Gene info: ID 7768

Gene: ZNF225

GENE ID: 7768

Synonyms: -

Description: zinc finger protein 225

Gene type: protein-coding

Location: 19q13.31

dbXrefs: Ensembl:ENSG00000256294 Vega:OTTHUMG00000182336 UniprotKB:Q9UK10

RefSeq: NC_000019.10

Retrived from: SNP Mapped

SNPs: 16 ANCO-SNPs

Phenotype: AD

# Publications: 0

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 1.575e-1 (AD) 5.859e-1 (ND)

ANCO-SNPs

SNP ID	Position	Alleles	Trait	Variation Type
rs10413195	chr19:44130750 (GRCh38.p7)	A>G	alcohol dependence	SNV(Single Nucleotide Variation)
rs10413511	chr19:44130658 (GRCh38.p7)	G>A	alcohol dependence	SNV(Single Nucleotide Variation)
rs9304638	chr19:44129933 (GRCh38.p7)	C>G / C>T	alcohol dependence	SNV(Single Nucleotide Variation)
rs10406335	chr19:44129800 (GRCh38.p7)	G>A	alcohol dependence	SNV(Single Nucleotide Variation)
rs2284981	chr19:44129405 (GRCh38.p7)	G>C	alcohol dependence	SNV(Single Nucleotide Variation)
rs2284980	chr19:44129321 (GRCh38.p7)	T>C	alcohol dependence	SNV(Single Nucleotide Variation)
rs2168778	chr19:44127066 (GRCh38.p7)	T>C	alcohol dependence	SNV(Single Nucleotide Variation)
rs7508762	chr19:44125725 (GRCh38.p7)	T>C	alcohol dependence	SNV(Single Nucleotide Variation)
rs10853771	chr19:44125295 (GRCh38.p7)	C>T	alcohol dependence	SNV(Single Nucleotide Variation)
rs7251868	chr19:44124204 (GRCh38.p7)	G>A	alcohol dependence	SNV(Single Nucleotide Variation)
rs4802208	chr19:44123759 (GRCh38.p7)	G>C	alcohol dependence	SNV(Single Nucleotide Variation)
rs2356750	chr19:44121756 (GRCh38.p7)	G>A	alcohol dependence	SNV(Single Nucleotide Variation)
rs7253485	chr19:44120889 (GRCh38.p7)	A>G	alcohol dependence	SNV(Single Nucleotide Variation)
rs8099869	chr19:44119223 (GRCh38.p7)	C>T	alcohol dependence	SNV(Single Nucleotide Variation)
rs2300962	chr19:44116050 (GRCh38.p7)	C>T	alcohol dependence	SNV(Single Nucleotide Variation)
rs2284978	chr19:44113157 (GRCh38.p7)	A>G	alcohol dependence	SNV(Single Nucleotide Variation)

DNA Methylation

Probe	Locus(GRCh37)	Gene	Region	p-val	Trait	PubMed ID
cg10786870	chr19:44616116	ZNF225	Promoter	7.764e-4	Alcohol use disorders	26763658

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
XPO4	0.851
MED23	0.844
MLLT10	0.831
POLH	0.829
GEMIN5	0.829
ZMYM6	0.829
MED14	0.827
ZNF175	0.827
ACVR2B	0.823
FKTN	0.823

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
OR4F5	-0.365
OR4F29	-0.333
KLRC2	-0.288
VAX2	-0.287
BCL7C	-0.287
NANOGNB	-0.265
HMX1	-0.256
S100A14	-0.256
PLA2G5	-0.248
S100A1	-0.247

There is no DrugBank record for this gene !

ID	Drug Name	Action	PubMed
D016604	Aflatoxin B1	Aflatoxin B1 results in increased methylation of ZNF225 gene	27153756
D000535	Aluminum	[APP protein modified form binds to Aluminum] which results in increased expression of ZNF225 mRNA	21298039
D000638	Amiodarone	Amiodarone results in increased expression of ZNF225 mRNA	19774075
C000611646	bisphenol F	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of ZNF225 mRNA	28628672
D019327	Copper Sulfate	Copper Sulfate results in increased expression of ZNF225 mRNA	19549813
D003907	Dexamethasone	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of ZNF225 mRNA	28628672
D005020	Ethyl Methanesulfonate	Ethyl Methanesulfonate results in increased expression of ZNF225 mRNA	23649840
D007213	Indomethacin	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of ZNF225 mRNA	28628672
D015056	1-Methyl-3-isobutylxanthine	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of ZNF225 mRNA	28628672
C544151	jinfukang	jinfukang results in decreased expression of ZNF225 mRNA	27392435
C004925	methylmercuric chloride	methylmercuric chloride results in decreased expression of ZNF225 mRNA	28001369
D008741	Methyl Methanesulfonate	Methyl Methanesulfonate results in increased expression of ZNF225 mRNA	23649840
D010936	Plant Extracts	Plant Extracts results in increased expression of ZNF225 mRNA	23557933
D011794	Quercetin	Quercetin results in increased expression of ZNF225 mRNA	21632981
D014750	Vincristine	Vincristine results in decreased expression of ZNF225 mRNA	23649840

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0000981	RNA polymerase II transcription factor activity, sequence-specific DNA binding	-	ISA	-
GO:0003677	DNA binding	-	IEA	-
GO:0046872	metal ion binding	-	IEA	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0006351	transcription, DNA-templated	-	IEA	-
GO:0006357	regulation of transcription by RNA polymerase II	-	IEA	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005634	nucleus	-	IEA	-

KEGG ID	KEGG Term

Reactome ID	Reactome Term	Evidence
R-HSA-212436	Generic Transcription Pathway	TAS
R-HSA-73857	RNA Polymerase II Transcription	TAS
R-HSA-74160	Gene expression (Transcription)	TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal