Gene Page: MERTK

Summary
GeneID  10461
Symbol  MERTK
Synonyms  MER|MGC133349|RP38|c-mer
Description  c-mer proto-oncogene tyrosine kinase
See related  HGNC:7027|MIM:604705|Ensembl:ENSG00000153208|HPRD:05269|
Locus tag  -
Gene type  protein-coding
Map location  2q14.1
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
GSMA_Igenome scan meta-analysisPsr: 0.0004 
GSMA_IIAgenome scan meta-analysis (All samples)Psr: 0.00755 
GO_AnnotationMapping neuro-related keywords to Gene Ontology annotationsHits with neuro-related keywords: 1 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
MBD30.810.80
USF20.770.75
STK110.730.71
NUBP20.730.73
DBNL0.720.70
TSSC40.720.71
MRPS260.710.70
ZNF7870.710.69
E4F10.710.66
C19orf520.710.65
Top 10 negatively co-expressed genes
AF347015.27-0.49-0.47
MT-CYB-0.46-0.46
AF347015.33-0.46-0.44
AF347015.31-0.45-0.44
AF347015.8-0.45-0.45
AF347015.15-0.45-0.45
MT-CO2-0.44-0.42
AL139819.3-0.44-0.47
AF347015.21-0.43-0.44
MT-ATP8-0.42-0.47
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0004714transmembrane receptor protein tyrosine kinase activityTASneurite (GO term level: 8)8086340 
GO:0000166nucleotide bindingIEA-
GO:0004872receptor activityIEA-
GO:0005524ATP bindingIEA-
GO:0016740transferase activityIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0006468protein amino acid phosphorylationTAS8086340 
GO:0007267cell-cell signalingTAS8086340 
GO:0007166cell surface receptor linked signal transductionTAS8086340 
GO:0007601visual perceptionIEA-
GO:0050896response to stimulusIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005625soluble fractionTAS8086340 
GO:0016020membraneIEA-
GO:0005887integral to plasma membraneTAS8086340 
 
InteractionsShown by Network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
GAS6AXLLG | AXSF | DKFZp666G247 | FLJ34709growth arrest-specific 6-HPRD,BioGRID8939948 
GRB2ASH | EGFRBP-GRB2 | Grb3-3 | MST084 | MSTP084growth factor receptor-bound protein 2-HPRD9891051 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
REACTOME_CELL_SURFACE_INTERACTIONS_AT_THE_VASCULAR_WALL 9165All SZGR genes in this pathway
REACTOME_HEMOSTASIS 466331All SZGR genes in this pathway
SCHUETZ_BREAST_CANCER_DUCTAL_INVASIVE_UP 351230All SZGR genes in this pathway
DEURIG_T_CELL_PROLYMPHOCYTIC_LEUKEMIA_UP 368234All SZGR genes in this pathway
WANG_CLIM2_TARGETS_UP 269146All SZGR genes in this pathway
JAEGER_METASTASIS_UP 4423All SZGR genes in this pathway
GARGALOVIC_RESPONSE_TO_OXIDIZED_PHOSPHOLIPIDS_TURQUOISE_UP 7950All SZGR genes in this pathway
PEREZ_TP53_TARGETS 1174695All SZGR genes in this pathway
KOBAYASHI_RESPONSE_TO_ROMIDEPSIN 1914All SZGR genes in this pathway
GROSS_HYPOXIA_VIA_HIF1A_DN 11078All SZGR genes in this pathway
GROSS_HYPOXIA_VIA_ELK3_AND_HIF1A_UP 142104All SZGR genes in this pathway
TARTE_PLASMA_CELL_VS_PLASMABLAST_UP 398262All SZGR genes in this pathway
NELSON_RESPONSE_TO_ANDROGEN_UP 8661All SZGR genes in this pathway
SANSOM_APC_TARGETS_DN 366238All SZGR genes in this pathway
MATSUDA_NATURAL_KILLER_DIFFERENTIATION 475313All SZGR genes in this pathway
HESS_TARGETS_OF_HOXA9_AND_MEIS1_DN 7748All SZGR genes in this pathway
LI_WILMS_TUMOR_VS_FETAL_KIDNEY_1_UP 182119All SZGR genes in this pathway
CUI_TCF21_TARGETS_2_DN 830547All SZGR genes in this pathway
LEE_AGING_CEREBELLUM_DN 8666All SZGR genes in this pathway
CUI_TCF21_TARGETS_DN 3123All SZGR genes in this pathway
KAYO_AGING_MUSCLE_DN 12376All SZGR genes in this pathway
XU_GH1_AUTOCRINE_TARGETS_UP 268157All SZGR genes in this pathway
BROWNE_HCMV_INFECTION_24HR_UP 14896All SZGR genes in this pathway
MAHAJAN_RESPONSE_TO_IL1A_UP 8152All SZGR genes in this pathway
BONOME_OVARIAN_CANCER_SURVIVAL_SUBOPTIMAL_DEBULKING 510309All SZGR genes in this pathway
ZHENG_GLIOBLASTOMA_PLASTICITY_DN 5839All SZGR genes in this pathway
BOCHKIS_FOXA2_TARGETS 425261All SZGR genes in this pathway
FIRESTEIN_PROLIFERATION 175125All SZGR genes in this pathway
DAVIES_MULTIPLE_MYELOMA_VS_MGUS_DN 2818All SZGR genes in this pathway
PARK_TRETINOIN_RESPONSE 128All SZGR genes in this pathway
TAVAZOIE_METASTASIS 10868All SZGR genes in this pathway
BOYAULT_LIVER_CANCER_SUBCLASS_G6_UP 6543All SZGR genes in this pathway
CHIANG_LIVER_CANCER_SUBCLASS_CTNNB1_UP 176110All SZGR genes in this pathway
YAMASHITA_LIVER_CANCER_STEM_CELL_UP 4738All SZGR genes in this pathway
YANG_BCL3_TARGETS_UP 364236All SZGR genes in this pathway
BOSCO_TH1_CYTOTOXIC_MODULE 11462All SZGR genes in this pathway
LIM_MAMMARY_LUMINAL_MATURE_DN 9974All SZGR genes in this pathway


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