DegronMD

Uniprot ID: Q02817

Source protein: Mucin-2

Source gene: MUC2

Class: DEG_SCF_FBW7_1

Location: 2482:2489

E3 ligase: FBXW7

DEGRON score: 0.9415

ASA_SCORE: 106.0375

COIL: 0.9761

CONS_SCORE: 0.2969

DSS_SCORE: 0.7019

HELIX: 0.0063

FCONS_SCORE: 1.0276

RIG_SCORE: 0.6774

Degron related mutations and impact score

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G2482E	TCGA-D3-A3MV	SKCM	TCGA	VTPTPTPT	DEG_SCF_FBW7_1	0.7199
p.G2482E	DO37727	SKCM	ICGC	VTPTPTPT	DEG_SCF_FBW7_1	0.7199
p.R2491W	TCGA-DF-A2KU	UCEC	TCGA	VTPTPTPT	DEG_SCF_FBW7_1	0.2778
p.R2491W	DO223286	UCEC	ICGC	VTPTPTPT	DEG_SCF_FBW7_1	0.2778
p.C2492G	DO50346	ESAD	ICGC	VTPTPTPT	DEG_SCF_FBW7_1	0.25
p.S2493G	DO222528	COCA	ICGC	VTPTPTPT	DEG_SCF_FBW7_1	0.2222
p.S2493G	DO230550	LUSC	ICGC	VTPTPTPT	DEG_SCF_FBW7_1	0.2222

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Drug responses associated with MUC2 mutations

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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All proteins holding degron of VTPTPTPT

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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q02817	Mucin-2	DEG_SCF_FBW7_1	1907:1914	VTPTPTPT	FBXW7	0.9753	More...
Q02817	Mucin-2	DEG_SCF_FBW7_1	1930:1937	VTPTPTPT	FBXW7	0.9561	More...
Q02817	Mucin-2	DEG_SCF_FBW7_1	1953:1960	VTPTPTPT	FBXW7	0.9563	More...
Q02817	Mucin-2	DEG_SCF_FBW7_1	1976:1983	VTPTPTPT	FBXW7	0.9339	More...
Q02817	Mucin-2	DEG_SCF_FBW7_1	1999:2006	VTPTPTPT	FBXW7	0.9561	More...
Q02817	Mucin-2	DEG_SCF_FBW7_1	2022:2029	VTPTPTPT	FBXW7	0.9601	More...
Q02817	Mucin-2	DEG_SCF_FBW7_1	2045:2052	VTPTPTPT	FBXW7	0.9339	More...
Q02817	Mucin-2	DEG_SCF_FBW7_1	2068:2075	VTPTPTPT	FBXW7	0.9481	More...
Q02817	Mucin-2	DEG_SCF_FBW7_1	2091:2098	VTPTPTPT	FBXW7	0.9601	More...
Q02817	Mucin-2	DEG_SCF_FBW7_1	2114:2121	VTPTPTPT	FBXW7	0.9161	More...
Q02817	Mucin-2	DEG_SCF_FBW7_1	2137:2144	VTPTPTPT	FBXW7	0.9563	More...
Q02817	Mucin-2	DEG_SCF_FBW7_1	2160:2167	VTPTPTPT	FBXW7	0.9481	More...
Q02817	Mucin-2	DEG_SCF_FBW7_1	2183:2190	VTPTPTPT	FBXW7	0.9601	More...
Q02817	Mucin-2	DEG_SCF_FBW7_1	2206:2213	VTPTPTPT	FBXW7	0.9426	More...
Q02817	Mucin-2	DEG_SCF_FBW7_1	2229:2236	VTPTPTPT	FBXW7	0.8816	More...
Q02817	Mucin-2	DEG_SCF_FBW7_1	2252:2259	VTPTPTPT	FBXW7	0.9339	More...
Q02817	Mucin-2	DEG_SCF_FBW7_1	2275:2282	VTPTPTPT	FBXW7	0.9481	More...
Q02817	Mucin-2	DEG_SCF_FBW7_1	2298:2305	VTPTPTPT	FBXW7	0.9481	More...
Q02817	Mucin-2	DEG_SCF_FBW7_1	2321:2328	VTPTPTPT	FBXW7	0.9161	More...
Q02817	Mucin-2	DEG_SCF_FBW7_1	2344:2351	VTPTPTPT	FBXW7	0.9481	More...
Q02817	Mucin-2	DEG_SCF_FBW7_1	2367:2374	VTPTPTPT	FBXW7	0.9426	More...
Q02817	Mucin-2	DEG_SCF_FBW7_1	2390:2397	VTPTPTPT	FBXW7	0.9958	More...
Q02817	Mucin-2	DEG_SCF_FBW7_1	2413:2420	VTPTPTPT	FBXW7	0.9601	More...
Q02817	Mucin-2	DEG_SCF_FBW7_1	2436:2443	VTPTPTPT	FBXW7	0.979	More...
Q02817	Mucin-2	DEG_SCF_FBW7_1	2459:2466	VTPTPTPT	FBXW7	0.9601	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: VTPTPTPT

Degron related mutations and impact score

Drug responses associated with MUC2 mutations

All proteins holding degron of VTPTPTPT