SZGR2

Summary ?

GeneID	983
Symbol	CDK1
Synonyms	CDC2\|CDC28A\|P34CDC2
Description	cyclin-dependent kinase 1
Reference	MIM:116940\|HGNC:HGNC:1722\|Ensembl:ENSG00000170312\|HPRD:00302\|Vega:OTTHUMG00000018290
Gene type	protein-coding
Map location	10q21.1
Pascal p-value	0.901
Fetal beta	3.972

Gene in Data Sources

Gene set name	Method of gene set	Description	Info
CV:GWASdb	Genome-wide Association Studies	GWASdb records for schizophrenia
CV:PGCnp	Genome-wide Association Study	GWAS
DMG:Wockner_2014	Genome-wide DNA methylation analysis	This dataset includes 4641 differentially methylated probes corresponding to 2929 unique genes between schizophrenia patients (n=24) and controls (n=24).	1

Section I. Genetics and epigenetics annotation

Differentially methylated gene

Probe	Chromosome	Position	Nearest gene	P (dis)	Beta (dis)	FDR (dis)	Study
cg25228510	10	62538235	CDK1;CDC2	2.51E-5	-0.201	0.017	DMG:Wockner_2014

Section II. Transcriptome annotation

General gene expression (GTEx)

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
Gene	Pearson's Correlation	Spearman's Correlation
MATR3	0.96	0.97
POLR2B	0.96	0.97
COIL	0.96	0.96
SNW1	0.96	0.96
ACTR3	0.96	0.96
CRNKL1	0.96	0.96
EPRS	0.96	0.96
CEBPZ	0.96	0.95
PLAA	0.96	0.96
NOL11	0.95	0.96

Top 10 negatively co-expressed genes
Gene	Pearson's Correlation	Spearman's Correlation
MT-CO2	-0.79	-0.90
AF347015.31	-0.78	-0.89
AF347015.33	-0.76	-0.87
AF347015.27	-0.76	-0.87
MT-CYB	-0.76	-0.87
FXYD1	-0.75	-0.88
IFI27	-0.75	-0.88
HLA-F	-0.75	-0.81
AF347015.8	-0.75	-0.88
AIFM3	-0.73	-0.80

Section III. Gene Ontology annotation

Molecular function	GO term	Evidence	Neuro keywords	PubMed ID
GO:0004693	cyclin-dependent protein kinase activity	EXP	neuron (GO term level: 8)	7969176
GO:0004693	cyclin-dependent protein kinase activity	IDA	neuron (GO term level: 8)	11069302
GO:0000166	nucleotide binding	IEA		-
GO:0005515	protein binding	IPI		11069302
GO:0005524	ATP binding	IEA		-
GO:0016740	transferase activity	IEA		-
GO:0008353	RNA polymerase subunit kinase activity	IEA		-
Biological process	GO term	Evidence	Neuro keywords	PubMed ID
GO:0006468	protein amino acid phosphorylation	IEA		-
GO:0007049	cell cycle	IEA		-
GO:0007067	mitosis	IEA		-
GO:0006916	anti-apoptosis	IDA		11069302
GO:0031145	anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process	EXP		11285280
GO:0051301	cell division	IEA		-
GO:0051437	positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle	EXP		10793135
Cellular component	GO term	Evidence	Neuro keywords	PubMed ID
GO:0005829	cytosol	EXP		1717476 \|9001210 \|10395539 \|11285280
GO:0005876	spindle microtubule	IDA		11069302
GO:0005634	nucleus	IDA		16109376
GO:0005654	nucleoplasm	EXP		1384126 \|1717476 \|1828290 \|7799941 \|7969176 \|10395539 \|11598127 \|12791267
GO:0005737	cytoplasm	IDA		18029348
GO:0030496	midbody	IDA		11069302

