DegronMD

Uniprot ID: Q02817

Source protein: Mucin-2

Source gene: MUC2

Class: DEG_SCF_FBW7_1

Location: 2275:2282

E3 ligase: FBXW7

DEGRON score: 0.9481

ASA_SCORE: 104.275

COIL: 0.9773

CONS_SCORE: 0.3743

DSS_SCORE: 0.7019

HELIX: 0.007

FCONS_SCORE: 0.9841

RIG_SCORE: 0.6774

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G2276V	TCGA-55-6979	LUAD	TCGA	VTPTPTPT	DEG_SCF_FBW7_1	0.7532
p.G2276V	TCGA-DA-A1I1	SKCM	TCGA	VTPTPTPT	DEG_SCF_FBW7_1	0.7532
p.G2276V	DO24110	LUAD	ICGC	VTPTPTPT	DEG_SCF_FBW7_1	0.7532
p.G2276V	DO37966	SKCM	ICGC	VTPTPTPT	DEG_SCF_FBW7_1	0.7532
p.L2273V	TCGA-77-7141	LUSC	TCGA	VTPTPTPT	DEG_SCF_FBW7_1	0.2778
p.L2273V	DO26450	LUSC	ICGC	VTPTPTPT	DEG_SCF_FBW7_1	0.2778
p.S2280F	TCGA-AK-3451	KIRC	TCGA	VTPTPTPT	DEG_SCF_FBW7_1	0.7982
p.S2280F	DO18899	KIRC	ICGC	VTPTPTPT	DEG_SCF_FBW7_1	0.7982
p.P2274R	TCGA-B4-5832	KIRC	TCGA	VTPTPTPT	DEG_SCF_FBW7_1	0.3056
p.P2274R	DO17236	KIRC	ICGC	VTPTPTPT	DEG_SCF_FBW7_1	0.3056
p.P2274H	TCGA-D1-A17H	UCEC	TCGA	VTPTPTPT	DEG_SCF_FBW7_1	0.3056
p.P2274H	DO41847	UCEC	ICGC	VTPTPTPT	DEG_SCF_FBW7_1	0.3056
p.G2276W	TCGA-D3-A3CE	SKCM	TCGA	VTPTPTPT	DEG_SCF_FBW7_1	0.7825
p.G2276W	DO37405	SKCM	ICGC	VTPTPTPT	DEG_SCF_FBW7_1	0.7825
p.I2278M	ACH-000869	Lung Cancer	CCLE	VTPTPTPT	DEG_SCF_FBW7_1	0.7618

