| VIS ID | Virus | Ensembl ID | Gene Type | Target Gene | Oncogene | Tumor Suppressor Gene | NCBI ID | Uniprot ID |
|---|---|---|---|---|---|---|---|---|
| TVIS10016573 | HBV | ENSG00000102468.11 | protein_coding | HTR2A | No | No | 3356 | P28223 |
| TVIS44041305 | HTLV-1 | ENSG00000102468.11 | protein_coding | HTR2A | No | No | 3356 | P28223 |
Target Gene Table
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TCGA Plot Options
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Drug Information
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| Gene | HTR2A |
|---|---|
| DrugBank ID | DB01186 |
| Drug Name | Pergolide |
| Target ID | BE0000451 |
| UniProt ID | P28223 |
| Regulation Type | agonist |
| PubMed IDs | 18703043; 18691132; 10641988; 18096760 |
| Citations | Cussac D, Boutet-Robinet E, Ailhaud MC, Newman-Tancredi A, Martel JC, Danty N, Rauly-Lestienne I: Agonist-directed trafficking of signalling at serotonin 5-HT2A, 5-HT2B and 5-HT2C-VSV receptors mediated Gq/11 activation and calcium mobilisation in CHO cells. Eur J Pharmacol. 2008 Oct 10;594(1-3):32-8. doi: 10.1016/j.ejphar.2008.07.040. Epub 2008 Jul 30.@@Kvernmo T, Houben J, Sylte I: Receptor-binding and pharmacokinetic properties of dopaminergic agonists. Curr Top Med Chem. 2008;8(12):1049-67.@@Lam YW: Clinical pharmacology of dopamine agonists. Pharmacotherapy. 2000 Jan;20(1 Pt 2):17S-25S.@@Gornemann T, Hubner H, Gmeiner P, Horowski R, Latte KP, Flieger M, Pertz HH: Characterization of the molecular fragment that is responsible for agonism of pergolide at serotonin 5-Hydroxytryptamine2B and 5-Hydroxytryptamine2A receptors. J Pharmacol Exp Ther. 2008 Mar;324(3):1136-45. doi: 10.1124/jpet.107.133165. Epub 2007 Dec 20. |
| Groups | Approved; Investigational; Vet_approved; Withdrawn |
| Direct Classification | Indoloquinolines |
| SMILES | [H][C@@]12CC3=CNC4=CC=CC(=C34)[C@@]1([H])C[C@@H](CSC)CN2CCC |
| Pathways | |
| PharmGKB | PA450873 |
| ChEMBL | CHEMBL531 |
