Gene Page: YAP1

Summary
GeneID  10413
Symbol  YAP1
Synonyms  YAP|YAP2|YAP65|YKI
Description  Yes-associated protein 1, 65kDa
See related  HGNC:16262|MIM:606608|Ensembl:ENSG00000137693|HPRD:09424|
Locus tag  -
Gene type  protein-coding
Map location  11q13
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
ExpressionExpressionP value: 3.166 
NetworkShortest path distance of core genes in the Human protein-protein interaction networkContribution to shortest path in PPI network: 0.6564 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
CGGBP10.900.91
KBTBD70.890.89
DLSTP0.890.89
LEPROTL10.880.90
ASB70.880.88
ADNP20.880.89
PIP5K1A0.880.89
DCTN40.880.88
MINPP10.880.88
PTPN90.880.87
Top 10 negatively co-expressed genes
MT-CO2-0.71-0.80
AF347015.31-0.70-0.79
AF347015.27-0.68-0.77
AF347015.8-0.68-0.80
MT-CYB-0.68-0.78
AF347015.33-0.68-0.76
FXYD1-0.68-0.78
HSD17B14-0.67-0.73
HIGD1B-0.66-0.77
AF347015.21-0.66-0.81
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0005515protein bindingIEA-
GO:0005515protein bindingIPI7644498 
GO:0016563transcription activator activityIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0045944positive regulation of transcription from RNA polymerase II promoterIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005667transcription factor complexIEA-
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
DENND3KIAA0870DENN/MADD domain containing 3Two-hybridBioGRID11278422 
ERBB4HER4 | MGC138404 | p180erbB4v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian)-HPRD,BioGRID15023535 
KIF5AD12S1889 | MY050 | NKHC | SPG10kinesin family member 5ATwo-hybridBioGRID11278422 
NFE2NF-E2 | p45nuclear factor (erythroid-derived 2), 45kDap45 interacts with hYAP.BIND9305852 
RUNX1AML1 | AML1-EVI-1 | AMLCR1 | CBFA2 | EVI-1 | PEBP2aBrunt-related transcription factor 1-HPRD,BioGRID10228168 
RUNX2AML3 | CBFA1 | CCD | CCD1 | MGC120022 | MGC120023 | OSF2 | PEA2aA | PEBP2A1 | PEBP2A2 | PEBP2aA | PEBP2aA1runt-related transcription factor 2-HPRD,BioGRID10228168 
RUNX3AML2 | CBFA3 | FLJ34510 | MGC16070 | PEBP2aCrunt-related transcription factor 3Reconstituted ComplexBioGRID10228168 
SLC9A3R1EBP50 | NHERF | NHERF1 | NPHLOP2solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 1-HPRD,BioGRID10562288 
SMAD7CRCS3 | FLJ16482 | MADH7 | MADH8SMAD family member 7-HPRD,BioGRID12118366 
TEAD1AA | REF1 | TCF13 | TEF-1TEA domain family member 1 (SV40 transcriptional enhancer factor)-HPRD11358867 
TEAD2ETF | TEF-4 | TEF4TEA domain family member 2-HPRD11358867 
TEAD3DTEF-1 | ETFR-1 | TEAD5 | TEF-5 | TEF5TEA domain family member 3-HPRD11358867 
TEAD4EFTR-2 | MGC9014 | RTEF1 | TCF13L1 | TEF-3 | TEFR-1 | hRTEF-1BTEA domain family member 4-HPRD11358867 
TP53BP253BP2 | ASPP2 | BBP | PPP1R13A | p53BP2tumor protein p53 binding protein, 2-HPRD,BioGRID11278422 
TP63AIS | B(p51A) | B(p51B) | EEC3 | KET | LMS | NBP | OFC8 | RHS | SHFM4 | TP53CP | TP53L | TP73L | p40 | p51 | p53CP | p63 | p73H | p73Ltumor protein p63Reconstituted ComplexBioGRID11278685 
TP73P73tumor protein p73-HPRD,BioGRID11278685 
p73-alpha interacts with YAP.BIND15893728 
WBP1MGC15305 | WBP-1WW domain binding protein 1in vitro
in vivo
Protein-peptide		BioGRID7644498 |11604498 
WBP2MGC18269 | WBP-2WW domain binding protein 2in vitroBioGRID7644498 
YES1HsT441 | P61-YES | Yes | c-yesv-yes-1 Yamaguchi sarcoma viral oncogene homolog 1-HPRD10562288 
