Gene Page: CD2
Summary ?
| GeneID | 914 |
| Symbol | CD2 |
| Synonyms | LFA-2|SRBC|T11 |
| Description | CD2 molecule |
| Reference | MIM:186990|HGNC:HGNC:1639|Ensembl:ENSG00000116824|HPRD:01750|Vega:OTTHUMG00000022750 |
| Gene type | protein-coding |
| Map location | 1p13.1 |
| Pascal p-value | 7.14E-4 |
| eGene | Meta |
Gene in Data Sources
| Gene set name | Method of gene set | Description | Info |
|---|---|---|---|
| CV:PGCnp | Genome-wide Association Study | GWAS | |
| GSMA_I | Genome scan meta-analysis | Psr: 0.0235 | |
| GSMA_IIA | Genome scan meta-analysis (All samples) | Psr: 0.00814 | |
| GO_Annotation | Mapping neuro-related keywords to Gene Ontology annotations | Hits with neuro-related keywords: 1 |
Section I. Genetics and epigenetics annotation
Section II. Transcriptome annotation
General gene expression (GTEx)
Gene expression during devlopment (BrainCloud)
Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.
Gene expression of temporal and spatial changes (BrainSpan)
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
Top co-expressed genes in brain regions
| Top 10 positively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| NAGS | 0.90 | 0.26 |
| ZIC4 | 0.88 | 0.27 |
| ZIC1 | 0.88 | 0.27 |
| FZD10 | 0.87 | 0.20 |
| ZIC2 | 0.84 | 0.24 |
| PROX1 | 0.83 | 0.41 |
| KRT18P19 | 0.80 | 0.13 |
| GBX2 | 0.80 | 0.36 |
| PGAM2 | 0.78 | 0.35 |
| KITLG | 0.77 | 0.26 |
| Top 10 negatively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| C20orf39 | -0.14 | -0.05 |
| SLC26A4 | -0.14 | -0.13 |
| BAIAP2 | -0.13 | 0.08 |
| PIK3IP1 | -0.13 | 0.12 |
| GRIA3 | -0.13 | -0.00 |
| GTDC1 | -0.13 | -0.13 |
| ADCY2 | -0.13 | 0.02 |
| CRYM | -0.13 | -0.14 |
| CACNG3 | -0.12 | -0.01 |
| KIAA1614 | -0.12 | 0.16 |
Section III. Gene Ontology annotation
| Molecular function | GO term | Evidence | Neuro keywords | PubMed ID |
|---|---|---|---|---|
| GO:0004872 | receptor activity | NAS | 7544493 | |
| GO:0005515 | protein binding | IPI | 1970422 |7544493 |12356317 | |
| GO:0005515 | protein binding | ISS | 7544493 |12356317 | |
| Biological process | GO term | Evidence | Neuro keywords | PubMed ID |
| GO:0030887 | positive regulation of myeloid dendritic cell activation | NAS | dendrite (GO term level: 9) | 12714509 |
| GO:0001766 | membrane raft polarization | TAS | 11376005 |11591762 | |
| GO:0030101 | natural killer cell activation | NAS | 12714509 | |
| GO:0006917 | induction of apoptosis | TAS | 9270771 |10575274 | |
| GO:0007166 | cell surface receptor linked signal transduction | TAS | 10575274 | |
| GO:0016337 | cell-cell adhesion | NAS | 7544493 | |
| GO:0042110 | T cell activation | TAS | 2471997 | |
| GO:0045580 | regulation of T cell differentiation | NAS | 11544295 | |
| Cellular component | GO term | Evidence | Neuro keywords | PubMed ID |
| GO:0016020 | membrane | IEA | - | |
| GO:0009897 | external side of plasma membrane | IEA | - | |
| GO:0005887 | integral to plasma membrane | NAS | 7544493 |
Section IV. Protein-protein interaction annotation
| Interactors | Aliases B | Official full name B | Experimental | Source | PubMed ID |
|---|---|---|---|---|---|
