Gene Page: SMC3

Summary
GeneID  9126
Symbol  SMC3
Synonyms  BAM|BMH|CDLS3|CSPG6|HCAP|SMC3L1
Description  structural maintenance of chromosomes 3
See related  HGNC:2468|MIM:606062|Ensembl:ENSG00000108055|HPRD:05829|
Locus tag  -
Gene type  protein-coding
Map location  10q25
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
NetworkShortest path distance of core genes in the Human protein-protein interaction networkContribution to shortest path in PPI network: 0.6061 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
LINGO10.930.94
DMWD0.890.89
MCOLN10.890.88
FAM160A20.890.89
CACNB30.880.89
EPN10.880.89
GSK3A0.880.89
APBB10.870.89
CLIP30.870.87
DLGAP40.870.87
Top 10 negatively co-expressed genes
MT-CO2-0.68-0.63
AF347015.31-0.67-0.62
AF347015.21-0.67-0.67
AF347015.8-0.67-0.63
AL139819.3-0.66-0.67
AF347015.33-0.66-0.60
MT-CYB-0.66-0.61
AF347015.27-0.65-0.63
AF347015.26-0.64-0.59
AP002478.3-0.64-0.65
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0000166nucleotide bindingIEA-
GO:0003777microtubule motor activityNAS11590136 
GO:0005524ATP bindingIEA-
GO:0016887ATPase activityIEA-
GO:0046982protein heterodimerization activityIPI11590136 
GO:0045502dynein bindingIDA11590136 
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0006281DNA repairIEA-
GO:0007165signal transductionIDA12651860 
GO:0007049cell cycleIEA-
GO:0007062sister chromatid cohesionNAS11590136 
GO:0007067mitosisTAS9506951 
GO:0007126meiosisIDA12498344 
GO:0009294DNA mediated transformationTAS10801778 
GO:0007052mitotic spindle organizationIEP11590136 
GO:0051301cell divisionIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0000800lateral elementIEA-
GO:0000922spindle poleIDA11590136 
GO:0005604basement membraneTAS9015313 
GO:0005634nucleusTAS9506951 
GO:0005694chromosomeIEA-
GO:0005737cytoplasmIDA11590136 
GO:0008278cohesin complexNAS9506951 
GO:0016363nuclear matrixIDA11590136 
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
CASP4ICE(rel)II | ICEREL-II | ICH-2 | Mih1/TX | TXcaspase 4, apoptosis-related cysteine peptidaseAffinity Capture-MSBioGRID17353931 
CDK4CMM3 | MGC14458 | PSK-J3cyclin-dependent kinase 4Affinity Capture-MSBioGRID17353931 
HDAC2RPD3 | YAF1histone deacetylase 2Co-purificationBioGRID12198550 
KIFAP3FLJ22818 | KAP3 | SMAP | Smg-GDS | dJ190I16.1kinesin-associated protein 3-HPRD,BioGRID9506951 
MAGED1DLXIN-1 | NRAGEmelanoma antigen family D, 1Affinity Capture-MSBioGRID17353931 
MXD1MAD | MAD1 | MGC104659MAX dimerization protein 1Reconstituted Complex
Two-hybrid		BioGRID9528857 
MXD3MAD3 | MGC2383 | bHLHc13MAX dimerization protein 3Reconstituted Complex
Two-hybrid		BioGRID9528857 
MXD4MAD4 | MST149 | MSTP149 | bHLHc12MAX dimerization protein 4Reconstituted Complex
Two-hybrid		BioGRID9528857 
MXI1MAD2 | MGC43220 | MXD2 | MXI | bHLHc11MAX interactor 1Reconstituted Complex
Two-hybrid		BioGRID9528857 
NEK6SID6-1512NIMA (never in mitosis gene a)-related kinase 6Affinity Capture-MSBioGRID17353931 
NUMA1NUMAnuclear mitotic apparatus protein 1Affinity Capture-WesternBioGRID11590136 
REC8HR21spB | MGC950 | REC8L1 | Rec8pREC8 homolog (yeast)Affinity Capture-WesternBioGRID12759374 
SMARCA5ISWI | SNF2H | WCRF135 | hISWI | hSNF2HSWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5Co-purificationBioGRID12198550 
SMC1ACDLS2 | DKFZp686L19178 | DXS423E | KIAA0178 | MGC138332 | SB1.8 | SMC1 | SMC1L1 | SMC1alpha | SMCBstructural maintenance of chromosomes 1AAffinity Capture-WesternBioGRID9789013 |11590136 
|11877376 |12759374 
-HPRD9789013 |11076961 
SMC1BFLJ43748 | SMC1BETA | SMC1L2 | bK268H5 | bK268H5.5structural maintenance of chromosomes 1B-HPRD11564881 |12759374 
|15125634 
STAG1DKFZp781D1416 | SA1stromal antigen 1Co-purificationBioGRID11076961 
SYCP3COR1 | MGC71888 | SCP3synaptonemal complex protein 3Affinity Capture-WesternBioGRID12759374 