Section IV. Protein-protein interaction annotation

Interactors	Aliases B	Official full name B	Experimental	Source	PubMed ID
BCL2	Bcl-2	B-cell CLL/lymphoma 2	Affinity Capture-Western	BioGRID	11326318 \|11774038
BIRC5	API4 \| EPR-1	baculoviral IAP repeat-containing 5	-	HPRD	11069302
BRCA1	BRCAI \| BRCC1 \| IRIS \| PSCP \| RNF53	breast cancer 1, early onset	-	HPRD,BioGRID	9244350
C13orf15	KIAA0564 \| MGC87338 \| RGC-32 \| RGC32 \| bA157L14.2	chromosome 13 open reading frame 15	-	HPRD	11687586
CCNA1	-	cyclin A1	-	HPRD,BioGRID	8565853
CCNA1	-	cyclin A1	CCNA1 (CYCA) interacts with CDC2.	BIND	8463339
CCNA2	CCN1 \| CCNA	cyclin A2	-	HPRD	10924145
CCNA2	CCN1 \| CCNA	cyclin A2	CCNA2 (Cyclin A) interacts with CDC2.	BIND	15674323
CCNA2	CCN1 \| CCNA	cyclin A2	The cyclin-dependent kinase CDC2 (cdc2) interacts with cyclin A2 (cyclin A).	BIND	8423786
CCNA2	CCN1 \| CCNA	cyclin A2	Affinity Capture-Western	BioGRID	12853968
CCNB1	CCNB	cyclin B1	The cyclin-dependent kinase CDC2 interacts with cyclin B1.	BIND	9515786
CCNB1	CCNB	cyclin B1	-	HPRD,BioGRID	2570636
CCNB1	CCNB	cyclin B1	CCNB1 (cyclin B1) interacts with CDC2.	BIND	8662825
CCNB1	CCNB	cyclin B1	CDC2 interacts with CCNB1 (cyclin B1) to form a complex.	BIND	8475101
CCNB1	CCNB	cyclin B1	CCNB1 (CYCB) interacts with CDC2.	BIND	8463339
CCNB1	CCNB	cyclin B1	CDC2 (CDK1) interacts with CCNB1 (cyclin B1). This interaction was modeled on a demonstrated interaction between monkey CDC2 and human CCNB1.	BIND	8070405
CCNB1	CCNB	cyclin B1	Cyclin B1 interacts with Cdk1.	BIND	15989971
CCNB2	HsT17299	cyclin B2	-	HPRD	9926943
CCNB2	HsT17299	cyclin B2	The cyclin-dependent kinase CDC2 (p34cdc2) interacts with cyclin B2.	BIND	7737117
CCNB2	HsT17299	cyclin B2	CDC2 (CDK1) interacts with CCNB2 (cyclin B2). This interaction was modeled on a demonstrated interaction between monkey CDC2 and human CCNB2.	BIND	8070405
CCNE1	CCNE	cyclin E1	-	HPRD,BioGRID	1388288
CDC25C	CDC25	cell division cycle 25 homolog C (S. pombe)	-	HPRD	11836499
CDKN1A	CAP20 \| CDKN1 \| CIP1 \| MDA-6 \| P21 \| SDI1 \| WAF1 \| p21CIP1	cyclin-dependent kinase inhibitor 1A (p21, Cip1)	p21 interacts with CDC2. This interaction was modeled on a demonstrated interaction between human p21 and hamster CDC2.	BIND	9467962
CDKN3	CDI1 \| CIP2 \| FLJ25787 \| KAP \| KAP1 \| MGC70625	cyclin-dependent kinase inhibitor 3	-	HPRD,BioGRID	8127873
CHAF1B	CAF-1 \| CAF-IP60 \| CAF1 \| CAF1A \| CAF1P60 \| MPHOSPH7 \| MPP7	chromatin assembly factor 1, subunit B (p60)	-	HPRD	10938080
CKS2	CKSHS2	CDC28 protein kinase regulatory subunit 2	-	HPRD	2227411
CNOT7	CAF1 \| hCAF-1	CCR4-NOT transcription complex, subunit 7	-	HPRD,BioGRID	10602502
CUX1	CASP \| CDP \| CDP/Cut \| CDP1 \| COY1 \| CUTL1 \| CUX \| Clox \| Cux/CDP \| GOLIM6 \| Nbla10317 \| p100 \| p110 \| p200 \| p75	cut-like homeobox 1	Biochemical Activity	BioGRID	11584018
DAB2	DOC-2 \| DOC2 \| FLJ26626	disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila)	-	HPRD,BioGRID	12881709
DNM2	CMTDI1 \| CMTDIB \| DI-CMTB \| DYN2 \| DYNII	dynamin 2	-	HPRD	7590285
E2F1	E2F-1 \| RBAP1 \| RBBP3 \| RBP3	E2F transcription factor 1	E2F1 interacts with the Cdc2 promoter.	BIND	10766737
E2F3	DKFZp686C18211 \| E2F-3 \| KIAA0075 \| MGC104598	E2F transcription factor 3	E2F3 interacts with the Cdc2 promoter.	BIND	10766737
E2F4	E2F-4	E2F transcription factor 4, p107/p130-binding	E2F4 interacts with the Cdc2 promoter.	BIND	10766737
E2F4	E2F-4	E2F transcription factor 4, p107/p130-binding	E2F4 interacts with CDC2 promoter.	BIND	15782160
E2F4	E2F-4	E2F transcription factor 4, p107/p130-binding	E2F4 interacts with the CDC2 promoter.	BIND	15525513
EEF1D	EF-1D \| EF1D \| FLJ20897 \| FP1047	eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein)	-	HPRD	8051108
ERCC2	COFS2 \| EM9 \| MGC102762 \| MGC126218 \| MGC126219 \| TTD \| XPD	excision repair cross-complementing rodent repair deficiency, complementation group 2	-	HPRD	8652557
ESPL1	ESP1 \| FLJ46492 \| KIAA0165 \| SEPARASE \| SEPARIN	extra spindle pole bodies homolog 1 (S. cerevisiae)	Separase interacts with Cdk1.	BIND	15989971
FANCA	FA \| FA-H \| FA1 \| FAA \| FACA \| FAH \| FANCH \| MGC75158	Fanconi anemia, complementation group A	Affinity Capture-MS	BioGRID	15082718
FANCC	FA3 \| FAC \| FACC \| FLJ14675	Fanconi anemia, complementation group C	-	HPRD,BioGRID	9242535
