SZGR2

Summary ?

GeneID	10659
Symbol	CELF2
Synonyms	BRUNOL3\|CUGBP2\|ETR-3\|ETR3\|NAPOR
Description	CUGBP, Elav-like family member 2
Reference	MIM:602538\|HGNC:HGNC:2550\|Ensembl:ENSG00000048740\|HPRD:03964\|Vega:OTTHUMG00000017668
Gene type	protein-coding
Map location	10p13
Pascal p-value	0.002
Sherlock p-value	0.617
TADA p-value	0.001
Fetal beta	1.193
eGene	Myers' cis & trans
Support	CompositeSet

Gene in Data Sources

Gene set name	Method of gene set	Description	Info
CV:PGCnp	Genome-wide Association Study	GWAS
DNM:Xu_2012	Whole Exome Sequencing analysis	De novo mutations of 4 genes were identified by exome sequencing of 795 samples in this study

Section I. Genetics and epigenetics annotation

DNM table

Gene	Chromosome	Position	Ref	Alt	Transcript	AA change	Mutation type	Sift	CG46	Trait	Study
CELF2	chr10	11356223	T	N	NM_001025076 NM_001025076 NM_001025077 NM_001025077 NM_001083591 NM_006561 NM_006561	. . . . p.335G>? . .	intronic splice-donor-in2 intronic splice-donor-in2 exonic-unknown intronic splice-donor-in2			Schizophrenia	DNM:Xu_2012

eQTL annotation

SNP ID	Chromosome	Position	eGene	Gene Entrez ID	pvalue	qvalue	TSS distance	eQTL type
rs10508433	chr10	11869520	CELF2	10659		0.06		cis
rs10868543	chr9	89852686	CELF2	10659		0.15		trans

Section II. Transcriptome annotation

General gene expression (GTEx)

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
Gene	Pearson's Correlation	Spearman's Correlation
GFOD2	0.87	0.88
DGCR14	0.87	0.90
CARM1	0.87	0.90
CTBP1	0.87	0.89
RAB11B	0.87	0.89
RAB35	0.86	0.89
BAT3	0.86	0.89
PRCC	0.86	0.89
G6PD	0.86	0.89
C7orf26	0.86	0.90

Top 10 negatively co-expressed genes
Gene	Pearson's Correlation	Spearman's Correlation
MT-CO2	-0.77	-0.84
AF347015.31	-0.77	-0.83
MT-CYB	-0.74	-0.81
AF347015.33	-0.73	-0.80
AF347015.8	-0.73	-0.82
AF347015.27	-0.72	-0.81
AF347015.21	-0.70	-0.83
NOSTRIN	-0.70	-0.79
AF347015.2	-0.69	-0.79
AF347015.15	-0.69	-0.79

Section III. Gene Ontology annotation

Molecular function	GO term	Evidence	Neuro keywords	PubMed ID
GO:0000166	nucleotide binding	IEA		-
GO:0003723	RNA binding	TAS		9887331
Biological process	GO term	Evidence	Neuro keywords	PubMed ID
GO:0006397	mRNA processing	IEA		-
GO:0008016	regulation of heart contraction	TAS		9887331
Cellular component	GO term	Evidence	Neuro keywords	PubMed ID
GO:0005634	nucleus	IEA		-
GO:0005737	cytoplasm	IEA		-

Section V. Pathway annotation

Pathway name	Pathway size	# SZGR 2.0 genes in pathway	Info
WINTER HYPOXIA DN	52	30	All SZGR 2.0 genes in this pathway
LU TUMOR VASCULATURE DN	13	6	All SZGR 2.0 genes in this pathway
ONKEN UVEAL MELANOMA UP	783	507	All SZGR 2.0 genes in this pathway
SCHUETZ BREAST CANCER DUCTAL INVASIVE UP	351	230	All SZGR 2.0 genes in this pathway
TURASHVILI BREAST NORMAL DUCTAL VS LOBULAR UP	68	40	All SZGR 2.0 genes in this pathway
THUM SYSTOLIC HEART FAILURE DN	244	147	All SZGR 2.0 genes in this pathway
OSMAN BLADDER CANCER DN	406	230	All SZGR 2.0 genes in this pathway
SENESE HDAC1 AND HDAC2 TARGETS DN	232	139	All SZGR 2.0 genes in this pathway
WAMUNYOKOLI OVARIAN CANCER LMP DN	199	124	All SZGR 2.0 genes in this pathway
WAMUNYOKOLI OVARIAN CANCER GRADES 1 2 DN	67	43	All SZGR 2.0 genes in this pathway
LINDGREN BLADDER CANCER CLUSTER 2A DN	141	84	All SZGR 2.0 genes in this pathway
BERENJENO TRANSFORMED BY RHOA DN	394	258	All SZGR 2.0 genes in this pathway
HAMAI APOPTOSIS VIA TRAIL UP	584	356	All SZGR 2.0 genes in this pathway
PEREZ TP53 TARGETS	1174	695	All SZGR 2.0 genes in this pathway
PEREZ TP63 TARGETS	355	243	All SZGR 2.0 genes in this pathway
PEREZ TP53 AND TP63 TARGETS	205	145	All SZGR 2.0 genes in this pathway
LINDGREN BLADDER CANCER CLUSTER 2B	392	251	All SZGR 2.0 genes in this pathway
DAIRKEE TERT TARGETS DN	124	79	All SZGR 2.0 genes in this pathway
GRUETZMANN PANCREATIC CANCER UP	358	245	All SZGR 2.0 genes in this pathway
JAZAG TGFB1 SIGNALING UP	108	69	All SZGR 2.0 genes in this pathway
JAZAG TGFB1 SIGNALING VIA SMAD4 UP	108	66	All SZGR 2.0 genes in this pathway
SHETH LIVER CANCER VS TXNIP LOSS PAM4	261	153	All SZGR 2.0 genes in this pathway
PASQUALUCCI LYMPHOMA BY GC STAGE DN	165	104	All SZGR 2.0 genes in this pathway
BENPORATH NANOG TARGETS	988	594	All SZGR 2.0 genes in this pathway
KENNY CTNNB1 TARGETS UP	50	30	All SZGR 2.0 genes in this pathway
PARK HSC VS MULTIPOTENT PROGENITORS UP	19	14	All SZGR 2.0 genes in this pathway
FLECHNER BIOPSY KIDNEY TRANSPLANT REJECTED VS OK UP	87	58	All SZGR 2.0 genes in this pathway
ASTON MAJOR DEPRESSIVE DISORDER UP	49	36	All SZGR 2.0 genes in this pathway
MANALO HYPOXIA UP	207	145	All SZGR 2.0 genes in this pathway
THEILGAARD NEUTROPHIL AT SKIN WOUND DN	225	163	All SZGR 2.0 genes in this pathway
REN ALVEOLAR RHABDOMYOSARCOMA UP	98	64	All SZGR 2.0 genes in this pathway
CUI TCF21 TARGETS 2 DN	830	547	All SZGR 2.0 genes in this pathway
MCCLUNG COCAINE REWARD 5D	79	62	All SZGR 2.0 genes in this pathway
LINDVALL IMMORTALIZED BY TERT DN	80	56	All SZGR 2.0 genes in this pathway
BROWNE HCMV INFECTION 48HR DN	504	323	All SZGR 2.0 genes in this pathway