YWHAQ14-3-3 | 1C5 | HS1tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide-HPRD,BioGRID12535517 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
PID_ERBB4_PATHWAY 3832All SZGR genes in this pathway
PID_P73PATHWAY 7959All SZGR genes in this pathway
PID_DELTA_NP63_PATHWAY 4734All SZGR genes in this pathway
PID_TGFBR_PATHWAY 5538All SZGR genes in this pathway
REACTOME_SIGNALING_BY_ERBB4 9067All SZGR genes in this pathway
REACTOME_NUCLEAR_SIGNALING_BY_ERBB4 3830All SZGR genes in this pathway
REACTOME_PPARA_ACTIVATES_GENE_EXPRESSION 10472All SZGR genes in this pathway
REACTOME_SIGNALING_BY_HIPPO 2215All SZGR genes in this pathway
REACTOME_YAP1_AND_WWTR1_TAZ_STIMULATED_GENE_EXPRESSION 2416All SZGR genes in this pathway
REACTOME_GENERIC_TRANSCRIPTION_PATHWAY 352181All SZGR genes in this pathway
REACTOME_METABOLISM_OF_LIPIDS_AND_LIPOPROTEINS 478302All SZGR genes in this pathway
REACTOME_FATTY_ACID_TRIACYLGLYCEROL_AND_KETONE_BODY_METABOLISM 168115All SZGR genes in this pathway
PICCALUGA_ANGIOIMMUNOBLASTIC_LYMPHOMA_UP 205140All SZGR genes in this pathway
CHARAFE_BREAST_CANCER_LUMINAL_VS_BASAL_DN 455304All SZGR genes in this pathway
SENESE_HDAC3_TARGETS_DN 536332All SZGR genes in this pathway
ENK_UV_RESPONSE_EPIDERMIS_DN 508354All SZGR genes in this pathway
SUZUKI_AMPLIFIED_IN_ORAL_CANCER 1612All SZGR genes in this pathway
FARMER_BREAST_CANCER_APOCRINE_VS_LUMINAL 326213All SZGR genes in this pathway
SNIJDERS_AMPLIFIED_IN_HEAD_AND_NECK_TUMORS 3727All SZGR genes in this pathway
DACOSTA_UV_RESPONSE_VIA_ERCC3_DN 855609All SZGR genes in this pathway
DACOSTA_UV_RESPONSE_VIA_ERCC3_COMMON_DN 483336All SZGR genes in this pathway
PASQUALUCCI_LYMPHOMA_BY_GC_STAGE_UP 283177All SZGR genes in this pathway
BENPORATH_NANOG_TARGETS 988594All SZGR genes in this pathway
BYSTRYKH_HEMATOPOIESIS_STEM_CELL_QTL_TRANS 882572All SZGR genes in this pathway
DEBIASI_APOPTOSIS_BY_REOVIRUS_INFECTION_UP 314201All SZGR genes in this pathway
RAMALHO_STEMNESS_UP 206118All SZGR genes in this pathway
JIANG_HYPOXIA_NORMAL 311205All SZGR genes in this pathway
MONNIER_POSTRADIATION_TUMOR_ESCAPE_UP 393244All SZGR genes in this pathway
ACEVEDO_NORMAL_TISSUE_ADJACENT_TO_LIVER_TUMOR_UP 17496All SZGR genes in this pathway
ACEVEDO_LIVER_CANCER_WITH_H3K27ME3_DN 228114All SZGR genes in this pathway
GRADE_COLON_CANCER_UP 871505All SZGR genes in this pathway
CHIANG_LIVER_CANCER_SUBCLASS_UNANNOTATED_DN 193112All SZGR genes in this pathway
WONG_EMBRYONIC_STEM_CELL_CORE 335193All SZGR genes in this pathway
VERHAAK_GLIOBLASTOMA_MESENCHYMAL 216130All SZGR genes in this pathway
JOHNSTONE_PARVB_TARGETS_3_DN 918550All SZGR genes in this pathway
KOINUMA_TARGETS_OF_SMAD2_OR_SMAD3 824528All SZGR genes in this pathway
WAKABAYASHI_ADIPOGENESIS_PPARG_RXRA_BOUND_8D 882506All SZGR genes in this pathway
DELACROIX_RARG_BOUND_MEF 367231All SZGR genes in this pathway
RAO_BOUND_BY_SALL4_ISOFORM_B 517302All SZGR genes in this pathway
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-129-5p199319991Ahsa-miR-129brainCUUUUUGCGGUCUGGGCUUGC
hsa-miR-129-5pCUUUUUGCGGUCUGGGCUUGCU
miR-21171417211A,m8hsa-miR-21brainUAGCUUAUCAGACUGAUGUUGA
hsa-miR-590GAGCUUAUUCAUAAAAGUGCAG
miR-299-3p6526581Ahsa-miR-299-3pUAUGUGGGAUGGUAAACCGCUU
miR-299-5p277627821Ahsa-miR-299-5pUGGUUUACCGUCCCACAUACAU
miR-375168316891Ahsa-miR-375UUUGUUCGUUCGGCUCGCGUGA
miR-9166316691Ahsa-miR-9SZUCUUUGGUUAUCUAGCUGUAUGA
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


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