FANCG	FAG \| XRCC9	Fanconi anemia, complementation group G	Reconstituted Complex	BioGRID	15367677
FEN1	FEN-1 \| MF1 \| RAD2	flap structure-specific endonuclease 1	Reconstituted Complex	BioGRID	12853968
FYN	MGC45350 \| SLK \| SYN	FYN oncogene related to SRC, FGR, YES	-	HPRD,BioGRID	8910336
GADD45A	DDIT1 \| GADD45	growth arrest and DNA-damage-inducible, alpha	Cdk1 interacts with Gadd45a. This interaction was modeled on a demonstrated interaction between human Cdk1 and Gadd45a from an unspecified species.	BIND	12124778
GADD45A	DDIT1 \| GADD45	growth arrest and DNA-damage-inducible, alpha	-	HPRD,BioGRID	10973963
GADD45B	DKFZp566B133 \| GADD45BETA \| MYD118	growth arrest and DNA-damage-inducible, beta	-	HPRD	10973963
GADD45B	DKFZp566B133 \| GADD45BETA \| MYD118	growth arrest and DNA-damage-inducible, beta	Cdk1 interacts with Gadd45b. This interaction was modeled on a demonstrated interaction between human Cdk1 and Gadd45b from an unspecified species.	BIND	12124778
GADD45G	CR6 \| DDIT2 \| GADD45gamma \| GRP17	growth arrest and DNA-damage-inducible, gamma	Cdk1 interacts with Gadd45g. This interaction was modeled on a demonstrated interaction between human Cdk1 and Gadd45g from an unspecified species.	BIND	12124778
GADD45G	CR6 \| DDIT2 \| GADD45gamma \| GRP17	growth arrest and DNA-damage-inducible, gamma	-	HPRD	10973963
GORASP1	FLJ23443 \| GOLPH5 \| GRASP65 \| MGC118894 \| MGC118897 \| P65	golgi reassembly stacking protein 1, 65kDa	-	HPRD	12839990
HSPA2	HSP70-2 \| HSP70-3	heat shock 70kDa protein 2	-	HPRD	9247342
LATS1	WARTS \| wts	LATS, large tumor suppressor, homolog 1 (Drosophila)	-	HPRD,BioGRID	9988268
LMNB1	ADLD \| LMN \| LMN2 \| LMNB \| MGC111419	lamin B1	-	HPRD	11901153
LYN	FLJ26625 \| JTK8	v-yes-1 Yamaguchi sarcoma viral related oncogene homolog	-	HPRD,BioGRID	8051175 \|8910336
LZTS1	F37 \| FEZ1	leucine zipper, putative tumor suppressor 1	-	HPRD,BioGRID	11504921
MDM4	DKFZp781B1423 \| HDMX \| MDMX \| MGC132766 \| MRP1	Mdm4 p53 binding protein homolog (mouse)	CDC2 interacts with MDM4 (MDMX). This interaction was modeled on a demonstrated interaction between human CDC2, and MDM4 from an unspecified species.	BIND	15735705
MKI67	KIA \| Ki-67	antigen identified by monoclonal antibody Ki-67	Biochemical Activity	BioGRID	10502411
NRF1	ALPHA-PAL	nuclear respiratory factor 1	NRF1 interacts with the CDC2 promoter.	BIND	15525513
NSFL1C	MGC3347 \| UBX1 \| UBXD10 \| UBXN2C \| dJ776F14.1 \| p47	NSFL1 (p97) cofactor (p47)	Biochemical Activity	BioGRID	12810701
PCNA	MGC8367	proliferating cell nuclear antigen	-	HPRD	7949095
PIN1	DOD \| UBL5	peptidylprolyl cis/trans isomerase, NIMA-interacting 1	-	HPRD	11774038
PITPNM1	DRES9 \| FLJ44997 \| NIR2 \| PITPNM \| RDGB \| RDGB1 \| RDGBA \| RDGBA1 \| Rd9	phosphatidylinositol transfer protein, membrane-associated 1	Nir2 is phosphorylated by Cdk1.	BIND	15125835
PKMYT1	DKFZp547K1610 \| FLJ20093 \| MYT1	protein kinase, membrane associated tyrosine/threonine 1	-	HPRD	10504341
PKMYT1	DKFZp547K1610 \| FLJ20093 \| MYT1	protein kinase, membrane associated tyrosine/threonine 1	Myt1 interacts with and phosphorylates Cdc2. This interaction was modelled on a demonstrated interaction between human Myt1 and Cdc2 from an unspecified species.	BIND	10504341
PRKCB	MGC41878 \| PKC-beta \| PKCB \| PRKCB1 \| PRKCB2	protein kinase C, beta	Affinity Capture-Western	BioGRID	11901153
PTMA	MGC104802 \| TMSA	prothymosin, alpha	-	HPRD	11310559
RPA2	REPA2 \| RPA32	replication protein A2, 32kDa	-	HPRD	1318195
SFN	YWHAS	stratifin	-	HPRD,BioGRID	10524633
SPAG5	DEEPEST \| MAP126 \| hMAP126	sperm associated antigen 5	-	HPRD,BioGRID	11549262
TLE1	ESG \| ESG1 \| GRG1	transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)	-	HPRD	12397081
TP53	FLJ92943 \| LFS1 \| TRP53 \| p53	tumor protein p53	-	HPRD,BioGRID	11327730
TSC1	KIAA0243 \| LAM \| MGC86987 \| TSC	tuberous sclerosis 1	Reconstituted Complex	BioGRID	14551205
TSC1	KIAA0243 \| LAM \| MGC86987 \| TSC	tuberous sclerosis 1	-	HPRD	11444800
USP16	UBP-M	ubiquitin specific peptidase 16	-	HPRD	10077596
WEE1	DKFZp686I18166 \| FLJ16446 \| WEE1A \| WEE1hu	WEE1 homolog (S. pombe)	WEE1 phosphorylates CDC2.	BIND	15735702
ZBTB16	PLZF \| ZNF145	zinc finger and BTB domain containing 16	-	HPRD,BioGRID	10497277