RODWELL AGING KIDNEY UP	487	303	All SZGR 2.0 genes in this pathway
KRASNOSELSKAYA ILF3 TARGETS DN	46	38	All SZGR 2.0 genes in this pathway
ZHENG BOUND BY FOXP3	491	310	All SZGR 2.0 genes in this pathway
ZHENG FOXP3 TARGETS IN THYMUS UP	196	137	All SZGR 2.0 genes in this pathway
HELLER HDAC TARGETS DN	292	189	All SZGR 2.0 genes in this pathway
HELLER HDAC TARGETS SILENCED BY METHYLATION DN	281	179	All SZGR 2.0 genes in this pathway
MARTINEZ RB1 TARGETS UP	673	430	All SZGR 2.0 genes in this pathway
MARTINEZ TP53 TARGETS UP	602	364	All SZGR 2.0 genes in this pathway
MARTINEZ RB1 AND TP53 TARGETS UP	601	369	All SZGR 2.0 genes in this pathway
WALLACE PROSTATE CANCER RACE UP	299	167	All SZGR 2.0 genes in this pathway
SMID BREAST CANCER NORMAL LIKE UP	476	285	All SZGR 2.0 genes in this pathway
IZADPANAH STEM CELL ADIPOSE VS BONE DN	108	68	All SZGR 2.0 genes in this pathway
BOQUEST STEM CELL UP	260	174	All SZGR 2.0 genes in this pathway
BOQUEST STEM CELL CULTURED VS FRESH UP	425	298	All SZGR 2.0 genes in this pathway
WANG TUMOR INVASIVENESS DN	210	128	All SZGR 2.0 genes in this pathway
RUTELLA RESPONSE TO CSF2RB AND IL4 UP	338	225	All SZGR 2.0 genes in this pathway
RUTELLA RESPONSE TO HGF DN	235	144	All SZGR 2.0 genes in this pathway
RUTELLA RESPONSE TO HGF VS CSF2RB AND IL4 DN	245	150	All SZGR 2.0 genes in this pathway
LEE DIFFERENTIATING T LYMPHOCYTE	200	115	All SZGR 2.0 genes in this pathway
COLINA TARGETS OF 4EBP1 AND 4EBP2	356	214	All SZGR 2.0 genes in this pathway
MILI PSEUDOPODIA HAPTOTAXIS UP	518	299	All SZGR 2.0 genes in this pathway
BOYAULT LIVER CANCER SUBCLASS G5 DN	27	17	All SZGR 2.0 genes in this pathway
MARSON FOXP3 TARGETS UP	66	43	All SZGR 2.0 genes in this pathway
HOSHIDA LIVER CANCER SUBCLASS S1	237	159	All SZGR 2.0 genes in this pathway
KARLSSON TGFB1 TARGETS DN	207	139	All SZGR 2.0 genes in this pathway
MARTENS BOUND BY PML RARA FUSION	456	287	All SZGR 2.0 genes in this pathway
GREGORY SYNTHETIC LETHAL WITH IMATINIB	145	83	All SZGR 2.0 genes in this pathway
PANGAS TUMOR SUPPRESSION BY SMAD1 AND SMAD5 UP	134	85	All SZGR 2.0 genes in this pathway
CHYLA CBFA2T3 TARGETS UP	387	225	All SZGR 2.0 genes in this pathway
PILON KLF1 TARGETS DN	1972	1213	All SZGR 2.0 genes in this pathway
LEE BMP2 TARGETS UP	745	475	All SZGR 2.0 genes in this pathway
TORCHIA TARGETS OF EWSR1 FLI1 FUSION DN	321	200	All SZGR 2.0 genes in this pathway
IKEDA MIR30 TARGETS UP	116	87	All SZGR 2.0 genes in this pathway
PLASARI TGFB1 TARGETS 10HR DN	244	157	All SZGR 2.0 genes in this pathway
PLASARI TGFB1 SIGNALING VIA NFIC 10HR DN	30	25	All SZGR 2.0 genes in this pathway
RATTENBACHER BOUND BY CELF1	467	251	All SZGR 2.0 genes in this pathway

