Gene Page: EIF2AK3

Summary
GeneID  9451
Symbol  EIF2AK3
Synonyms  DKFZp781H1925|HRI|PEK|PERK|WRS
Description  eukaryotic translation initiation factor 2-alpha kinase 3
See related  HGNC:3255|MIM:604032|Ensembl:ENSG00000172071|HPRD:04942|
Locus tag  -
Gene type  protein-coding
Map location  2p12
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
GSMA_Igenome scan meta-analysisPsr: 0.0004 
GO_AnnotationMapping neuro-related keywords to Gene Ontology annotationsHits with neuro-related keywords: 1 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
Top 10 negatively co-expressed genes
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0000166nucleotide bindingIEA-
GO:0005524ATP bindingIEA-
GO:0004694eukaryotic translation initiation factor 2alpha kinase activityIDA10026192 |10677345 |11907036 
GO:0004694eukaryotic translation initiation factor 2alpha kinase activityIMP12086964 
GO:0016740transferase activityIEA-
GO:0042802identical protein bindingIPI11907036 
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0031642negative regulation of myelinationIEAaxon (GO term level: 15)-
GO:0001501skeletal system developmentIEA-
GO:0002063chondrocyte developmentIEA-
GO:0006986response to unfolded proteinIEA-
GO:0048009insulin-like growth factor receptor signaling pathwayIEA-
GO:0007029endoplasmic reticulum organizationIEA-
GO:0006983ER overload responseIDA10677345 |11907036 
GO:0006926virus-infected cell apoptosisIEA-
GO:0006919caspase activationIEA-
GO:0019722calcium-mediated signalingIEA-
GO:0030073insulin secretionIEA-
GO:0031018endocrine pancreas developmentIMP12086964 
GO:0032092positive regulation of protein bindingIEA-
GO:0030968endoplasmic reticulum unfolded protein responseIDA10677345 |11907036 
GO:0032057negative regulation of translational initiation in response to stressTAS10677345 |12086964 
GO:0051260protein homooligomerizationIMP11907036 
GO:0030282bone mineralizationIEA-
GO:0017148negative regulation of translationTAS12086964 
GO:0046777protein amino acid autophosphorylationIDA10026192 |11907036 
GO:0046777protein amino acid autophosphorylationIMP12086964 
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005789endoplasmic reticulum membraneNAS11907036 
GO:0005737cytoplasmIEA-
GO:0005783endoplasmic reticulumIC11907036 
GO:0005783endoplasmic reticulumTAS12086964 
GO:0016020membraneIEA-
GO:0016021integral to membraneIEA-
 