Section V. Pathway annotation

Pathway name	Pathway size	# SZGR 2.0 genes in pathway	Info
KEGG CELL CYCLE	128	84	All SZGR 2.0 genes in this pathway
KEGG OOCYTE MEIOSIS	114	79	All SZGR 2.0 genes in this pathway
KEGG P53 SIGNALING PATHWAY	69	45	All SZGR 2.0 genes in this pathway
KEGG GAP JUNCTION	90	68	All SZGR 2.0 genes in this pathway
KEGG PROGESTERONE MEDIATED OOCYTE MATURATION	86	59	All SZGR 2.0 genes in this pathway
BIOCARTA SRCRPTP PATHWAY	11	9	All SZGR 2.0 genes in this pathway
BIOCARTA AKAP95 PATHWAY	12	9	All SZGR 2.0 genes in this pathway
BIOCARTA G1 PATHWAY	28	21	All SZGR 2.0 genes in this pathway
BIOCARTA G2 PATHWAY	24	20	All SZGR 2.0 genes in this pathway
BIOCARTA CELLCYCLE PATHWAY	23	15	All SZGR 2.0 genes in this pathway
BIOCARTA MPR PATHWAY	34	28	All SZGR 2.0 genes in this pathway
BIOCARTA AKAPCENTROSOME PATHWAY	15	14	All SZGR 2.0 genes in this pathway
BIOCARTA RB PATHWAY	13	11	All SZGR 2.0 genes in this pathway
BIOCARTA PTC1 PATHWAY	11	6	All SZGR 2.0 genes in this pathway
BIOCARTA STATHMIN PATHWAY	19	17	All SZGR 2.0 genes in this pathway
SA G2 AND M PHASES	8	7	All SZGR 2.0 genes in this pathway
PID P73PATHWAY	79	59	All SZGR 2.0 genes in this pathway
PID E2F PATHWAY	74	48	All SZGR 2.0 genes in this pathway
PID PLK1 PATHWAY	46	25	All SZGR 2.0 genes in this pathway
PID AP1 PATHWAY	70	60	All SZGR 2.0 genes in this pathway
PID FOXM1 PATHWAY	40	30	All SZGR 2.0 genes in this pathway
PID RETINOIC ACID PATHWAY	30	23	All SZGR 2.0 genes in this pathway
REACTOME SIGNALLING BY NGF	217	167	All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY SCF KIT	78	59	All SZGR 2.0 genes in this pathway
REACTOME DEVELOPMENTAL BIOLOGY	396	292	All SZGR 2.0 genes in this pathway
REACTOME TRIF MEDIATED TLR3 SIGNALING	74	54	All SZGR 2.0 genes in this pathway
REACTOME G0 AND EARLY G1	25	13	All SZGR 2.0 genes in this pathway
REACTOME CELL CYCLE	421	253	All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY ERBB4	90	67	All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY ERBB2	101	78	All SZGR 2.0 genes in this pathway
REACTOME GRB2 EVENTS IN ERBB2 SIGNALING	22	20	All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY EGFR IN CANCER	109	80	All SZGR 2.0 genes in this pathway
REACTOME SHC1 EVENTS IN ERBB4 SIGNALING	20	17	All SZGR 2.0 genes in this pathway
REACTOME INSULIN RECEPTOR SIGNALLING CASCADE	87	64	All SZGR 2.0 genes in this pathway
REACTOME ARMS MEDIATED ACTIVATION	17	17	All SZGR 2.0 genes in this pathway
REACTOME PROLONGED ERK ACTIVATION EVENTS	19	18	All SZGR 2.0 genes in this pathway
REACTOME SIGNALLING TO RAS	27	23	All SZGR 2.0 genes in this pathway
REACTOME NGF SIGNALLING VIA TRKA FROM THE PLASMA MEMBRANE	137	105	All SZGR 2.0 genes in this pathway
REACTOME SIGNALLING TO ERKS	36	30	All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY FGFR IN DISEASE	127	88	All SZGR 2.0 genes in this pathway
REACTOME SIGNALLING TO P38 VIA RIT AND RIN	15	14	All SZGR 2.0 genes in this pathway
REACTOME GASTRIN CREB SIGNALLING PATHWAY VIA PKC AND MAPK	205	136	All SZGR 2.0 genes in this pathway
REACTOME SHC1 EVENTS IN EGFR SIGNALING	15	13	All SZGR 2.0 genes in this pathway
REACTOME E2F ENABLED INHIBITION OF PRE REPLICATION COMPLEX FORMATION	10	5	All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY GPCR	920	449	All SZGR 2.0 genes in this pathway
REACTOME CELL CYCLE MITOTIC	325	185	All SZGR 2.0 genes in this pathway
REACTOME RECRUITMENT OF MITOTIC CENTROSOME PROTEINS AND COMPLEXES	66	43	All SZGR 2.0 genes in this pathway
REACTOME LOSS OF NLP FROM MITOTIC CENTROSOMES	59	38	All SZGR 2.0 genes in this pathway
REACTOME CELL CYCLE CHECKPOINTS	124	70	All SZGR 2.0 genes in this pathway
REACTOME RECRUITMENT OF NUMA TO MITOTIC CENTROSOMES	10	8	All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY PDGF	122	93	All SZGR 2.0 genes in this pathway
REACTOME DOWNSTREAM SIGNAL TRANSDUCTION	95	76	All SZGR 2.0 genes in this pathway
REACTOME G1 S TRANSITION	112	63	All SZGR 2.0 genes in this pathway
