DegronMD

Uniprot ID: Q02817

Source protein: Mucin-2

Source gene: MUC2

Class: DEG_SCF_FBW7_1

Location: 1907:1914

E3 ligase: FBXW7

DEGRON score: 0.9753

ASA_SCORE: 100.0875

COIL: 0.9746

CONS_SCORE: 0.4464

DSS_SCORE: 0.7176

HELIX: 0.0079

FCONS_SCORE: 1.2036

RIG_SCORE: 0.669

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S1907F	TCGA-06-5416	GBM	TCGA	VTPTPTPT	DEG_SCF_FBW7_1	0.7982
p.S1907F	DO10880	GBM	ICGC	VTPTPTPT	DEG_SCF_FBW7_1	0.7982
p.T1905I	TCGA-78-7220	LUAD	TCGA	VTPTPTPT	DEG_SCF_FBW7_1	0.2778
p.T1905I	DO24409	LUAD	ICGC	VTPTPTPT	DEG_SCF_FBW7_1	0.2778
p.T1905I	ACH-000947	Ovarian Cancer	CCLE	VTPTPTPT	DEG_SCF_FBW7_1	0.2778
p.P1916S	TCGA-D3-A3MU	SKCM	TCGA	VTPTPTPT	DEG_SCF_FBW7_1	0.2778
p.P1916S	DO47337	SKCM	ICGC	VTPTPTPT	DEG_SCF_FBW7_1	0.2778
p.T1914M	TCGA-L5-A4OI	ESCA	TCGA	VTPTPTPT	DEG_SCF_FBW7_1	0.6312
p.P1910T	TCGA-MP-A4TJ	LUAD	TCGA	VTPTPTPT	DEG_SCF_FBW7_1	0.7031
p.P1910T	DO45394	LUAD	ICGC	VTPTPTPT	DEG_SCF_FBW7_1	0.7031
p.P1909L	DO229016	COCA	ICGC	VTPTPTPT	DEG_SCF_FBW7_1	0.6471
p.S1915F	ACH-000491	Colon/Colorectal Cancer	CCLE	VTPTPTPT	DEG_SCF_FBW7_1	0.3056
p.T1913A	ACH-000946	Endometrial/Uterine Cancer	CCLE	VTPTPTPT	DEG_SCF_FBW7_1	0.7139

