Gene Page: TRAF4

Summary ?
GeneID9618
SymbolTRAF4
SynonymsCART1|MLN62|RNF83
DescriptionTNF receptor associated factor 4
ReferenceMIM:602464|HGNC:HGNC:12034|Ensembl:ENSG00000076604|HPRD:03915|Vega:OTTHUMG00000132677
Gene typeprotein-coding
Map location17q11-q12
Pascal p-value0.274
Sherlock p-value0.062
Fetal beta1.447
eGeneMyers' cis & trans
Meta

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
CV:PGCnpGenome-wide Association StudyGWAS
PMID:cooccurHigh-throughput literature-searchSystematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
LiteratureHigh-throughput literature-searchCo-occurance with Schizophrenia keywords: schizophrenia,schizophreniasClick to show details

Section I. Genetics and epigenetics annotation

@eQTL annotation

SNP IDChromosomePositioneGeneGene Entrez IDpvalueqvalueTSS distanceeQTL type
rs2070265chr1727075422TRAF496180.16cis
rs4794836chr1727082709TRAF496180.08cis
rs4795457chr1727087928TRAF496180.14cis
rs11658884chr1727132741TRAF496180.12cis
rs2242345chr1727185826TRAF496180.08cis
rs2277664chr1727286661TRAF496180.18cis

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
GenePearson's Correlation Spearman's Correlation
PPP1R3F0.920.94
ABLIM20.920.94
ZFYVE280.910.88
AC105206.10.910.91
HTR5A0.890.91
PRRT30.890.94
NPTN0.890.90
C2orf550.890.79
MAST30.890.92
SYNPO0.890.85
Top 10 negatively co-expressed genes
GenePearson's Correlation Spearman's Correlation
C9orf46-0.46-0.47
GTF3C6-0.46-0.43
RBMX2-0.44-0.47
EXOSC8-0.44-0.37
BCL7C-0.44-0.48
RPL23A-0.44-0.47
RPS8-0.43-0.44
RPS20-0.42-0.49
RPS6-0.42-0.44
DYNLT1-0.42-0.48

Section IV. Protein-protein interaction annotation

InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
ACTN1FLJ40884actinin, alpha 1TRAF4 interacts with alpha-actinin.BIND12023963 
BCKDK-branched chain ketoacid dehydrogenase kinaseTRAF4 interacts with BCKDK.BIND12023963 
CCHCR1C6orf18 | HCR | MGC126371 | MGC126372 | SBPcoiled-coil alpha-helical rod protein 1TRAF4 interacts with HCR.BIND12023963 
LTBRCD18 | D12S370 | LT-BETA-R | TNF-R-III | TNFCR | TNFR-RP | TNFR2-RP | TNFRSF3lymphotoxin beta receptor (TNFR superfamily, member 3)-HPRD,BioGRID9626059 
MAGED1DLXIN-1 | NRAGEmelanoma antigen family D, 1TRAF4 interacts with NRAGE.BIND12023963 
ME3FLJ34862malic enzyme 3, NADP(+)-dependent, mitochondrialTRAF4 interacts with NADP-ME.BIND12023963 
NCF1FLJ79451 | NCF1A | NOXO2 | SH3PXD1A | p47phoxneutrophil cytosolic factor 1Affinity Capture-WesternBioGRID12023963 
NCF1CSH3PXD1Cneutrophil cytosolic factor 1C pseudogeneTRAF4 interacts with p47phox.BIND12023963 
NCF1CSH3PXD1Cneutrophil cytosolic factor 1C pseudogene-HPRD12023963 
NGFRCD271 | Gp80-LNGFR | TNFRSF16 | p75(NTR) | p75NTRnerve growth factor receptor (TNFR superfamily, member 16)-HPRD,BioGRID10514511 
PLSCR1MMTRA1Bphospholipid scramblase 1TRAF4 interacts with PLSCR1.BIND12023963 
PXDND2S448 | D2S448E | KIAA0230 | MG50 | PRG2 | PXN | VPOperoxidasin homolog (Drosophila)TRAF4 interacts with MAGE.BIND12023963 
RPS6KB1PS6K | S6K | S6K1 | STK14A | p70(S6K)-alpha | p70-S6K | p70-alpharibosomal protein S6 kinase, 70kDa, polypeptide 1-HPRD,BioGRID12801526 
SIGLEC7AIRM1 | CD328 | CDw328 | D-siglec | QA79 | SIGLEC-7 | p75 | p75/AIRM1sialic acid binding Ig-like lectin 7-HPRD10514511 
SORBS2ARGBP2 | FLJ93447 | KIAA0777 | PRO0618sorbin and SH3 domain containing 2TRAF4 interacts with ArgBP2.BIND12023963 
TARBP2LOQS | TRBP | TRBP1 | TRBP2TAR (HIV-1) RNA binding protein 2TRAF4 interacts with TARBP2.BIND12023963 
TBC1D8AD3 | HBLP1 | VRPTBC1 domain family, member 8 (with GRAM domain)TRAF4 interacts with VRP.BIND12023963 
TGFB1I1ARA55 | HIC-5 | HIC5 | TSC-5transforming growth factor beta 1 induced transcript 1TRAF4 interacts with Hic-5.BIND12023963 
TRIM37KIAA0898 | MUL | POB1 | TEF3tripartite motif-containing 37-HPRD,BioGRID11279055 
UBE2IC358B7.1 | P18 | UBC9ubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast)TRAF4 interacts with UBC9.BIND12023963 
USP7HAUSP | TEF1ubiquitin specific peptidase 7 (herpes virus-associated)-HPRD,BioGRID11279055 


Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
KEGG PATHWAYS IN CANCER 328259All SZGR 2.0 genes in this pathway
KEGG SMALL CELL LUNG CANCER 8467All SZGR 2.0 genes in this pathway
PID TAP63 PATHWAY 5440All SZGR 2.0 genes in this pathway
LIU SOX4 TARGETS DN 309191All SZGR 2.0 genes in this pathway
CHARAFE BREAST CANCER LUMINAL VS MESENCHYMAL UP 450256All SZGR 2.0 genes in this pathway
HOEBEKE LYMPHOID STEM CELL UP 9564All SZGR 2.0 genes in this pathway
TONKS TARGETS OF RUNX1 RUNX1T1 FUSION HSC DN 187115All SZGR 2.0 genes in this pathway
WAMUNYOKOLI OVARIAN CANCER LMP UP 265158All SZGR 2.0 genes in this pathway
ENK UV RESPONSE KERATINOCYTE UP 530342All SZGR 2.0 genes in this pathway
LAU APOPTOSIS CDKN2A UP 5540All SZGR 2.0 genes in this pathway
GRAESSMANN APOPTOSIS BY DOXORUBICIN UP 1142669All SZGR 2.0 genes in this pathway
GRAESSMANN RESPONSE TO MC AND DOXORUBICIN UP 612367All SZGR 2.0 genes in this pathway
LANDIS ERBB2 BREAST TUMORS 324 UP 15093All SZGR 2.0 genes in this pathway
HAMAI APOPTOSIS VIA TRAIL DN 186107All SZGR 2.0 genes in this pathway
LUCAS HNF4A TARGETS UP 5836All SZGR 2.0 genes in this pathway
PEREZ TP53 TARGETS 1174695All SZGR 2.0 genes in this pathway
LI AMPLIFIED IN LUNG CANCER 178108All SZGR 2.0 genes in this pathway
DIRMEIER LMP1 RESPONSE EARLY 6648All SZGR 2.0 genes in this pathway
MOHANKUMAR TLX1 TARGETS UP 414287All SZGR 2.0 genes in this pathway
PUJANA BRCA1 PCC NETWORK 16521023All SZGR 2.0 genes in this pathway
RICKMAN TUMOR DIFFERENTIATED WELL VS POORLY UP 236139All SZGR 2.0 genes in this pathway
AMIT EGF RESPONSE 480 HELA 164118All SZGR 2.0 genes in this pathway
SHIN B CELL LYMPHOMA CLUSTER 7 2722All SZGR 2.0 genes in this pathway
MORI EMU MYC LYMPHOMA BY ONSET TIME UP 11069All SZGR 2.0 genes in this pathway
NIKOLSKY BREAST CANCER 17Q11 Q21 AMPLICON 13378All SZGR 2.0 genes in this pathway
SCHURINGA STAT5A TARGETS UP 2113All SZGR 2.0 genes in this pathway
HADDAD T LYMPHOCYTE AND NK PROGENITOR DN 6341All SZGR 2.0 genes in this pathway
KUMAR TARGETS OF MLL AF9 FUSION 405264All SZGR 2.0 genes in this pathway
RHODES CANCER META SIGNATURE 6447All SZGR 2.0 genes in this pathway
DAZARD RESPONSE TO UV SCC DN 12386All SZGR 2.0 genes in this pathway
SESTO RESPONSE TO UV C0 10772All SZGR 2.0 genes in this pathway
JACKSON DNMT1 TARGETS UP 7757All SZGR 2.0 genes in this pathway
MONNIER POSTRADIATION TUMOR ESCAPE UP 393244All SZGR 2.0 genes in this pathway
CREIGHTON ENDOCRINE THERAPY RESISTANCE 3 720440All SZGR 2.0 genes in this pathway
MASSARWEH TAMOXIFEN RESISTANCE UP 578341All SZGR 2.0 genes in this pathway
SMID BREAST CANCER ERBB2 UP 14783All SZGR 2.0 genes in this pathway
HSIAO HOUSEKEEPING GENES 389245All SZGR 2.0 genes in this pathway
DORN ADENOVIRUS INFECTION 12HR DN 3325All SZGR 2.0 genes in this pathway
DORN ADENOVIRUS INFECTION 24HR DN 4332All SZGR 2.0 genes in this pathway
DORN ADENOVIRUS INFECTION 32HR DN 3928All SZGR 2.0 genes in this pathway
DORN ADENOVIRUS INFECTION 48HR DN 4029All SZGR 2.0 genes in this pathway
HIRSCH CELLULAR TRANSFORMATION SIGNATURE UP 242159All SZGR 2.0 genes in this pathway
BRUINS UVC RESPONSE MIDDLE 9856All SZGR 2.0 genes in this pathway
CHANGOLKAR H2AFY TARGETS UP 4828All SZGR 2.0 genes in this pathway
WAKABAYASHI ADIPOGENESIS PPARG BOUND 8D 658397All SZGR 2.0 genes in this pathway
PHONG TNF RESPONSE VIA P38 COMPLETE 227151All SZGR 2.0 genes in this pathway
SMIRNOV RESPONSE TO IR 6HR UP 16697All SZGR 2.0 genes in this pathway