Gene Page: GAB2

Summary ?
GeneID9846
SymbolGAB2
Synonyms-
DescriptionGRB2 associated binding protein 2
ReferenceMIM:606203|HGNC:HGNC:14458|Ensembl:ENSG00000033327|HPRD:05866|Vega:OTTHUMG00000166673
Gene typeprotein-coding
Map location11q14.1
Pascal p-value0.022
Sherlock p-value0.739
Fetal beta0.76
DMG1 (# studies)
eGeneMyers' cis & trans

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
CV:PGCnpGenome-wide Association StudyGWAS
DMG:Wockner_2014Genome-wide DNA methylation analysisThis dataset includes 4641 differentially methylated probes corresponding to 2929 unique genes between schizophrenia patients (n=24) and controls (n=24). 1

Section I. Genetics and epigenetics annotation

@Differentially methylated gene

ProbeChromosomePositionNearest geneP (dis)Beta (dis)FDR (dis)Study
cg247693811178052863GAB22.254E-4-1.4720.036DMG:Wockner_2014

@eQTL annotation

SNP IDChromosomePositioneGeneGene Entrez IDpvalueqvalueTSS distanceeQTL type
rs16971302chr1580032326GAB298460.15trans

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
GenePearson's Correlation Spearman's Correlation
PCNX0.950.97
CRKRS0.950.96
HUWE10.940.94
ANKRD170.940.95
KIF1B0.940.96
KIAA02400.940.96
SON0.940.93
SSH20.930.95
POLR1A0.930.94
HERC10.930.94
Top 10 negatively co-expressed genes
GenePearson's Correlation Spearman's Correlation
AF347015.31-0.72-0.81
FXYD1-0.71-0.79
MT-CO2-0.71-0.80
HIGD1B-0.70-0.81
IFI27-0.70-0.79
S100A16-0.68-0.76
AF347015.21-0.68-0.84
CST3-0.67-0.78
HSD17B14-0.67-0.73
AF347015.27-0.67-0.76