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q02817	Mucin-2	DEG_SCF_FBW7_1	1907:1914	VTPTPTPT	FBXW7	0.9753	More...
Q02817	Mucin-2	DEG_SCF_FBW7_1	1930:1937	VTPTPTPT	FBXW7	0.9561	More...
Q02817	Mucin-2	DEG_SCF_FBW7_1	1953:1960	VTPTPTPT	FBXW7	0.9563	More...
Q02817	Mucin-2	DEG_SCF_FBW7_1	1976:1983	VTPTPTPT	FBXW7	0.9339	More...
Q02817	Mucin-2	DEG_SCF_FBW7_1	1999:2006	VTPTPTPT	FBXW7	0.9561	More...
Q02817	Mucin-2	DEG_SCF_FBW7_1	2022:2029	VTPTPTPT	FBXW7	0.9601	More...
Q02817	Mucin-2	DEG_SCF_FBW7_1	2045:2052	VTPTPTPT	FBXW7	0.9339	More...
Q02817	Mucin-2	DEG_SCF_FBW7_1	2068:2075	VTPTPTPT	FBXW7	0.9481	More...
Q02817	Mucin-2	DEG_SCF_FBW7_1	2091:2098	VTPTPTPT	FBXW7	0.9601	More...
Q02817	Mucin-2	DEG_SCF_FBW7_1	2114:2121	VTPTPTPT	FBXW7	0.9161	More...
Q02817	Mucin-2	DEG_SCF_FBW7_1	2137:2144	VTPTPTPT	FBXW7	0.9563	More...
Q02817	Mucin-2	DEG_SCF_FBW7_1	2160:2167	VTPTPTPT	FBXW7	0.9481	More...
Q02817	Mucin-2	DEG_SCF_FBW7_1	2183:2190	VTPTPTPT	FBXW7	0.9601	More...
Q02817	Mucin-2	DEG_SCF_FBW7_1	2206:2213	VTPTPTPT	FBXW7	0.9426	More...
Q02817	Mucin-2	DEG_SCF_FBW7_1	2229:2236	VTPTPTPT	FBXW7	0.8816	More...
Q02817	Mucin-2	DEG_SCF_FBW7_1	2252:2259	VTPTPTPT	FBXW7	0.9339	More...
Q02817	Mucin-2	DEG_SCF_FBW7_1	2275:2282	VTPTPTPT	FBXW7	0.9481	More...
Q02817	Mucin-2	DEG_SCF_FBW7_1	2298:2305	VTPTPTPT	FBXW7	0.9481	More...
Q02817	Mucin-2	DEG_SCF_FBW7_1	2321:2328	VTPTPTPT	FBXW7	0.9161	More...
Q02817	Mucin-2	DEG_SCF_FBW7_1	2344:2351	VTPTPTPT	FBXW7	0.9481	More...
Q02817	Mucin-2	DEG_SCF_FBW7_1	2367:2374	VTPTPTPT	FBXW7	0.9426	More...
Q02817	Mucin-2	DEG_SCF_FBW7_1	2390:2397	VTPTPTPT	FBXW7	0.9958	More...
Q02817	Mucin-2	DEG_SCF_FBW7_1	2413:2420	VTPTPTPT	FBXW7	0.9601	More...
Q02817	Mucin-2	DEG_SCF_FBW7_1	2436:2443	VTPTPTPT	FBXW7	0.979	More...
Q02817	Mucin-2	DEG_SCF_FBW7_1	2459:2466	VTPTPTPT	FBXW7	0.9601	More...
Q02817	Mucin-2	DEG_SCF_FBW7_1	2482:2489	VTPTPTPT	FBXW7	0.9415	More...
Q02817	Mucin-2	DEG_SCF_FBW7_1	2505:2512	VTPTPTPT	FBXW7	0.8795	More...
Q02817	Mucin-2	DEG_SCF_FBW7_1	2528:2535	VTPTPTPT	FBXW7	0.9415	More...
Q02817	Mucin-2	DEG_SCF_FBW7_1	2551:2558	VTPTPTPT	FBXW7	0.9481	More...
Q02817	Mucin-2	DEG_SCF_FBW7_1	2574:2581	VTPTPTPT	FBXW7	0.9426	More...
Q02817	Mucin-2	DEG_SCF_FBW7_1	2597:2604	VTPTPTPT	FBXW7	0.9339	More...
Q02817	Mucin-2	DEG_SCF_FBW7_1	2620:2627	VTPTPTPT	FBXW7	0.9481	More...
Q02817	Mucin-2	DEG_SCF_FBW7_1	2643:2650	VTPTPTPT	FBXW7	0.9958	More...
Q02817	Mucin-2	DEG_SCF_FBW7_1	2666:2673	VTPTPTPT	FBXW7	0.9601	More...
