD40bp | CRAF1 | LAP1TNF receptor-associated factor 3-HPRD,BioGRID8612133 
TRAF5MGC:39780 | RNF84TNF receptor-associated factor 5-HPRD,BioGRID11479302 
TRIM38MGC8946 | RNF15 | RORETtripartite motif-containing 38-HPRD11854271 
TRPC4APC20orf188 | TRRP4AP | TRUSStransient receptor potential cation channel, subfamily C, member 4 associated proteinAffinity Capture-WesternBioGRID14585990 
TUBA3CTUBA2 | bA408E5.3tubulin, alpha 3c-HPRD14743216 
ZFAND5ZA20D2 | ZFAND5A | ZNF216zinc finger, AN1-type domain 5ZNF216 interacts with RIP.BIND14754897 


Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
KEGG APOPTOSIS 8862All SZGR 2.0 genes in this pathway
KEGG TOLL LIKE RECEPTOR SIGNALING PATHWAY 10288All SZGR 2.0 genes in this pathway
KEGG RIG I LIKE RECEPTOR SIGNALING PATHWAY 7151All SZGR 2.0 genes in this pathway
KEGG CYTOSOLIC DNA SENSING PATHWAY 5644All SZGR 2.0 genes in this pathway
BIOCARTA RELA PATHWAY 1612All SZGR 2.0 genes in this pathway
BIOCARTA CERAMIDE PATHWAY 2216All SZGR 2.0 genes in this pathway
BIOCARTA HIVNEF PATHWAY 5843All SZGR 2.0 genes in this pathway
BIOCARTA DEATH PATHWAY 3324All SZGR 2.0 genes in this pathway
BIOCARTA KERATINOCYTE PATHWAY 4638All SZGR 2.0 genes in this pathway
BIOCARTA MAPK PATHWAY 8768All SZGR 2.0 genes in this pathway
BIOCARTA NFKB PATHWAY 2319All SZGR 2.0 genes in this pathway
BIOCARTA P38MAPK PATHWAY 4031All SZGR 2.0 genes in this pathway
BIOCARTA SODD PATHWAY 107All SZGR 2.0 genes in this pathway
BIOCARTA STRESS PATHWAY 2518All SZGR 2.0 genes in this pathway
BIOCARTA TNFR1 PATHWAY 2921All SZGR 2.0 genes in this pathway
BIOCARTA TNFR2 PATHWAY 1815All SZGR 2.0 genes in this pathway
ST TUMOR NECROSIS FACTOR PATHWAY 2920All SZGR 2.0 genes in this pathway
ST FAS SIGNALING PATHWAY 6554All SZGR 2.0 genes in this pathway
PID P38 ALPHA BETA PATHWAY 3125All SZGR 2.0 genes in this pathway
PID TRAIL PATHWAY 2820All SZGR 2.0 genes in this pathway
PID FAS PATHWAY 3829All SZGR 2.0 genes in this pathway
PID TNF PATHWAY 4633All SZGR 2.0 genes in this pathway
PID CERAMIDE PATHWAY 4837All SZGR 2.0 genes in this pathway
PID HIV NEF PATHWAY 3526All SZGR 2.0 genes in this pathway
PID CASPASE PATHWAY 5239All SZGR 2.0 genes in this pathway
REACTOME EXTRINSIC PATHWAY FOR APOPTOSIS 138All SZGR 2.0 genes in this pathway
REACTOME TRIF MEDIATED TLR3 SIGNALING 7454All SZGR 2.0 genes in this pathway
REACTOME RIP MEDIATED NFKB ACTIVATION VIA DAI 1815All SZGR 2.0 genes in this pathway
REACTOME NFKB ACTIVATION THROUGH FADD RIP1 PATHWAY MEDIATED BY CASPASE 8 AND10 129All SZGR 2.0 genes in this pathway
REACTOME NFKB AND MAP KINASES ACTIVATION MEDIATED BY TLR4 SIGNALING REPERTOIRE 7253All SZGR 2.0 genes in this pathway
REACTOME RIG I MDA5 MEDIATED INDUCTION OF IFN ALPHA BETA PATHWAYS 7357All SZGR 2.0 genes in this pathway
REACTOME IKK COMPLEX RECRUITMENT MEDIATED BY RIP1 107All SZGR 2.0 genes in this pathway
REACTOME APOPTOSIS 14894All SZGR 2.0 genes in this pathway
REACTOME INNATE IMMUNE SYSTEM 279178All SZGR 2.0 genes in this pathway
REACTOME ACTIVATED TLR4 SIGNALLING 9369All SZGR 2.0 genes in this pathway
REACTOME IMMUNE SYSTEM 933616All SZGR 2.0 genes in this pathway
REACTOME TOLL RECEPTOR CASCADES 11884All SZGR 2.0 genes in this pathway
OSMAN BLADDER CANCER DN 406230All SZGR 2.0 genes in this pathway
ZHOU INFLAMMATORY RESPONSE LPS UP 431237All SZGR 2.0 genes in this pathway
GRAESSMANN APOPTOSIS BY DOXORUBICIN DN 17811082All SZGR 2.0 genes in this pathway
GRAESSMANN RESPONSE TO MC AND DOXORUBICIN DN 770415All SZGR 2.0 genes in this pathway
SCHEIDEREIT IKK INTERACTING PROTEINS 5845All SZGR 2.0 genes in this pathway
BENPORATH NANOG TARGETS 988594All SZGR 2.0 genes in this pathway
BENPORATH SOX2 TARGETS 734436All SZGR 2.0 genes in this pathway
THEILGAARD NEUTROPHIL AT SKIN WOUND DN 225163All SZGR 2.0 genes in this pathway
IVANOVA HEMATOPOIESIS EARLY PROGENITOR 532309All SZGR 2.0 genes in this pathway
ZHU CMV ALL UP 12089All SZGR 2.0 genes in this pathway
GENTILE UV HIGH DOSE DN 312203All SZGR 2.0 genes in this pathway
BROWNE HCMV INFECTION 6HR UP 7148All SZGR 2.0 genes in this pathway
ZAMORA NOS2 TARGETS DN 9671All SZGR 2.0 genes in this pathway
GENTILE RESPONSE CLUSTER D3 6139All SZGR 2.0 genes in this pathway
ZHU CMV 8 HR UP 4739All SZGR 2.0 genes in this pathway
MARTINEZ RESPONSE TO TRABECTEDIN DN 271175All SZGR 2.0 genes in this pathway
MAHAJAN RESPONSE TO IL1A UP 8152All SZGR 2.0 genes in this pathway
DURCHDEWALD SKIN CARCINOGENESIS DN 264168All SZGR 2.0 genes in this pathway
MARSON BOUND BY FOXP3 UNSTIMULATED 1229713All SZGR 2.0 genes in this pathway
NAKAMURA ADIPOGENESIS EARLY UP 6644All SZGR 2.0 genes in this pathway
BROWNE HCMV INFECTION 4HR UP 5541All SZGR 2.0 genes in this pathway
PILON KLF1 TARGETS DN 19721213All SZGR 2.0 genes in this pathway
ZWANG TRANSIENTLY UP BY 1ST EGF PULSE ONLY 1839928All SZGR 2.0 genes in this pathway