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: VTPTPTPT

Degron related mutations and impact score

Drug responses associated with MUC2 mutations

All proteins holding degron of VTPTPTPT

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q02817	Mucin-2	DEG_SCF_FBW7_1	1907:1914	VTPTPTPT	FBXW7	0.9753	More...
Q02817	Mucin-2	DEG_SCF_FBW7_1	1930:1937	VTPTPTPT	FBXW7	0.9561	More...
Q02817	Mucin-2	DEG_SCF_FBW7_1	1953:1960	VTPTPTPT	FBXW7	0.9563	More...
Q02817	Mucin-2	DEG_SCF_FBW7_1	1976:1983	VTPTPTPT	FBXW7	0.9339	More...
Q02817	Mucin-2	DEG_SCF_FBW7_1	1999:2006	VTPTPTPT	FBXW7	0.9561	More...
Q02817	Mucin-2	DEG_SCF_FBW7_1	2022:2029	VTPTPTPT	FBXW7	0.9601	More...
Q02817	Mucin-2	DEG_SCF_FBW7_1	2045:2052	VTPTPTPT	FBXW7	0.9339	More...
Q02817	Mucin-2	DEG_SCF_FBW7_1	2068:2075	VTPTPTPT	FBXW7	0.9481	More...
Q02817	Mucin-2	DEG_SCF_FBW7_1	2091:2098	VTPTPTPT	FBXW7	0.9601	More...
Q02817	Mucin-2	DEG_SCF_FBW7_1	2114:2121	VTPTPTPT	FBXW7	0.9161	More...
Q02817	Mucin-2	DEG_SCF_FBW7_1	2137:2144	VTPTPTPT	FBXW7	0.9563	More...
Q02817	Mucin-2	DEG_SCF_FBW7_1	2160:2167	VTPTPTPT	FBXW7	0.9481	More...
Q02817	Mucin-2	DEG_SCF_FBW7_1	2183:2190	VTPTPTPT	FBXW7	0.9601	More...
Q02817	Mucin-2	DEG_SCF_FBW7_1	2206:2213	VTPTPTPT	FBXW7	0.9426	More...
Q02817	Mucin-2	DEG_SCF_FBW7_1	2229:2236	VTPTPTPT	FBXW7	0.8816	More...
Q02817	Mucin-2	DEG_SCF_FBW7_1	2252:2259	VTPTPTPT	FBXW7	0.9339	More...
Q02817	Mucin-2	DEG_SCF_FBW7_1	2275:2282	VTPTPTPT	FBXW7	0.9481	More...
Q02817	Mucin-2	DEG_SCF_FBW7_1	2298:2305	VTPTPTPT	FBXW7	0.9481	More...
Q02817	Mucin-2	DEG_SCF_FBW7_1	2321:2328	VTPTPTPT	FBXW7	0.9161	More...
Q02817	Mucin-2	DEG_SCF_FBW7_1	2344:2351	VTPTPTPT	FBXW7	0.9481	More...
Q02817	Mucin-2	DEG_SCF_FBW7_1	2367:2374	VTPTPTPT	FBXW7	0.9426	More...
Q02817	Mucin-2	DEG_SCF_FBW7_1	2390:2397	VTPTPTPT	FBXW7	0.9958	More...
Q02817	Mucin-2	DEG_SCF_FBW7_1	2413:2420	VTPTPTPT	FBXW7	0.9601	More...
Q02817	Mucin-2	DEG_SCF_FBW7_1	2436:2443	VTPTPTPT	FBXW7	0.979	More...
Q02817	Mucin-2	DEG_SCF_FBW7_1	2459:2466	VTPTPTPT	FBXW7	0.9601	More...
Q02817	Mucin-2	DEG_SCF_FBW7_1	2482:2489	VTPTPTPT	FBXW7	0.9415	More...
Q02817	Mucin-2	DEG_SCF_FBW7_1	2505:2512	VTPTPTPT	FBXW7	0.8795	More...
Q02817	Mucin-2	DEG_SCF_FBW7_1	2528:2535	VTPTPTPT	FBXW7	0.9415	More...
Q02817	Mucin-2	DEG_SCF_FBW7_1	2551:2558	VTPTPTPT	FBXW7	0.9481	More...
Q02817	Mucin-2	DEG_SCF_FBW7_1	2574:2581	VTPTPTPT	FBXW7	0.9426	More...
Q02817	Mucin-2	DEG_SCF_FBW7_1	2597:2604	VTPTPTPT	FBXW7	0.9339	More...