Q02817	Mucin-2	DEG_SCF_FBW7_1	2689:2696	VTPTPTPT	FBXW7	0.979	More...
Q02817	Mucin-2	DEG_SCF_FBW7_1	2712:2719	VTPTPTPT	FBXW7	0.9958	More...
Q02817	Mucin-2	DEG_SCF_FBW7_1	2735:2742	VTPTPTPT	FBXW7	0.9601	More...
Q02817	Mucin-2	DEG_SCF_FBW7_1	2758:2765	VTPTPTPT	FBXW7	0.9426	More...
Q02817	Mucin-2	DEG_SCF_FBW7_1	2781:2788	VTPTPTPT	FBXW7	0.8843	More...
Q02817	Mucin-2	DEG_SCF_FBW7_1	2804:2811	VTPTPTPT	FBXW7	0.9481	More...
Q02817	Mucin-2	DEG_SCF_FBW7_1	2827:2834	VTPTPTPT	FBXW7	0.979	More...
Q02817	Mucin-2	DEG_SCF_FBW7_1	2850:2857	VTPTPTPT	FBXW7	0.9601	More...
Q02817	Mucin-2	DEG_SCF_FBW7_1	2873:2880	VTPTPTPT	FBXW7	0.9339	More...
Q02817	Mucin-2	DEG_SCF_FBW7_1	2896:2903	VTPTPTPT	FBXW7	0.9415	More...
Q02817	Mucin-2	DEG_SCF_FBW7_1	2919:2926	VTPTPTPT	FBXW7	0.9523	More...
Q02817	Mucin-2	DEG_SCF_FBW7_1	2942:2949	VTPTPTPT	FBXW7	0.8923	More...
Q02817	Mucin-2	DEG_SCF_FBW7_1	2965:2972	VTPTPTPT	FBXW7	0.9426	More...
Q02817	Mucin-2	DEG_SCF_FBW7_1	2988:2995	VTPTPTPT	FBXW7	0.9426	More...
Q02817	Mucin-2	DEG_SCF_FBW7_1	3011:3018	VTPTPTPT	FBXW7	0.9956	More...
Q02817	Mucin-2	DEG_SCF_FBW7_1	3034:3041	VTPTPTPT	FBXW7	0.8923	More...
Q02817	Mucin-2	DEG_SCF_FBW7_1	3057:3064	VTPTPTPT	FBXW7	0.9601	More...
Q02817	Mucin-2	DEG_SCF_FBW7_1	3080:3087	VTPTPTPT	FBXW7	0.9789	More...
Q02817	Mucin-2	DEG_SCF_FBW7_1	3103:3110	VTPTPTPT	FBXW7	0.9481	More...
Q02817	Mucin-2	DEG_SCF_FBW7_1	3126:3133	VTPTPTPT	FBXW7	0.9561	More...
Q02817	Mucin-2	DEG_SCF_FBW7_1	3149:3156	VTPTPTPT	FBXW7	0.9601	More...
Q02817	Mucin-2	DEG_SCF_FBW7_1	3172:3179	VTPTPTPT	FBXW7	0.9161	More...
Q02817	Mucin-2	DEG_SCF_FBW7_1	3195:3202	VTPTPTPT	FBXW7	0.9601	More...
Q02817	Mucin-2	DEG_SCF_FBW7_1	3218:3225	VTPTPTPT	FBXW7	0.9563	More...
Q02817	Mucin-2	DEG_SCF_FBW7_1	3241:3248	VTPTPTPT	FBXW7	0.9958	More...
Q02817	Mucin-2	DEG_SCF_FBW7_1	3264:3271	VTPTPTPT	FBXW7	0.9601	More...
Q02817	Mucin-2	DEG_SCF_FBW7_1	3287:3294	VTPTPTPT	FBXW7	0.9339	More...
Q02817	Mucin-2	DEG_SCF_FBW7_1	3310:3317	VTPTPTPT	FBXW7	0.979	More...
Q02817	Mucin-2	DEG_SCF_FBW7_1	3333:3340	VTPTPTPT	FBXW7	0.9963	More...
Q02817	Mucin-2	DEG_SCF_FBW7_1	3356:3363	VTPTPTPT	FBXW7	0.9481	More...
Q02817	Mucin-2	DEG_SCF_FBW7_1	3379:3386	VTPTPTPT	FBXW7	0.9481	More...
Q02817	Mucin-2	DEG_SCF_FBW7_1	3402:3409	VTPTPTPT	FBXW7	0.9481	More...
Q02817	Mucin-2	DEG_SCF_FBW7_1	3425:3432	VTPTPTPT	FBXW7	0.9415	More...
Q02817	Mucin-2	DEG_SCF_FBW7_1	3448:3455	VTPTPTPT	FBXW7	0.9563	More...