Section VI. microRNA annotation

miRNA family	Target position			miRNA ID	miRNA seq
miRNA family	UTR start	UTR end	Match method	miRNA ID	miRNA seq
miR-10	717	723	m8	hsa-miR-10a	UACCCUGUAGAUCCGAAUUUGUG
miR-10	717	723	m8	hsa-miR-10b	UACCCUGUAGAACCGAAUUUGU
miR-101	2121	2127	1A	hsa-miR-101	UACAGUACUGUGAUAACUGAAG
miR-103/107	1612	1618	1A	hsa-miR-103^brain	AGCAGCAUUGUACAGGGCUAUGA
miR-103/107	1612	1618	1A	hsa-miR-107^brain	AGCAGCAUUGUACAGGGCUAUCA
miR-129-5p	2250	2256	1A	hsa-miR-129^brain	CUUUUUGCGGUCUGGGCUUGC
				hsa-miR-129-5p	CUUUUUGCGGUCUGGGCUUGCU
				hsa-miR-129^brain	CUUUUUGCGGUCUGGGCUUGC
				hsa-miR-129-5p	CUUUUUGCGGUCUGGGCUUGCU
				hsa-miR-129^brain	CUUUUUGCGGUCUGGGCUUGC
				hsa-miR-129-5p	CUUUUUGCGGUCUGGGCUUGCU
miR-132/212	7206	7212	m8	hsa-miR-212^SZ	UAACAGUCUCCAGUCACGGCC
miR-132/212	7206	7212	m8	hsa-miR-132^brain	UAACAGUCUACAGCCAUGGUCG
miR-134	5102	5108	m8	hsa-miR-134^brain	UGUGACUGGUUGACCAGAGGG
miR-137	1769	1775	1A	hsa-miR-137	UAUUGCUUAAGAAUACGCGUAG
miR-142-3p	550	556	1A	hsa-miR-142-3p	UGUAGUGUUUCCUACUUUAUGGA
miR-144	2121	2127	1A	hsa-miR-144	UACAGUAUAGAUGAUGUACUAG
miR-144	2121	2127	1A	hsa-miR-144	UACAGUAUAGAUGAUGUACUAG
miR-145	1147	1153	m8	hsa-miR-145	GUCCAGUUUUCCCAGGAAUCCCUU
miR-146	942	948	m8	hsa-miR-146a	UGAGAACUGAAUUCCAUGGGUU
miR-146	942	948	m8	hsa-miR-146b^brain	UGAGAACUGAAUUCCAUAGGCU
miR-153	7370	7376	m8	hsa-miR-153	UUGCAUAGUCACAAAAGUGA
miR-155	5006	5012	m8	hsa-miR-155	UUAAUGCUAAUCGUGAUAGGGG
miR-17-5p/20/93.mr/106/519.d	5106	5112	1A	hsa-miR-17-5p	CAAAGUGCUUACAGUGCAGGUAGU
				hsa-miR-20a^brain	UAAAGUGCUUAUAGUGCAGGUAG
				hsa-miR-106a	AAAAGUGCUUACAGUGCAGGUAGC
				hsa-miR-106b^SZ	UAAAGUGCUGACAGUGCAGAU
				hsa-miR-20b^SZ	CAAAGUGCUCAUAGUGCAGGUAG
				hsa-miR-519d	CAAAGUGCCUCCCUUUAGAGUGU
miR-182	2442	2448	1A	hsa-miR-182	UUUGGCAAUGGUAGAACUCACA
miR-183	3480	3487	1A,m8	hsa-miR-183	UAUGGCACUGGUAGAAUUCACUG
miR-196	2014	2020	1A	hsa-miR-196a	UAGGUAGUUUCAUGUUGUUGG
miR-196	2014	2020	1A	hsa-miR-196b	UAGGUAGUUUCCUGUUGUUGG
miR-199	628	634	m8	hsa-miR-199a	CCCAGUGUUCAGACUACCUGUUC
miR-199	628	634	m8	hsa-miR-199b	CCCAGUGUUUAGACUAUCUGUUC
miR-200bc/429	1724	1730	1A	hsa-miR-200b	UAAUACUGCCUGGUAAUGAUGAC
				hsa-miR-200c	UAAUACUGCCGGGUAAUGAUGG
				hsa-miR-429	UAAUACUGUCUGGUAAAACCGU
miR-208	5020	5026	1A	hsa-miR-208	AUAAGACGAGCAAAAAGCUUGU
miR-208	5020	5026	1A	hsa-miR-208	AUAAGACGAGCAAAAAGCUUGU
miR-214	3461	3467	m8	hsa-miR-214^brain	ACAGCAGGCACAGACAGGCAG
miR-216	4832	4838	1A	hsa-miR-216	UAAUCUCAGCUGGCAACUGUG
miR-219	7177	7183	1A	hsa-miR-219^brain	UGAUUGUCCAAACGCAAUUCU
miR-219	7177	7183	1A	hsa-miR-219^brain	UGAUUGUCCAAACGCAAUUCU
miR-23	1598	1605	1A,m8	hsa-miR-23a^brain	AUCACAUUGCCAGGGAUUUCC
				hsa-miR-23b^brain	AUCACAUUGCCAGGGAUUACC