Q02817	Mucin-2	DEG_SCF_FBW7_1	2620:2627	VTPTPTPT	FBXW7	0.9481	More...
Q02817	Mucin-2	DEG_SCF_FBW7_1	2643:2650	VTPTPTPT	FBXW7	0.9958	More...
Q02817	Mucin-2	DEG_SCF_FBW7_1	2666:2673	VTPTPTPT	FBXW7	0.9601	More...
Q02817	Mucin-2	DEG_SCF_FBW7_1	2689:2696	VTPTPTPT	FBXW7	0.979	More...
Q02817	Mucin-2	DEG_SCF_FBW7_1	2712:2719	VTPTPTPT	FBXW7	0.9958	More...
Q02817	Mucin-2	DEG_SCF_FBW7_1	2735:2742	VTPTPTPT	FBXW7	0.9601	More...
Q02817	Mucin-2	DEG_SCF_FBW7_1	2758:2765	VTPTPTPT	FBXW7	0.9426	More...
Q02817	Mucin-2	DEG_SCF_FBW7_1	2781:2788	VTPTPTPT	FBXW7	0.8843	More...
Q02817	Mucin-2	DEG_SCF_FBW7_1	2804:2811	VTPTPTPT	FBXW7	0.9481	More...
Q02817	Mucin-2	DEG_SCF_FBW7_1	2827:2834	VTPTPTPT	FBXW7	0.979	More...
Q02817	Mucin-2	DEG_SCF_FBW7_1	2850:2857	VTPTPTPT	FBXW7	0.9601	More...
Q02817	Mucin-2	DEG_SCF_FBW7_1	2873:2880	VTPTPTPT	FBXW7	0.9339	More...
Q02817	Mucin-2	DEG_SCF_FBW7_1	2896:2903	VTPTPTPT	FBXW7	0.9415	More...
Q02817	Mucin-2	DEG_SCF_FBW7_1	2919:2926	VTPTPTPT	FBXW7	0.9523	More...
Q02817	Mucin-2	DEG_SCF_FBW7_1	2942:2949	VTPTPTPT	FBXW7	0.8923	More...
Q02817	Mucin-2	DEG_SCF_FBW7_1	2965:2972	VTPTPTPT	FBXW7	0.9426	More...
Q02817	Mucin-2	DEG_SCF_FBW7_1	2988:2995	VTPTPTPT	FBXW7	0.9426	More...
Q02817	Mucin-2	DEG_SCF_FBW7_1	3011:3018	VTPTPTPT	FBXW7	0.9956	More...
Q02817	Mucin-2	DEG_SCF_FBW7_1	3034:3041	VTPTPTPT	FBXW7	0.8923	More...
Q02817	Mucin-2	DEG_SCF_FBW7_1	3057:3064	VTPTPTPT	FBXW7	0.9601	More...
Q02817	Mucin-2	DEG_SCF_FBW7_1	3080:3087	VTPTPTPT	FBXW7	0.9789	More...
Q02817	Mucin-2	DEG_SCF_FBW7_1	3103:3110	VTPTPTPT	FBXW7	0.9481	More...
Q02817	Mucin-2	DEG_SCF_FBW7_1	3126:3133	VTPTPTPT	FBXW7	0.9561	More...
Q02817	Mucin-2	DEG_SCF_FBW7_1	3149:3156	VTPTPTPT	FBXW7	0.9601	More...
Q02817	Mucin-2	DEG_SCF_FBW7_1	3172:3179	VTPTPTPT	FBXW7	0.9161	More...
Q02817	Mucin-2	DEG_SCF_FBW7_1	3195:3202	VTPTPTPT	FBXW7	0.9601	More...
Q02817	Mucin-2	DEG_SCF_FBW7_1	3218:3225	VTPTPTPT	FBXW7	0.9563	More...
Q02817	Mucin-2	DEG_SCF_FBW7_1	3241:3248	VTPTPTPT	FBXW7	0.9958	More...
Q02817	Mucin-2	DEG_SCF_FBW7_1	3264:3271	VTPTPTPT	FBXW7	0.9601	More...
Q02817	Mucin-2	DEG_SCF_FBW7_1	3287:3294	VTPTPTPT	FBXW7	0.9339	More...
Q02817	Mucin-2	DEG_SCF_FBW7_1	3310:3317	VTPTPTPT	FBXW7	0.979	More...
Q02817	Mucin-2	DEG_SCF_FBW7_1	3333:3340	VTPTPTPT	FBXW7	0.9963	More...
Q02817	Mucin-2	DEG_SCF_FBW7_1	3356:3363	VTPTPTPT	FBXW7	0.9481	More...
Q02817	Mucin-2	DEG_SCF_FBW7_1	3379:3386	VTPTPTPT	FBXW7	0.9481	More...