| CD247 | CD3-ZETA | CD3H | CD3Q | CD3Z | T3Z | TCRZ | CD247 molecule | - | HPRD | 8977276 |
| CD2AP | CMS | DKFZp586H0519 | CD2-associated protein | Reconstituted Complex | BioGRID | 12690097 |
| CD2AP | CMS | DKFZp586H0519 | CD2-associated protein | - | HPRD | 9741631 |
| CD2BP2 | FWP010 | LIN1 | Snu40 | U5-52K | CD2 (cytoplasmic tail) binding protein 2 | - | HPRD,BioGRID | 9843987 |
| CD4 | CD4mut | CD4 molecule | - | HPRD | 7539755 |
| CD48 | BCM1 | BLAST | BLAST1 | MEM-102 | SLAMF2 | hCD48 | mCD48 | CD48 molecule | - | HPRD,BioGRID | 12356317 |
| CD5 | LEU1 | T1 | CD5 molecule | - | HPRD,BioGRID | 10510361 |
| CD53 | MOX44 | TSPAN25 | CD53 molecule | - | HPRD,BioGRID | 1346273 |
| CD58 | LFA-3 | LFA3 | CD58 molecule | - | HPRD,BioGRID | 1377404 |11575926 |
| CD59 | 16.3A5 | 1F5 | EJ16 | EJ30 | EL32 | FLJ38134 | FLJ92039 | G344 | HRF-20 | HRF20 | MAC-IP | MACIF | MEM43 | MGC2354 | MIC11 | MIN1 | MIN2 | MIN3 | MIRL | MSK21 | p18-20 | CD59 molecule, complement regulatory protein | - | HPRD | 1377404 |
| FYN | MGC45350 | SLK | SYN | FYN oncogene related to SRC, FGR, YES | - | HPRD,BioGRID | 9677430 |
| ITK | EMT | LYK | MGC126257 | MGC126258 | PSCTK2 | IL2-inducible T-cell kinase | Affinity Capture-Western | BioGRID | 9677430 |
| LCK | YT16 | p56lck | pp58lck | lymphocyte-specific protein tyrosine kinase | - | HPRD,BioGRID | 8551220 |
| LGALS1 | DKFZp686E23103 | GAL1 | GBP | lectin, galactoside-binding, soluble, 1 | - | HPRD,BioGRID | 10642604 |
| MXD1 | MAD | MAD1 | MGC104659 | MAX dimerization protein 1 | - | HPRD,BioGRID | 11602341 |
| PSTPIP1 | CD2BP1 | CD2BP1L | CD2BP1S | H-PIP | PAPAS | PSTPIP | proline-serine-threonine phosphatase interacting protein 1 | - | HPRD,BioGRID | 9857189 |
| PTPRC | B220 | CD45 | CD45R | GP180 | LCA | LY5 | T200 | protein tyrosine phosphatase, receptor type, C | - | HPRD,BioGRID | 1970422 |1976695 |
| SH3KBP1 | CIN85 | GIG10 | MIG18 | SH3-domain kinase binding protein 1 | - | HPRD | 12690097 |
| SH3KBP1 | CIN85 | GIG10 | MIG18 | SH3-domain kinase binding protein 1 | - | HPRD,BioGRID | 9857189 |12690097|12690097 |
| SH3KBP1 | CIN85 | GIG10 | MIG18 | SH3-domain kinase binding protein 1 | SETA interacts with CD2. This interaction was modelled on a demonstrated interaction between rat SETA and human CD2. | BIND | 11152963 |
| SP1 | - | Sp1 transcription factor | - | HPRD | 7933095 |
Section V. Pathway annotation
| Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
|---|---|---|---|
| KEGG CELL ADHESION MOLECULES CAMS | 134 | 93 | All SZGR 2.0 genes in this pathway |
| KEGG HEMATOPOIETIC CELL LINEAGE | 88 | 60 | All SZGR 2.0 genes in this pathway |
| BIOCARTA DC PATHWAY | 22 | 20 | All SZGR 2.0 genes in this pathway |
| BIOCARTA IL17 PATHWAY | 17 | 12 | All SZGR 2.0 genes in this pathway |
| BIOCARTA NO2IL12 PATHWAY | 17 | 14 | All SZGR 2.0 genes in this pathway |
| BIOCARTA STATHMIN PATHWAY | 19 | 17 | All SZGR 2.0 genes in this pathway |
| BIOCARTA TCYTOTOXIC PATHWAY | 14 | 11 | All SZGR 2.0 genes in this pathway |
| BIOCARTA THELPER PATHWAY | 14 | 11 | All SZGR 2.0 genes in this pathway |
| REACTOME CELL SURFACE INTERACTIONS AT THE VASCULAR WALL | 91 | 65 | All SZGR 2.0 genes in this pathway |