REACTOME AXON GUIDANCE	251	188	All SZGR 2.0 genes in this pathway
REACTOME NCAM SIGNALING FOR NEURITE OUT GROWTH	64	49	All SZGR 2.0 genes in this pathway
REACTOME CYCLIN A B1 ASSOCIATED EVENTS DURING G2 M TRANSITION	15	8	All SZGR 2.0 genes in this pathway
REACTOME FRS2 MEDIATED CASCADE	36	27	All SZGR 2.0 genes in this pathway
REACTOME MITOTIC G1 G1 S PHASES	137	79	All SZGR 2.0 genes in this pathway
REACTOME DOWNSTREAM SIGNALING OF ACTIVATED FGFR	100	74	All SZGR 2.0 genes in this pathway
REACTOME REGULATION OF MITOTIC CELL CYCLE	85	46	All SZGR 2.0 genes in this pathway
REACTOME MAP KINASE ACTIVATION IN TLR CASCADE	50	37	All SZGR 2.0 genes in this pathway
REACTOME MITOTIC G2 G2 M PHASES	81	50	All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY ILS	107	86	All SZGR 2.0 genes in this pathway
REACTOME TRAF6 MEDIATED INDUCTION OF NFKB AND MAP KINASES UPON TLR7 8 OR 9 ACTIVATION	77	57	All SZGR 2.0 genes in this pathway
REACTOME NFKB AND MAP KINASES ACTIVATION MEDIATED BY TLR4 SIGNALING REPERTOIRE	72	53	All SZGR 2.0 genes in this pathway
REACTOME IL 2 SIGNALING	41	34	All SZGR 2.0 genes in this pathway
REACTOME E2F MEDIATED REGULATION OF DNA REPLICATION	35	17	All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY INSULIN RECEPTOR	108	72	All SZGR 2.0 genes in this pathway
REACTOME SOS MEDIATED SIGNALLING	14	13	All SZGR 2.0 genes in this pathway
REACTOME RAF MAP KINASE CASCADE	10	10	All SZGR 2.0 genes in this pathway
REACTOME SHC MEDIATED SIGNALLING	15	12	All SZGR 2.0 genes in this pathway
REACTOME APC C CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS	73	40	All SZGR 2.0 genes in this pathway
REACTOME MYD88 MAL CASCADE INITIATED ON PLASMA MEMBRANE	83	63	All SZGR 2.0 genes in this pathway
REACTOME INNATE IMMUNE SYSTEM	279	178	All SZGR 2.0 genes in this pathway
REACTOME APC C CDC20 MEDIATED DEGRADATION OF CYCLIN B	26	10	All SZGR 2.0 genes in this pathway
REACTOME G1 S SPECIFIC TRANSCRIPTION	19	9	All SZGR 2.0 genes in this pathway
REACTOME ACTIVATED TLR4 SIGNALLING	93	69	All SZGR 2.0 genes in this pathway
REACTOME IMMUNE SYSTEM	933	616	All SZGR 2.0 genes in this pathway
REACTOME PHOSPHORYLATION OF THE APC C	23	10	All SZGR 2.0 genes in this pathway
REACTOME TOLL RECEPTOR CASCADES	118	84	All SZGR 2.0 genes in this pathway
REACTOME CYTOKINE SIGNALING IN IMMUNE SYSTEM	270	204	All SZGR 2.0 genes in this pathway
REACTOME G2 M CHECKPOINTS	45	23	All SZGR 2.0 genes in this pathway
REACTOME G2 M DNA DAMAGE CHECKPOINT	12	8	All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY FGFR	112	80	All SZGR 2.0 genes in this pathway
REACTOME SHC RELATED EVENTS	17	13	All SZGR 2.0 genes in this pathway
WEST ADRENOCORTICAL TUMOR MARKERS UP	21	13	All SZGR 2.0 genes in this pathway
NAKAMURA TUMOR ZONE PERIPHERAL VS CENTRAL UP	285	181	All SZGR 2.0 genes in this pathway
ONKEN UVEAL MELANOMA UP	783	507	All SZGR 2.0 genes in this pathway
SENGUPTA NASOPHARYNGEAL CARCINOMA UP	294	178	All SZGR 2.0 genes in this pathway
SOTIRIOU BREAST CANCER GRADE 1 VS 3 UP	151	84	All SZGR 2.0 genes in this pathway
ZERBINI RESPONSE TO SULINDAC DN	6	5	All SZGR 2.0 genes in this pathway
WILCOX RESPONSE TO PROGESTERONE UP	152	90	All SZGR 2.0 genes in this pathway
PUIFFE INVASION INHIBITED BY ASCITES DN	145	91	All SZGR 2.0 genes in this pathway
CASORELLI ACUTE PROMYELOCYTIC LEUKEMIA DN	663	425	All SZGR 2.0 genes in this pathway
DOANE RESPONSE TO ANDROGEN DN	241	146	All SZGR 2.0 genes in this pathway
HORIUCHI WTAP TARGETS DN	310	188	All SZGR 2.0 genes in this pathway
GAL LEUKEMIC STEM CELL DN	244	153	All SZGR 2.0 genes in this pathway
BASAKI YBX1 TARGETS UP	290	177	All SZGR 2.0 genes in this pathway
VECCHI GASTRIC CANCER EARLY UP	430	232	All SZGR 2.0 genes in this pathway
RHEIN ALL GLUCOCORTICOID THERAPY DN	362	238	All SZGR 2.0 genes in this pathway
DITTMER PTHLH TARGETS UP	112	68	All SZGR 2.0 genes in this pathway
ODONNELL TFRC TARGETS DN	139	76	All SZGR 2.0 genes in this pathway