Section IV. Protein-protein interaction annotation

InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
AKT1AKT | MGC99656 | PKB | PKB-ALPHA | PRKBA | RAC | RAC-ALPHAv-akt murine thymoma viral oncogene homolog 1-HPRD,BioGRID11782427 
BCRALL | BCR-ABL1 | BCR1 | CML | D22S11 | D22S662 | FLJ16453 | PHLbreakpoint cluster regionAffinity Capture-WesternBioGRID15143164 
CD247CD3-ZETA | CD3H | CD3Q | CD3Z | T3Z | TCRZCD247 molecule-HPRD,BioGRID11572860 
CRKL-v-crk sarcoma virus CT10 oncogene homolog (avian)-like-HPRD,BioGRID11334882 
E2F1E2F-1 | RBAP1 | RBBP3 | RBP3E2F transcription factor 1The Gab2 promoter region interacts with E2F1.BIND15574337 
E2F2E2F-2E2F transcription factor 2The Gab2 promoter region interacts with E2F2.BIND15574337 
E2F3DKFZp686C18211 | E2F-3 | KIAA0075 | MGC104598E2F transcription factor 3The Gab2 promoter region interacts with E2F3.BIND15574337 
EPORMGC138358erythropoietin receptor-HPRD10455108 
ETV6TEL | TEL/ABLets variant 6Affinity Capture-WesternBioGRID15143164 
GRAPMGC64880GRB2-related adaptor proteinReconstituted ComplexBioGRID10391903 
GRAP2GADS | GRAP-2 | GRB2L | GRBLG | GRID | GRPL | GrbX | Grf40 | Mona | P38GRB2-related adaptor protein 2-HPRD11997510 
GRB2ASH | EGFRBP-GRB2 | Grb3-3 | MST084 | MSTP084growth factor receptor-bound protein 2Affinity Capture-Western
Reconstituted Complex		BioGRID10391903 |11782427 
|15143164 
GRB2ASH | EGFRBP-GRB2 | Grb3-3 | MST084 | MSTP084growth factor receptor-bound protein 2-HPRD10068651 |11882361 
LATLAT1 | pp36linker for activation of T cells-HPRD,BioGRID11572860 
LYNFLJ26625 | JTK8v-yes-1 Yamaguchi sarcoma viral related oncogene homolog-HPRD,BioGRID11971018 
NCK1MGC12668 | NCK | NCKalphaNCK adaptor protein 1Reconstituted ComplexBioGRID10391903 
PIK3R1GRB1 | p85 | p85-ALPHAphosphoinositide-3-kinase, regulatory subunit 1 (alpha)Affinity Capture-Western
Two-hybrid		BioGRID11334882 |11782427 
PIK3R1GRB1 | p85 | p85-ALPHAphosphoinositide-3-kinase, regulatory subunit 1 (alpha)-HPRD10068651 
PLCG1PLC-II | PLC1 | PLC148 | PLCgamma1phospholipase C, gamma 1Reconstituted ComplexBioGRID10391903 
PLCG2-phospholipase C, gamma 2 (phosphatidylinositol-specific)-HPRD,BioGRID12135708 
PTPN11BPTP3 | CFC | MGC14433 | NS1 | PTP-1D | PTP2C | SH-PTP2 | SH-PTP3 | SHP2protein tyrosine phosphatase, non-receptor type 11-HPRD10068651 |11287610 
PTPN11BPTP3 | CFC | MGC14433 | NS1 | PTP-1D | PTP2C | SH-PTP2 | SH-PTP3 | SHP2protein tyrosine phosphatase, non-receptor type 11Affinity Capture-Western
Two-hybrid		BioGRID10391903 |11334882 
|11782427 |12135708 
PTPN6HCP | HCPH | HPTP1C | PTP-1C | SH-PTP1 | SHP-1 | SHP-1L | SHP1protein tyrosine phosphatase, non-receptor type 6-HPRD,BioGRID11895767 
RICSGC-GAP | GRIT | KIAA0712 | MGC1892 | p200RhoGAP | p250GAPRho GTPase-activating proteinGab2 interacts with GC-GAP.BIND12819203 
RICSGC-GAP | GRIT | KIAA0712 | MGC1892 | p200RhoGAP | p250GAPRho GTPase-activating protein-HPRD,BioGRID12819203 
SHC1FLJ26504 | SHC | SHCASHC (Src homology 2 domain containing) transforming protein 1Affinity Capture-WesternBioGRID11782427 |12135708 
SRCASV | SRC1 | c-SRC | p60-Srcv-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)-HPRD,BioGRID10391903 
ZAP70FLJ17670 | FLJ17679 | SRK | STD | TZK | ZAP-70zeta-chain (TCR) associated protein kinase 70kDa-HPRD,BioGRID11572860 


Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
KEGG FC EPSILON RI SIGNALING PATHWAY 7958All SZGR 2.0 genes in this pathway
KEGG FC GAMMA R MEDIATED PHAGOCYTOSIS 9771All SZGR 2.0 genes in this pathway
KEGG CHRONIC MYELOID LEUKEMIA 7359All SZGR 2.0 genes in this pathway
PID FCER1 PATHWAY 6243All SZGR 2.0 genes in this pathway
PID GMCSF PATHWAY 3731All SZGR 2.0 genes in this pathway
PID TCR PATHWAY 6651All SZGR 2.0 genes in this pathway
PID MET PATHWAY 8060All SZGR 2.0 genes in this pathway
PID SHP2 PATHWAY 5846All SZGR 2.0 genes in this pathway
PID IL2 1PATHWAY 5543All SZGR 2.0 genes in this pathway
PID IL2 PI3K PATHWAY 3427All SZGR 2.0 genes in this pathway
PID IL3 PATHWAY 2719All SZGR 2.0 genes in this pathway
PID IL6 7 PATHWAY 4740All SZGR 2.0 genes in this pathway
PID TRKR PATHWAY 6248All SZGR 2.0 genes in this pathway
PID IL2 STAT5 PATHWAY 3023All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY SCF KIT 7859All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY FGFR IN DISEASE 12788All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY FGFR1 MUTANTS 3020All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY FGFR1 FUSION MUTANTS 1912All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY FGFR MUTANTS 4429All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY ILS 10786All SZGR 2.0 genes in this pathway
REACTOME IL 3 5 AND GM CSF SIGNALING 4334All SZGR 2.0 genes in this pathway
REACTOME IL RECEPTOR SHC SIGNALING 2721All SZGR 2.0 genes in this pathway
REACTOME IL 2 SIGNALING 4134All SZGR 2.0 genes in this pathway
REACTOME IMMUNE SYSTEM 933616All SZGR 2.0 genes in this pathway
REACTOME CYTOKINE SIGNALING IN IMMUNE SYSTEM 270204All SZGR 2.0 genes in this pathway
HOLLMANN APOPTOSIS VIA CD40 DN 267178All SZGR 2.0 genes in this pathway
ZHONG RESPONSE TO AZACITIDINE AND TSA UP 183119All SZGR 2.0 genes in this pathway
FULCHER INFLAMMATORY RESPONSE LECTIN VS LPS DN 463290All SZGR 2.0 genes in this pathway
SMIRNOV CIRCULATING ENDOTHELIOCYTES IN CANCER UP 158103All SZGR 2.0 genes in this pathway
TIEN INTESTINE PROBIOTICS 2HR DN 8853All SZGR 2.0 genes in this pathway
TIEN INTESTINE PROBIOTICS 6HR DN 167100All SZGR 2.0 genes in this pathway
KINSEY TARGETS OF EWSR1 FLII FUSION DN 329219All SZGR 2.0 genes in this pathway
ENK UV RESPONSE EPIDERMIS DN 508354All SZGR 2.0 genes in this pathway
KIM MYC AMPLIFICATION TARGETS DN 9751All SZGR 2.0 genes in this pathway
GEORGES TARGETS OF MIR192 AND MIR215 893528All SZGR 2.0 genes in this pathway
NIKOLSKY BREAST CANCER 11Q12 Q14 AMPLICON 15893All SZGR 2.0 genes in this pathway
BYSTRYKH HEMATOPOIESIS STEM CELL QTL TRANS 882572All SZGR 2.0 genes in this pathway
CUI TCF21 TARGETS 2 DN 830547All SZGR 2.0 genes in this pathway
BLALOCK ALZHEIMERS DISEASE UP 16911088All SZGR 2.0 genes in this pathway
LU AGING BRAIN UP 262186All SZGR 2.0 genes in this pathway
BAELDE DIABETIC NEPHROPATHY DN 434302All SZGR 2.0 genes in this pathway
PODAR RESPONSE TO ADAPHOSTIN UP 14798All SZGR 2.0 genes in this pathway
ZHANG TLX TARGETS 36HR UP 221150All SZGR 2.0 genes in this pathway
MILI PSEUDOPODIA 4327All SZGR 2.0 genes in this pathway
MILI PSEUDOPODIA CHEMOTAXIS UP 7445All SZGR 2.0 genes in this pathway
MILI PSEUDOPODIA HAPTOTAXIS UP 518299All SZGR 2.0 genes in this pathway
POOLA INVASIVE BREAST CANCER UP 288168All SZGR 2.0 genes in this pathway
HOFFMAN CLOCK TARGETS DN 106All SZGR 2.0 genes in this pathway
KIM ALL DISORDERS OLIGODENDROCYTE NUMBER CORR UP 756494All SZGR 2.0 genes in this pathway
DUTERTRE ESTRADIOL RESPONSE 6HR UP 229149All SZGR 2.0 genes in this pathway
PILON KLF1 TARGETS DN 19721213All SZGR 2.0 genes in this pathway
BHAT ESR1 TARGETS NOT VIA AKT1 UP 211131All SZGR 2.0 genes in this pathway
BHAT ESR1 TARGETS VIA AKT1 UP 281183All SZGR 2.0 genes in this pathway
WAKABAYASHI ADIPOGENESIS PPARG RXRA BOUND 8D 882506All SZGR 2.0 genes in this pathway
KRIEG HYPOXIA NOT VIA KDM3A 770480All SZGR 2.0 genes in this pathway