Gene Page: ARHGEF7

Summary ?
GeneID8874
SymbolARHGEF7
SynonymsBETA-PIX|COOL-1|COOL1|Nbla10314|P50|P50BP|P85|P85COOL1|P85SPR|PAK3|PIXB
DescriptionRho guanine nucleotide exchange factor 7
ReferenceMIM:605477|HGNC:HGNC:15607|Ensembl:ENSG00000102606|HPRD:05688|Vega:OTTHUMG00000017357
Gene typeprotein-coding
Map location13q34
Pascal p-value0.246
Sherlock p-value0.414
Fetal beta0.355
DMG2 (# studies)
eGeneCaudate basal ganglia
Cerebellar Hemisphere
Cerebellum
Nucleus accumbens basal ganglia
SupportG2Cdb.human_BAYES-COLLINS-HUMAN-PSD-FULL
CompositeSet
Darnell FMRP targets
Ascano FMRP targets
Potential synaptic genes

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
CV:PGCnpGenome-wide Association StudyGWAS
DMG:Nishioka_2013Genome-wide DNA methylation analysisThe authors investigated the methylation profiles of DNA in peripheral blood cells from 18 patients with first-episode schizophrenia (FESZ) and from 15 normal controls. 2
DMG:Wockner_2014Genome-wide DNA methylation analysisThis dataset includes 4641 differentially methylated probes corresponding to 2929 unique genes between schizophrenia patients (n=24) and controls (n=24). 2

Section I. Genetics and epigenetics annotation

@Differentially methylated gene

ProbeChromosomePositionNearest geneP (dis)Beta (dis)FDR (dis)Study
cg1429993113111839335ARHGEF75.177E-40.5770.047DMG:Wockner_2014
cg0055735413111767899ARHGEF7-0.0240.5DMG:Nishioka_2013


Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
GenePearson's Correlation Spearman's Correlation
YWHAH0.820.84
AC012652.10.820.84
RAPGEFL10.800.82
PPFIA30.800.82
CHGB0.800.82
DCTN10.790.79
SGSM10.790.82
APLP20.790.79
OXCT10.790.81
SNCA0.790.82
Top 10 negatively co-expressed genes
GenePearson's Correlation Spearman's Correlation
IMPA2-0.43-0.47
AF347015.21-0.41-0.20
C21orf57-0.40-0.38
C1orf61-0.38-0.33
AC098691.2-0.38-0.33
RPL35-0.38-0.40
UXT-0.37-0.32
RPL24-0.37-0.34
RPS7-0.37-0.32
C1orf54-0.37-0.23

Section IV. Protein-protein interaction annotation

InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
ARHGEF6COOL2 | Cool-2 | KIAA0006 | MRX46 | PIXA | alpha-PIX | alphaPIXRac/Cdc42 guanine nucleotide exchange factor (GEF) 6ARHGEF6 interacts with ARHGEF7BIND12499396 
CBLC-CBL | CBL2 | RNF55Cas-Br-M (murine) ecotropic retroviral transforming sequenceTwo-hybridBioGRID12935897 
CDC42CDC42Hs | G25Kcell division cycle 42 (GTP binding protein, 25kDa)ARHGEF7 (p85Cool-1) interacts with Cdc42.BIND15649357 
GIT1-G protein-coupled receptor kinase interacting ArfGAP 1Affinity Capture-Western
Two-hybrid		BioGRID10428811 |12473661 
GIT1-G protein-coupled receptor kinase interacting ArfGAP 1-HPRD10896954 
GIT2CAT-2 | DKFZp686G01261 | KIAA0148 | MGC760G protein-coupled receptor kinase interacting ArfGAP 2-HPRD10428811 |10896954 
PAK1MGC130000 | MGC130001 | PAKalphap21 protein (Cdc42/Rac)-activated kinase 1-HPRD,BioGRID11157752|12006652 
PAK2PAK65 | PAKgammap21 protein (Cdc42/Rac)-activated kinase 2-HPRD,BioGRID12226077 
PAK3CDKN1A | MRX30 | MRX47 | OPHN3 | PAK3beta | bPAK | hPAK3p21 protein (Cdc42/Rac)-activated kinase 3-HPRD,BioGRID9726964 
PPM1EDKFZp781F1422 | KIAA1072 | POPX1 | PP2CHprotein phosphatase 1E (PP2C domain containing)Reconstituted ComplexBioGRID11864573 
PPM1FCaMKPase | FEM-2 | KIAA0015 | POPX2 | hFEM-2protein phosphatase 1F (PP2C domain containing)-HPRD,BioGRID11864573 
SHANK1SPANK-1 | SSTRIP | synamonSH3 and multiple ankyrin repeat domains 1-HPRD,BioGRID12626503 
SHANK2CORTBP1 | CTTNBP1 | ProSAP1 | SHANK | SPANK-3SH3 and multiple ankyrin repeat domains 2-HPRD,BioGRID12626503 
SHANK3KIAA1650 | PROSAP2 | PSAP2 | SPANK-2SH3 and multiple ankyrin repeat domains 3Affinity Capture-Western
Two-hybrid		BioGRID12626503 
TGFBR2AAT3 | FAA3 | LDS1B | LDS2B | MFS2 | RIIC | TAAD2 | TGFR-2 | TGFbeta-RIItransforming growth factor, beta receptor II (70/80kDa)T-beta-RII interacts with Beta-PIX. This interaction was modeled on a demonstrated interaction between human T-beta-RII and mouse Beta-PIX.BIND15761153 
TUBB3MC1R | TUBB4 | beta-4tubulin, beta 3Two-hybridBioGRID16169070 


Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
KEGG REGULATION OF ACTIN CYTOSKELETON 216144All SZGR 2.0 genes in this pathway
BIOCARTA MYOSIN PATHWAY 3122All SZGR 2.0 genes in this pathway
BIOCARTA PAR1 PATHWAY 3728All SZGR 2.0 genes in this pathway
ST INTEGRIN SIGNALING PATHWAY 8262All SZGR 2.0 genes in this pathway
PID ILK PATHWAY 4532All SZGR 2.0 genes in this pathway
PID CDC42 PATHWAY 7051All SZGR 2.0 genes in this pathway
PID CDC42 REG PATHWAY 3022All SZGR 2.0 genes in this pathway
PID ERBB1 INTERNALIZATION PATHWAY 4135All SZGR 2.0 genes in this pathway
PID RAC1 REG PATHWAY 3825All SZGR 2.0 genes in this pathway
PID AURORA A PATHWAY 3120All SZGR 2.0 genes in this pathway
PID FAK PATHWAY 5945All SZGR 2.0 genes in this pathway
NAKAMURA TUMOR ZONE PERIPHERAL VS CENTRAL DN 634384All SZGR 2.0 genes in this pathway
SENGUPTA NASOPHARYNGEAL CARCINOMA WITH LMP1 UP 408247All SZGR 2.0 genes in this pathway
THUM SYSTOLIC HEART FAILURE DN 244147All SZGR 2.0 genes in this pathway
RODRIGUES THYROID CARCINOMA POORLY DIFFERENTIATED DN 805505All SZGR 2.0 genes in this pathway
RODRIGUES THYROID CARCINOMA ANAPLASTIC UP 722443All SZGR 2.0 genes in this pathway
RODRIGUES THYROID CARCINOMA DN 7752All SZGR 2.0 genes in this pathway
ENK UV RESPONSE KERATINOCYTE DN 485334All SZGR 2.0 genes in this pathway
ODONNELL METASTASIS UP 8258All SZGR 2.0 genes in this pathway
ROVERSI GLIOMA COPY NUMBER DN 5437All SZGR 2.0 genes in this pathway
DACOSTA UV RESPONSE VIA ERCC3 DN 855609All SZGR 2.0 genes in this pathway
DACOSTA UV RESPONSE VIA ERCC3 COMMON DN 483336All SZGR 2.0 genes in this pathway
SPIELMAN LYMPHOBLAST EUROPEAN VS ASIAN DN 584395All SZGR 2.0 genes in this pathway
PUJANA BRCA2 PCC NETWORK 423265All SZGR 2.0 genes in this pathway
BUYTAERT PHOTODYNAMIC THERAPY STRESS UP 811508All SZGR 2.0 genes in this pathway
BENPORATH SUZ12 TARGETS 1038678All SZGR 2.0 genes in this pathway
BENPORATH ES WITH H3K27ME3 1118744All SZGR 2.0 genes in this pathway
BENPORATH MYC MAX TARGETS 775494All SZGR 2.0 genes in this pathway
HADDAD B LYMPHOCYTE PROGENITOR 293193All SZGR 2.0 genes in this pathway
HEDENFALK BREAST CANCER BRACX DN 2014All SZGR 2.0 genes in this pathway
DAZARD RESPONSE TO UV SCC DN 12386All SZGR 2.0 genes in this pathway
DAZARD RESPONSE TO UV NHEK DN 318220All SZGR 2.0 genes in this pathway
DAZARD UV RESPONSE CLUSTER G6 153112All SZGR 2.0 genes in this pathway
GENTILE UV RESPONSE CLUSTER D8 4029All SZGR 2.0 genes in this pathway
KRIGE RESPONSE TO TOSEDOSTAT 6HR UP 953554All SZGR 2.0 genes in this pathway
KRIGE RESPONSE TO TOSEDOSTAT 24HR UP 783442All SZGR 2.0 genes in this pathway
LIN NPAS4 TARGETS UP 163100All SZGR 2.0 genes in this pathway
JISON SICKLE CELL DISEASE DN 18197All SZGR 2.0 genes in this pathway
YAGI AML WITH INV 16 TRANSLOCATION 422277All SZGR 2.0 genes in this pathway
DANG REGULATED BY MYC DN 253192All SZGR 2.0 genes in this pathway
DANG BOUND BY MYC 1103714All SZGR 2.0 genes in this pathway
STAMBOLSKY TARGETS OF MUTATED TP53 UP 4935All SZGR 2.0 genes in this pathway
STAMBOLSKY RESPONSE TO VITAMIN D3 UP 8448All SZGR 2.0 genes in this pathway
BRUINS UVC RESPONSE LATE 1137655All SZGR 2.0 genes in this pathway
WAKABAYASHI ADIPOGENESIS PPARG BOUND 8D 658397All SZGR 2.0 genes in this pathway
KRIEG HYPOXIA NOT VIA KDM3A 770480All SZGR 2.0 genes in this pathway