ODONNELL TARGETS OF MYC AND TFRC DN	45	25	All SZGR 2.0 genes in this pathway
KINSEY TARGETS OF EWSR1 FLII FUSION UP	1278	748	All SZGR 2.0 genes in this pathway
SCIBETTA KDM5B TARGETS DN	81	55	All SZGR 2.0 genes in this pathway
KIM WT1 TARGETS DN	459	276	All SZGR 2.0 genes in this pathway
GRAHAM CML QUIESCENT VS CML DIVIDING DN	11	8	All SZGR 2.0 genes in this pathway
GRAHAM CML QUIESCENT VS NORMAL QUIESCENT UP	87	45	All SZGR 2.0 genes in this pathway
GRAHAM CML DIVIDING VS NORMAL QUIESCENT UP	181	101	All SZGR 2.0 genes in this pathway
GRAHAM NORMAL QUIESCENT VS NORMAL DIVIDING DN	87	49	All SZGR 2.0 genes in this pathway
BIDUS METASTASIS UP	214	134	All SZGR 2.0 genes in this pathway
MAYBURD RESPONSE TO L663536 DN	56	32	All SZGR 2.0 genes in this pathway
DODD NASOPHARYNGEAL CARCINOMA DN	1375	806	All SZGR 2.0 genes in this pathway
RODRIGUES THYROID CARCINOMA POORLY DIFFERENTIATED UP	633	376	All SZGR 2.0 genes in this pathway
RODRIGUES THYROID CARCINOMA ANAPLASTIC UP	722	443	All SZGR 2.0 genes in this pathway
PROVENZANI METASTASIS UP	194	112	All SZGR 2.0 genes in this pathway
KOKKINAKIS METHIONINE DEPRIVATION 48HR UP	128	95	All SZGR 2.0 genes in this pathway
KOKKINAKIS METHIONINE DEPRIVATION 96HR DN	75	50	All SZGR 2.0 genes in this pathway
LINDGREN BLADDER CANCER CLUSTER 1 DN	378	231	All SZGR 2.0 genes in this pathway
LINDGREN BLADDER CANCER CLUSTER 3 UP	329	196	All SZGR 2.0 genes in this pathway
MARKEY RB1 ACUTE LOF DN	228	137	All SZGR 2.0 genes in this pathway
CONCANNON APOPTOSIS BY EPOXOMICIN DN	172	112	All SZGR 2.0 genes in this pathway
LANDIS ERBB2 BREAST TUMORS 324 UP	150	93	All SZGR 2.0 genes in this pathway
BERENJENO TRANSFORMED BY RHOA UP	536	340	All SZGR 2.0 genes in this pathway
MISSIAGLIA REGULATED BY METHYLATION DN	122	67	All SZGR 2.0 genes in this pathway
TANG SENESCENCE TP53 TARGETS DN	57	33	All SZGR 2.0 genes in this pathway
JOHANSSON GLIOMAGENESIS BY PDGFB UP	58	44	All SZGR 2.0 genes in this pathway
MCBRYAN PUBERTAL BREAST 3 4WK UP	214	144	All SZGR 2.0 genes in this pathway
MCBRYAN PUBERTAL BREAST 6 7WK DN	79	54	All SZGR 2.0 genes in this pathway
MCBRYAN TERMINAL END BUD UP	12	12	All SZGR 2.0 genes in this pathway
OLSSON E2F3 TARGETS DN	49	33	All SZGR 2.0 genes in this pathway
SEIDEN ONCOGENESIS BY MET	88	53	All SZGR 2.0 genes in this pathway
ROSTY CERVICAL CANCER PROLIFERATION CLUSTER	140	73	All SZGR 2.0 genes in this pathway
HERNANDEZ MITOTIC ARREST BY DOCETAXEL 1 DN	38	23	All SZGR 2.0 genes in this pathway
PATIL LIVER CANCER	747	453	All SZGR 2.0 genes in this pathway
LI WILMS TUMOR ANAPLASTIC UP	19	12	All SZGR 2.0 genes in this pathway
BORLAK LIVER CANCER EGF UP	57	41	All SZGR 2.0 genes in this pathway
OXFORD RALA OR RALB TARGETS UP	48	23	All SZGR 2.0 genes in this pathway
MOHANKUMAR TLX1 TARGETS UP	414	287	All SZGR 2.0 genes in this pathway
LI WILMS TUMOR VS FETAL KIDNEY 2 UP	30	24	All SZGR 2.0 genes in this pathway
TSAI RESPONSE TO IONIZING RADIATION	149	101	All SZGR 2.0 genes in this pathway
PUJANA BREAST CANCER LIT INT NETWORK	101	73	All SZGR 2.0 genes in this pathway
PUJANA XPRSS INT NETWORK	168	103	All SZGR 2.0 genes in this pathway
PUJANA BRCA1 PCC NETWORK	1652	1023	All SZGR 2.0 genes in this pathway
PUJANA BRCA2 PCC NETWORK	423	265	All SZGR 2.0 genes in this pathway
PUJANA ATM PCC NETWORK	1442	892	All SZGR 2.0 genes in this pathway
PUJANA CHEK2 PCC NETWORK	779	480	All SZGR 2.0 genes in this pathway
PUJANA BRCA CENTERED NETWORK	117	72	All SZGR 2.0 genes in this pathway
NUYTTEN EZH2 TARGETS DN	1024	594	All SZGR 2.0 genes in this pathway
BUYTAERT PHOTODYNAMIC THERAPY STRESS DN	637	377	All SZGR 2.0 genes in this pathway
LOPEZ MBD TARGETS	957	597	All SZGR 2.0 genes in this pathway
WEI MYCN TARGETS WITH E BOX	795	478	All SZGR 2.0 genes in this pathway
CAFFAREL RESPONSE TO THC DN	31	23	All SZGR 2.0 genes in this pathway
CAFFAREL RESPONSE TO THC 24HR 5 DN	59	35	All SZGR 2.0 genes in this pathway
BENPORATH ES 1	379	235	All SZGR 2.0 genes in this pathway