TUBBM40 | MGC117247 | MGC16435 | OK/SW-cl.56 | TUBB1 | TUBB5tubulin, betaAffinity Capture-WesternBioGRID11590136 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
KEGG_CELL_CYCLE 12884All SZGR genes in this pathway
KEGG_OOCYTE_MEIOSIS 11479All SZGR genes in this pathway
PID_ATM_PATHWAY 3425All SZGR genes in this pathway
REACTOME_MEIOSIS 11681All SZGR genes in this pathway
REACTOME_CELL_CYCLE 421253All SZGR genes in this pathway
REACTOME_CELL_CYCLE_MITOTIC 325185All SZGR genes in this pathway
REACTOME_MITOTIC_M_M_G1_PHASES 17298All SZGR genes in this pathway
REACTOME_CHROMOSOME_MAINTENANCE 12280All SZGR genes in this pathway
REACTOME_DNA_REPLICATION 192110All SZGR genes in this pathway
REACTOME_MITOTIC_PROMETAPHASE 8751All SZGR genes in this pathway
REACTOME_MEIOTIC_SYNAPSIS 7357All SZGR genes in this pathway
LIU_SOX4_TARGETS_DN 309191All SZGR genes in this pathway
SENGUPTA_NASOPHARYNGEAL_CARCINOMA_WITH_LMP1_UP 408247All SZGR genes in this pathway
DIAZ_CHRONIC_MEYLOGENOUS_LEUKEMIA_UP 1382904All SZGR genes in this pathway
OSMAN_BLADDER_CANCER_UP 404246All SZGR genes in this pathway
OSWALD_HEMATOPOIETIC_STEM_CELL_IN_COLLAGEN_GEL_UP 233161All SZGR genes in this pathway
KINSEY_TARGETS_OF_EWSR1_FLII_FUSION_UP 1278748All SZGR genes in this pathway
KIM_WT1_TARGETS_DN 459276All SZGR genes in this pathway
GRAHAM_CML_QUIESCENT_VS_NORMAL_DIVIDING_UP 5733All SZGR genes in this pathway
RODRIGUES_THYROID_CARCINOMA_POORLY_DIFFERENTIATED_UP 633376All SZGR genes in this pathway
RODRIGUES_THYROID_CARCINOMA_ANAPLASTIC_UP 722443All SZGR genes in this pathway
HAHTOLA_MYCOSIS_FUNGOIDES_SKIN_DN 2720All SZGR genes in this pathway
MARKEY_RB1_ACUTE_LOF_DN 228137All SZGR genes in this pathway
HAMAI_APOPTOSIS_VIA_TRAIL_UP 584356All SZGR genes in this pathway
DACOSTA_UV_RESPONSE_VIA_ERCC3_DN 855609All SZGR genes in this pathway
PUJANA_XPRSS_INT_NETWORK 168103All SZGR genes in this pathway
PUJANA_BRCA1_PCC_NETWORK 16521023All SZGR genes in this pathway
PUJANA_BRCA2_PCC_NETWORK 423265All SZGR genes in this pathway
PUJANA_ATM_PCC_NETWORK 1442892All SZGR genes in this pathway
PUJANA_CHEK2_PCC_NETWORK 779480All SZGR genes in this pathway
PUJANA_BRCA_CENTERED_NETWORK 11772All SZGR genes in this pathway
NUYTTEN_EZH2_TARGETS_DN 1024594All SZGR genes in this pathway
SHEN_SMARCA2_TARGETS_UP 424268All SZGR genes in this pathway
ZHANG_RESPONSE_TO_IKK_INHIBITOR_AND_TNF_DN 10364All SZGR genes in this pathway
KAUFFMANN_DNA_REPAIR_GENES 230137All SZGR genes in this pathway
KAUFFMANN_DNA_REPLICATION_GENES 14787All SZGR genes in this pathway
OKUMURA_INFLAMMATORY_RESPONSE_LPS 183115All SZGR genes in this pathway
WANG_SMARCE1_TARGETS_DN 371218All SZGR genes in this pathway
MAHAJAN_RESPONSE_TO_IL1A_DN 7657All SZGR genes in this pathway
LU_AGING_BRAIN_UP 262186All SZGR genes in this pathway
BILD_CTNNB1_ONCOGENIC_SIGNATURE 8252All SZGR genes in this pathway
MARSON_BOUND_BY_E2F4_UNSTIMULATED 728415All SZGR genes in this pathway
ACEVEDO_LIVER_CANCER_UP 973570All SZGR genes in this pathway
ACEVEDO_LIVER_TUMOR_VS_NORMAL_ADJACENT_TISSUE_UP 863514All SZGR genes in this pathway
MITSIADES_RESPONSE_TO_APLIDIN_DN 249165All SZGR genes in this pathway
ZHANG_TLX_TARGETS_36HR_DN 185116All SZGR genes in this pathway
MILI_PSEUDOPODIA_HAPTOTAXIS_UP 518299All SZGR genes in this pathway
CHICAS_RB1_TARGETS_SENESCENT 572352All SZGR genes in this pathway
CHICAS_RB1_TARGETS_GROWING 243155All SZGR genes in this pathway
LI_DCP2_BOUND_MRNA 8957All SZGR genes in this pathway
JOHNSTONE_PARVB_TARGETS_2_DN 336211All SZGR genes in this pathway
JOHNSTONE_PARVB_TARGETS_3_DN 918550All SZGR genes in this pathway
BRUINS_UVC_RESPONSE_EARLY_LATE 317190All SZGR genes in this pathway
BAKKER_FOXO3_TARGETS_DN 187109All SZGR genes in this pathway
LEE_BMP2_TARGETS_DN 882538All SZGR genes in this pathway
FEVR_CTNNB1_TARGETS_DN 553343All SZGR genes in this pathway
ABRAMSON_INTERACT_WITH_AIRE 4533All SZGR genes in this pathway


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