InteractionsShown by Network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
DNAJC3HP58 | P58 | P58IPK | PRKRIDnaJ (Hsp40) homolog, subfamily C, member 3-HPRD,BioGRID12446838 
HSP90AA1FLJ31884 | HSP86 | HSP89A | HSP90A | HSP90N | HSPC1 | HSPCA | HSPCAL1 | HSPCAL4 | HSPN | Hsp89 | Hsp90 | LAP2heat shock protein 90kDa alpha (cytosolic), class A member 1-HPRD,BioGRID12446770 
HSP90B1ECGP | GP96 | GRP94 | TRA1heat shock protein 90kDa beta (Grp94), member 1Affinity Capture-WesternBioGRID11907036 
HSPA5BIP | FLJ26106 | GRP78 | MIF2heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)-HPRD,BioGRID11907036 
NFE2L2NRF2nuclear factor (erythroid-derived 2)-like 2-HPRD,BioGRID14517290 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
KEGG_ALZHEIMERS_DISEASE 169110All SZGR genes in this pathway
BIOCARTA_EIF2_PATHWAY 118All SZGR genes in this pathway
REACTOME_DIABETES_PATHWAYS 13391All SZGR genes in this pathway
REACTOME_PERK_REGULATED_GENE_EXPRESSION 2914All SZGR genes in this pathway
REACTOME_UNFOLDED_PROTEIN_RESPONSE 8051All SZGR genes in this pathway
UDAYAKUMAR_MED1_TARGETS_DN 240171All SZGR genes in this pathway
KIM_WT1_TARGETS_DN 459276All SZGR genes in this pathway
MAYBURD_RESPONSE_TO_L663536_UP 2918All SZGR genes in this pathway
ENK_UV_RESPONSE_EPIDERMIS_DN 508354All SZGR genes in this pathway
GRAESSMANN_APOPTOSIS_BY_SERUM_DEPRIVATION_DN 234147All SZGR genes in this pathway
BERENJENO_TRANSFORMED_BY_RHOA_DN 394258All SZGR genes in this pathway
SHETH_LIVER_CANCER_VS_TXNIP_LOSS_PAM2 153102All SZGR genes in this pathway
SPIELMAN_LYMPHOBLAST_EUROPEAN_VS_ASIAN_DN 584395All SZGR genes in this pathway
BUYTAERT_PHOTODYNAMIC_THERAPY_STRESS_UP 811508All SZGR genes in this pathway
BENPORATH_NANOG_TARGETS 988594All SZGR genes in this pathway
GEORGES_TARGETS_OF_MIR192_AND_MIR215 893528All SZGR genes in this pathway
BYSTRYKH_HEMATOPOIESIS_STEM_CELL_QTL_TRANS 882572All SZGR genes in this pathway
HADDAD_B_LYMPHOCYTE_PROGENITOR 293193All SZGR genes in this pathway
LEE_CALORIE_RESTRICTION_NEOCORTEX_UP 8366All SZGR genes in this pathway
CREIGHTON_ENDOCRINE_THERAPY_RESISTANCE_3 720440All SZGR genes in this pathway
MARSON_BOUND_BY_FOXP3_UNSTIMULATED 1229713All SZGR genes in this pathway
SANSOM_APC_MYC_TARGETS 217138All SZGR genes in this pathway
MITSIADES_RESPONSE_TO_APLIDIN_UP 439257All SZGR genes in this pathway
BONOME_OVARIAN_CANCER_SURVIVAL_SUBOPTIMAL_DEBULKING 510309All SZGR genes in this pathway
PODAR_RESPONSE_TO_ADAPHOSTIN_UP 14798All SZGR genes in this pathway
CUI_GLUCOSE_DEPRIVATION 6044All SZGR genes in this pathway
YOSHIMURA_MAPK8_TARGETS_UP 1305895All SZGR genes in this pathway
HOFFMANN_IMMATURE_TO_MATURE_B_LYMPHOCYTE_UP 4334All SZGR genes in this pathway
HAN_SATB1_TARGETS_DN 442275All SZGR genes in this pathway
MILI_PSEUDOPODIA_CHEMOTAXIS_DN 457302All SZGR genes in this pathway
MILI_PSEUDOPODIA_HAPTOTAXIS_DN 668419All SZGR genes in this pathway
GABRIELY_MIR21_TARGETS 289187All SZGR genes in this pathway
PILON_KLF1_TARGETS_DN 19721213All SZGR genes in this pathway
FEVR_CTNNB1_TARGETS_UP 682433All SZGR genes in this pathway
PURBEY_TARGETS_OF_CTBP1_AND_SATB1_UP 8752All SZGR genes in this pathway
ZWANG_CLASS_3_TRANSIENTLY_INDUCED_BY_EGF 222159All SZGR genes in this pathway
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-130/3014784841Ahsa-miR-130abrainCAGUGCAAUGUUAAAAGGGCAU
hsa-miR-301CAGUGCAAUAGUAUUGUCAAAGC
hsa-miR-130bbrainCAGUGCAAUGAUGAAAGGGCAU
hsa-miR-454-3pUAGUGCAAUAUUGCUUAUAGGGUUU
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


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