Q02817	Mucin-2	DEG_SCF_FBW7_1	3471:3478	VTPTPTPT	FBXW7	0.9789	More...
Q02817	Mucin-2	DEG_SCF_FBW7_1	3494:3501	VTPTPTPT	FBXW7	0.9601	More...
Q02817	Mucin-2	DEG_SCF_FBW7_1	3517:3524	VTPTPTPT	FBXW7	0.9601	More...
Q02817	Mucin-2	DEG_SCF_FBW7_1	3540:3547	VTPTPTPT	FBXW7	0.979	More...
Q02817	Mucin-2	DEG_SCF_FBW7_1	3563:3570	VTPTPTPT	FBXW7	0.944	More...
Q02817	Mucin-2	DEG_SCF_FBW7_1	3586:3593	VTPTPTPT	FBXW7	0.9958	More...
Q02817	Mucin-2	DEG_SCF_FBW7_1	3609:3616	VTPTPTPT	FBXW7	0.9549	More...
Q02817	Mucin-2	DEG_SCF_FBW7_1	3632:3639	VTPTPTPT	FBXW7	0.9601	More...
Q02817	Mucin-2	DEG_SCF_FBW7_1	3655:3662	VTPTPTPT	FBXW7	0.9958	More...
Q02817	Mucin-2	DEG_SCF_FBW7_1	3678:3685	VTPTPTPT	FBXW7	0.9415	More...
Q02817	Mucin-2	DEG_SCF_FBW7_1	3701:3708	VTPTPTPT	FBXW7	0.9426	More...
Q02817	Mucin-2	DEG_SCF_FBW7_1	3724:3731	VTPTPTPT	FBXW7	0.9601	More...
Q02817	Mucin-2	DEG_SCF_FBW7_1	3747:3754	VTPTPTPT	FBXW7	0.9339	More...
Q02817	Mucin-2	DEG_SCF_FBW7_1	3770:3777	VTPTPTPT	FBXW7	0.9958	More...
Q02817	Mucin-2	DEG_SCF_FBW7_1	3793:3800	VTPTPTPT	FBXW7	0.9415	More...
Q02817	Mucin-2	DEG_SCF_FBW7_1	3816:3823	VTPTPTPT	FBXW7	0.9549	More...
Q02817	Mucin-2	DEG_SCF_FBW7_1	3839:3846	VTPTPTPT	FBXW7	0.8795	More...
Q02817	Mucin-2	DEG_SCF_FBW7_1	3862:3869	VTPTPTPT	FBXW7	0.9964	More...
Q02817	Mucin-2	DEG_SCF_FBW7_1	3885:3892	VTPTPTPT	FBXW7	0.9161	More...
Q02817	Mucin-2	DEG_SCF_FBW7_1	3908:3915	VTPTPTPT	FBXW7	0.9426	More...
Q02817	Mucin-2	DEG_SCF_FBW7_1	3931:3938	VTPTPTPT	FBXW7	0.9339	More...
Q02817	Mucin-2	DEG_SCF_FBW7_1	3954:3961	VTPTPTPT	FBXW7	0.9339	More...
Q02817	Mucin-2	DEG_SCF_FBW7_1	3977:3984	VTPTPTPT	FBXW7	0.9561	More...
Q02817	Mucin-2	DEG_SCF_FBW7_1	4000:4007	VTPTPTPT	FBXW7	0.9958	More...
Q02817	Mucin-2	DEG_SCF_FBW7_1	4023:4030	VTPTPTPT	FBXW7	0.9534	More...
Q02817	Mucin-2	DEG_SCF_FBW7_1	4046:4053	VTPTPTPT	FBXW7	0.9561	More...
Q02817	Mucin-2	DEG_SCF_FBW7_1	4069:4076	VTPTPTPT	FBXW7	0.9204	More...
Q02817	Mucin-2	DEG_SCF_FBW7_1	4092:4099	VTPTPTPT	FBXW7	0.9339	More...
Q02817	Mucin-2	DEG_SCF_FBW7_1	4115:4122	VTPTPTPT	FBXW7	0.9339	More...
Q02817	Mucin-2	DEG_SCF_FBW7_1	4138:4145	VTPTPTPT	FBXW7	0.9481	More...
Q02817	Mucin-2	DEG_SCF_FBW7_1	4161:4168	VTPTPTPT	FBXW7	0.8723	More...
Q02817	Mucin-2	DEG_SCF_FBW7_1	4184:4191	VTPTPTPT	FBXW7	0.9965	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: VTPTPTPT

Degron related mutations and impact score

Drug responses associated with MUC2 mutations

All proteins holding degron of VTPTPTPT