| REACTOME HEMOSTASIS | 466 | 331 | All SZGR 2.0 genes in this pathway |
| DEURIG T CELL PROLYMPHOCYTIC LEUKEMIA DN | 320 | 184 | All SZGR 2.0 genes in this pathway |
| JAATINEN HEMATOPOIETIC STEM CELL DN | 226 | 132 | All SZGR 2.0 genes in this pathway |
| GRAESSMANN APOPTOSIS BY SERUM DEPRIVATION UP | 552 | 347 | All SZGR 2.0 genes in this pathway |
| GRAESSMANN RESPONSE TO MC AND SERUM DEPRIVATION UP | 211 | 136 | All SZGR 2.0 genes in this pathway |
| BARIS THYROID CANCER DN | 59 | 45 | All SZGR 2.0 genes in this pathway |
| DARWICHE PAPILLOMA PROGRESSION RISK | 74 | 44 | All SZGR 2.0 genes in this pathway |
| FARMER BREAST CANCER CLUSTER 1 | 44 | 23 | All SZGR 2.0 genes in this pathway |
| WATTEL AUTONOMOUS THYROID ADENOMA DN | 55 | 29 | All SZGR 2.0 genes in this pathway |
| BENPORATH MYC TARGETS WITH EBOX | 230 | 156 | All SZGR 2.0 genes in this pathway |
| MORI PRE BI LYMPHOCYTE DN | 77 | 49 | All SZGR 2.0 genes in this pathway |
| FERRANDO TAL1 NEIGHBORS | 21 | 15 | All SZGR 2.0 genes in this pathway |
| FLECHNER BIOPSY KIDNEY TRANSPLANT REJECTED VS OK UP | 87 | 58 | All SZGR 2.0 genes in this pathway |
| SANSOM APC TARGETS DN | 366 | 238 | All SZGR 2.0 genes in this pathway |
| FERRANDO T ALL WITH MLL ENL FUSION DN | 87 | 57 | All SZGR 2.0 genes in this pathway |
| YU MYC TARGETS DN | 55 | 38 | All SZGR 2.0 genes in this pathway |
| VERHAAK AML WITH NPM1 MUTATED DN | 246 | 180 | All SZGR 2.0 genes in this pathway |
| KUMAR TARGETS OF MLL AF9 FUSION | 405 | 264 | All SZGR 2.0 genes in this pathway |
| MOREIRA RESPONSE TO TSA UP | 28 | 23 | All SZGR 2.0 genes in this pathway |
| GAVIN FOXP3 TARGETS CLUSTER T7 | 98 | 63 | All SZGR 2.0 genes in this pathway |
| MARSON BOUND BY FOXP3 STIMULATED | 1022 | 619 | All SZGR 2.0 genes in this pathway |
| MARSON FOXP3 CORE DIRECT TARGETS | 19 | 14 | All SZGR 2.0 genes in this pathway |
| WALLACE PROSTATE CANCER RACE UP | 299 | 167 | All SZGR 2.0 genes in this pathway |
| ACEVEDO LIVER CANCER UP | 973 | 570 | All SZGR 2.0 genes in this pathway |
| SMID BREAST CANCER LUMINAL B DN | 564 | 326 | All SZGR 2.0 genes in this pathway |
| SMID BREAST CANCER NORMAL LIKE UP | 476 | 285 | All SZGR 2.0 genes in this pathway |
| VILIMAS NOTCH1 TARGETS UP | 52 | 41 | All SZGR 2.0 genes in this pathway |
| HOFFMANN LARGE TO SMALL PRE BII LYMPHOCYTE DN | 72 | 47 | All SZGR 2.0 genes in this pathway |
| LEE DIFFERENTIATING T LYMPHOCYTE | 200 | 115 | All SZGR 2.0 genes in this pathway |
| POOLA INVASIVE BREAST CANCER UP | 288 | 168 | All SZGR 2.0 genes in this pathway |
| CHIANG LIVER CANCER SUBCLASS CTNNB1 DN | 170 | 105 | All SZGR 2.0 genes in this pathway |
| MARSON FOXP3 TARGETS UP | 66 | 43 | All SZGR 2.0 genes in this pathway |
| ONO AML1 TARGETS DN | 41 | 25 | All SZGR 2.0 genes in this pathway |
| CHIARETTI T ALL RELAPSE PROGNOSIS | 19 | 15 | All SZGR 2.0 genes in this pathway |
| LI INDUCED T TO NATURAL KILLER DN | 116 | 83 | All SZGR 2.0 genes in this pathway |
| BRUINS UVC RESPONSE VIA TP53 GROUP D | 280 | 158 | All SZGR 2.0 genes in this pathway |
| ZWANG TRANSIENTLY UP BY 2ND EGF PULSE ONLY | 1725 | 838 | All SZGR 2.0 genes in this pathway |