BENPORATH NANOG TARGETS	988	594	All SZGR 2.0 genes in this pathway
BENPORATH SOX2 TARGETS	734	436	All SZGR 2.0 genes in this pathway
BENPORATH PROLIFERATION	147	80	All SZGR 2.0 genes in this pathway
MORI PRE BI LYMPHOCYTE UP	80	54	All SZGR 2.0 genes in this pathway
MORI LARGE PRE BII LYMPHOCYTE UP	86	49	All SZGR 2.0 genes in this pathway
MORI IMMATURE B LYMPHOCYTE DN	90	55	All SZGR 2.0 genes in this pathway
MORI EMU MYC LYMPHOMA BY ONSET TIME UP	110	69	All SZGR 2.0 genes in this pathway
BASSO B LYMPHOCYTE NETWORK	143	96	All SZGR 2.0 genes in this pathway
SHEPARD BMYB MORPHOLINO DN	200	112	All SZGR 2.0 genes in this pathway
LEE LIVER CANCER MYC UP	54	30	All SZGR 2.0 genes in this pathway
SHEPARD BMYB TARGETS	74	41	All SZGR 2.0 genes in this pathway
SHEPARD CRUSH AND BURN MUTANT DN	185	111	All SZGR 2.0 genes in this pathway
MANALO HYPOXIA DN	289	166	All SZGR 2.0 genes in this pathway
TENEDINI MEGAKARYOCYTE MARKERS	66	48	All SZGR 2.0 genes in this pathway
TARTE PLASMA CELL VS PLASMABLAST DN	309	206	All SZGR 2.0 genes in this pathway
LEE LIVER CANCER MYC E2F1 UP	56	34	All SZGR 2.0 genes in this pathway
LE EGR2 TARGETS UP	108	75	All SZGR 2.0 genes in this pathway
PENG GLUCOSE DEPRIVATION DN	169	112	All SZGR 2.0 genes in this pathway
REN BOUND BY E2F	61	40	All SZGR 2.0 genes in this pathway
MAGRANGEAS MULTIPLE MYELOMA IGLL VS IGLK UP	42	24	All SZGR 2.0 genes in this pathway
BHATTACHARYA EMBRYONIC STEM CELL	89	60	All SZGR 2.0 genes in this pathway
YU MYC TARGETS UP	42	26	All SZGR 2.0 genes in this pathway
MOREAUX B LYMPHOCYTE MATURATION BY TACI DN	73	45	All SZGR 2.0 genes in this pathway
LI WILMS TUMOR VS FETAL KIDNEY 1 DN	163	115	All SZGR 2.0 genes in this pathway
ZHAN MULTIPLE MYELOMA PR UP	45	20	All SZGR 2.0 genes in this pathway
PETROVA ENDOTHELIUM LYMPHATIC VS BLOOD UP	131	87	All SZGR 2.0 genes in this pathway
MOREAUX MULTIPLE MYELOMA BY TACI DN	172	107	All SZGR 2.0 genes in this pathway
PETROVA PROX1 TARGETS UP	28	16	All SZGR 2.0 genes in this pathway
RHODES CANCER META SIGNATURE	64	47	All SZGR 2.0 genes in this pathway
SU TESTIS	76	53	All SZGR 2.0 genes in this pathway
KANG DOXORUBICIN RESISTANCE UP	54	33	All SZGR 2.0 genes in this pathway
RHODES UNDIFFERENTIATED CANCER	69	44	All SZGR 2.0 genes in this pathway
BURTON ADIPOGENESIS 3	101	64	All SZGR 2.0 genes in this pathway
MA PITUITARY FETAL VS ADULT UP	29	21	All SZGR 2.0 genes in this pathway
BURTON ADIPOGENESIS PEAK AT 24HR	43	30	All SZGR 2.0 genes in this pathway
WELCSH BRCA1 TARGETS UP	198	132	All SZGR 2.0 genes in this pathway
SONG TARGETS OF IE86 CMV PROTEIN	60	42	All SZGR 2.0 genes in this pathway
CUI TCF21 TARGETS 2 UP	428	266	All SZGR 2.0 genes in this pathway
SARTIPY BLUNTED BY INSULIN RESISTANCE DN	18	14	All SZGR 2.0 genes in this pathway
BRACHAT RESPONSE TO CAMPTOTHECIN DN	46	31	All SZGR 2.0 genes in this pathway
DAZARD RESPONSE TO UV SCC UP	123	75	All SZGR 2.0 genes in this pathway
WANG CISPLATIN RESPONSE AND XPC UP	202	115	All SZGR 2.0 genes in this pathway
YIH RESPONSE TO ARSENITE C3	36	24	All SZGR 2.0 genes in this pathway
MARTINEZ RESPONSE TO TRABECTEDIN DN	271	175	All SZGR 2.0 genes in this pathway
GAVIN FOXP3 TARGETS CLUSTER P6	91	44	All SZGR 2.0 genes in this pathway
MARSON BOUND BY E2F4 UNSTIMULATED	728	415	All SZGR 2.0 genes in this pathway
AMUNDSON GAMMA RADIATION RESPONSE	40	25	All SZGR 2.0 genes in this pathway
FINETTI BREAST CANCER KINOME RED	16	11	All SZGR 2.0 genes in this pathway
SARRIO EPITHELIAL MESENCHYMAL TRANSITION UP	180	114	All SZGR 2.0 genes in this pathway
DE YY1 TARGETS DN	92	64	All SZGR 2.0 genes in this pathway
SMID BREAST CANCER BASAL UP	648	398	All SZGR 2.0 genes in this pathway
WHITEFORD PEDIATRIC CANCER MARKERS	116	63	All SZGR 2.0 genes in this pathway
GRADE COLON AND RECTAL CANCER UP	285	167	All SZGR 2.0 genes in this pathway
BOQUEST STEM CELL DN	216	143	All SZGR 2.0 genes in this pathway
BOQUEST STEM CELL CULTURED VS FRESH UP	425	298	All SZGR 2.0 genes in this pathway