Q02817	Mucin-2	DEG_SCF_FBW7_1	3402:3409	VTPTPTPT	FBXW7	0.9481	More...
Q02817	Mucin-2	DEG_SCF_FBW7_1	3425:3432	VTPTPTPT	FBXW7	0.9415	More...
Q02817	Mucin-2	DEG_SCF_FBW7_1	3448:3455	VTPTPTPT	FBXW7	0.9563	More...
Q02817	Mucin-2	DEG_SCF_FBW7_1	3471:3478	VTPTPTPT	FBXW7	0.9789	More...
Q02817	Mucin-2	DEG_SCF_FBW7_1	3494:3501	VTPTPTPT	FBXW7	0.9601	More...
Q02817	Mucin-2	DEG_SCF_FBW7_1	3517:3524	VTPTPTPT	FBXW7	0.9601	More...
Q02817	Mucin-2	DEG_SCF_FBW7_1	3540:3547	VTPTPTPT	FBXW7	0.979	More...
Q02817	Mucin-2	DEG_SCF_FBW7_1	3563:3570	VTPTPTPT	FBXW7	0.944	More...
Q02817	Mucin-2	DEG_SCF_FBW7_1	3586:3593	VTPTPTPT	FBXW7	0.9958	More...
Q02817	Mucin-2	DEG_SCF_FBW7_1	3609:3616	VTPTPTPT	FBXW7	0.9549	More...
Q02817	Mucin-2	DEG_SCF_FBW7_1	3632:3639	VTPTPTPT	FBXW7	0.9601	More...
Q02817	Mucin-2	DEG_SCF_FBW7_1	3655:3662	VTPTPTPT	FBXW7	0.9958	More...
Q02817	Mucin-2	DEG_SCF_FBW7_1	3678:3685	VTPTPTPT	FBXW7	0.9415	More...
Q02817	Mucin-2	DEG_SCF_FBW7_1	3701:3708	VTPTPTPT	FBXW7	0.9426	More...
Q02817	Mucin-2	DEG_SCF_FBW7_1	3724:3731	VTPTPTPT	FBXW7	0.9601	More...
Q02817	Mucin-2	DEG_SCF_FBW7_1	3747:3754	VTPTPTPT	FBXW7	0.9339	More...
Q02817	Mucin-2	DEG_SCF_FBW7_1	3770:3777	VTPTPTPT	FBXW7	0.9958	More...
Q02817	Mucin-2	DEG_SCF_FBW7_1	3793:3800	VTPTPTPT	FBXW7	0.9415	More...
Q02817	Mucin-2	DEG_SCF_FBW7_1	3816:3823	VTPTPTPT	FBXW7	0.9549	More...
Q02817	Mucin-2	DEG_SCF_FBW7_1	3839:3846	VTPTPTPT	FBXW7	0.8795	More...
Q02817	Mucin-2	DEG_SCF_FBW7_1	3862:3869	VTPTPTPT	FBXW7	0.9964	More...
Q02817	Mucin-2	DEG_SCF_FBW7_1	3885:3892	VTPTPTPT	FBXW7	0.9161	More...
Q02817	Mucin-2	DEG_SCF_FBW7_1	3908:3915	VTPTPTPT	FBXW7	0.9426	More...
Q02817	Mucin-2	DEG_SCF_FBW7_1	3931:3938	VTPTPTPT	FBXW7	0.9339	More...
Q02817	Mucin-2	DEG_SCF_FBW7_1	3954:3961	VTPTPTPT	FBXW7	0.9339	More...
Q02817	Mucin-2	DEG_SCF_FBW7_1	3977:3984	VTPTPTPT	FBXW7	0.9561	More...
Q02817	Mucin-2	DEG_SCF_FBW7_1	4000:4007	VTPTPTPT	FBXW7	0.9958	More...
Q02817	Mucin-2	DEG_SCF_FBW7_1	4023:4030	VTPTPTPT	FBXW7	0.9534	More...
Q02817	Mucin-2	DEG_SCF_FBW7_1	4046:4053	VTPTPTPT	FBXW7	0.9561	More...
Q02817	Mucin-2	DEG_SCF_FBW7_1	4069:4076	VTPTPTPT	FBXW7	0.9204	More...
Q02817	Mucin-2	DEG_SCF_FBW7_1	4092:4099	VTPTPTPT	FBXW7	0.9339	More...
Q02817	Mucin-2	DEG_SCF_FBW7_1	4115:4122	VTPTPTPT	FBXW7	0.9339	More...
Q02817	Mucin-2	DEG_SCF_FBW7_1	4138:4145	VTPTPTPT	FBXW7	0.9481	More...
Q02817	Mucin-2	DEG_SCF_FBW7_1	4161:4168	VTPTPTPT	FBXW7	0.8723	More...
Q02817	Mucin-2	DEG_SCF_FBW7_1	4184:4191	VTPTPTPT	FBXW7	0.9965	More...