Gene Page: CD79A

Summary ?
GeneID973
SymbolCD79A
SynonymsIGA|MB-1
DescriptionCD79a molecule
ReferenceMIM:112205|HGNC:HGNC:1698|Ensembl:ENSG00000105369|HPRD:00203|Vega:OTTHUMG00000182678
Gene typeprotein-coding
Map location19q13.2
Pascal p-value0.301
Fetal beta-0.294
DMG1 (# studies)
eGeneMyers' cis & trans

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
DMG:vanEijk_2014Genome-wide DNA methylation analysisThis dataset includes 432 differentially methylated CpG sites corresponding to 391 unique transcripts between schizophrenia patients (n=260) and unaffected controls (n=250). 1
GO_AnnotationMapping neuro-related keywords to Gene Ontology annotationsHits with neuro-related keywords: 1 

Section I. Genetics and epigenetics annotation

@Differentially methylated gene

ProbeChromosomePositionNearest geneP (dis)Beta (dis)FDR (dis)Study
cg117192831942574717CD79A8.41E-410.837DMG:vanEijk_2014

@eQTL annotation

SNP IDChromosomePositioneGeneGene Entrez IDpvalueqvalueTSS distanceeQTL type
rs10994209chr1061877705CD79A9730.11trans

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
GenePearson's Correlation Spearman's Correlation
IFITM20.570.50
MT2A0.560.44
MT1F0.540.41
CEBPD0.530.42
MT1X0.520.43
IFITM30.520.48
RARRES30.520.39
TREX10.520.44
SRGN0.520.43
MT1M0.520.41
Top 10 negatively co-expressed genes
GenePearson's Correlation Spearman's Correlation
CCDC49-0.37-0.38
ZNF638-0.36-0.36
ARID4A-0.36-0.38
ING2-0.35-0.39
RTF1-0.35-0.34
USP7-0.35-0.34
GIGYF2-0.35-0.33
ZNF417-0.35-0.34
STX3-0.35-0.35
HIVEP3-0.34-0.37

Section III. Gene Ontology annotation

Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0004888transmembrane receptor activityIEA-
GO:0005515protein bindingISS-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0007166cell surface receptor linked signal transductionIEA-
GO:0006955immune responseIEA-
GO:0042100B cell proliferationISS-
GO:0030183B cell differentiationISS-
GO:0050853B cell receptor signaling pathwayISS-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0019815B cell receptor complexISSSynap (GO term level: 8)-
GO:0005771multivesicular bodyISS-
GO:0016021integral to membraneIEA-
GO:0009897external side of plasma membraneISS-
GO:0005886plasma membraneIEA-
GO:0045121membrane raftISS-

Section IV. Protein-protein interaction annotation

InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
AMBPEDC1 | HCP | HI30 | IATIL | ITI | ITIL | ITILC | UTIalpha-1-microglobulin/bikunin precursorAffinity Capture-Western
Co-purification		BioGRID6196366 |9183005 
BLKMGC10442B lymphoid tyrosine kinase-HPRD,BioGRID7592958 
BLNKBASH | BLNK-S | LY57 | MGC111051 | SLP-65 | SLP65B-cell linker-HPRD,BioGRID11449366 |11909947 
CD19B4 | MGC12802CD19 molecule-HPRD,BioGRID9120258 
CD79AIGA | MB-1CD79a molecule, immunoglobulin-associated alpha-HPRD1881434 
CD79BB29 | IGBCD79b molecule, immunoglobulin-associated betaAffinity Capture-WesternBioGRID12886015 
CD79BB29 | IGBCD79b molecule, immunoglobulin-associated beta-HPRD1591006 |8656670 
FANCAFA | FA-H | FA1 | FAA | FACA | FAH | FANCH | MGC75158Fanconi anemia, complementation group ATwo-hybridBioGRID14499622 
FCARCD89Fc fragment of IgA, receptor for-HPRD8666916 |10438530 
HCLS1CTTNL | HS1hematopoietic cell-specific Lyn substrate 1-HPRD,BioGRID7927516 
IGHMDKFZp686I15196 | DKFZp686I15212 | FLJ00385 | MGC104996 | MGC52291 | MU | VHimmunoglobulin heavy constant mu-HPRD9561918 
IGJIGCJ | JCHimmunoglobulin J polypeptide, linker protein for immunoglobulin alpha and mu polypeptides-HPRD1292512 |8683109 
PIGRFLJ22667 | MGC125361 | MGC125362polymeric immunoglobulin receptor-HPRD1940346 |7989333 
|10540352 |12186846 
PTPRCB220 | CD45 | CD45R | GP180 | LCA | LY5 | T200protein tyrosine phosphatase, receptor type, C-HPRD,BioGRID7516335 
SYKDKFZp313N1010 | FLJ25043 | FLJ37489spleen tyrosine kinase-HPRD,BioGRID1569106|7500027 


Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
KEGG B CELL RECEPTOR SIGNALING PATHWAY 7556All SZGR 2.0 genes in this pathway
KEGG PRIMARY IMMUNODEFICIENCY 3528All SZGR 2.0 genes in this pathway
BIOCARTA BCR PATHWAY 3728All SZGR 2.0 genes in this pathway
BIOCARTA CTCF PATHWAY 2318All SZGR 2.0 genes in this pathway
PID BCR 5PATHWAY 6550All SZGR 2.0 genes in this pathway
REACTOME ANTIGEN ACTIVATES B CELL RECEPTOR LEADING TO GENERATION OF SECOND MESSENGERS 2924All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY THE B CELL RECEPTOR BCR 12690All SZGR 2.0 genes in this pathway
REACTOME IMMUNE SYSTEM 933616All SZGR 2.0 genes in this pathway
REACTOME ADAPTIVE IMMUNE SYSTEM 539350All SZGR 2.0 genes in this pathway
WINTER HYPOXIA DN 5230All SZGR 2.0 genes in this pathway
BORCZUK MALIGNANT MESOTHELIOMA DN 10459All SZGR 2.0 genes in this pathway
VECCHI GASTRIC CANCER EARLY DN 367220All SZGR 2.0 genes in this pathway
KLEIN TARGETS OF BCR ABL1 FUSION 4534All SZGR 2.0 genes in this pathway
TSAI RESPONSE TO IONIZING RADIATION 149101All SZGR 2.0 genes in this pathway
PUJANA BRCA1 PCC NETWORK 16521023All SZGR 2.0 genes in this pathway
PUJANA ATM PCC NETWORK 1442892All SZGR 2.0 genes in this pathway
PASQUALUCCI LYMPHOMA BY GC STAGE DN 165104All SZGR 2.0 genes in this pathway
SHIN B CELL LYMPHOMA CLUSTER 9 1913All SZGR 2.0 genes in this pathway
GOLUB ALL VS AML UP 2420All SZGR 2.0 genes in this pathway
KLEIN PRIMARY EFFUSION LYMPHOMA DN 5842All SZGR 2.0 genes in this pathway
BYSTRYKH HEMATOPOIESIS STEM CELL QTL TRANS 882572All SZGR 2.0 genes in this pathway
SANSOM APC TARGETS DN 366238All SZGR 2.0 genes in this pathway
ZHANG TARGETS OF EWSR1 FLI1 FUSION 8868All SZGR 2.0 genes in this pathway
ASTIER INTEGRIN SIGNALING 5944All SZGR 2.0 genes in this pathway
HADDAD B LYMPHOCYTE PROGENITOR 293193All SZGR 2.0 genes in this pathway
ZHAN MULTIPLE MYELOMA CD2 UP 4532All SZGR 2.0 genes in this pathway
KUMAR TARGETS OF MLL AF9 FUSION 405264All SZGR 2.0 genes in this pathway
KRASNOSELSKAYA ILF3 TARGETS UP 3824All SZGR 2.0 genes in this pathway
MCLACHLAN DENTAL CARIES DN 245144All SZGR 2.0 genes in this pathway
BANDRES RESPONSE TO CARMUSTIN MGMT 48HR DN 161105All SZGR 2.0 genes in this pathway
MCLACHLAN DENTAL CARIES UP 253147All SZGR 2.0 genes in this pathway
SMID BREAST CANCER LUMINAL B DN 564326All SZGR 2.0 genes in this pathway
SMID BREAST CANCER NORMAL LIKE UP 476285All SZGR 2.0 genes in this pathway
QI PLASMACYTOMA UP 259185All SZGR 2.0 genes in this pathway
WANG TUMOR INVASIVENESS UP 374247All SZGR 2.0 genes in this pathway
SHEDDEN LUNG CANCER GOOD SURVIVAL A12 317177All SZGR 2.0 genes in this pathway
POOLA INVASIVE BREAST CANCER UP 288168All SZGR 2.0 genes in this pathway
YAGI AML WITH 11Q23 REARRANGED 351238All SZGR 2.0 genes in this pathway
MIKKELSEN IPS LCP WITH H3K4ME3 174100All SZGR 2.0 genes in this pathway
MARTENS TRETINOIN RESPONSE UP 857456All SZGR 2.0 genes in this pathway
MIYAGAWA TARGETS OF EWSR1 ETS FUSIONS UP 259159All SZGR 2.0 genes in this pathway
ZWANG TRANSIENTLY UP BY 2ND EGF PULSE ONLY 1725838All SZGR 2.0 genes in this pathway