LABBE WNT3A TARGETS UP	112	71	All SZGR 2.0 genes in this pathway
WEST ADRENOCORTICAL TUMOR UP	294	199	All SZGR 2.0 genes in this pathway
CUI GLUCOSE DEPRIVATION	60	44	All SZGR 2.0 genes in this pathway
BLUM RESPONSE TO SALIRASIB DN	342	220	All SZGR 2.0 genes in this pathway
WINTER HYPOXIA METAGENE	242	168	All SZGR 2.0 genes in this pathway
MUELLER PLURINET	299	189	All SZGR 2.0 genes in this pathway
JIANG TIP30 TARGETS UP	46	28	All SZGR 2.0 genes in this pathway
FRASOR RESPONSE TO SERM OR FULVESTRANT DN	50	29	All SZGR 2.0 genes in this pathway
GOLDRATH ANTIGEN RESPONSE	346	192	All SZGR 2.0 genes in this pathway
RUIZ TNC TARGETS DN	142	79	All SZGR 2.0 genes in this pathway
CHANG CYCLING GENES	148	83	All SZGR 2.0 genes in this pathway
HOFFMANN LARGE TO SMALL PRE BII LYMPHOCYTE UP	163	102	All SZGR 2.0 genes in this pathway
LEE EARLY T LYMPHOCYTE UP	107	59	All SZGR 2.0 genes in this pathway
SHEDDEN LUNG CANCER POOR SURVIVAL A6	456	285	All SZGR 2.0 genes in this pathway
MEISSNER BRAIN HCP WITH H3K4ME3 AND H3K27ME3	1069	729	All SZGR 2.0 genes in this pathway
CROONQUIST IL6 DEPRIVATION DN	98	69	All SZGR 2.0 genes in this pathway
CROONQUIST NRAS SIGNALING DN	72	47	All SZGR 2.0 genes in this pathway
CROONQUIST NRAS VS STROMAL STIMULATION DN	99	65	All SZGR 2.0 genes in this pathway
IRITANI MAD1 TARGETS DN	47	30	All SZGR 2.0 genes in this pathway
ISHIDA E2F TARGETS	53	27	All SZGR 2.0 genes in this pathway
POOLA INVASIVE BREAST CANCER UP	288	168	All SZGR 2.0 genes in this pathway
CHIANG LIVER CANCER SUBCLASS PROLIFERATION UP	178	108	All SZGR 2.0 genes in this pathway
CHIANG LIVER CANCER SUBCLASS UNANNOTATED DN	193	112	All SZGR 2.0 genes in this pathway
PUJANA BREAST CANCER WITH BRCA1 MUTATED UP	56	27	All SZGR 2.0 genes in this pathway
KOBAYASHI EGFR SIGNALING 24HR DN	251	151	All SZGR 2.0 genes in this pathway
FOURNIER ACINAR DEVELOPMENT LATE 2	277	172	All SZGR 2.0 genes in this pathway
PYEON CANCER HEAD AND NECK VS CERVICAL UP	193	95	All SZGR 2.0 genes in this pathway
CAIRO HEPATOBLASTOMA CLASSES UP	605	377	All SZGR 2.0 genes in this pathway
WINNEPENNINCKX MELANOMA METASTASIS UP	162	86	All SZGR 2.0 genes in this pathway
KYNG WERNER SYNDROM AND NORMAL AGING UP	93	62	All SZGR 2.0 genes in this pathway
WONG EMBRYONIC STEM CELL CORE	335	193	All SZGR 2.0 genes in this pathway
NAKAYAMA SOFT TISSUE TUMORS PCA2 UP	87	50	All SZGR 2.0 genes in this pathway
YAO TEMPORAL RESPONSE TO PROGESTERONE CLUSTER 15	35	23	All SZGR 2.0 genes in this pathway
WHITFIELD CELL CYCLE LITERATURE	44	25	All SZGR 2.0 genes in this pathway
WU APOPTOSIS BY CDKN1A VIA TP53	55	31	All SZGR 2.0 genes in this pathway
BROWNE HCMV INFECTION 30MIN DN	150	99	All SZGR 2.0 genes in this pathway
WHITFIELD CELL CYCLE G2	182	102	All SZGR 2.0 genes in this pathway
MARTENS TRETINOIN RESPONSE DN	841	431	All SZGR 2.0 genes in this pathway
DUTERTRE ESTRADIOL RESPONSE 24HR UP	324	193	All SZGR 2.0 genes in this pathway
JOHNSTONE PARVB TARGETS 3 DN	918	550	All SZGR 2.0 genes in this pathway
BRUINS UVC RESPONSE LATE	1137	655	All SZGR 2.0 genes in this pathway
MIYAGAWA TARGETS OF EWSR1 ETS FUSIONS UP	259	159	All SZGR 2.0 genes in this pathway
FEVR CTNNB1 TARGETS DN	553	343	All SZGR 2.0 genes in this pathway
GOBERT OLIGODENDROCYTE DIFFERENTIATION UP	570	339	All SZGR 2.0 genes in this pathway
JUBAN TARGETS OF SPI1 AND FLI1 DN	92	60	All SZGR 2.0 genes in this pathway
YANG BCL3 TARGETS UP	364	236	All SZGR 2.0 genes in this pathway
YU BAP1 TARGETS	29	21	All SZGR 2.0 genes in this pathway
BOSCO INTERFERON INDUCED ANTIVIRAL MODULE	78	48	All SZGR 2.0 genes in this pathway
ZHOU CELL CYCLE GENES IN IR RESPONSE 24HR	128	73	All SZGR 2.0 genes in this pathway

Section VI. microRNA annotation

miRNA family	Target position			miRNA ID	miRNA seq
miRNA family	UTR start	UTR end	Match method	miRNA ID	miRNA seq
miR-496	148	154	1A	hsa-miR-496	AUUACAUGGCCAAUCUC

SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.

Gene Page: CDK1