Degron: VTPTPTPT
Mucin-2
MUC2
2804:2811
FBXW7
0.9481
103.6625
0.9766
0.2868
0.7019
0.0063
0.9705
0.6774
Degron related mutations and impact score
| Mutation |
Sample |
Cancer |
Dataset |
Degron |
Degron class |
Impact score |
| p.R2808W | TCGA-05-4390 | LUAD | TCGA | VTPTPTPT | DEG_SCF_FBW7_1 | 0.8634 |
| p.R2808W | DO23562 | LUAD | ICGC | VTPTPTPT | DEG_SCF_FBW7_1 | 0.8634 |
| p.R2808Q | TCGA-2W-A8YY | CESC | TCGA | VTPTPTPT | DEG_SCF_FBW7_1 | 0.7329 |
| p.R2808Q | TCGA-L5-A8NG | ESCA | TCGA | VTPTPTPT | DEG_SCF_FBW7_1 | 0.7329 |
| p.R2808Q | DO223732 | CESC | ICGC | VTPTPTPT | DEG_SCF_FBW7_1 | 0.7329 |
| p.S2804F | TCGA-34-2600 | LUSC | TCGA | VTPTPTPT | DEG_SCF_FBW7_1 | 0.7982 |
| p.S2804F | DO27081 | LUSC | ICGC | VTPTPTPT | DEG_SCF_FBW7_1 | 0.7982 |
| p.R2809C | TCGA-4Z-AA7M | BLCA | TCGA | VTPTPTPT | DEG_SCF_FBW7_1 | 0.8301 |
| p.R2809C | DO218976 | BLCA | ICGC | VTPTPTPT | DEG_SCF_FBW7_1 | 0.8301 |
| p.T2803N | TCGA-56-8307 | LUSC | TCGA | VTPTPTPT | DEG_SCF_FBW7_1 | 0.3056 |
| p.T2803N | DO219139 | LUSC | ICGC | VTPTPTPT | DEG_SCF_FBW7_1 | 0.3056 |
| p.G2815E | TCGA-AL-3473 | KIRP | TCGA | VTPTPTPT | DEG_SCF_FBW7_1 | 0.2222 |
| p.G2815E | DO20905 | KIRP | ICGC | VTPTPTPT | DEG_SCF_FBW7_1 | 0.2222 |
| p.G2815E | ACH-002177 | Lung Cancer | CCLE | VTPTPTPT | DEG_SCF_FBW7_1 | 0.2222 |
| p.A2807T | TCGA-FI-A2D0 | UCEC | TCGA | VTPTPTPT | DEG_SCF_FBW7_1 | 0.7139 |
| p.A2807T | DO43891 | UCEC | ICGC | VTPTPTPT | DEG_SCF_FBW7_1 | 0.7139 |
| p.R2809S | DO50797 | LICA | ICGC | VTPTPTPT | DEG_SCF_FBW7_1 | 0.7427 |
| p.R2805C | ACH-000678 | Gastric Cancer | CCLE | VTPTPTPT | DEG_SCF_FBW7_1 | 0.8301 |
Drug responses associated with MUC2 mutations
| Sample |
Cancer |
Mutation (In Degron?) |
Dataset |
Drug |
IC50 |
All proteins holding degron of VTPTPTPT