				hsa-miR-23a^brain	AUCACAUUGCCAGGGAUUUCC
				hsa-miR-23b^brain	AUCACAUUGCCAGGGAUUACC
				hsa-miR-23a^brain	AUCACAUUGCCAGGGAUUUCC
				hsa-miR-23b^brain	AUCACAUUGCCAGGGAUUACC
miR-24	4746	4752	1A	hsa-miR-24^SZ	UGGCUCAGUUCAGCAGGAACAG
miR-26	1717	1723	1A	hsa-miR-26a^brain	UUCAAGUAAUCCAGGAUAGGC
				hsa-miR-26b^SZ	UUCAAGUAAUUCAGGAUAGGUU
				hsa-miR-26a^brain	UUCAAGUAAUCCAGGAUAGGC
				hsa-miR-26b^SZ	UUCAAGUAAUUCAGGAUAGGUU
miR-299-5p	5288	5294	1A	hsa-miR-299-5p	UGGUUUACCGUCCCACAUACAU
miR-30-3p	1629	1635	m8	hsa-miR-30a-3p	CUUUCAGUCGGAUGUUUGCAGC
miR-30-3p	1629	1635	m8	hsa-miR-30e-3p	CUUUCAGUCGGAUGUUUACAGC
miR-30-5p	3776	3782	m8	hsa-miR-30a-5p	UGUAAACAUCCUCGACUGGAAG
				hsa-miR-30c^brain	UGUAAACAUCCUACACUCUCAGC
				hsa-miR-30d^SZ	UGUAAACAUCCCCGACUGGAAG
				hsa-miR-30b^SZ	UGUAAACAUCCUACACUCAGCU
				hsa-miR-30e-5p	UGUAAACAUCCUUGACUGGA
miR-323	1598	1604	1A	hsa-miR-323^brain	GCACAUUACACGGUCGACCUCU
				hsa-miR-323^brain	GCACAUUACACGGUCGACCUCU
				hsa-miR-323^brain	GCACAUUACACGGUCGACCUCU
miR-324-3p	1891	1897	m8	hsa-miR-324-3p	CCACUGCCCCAGGUGCUGCUGG
miR-326	2802	2808	m8	hsa-miR-326	CCUCUGGGCCCUUCCUCCAG
miR-33	1262	1268	1A	hsa-miR-33	GUGCAUUGUAGUUGCAUUG
				hsa-miR-33b	GUGCAUUGCUGUUGCAUUGCA
				hsa-miR-33	GUGCAUUGUAGUUGCAUUG
				hsa-miR-33b	GUGCAUUGCUGUUGCAUUGCA
miR-339	4300	4306	1A	hsa-miR-339	UCCCUGUCCUCCAGGAGCUCA
miR-339	4300	4306	1A	hsa-miR-339	UCCCUGUCCUCCAGGAGCUCA
miR-34/449	417	423	m8	hsa-miR-34a^brain	UGGCAGUGUCUUAGCUGGUUGUU
				hsa-miR-34c	AGGCAGUGUAGUUAGCUGAUUGC
				hsa-miR-449	UGGCAGUGUAUUGUUAGCUGGU
				hsa-miR-449b	AGGCAGUGUAUUGUUAGCUGGC
miR-340	116	122	m8	hsa-miR-340	UCCGUCUCAGUUACUUUAUAGCC
miR-342	2489	2495	1A	hsa-miR-342^brain	UCUCACACAGAAAUCGCACCCGUC
miR-34b	878	884	m8	hsa-miR-34b	UAGGCAGUGUCAUUAGCUGAUUG
miR-34b	878	884	m8	hsa-miR-34b	UAGGCAGUGUCAUUAGCUGAUUG
miR-361	7148	7154	1A	hsa-miR-361^brain	UUAUCAGAAUCUCCAGGGGUAC
miR-376	1579	1585	1A	hsa-miR-376a	AUCAUAGAGGAAAAUCCACGU
miR-376	1579	1585	1A	hsa-miR-376b	AUCAUAGAGGAAAAUCCAUGUU
miR-377	5253	5259	m8	hsa-miR-377	AUCACACAAAGGCAACUUUUGU
miR-378	7197	7203	1A	hsa-miR-378	CUCCUGACUCCAGGUCCUGUGU
miR-378	7197	7203	1A	hsa-miR-378	CUCCUGACUCCAGGUCCUGUGU
miR-381	2531	2537	1A	hsa-miR-381	UAUACAAGGGCAAGCUCUCUGU
miR-381	2531	2537	1A	hsa-miR-381	UAUACAAGGGCAAGCUCUCUGU
miR-384	992	998	m8	hsa-miR-384	AUUCCUAGAAAUUGUUCAUA
miR-410	7409	7415	1A	hsa-miR-410	AAUAUAACACAGAUGGCCUGU
miR-411	5207	5214	1A,m8	hsa-miR-411	AACACGGUCCACUAACCCUCAGU
miR-431	1624	1630	m8	hsa-miR-431	UGUCUUGCAGGCCGUCAUGCA
miR-433-5p	1010	1016	m8	hsa-miR-433-5p	UACGGUGAGCCUGUCAUUAUUC
miR-450	3689	3695	1A	hsa-miR-450	UUUUUGCGAUGUGUUCCUAAUA
miR-451	119	125	1A	hsa-miR-451^brain	AAACCGUUACCAUUACUGAGUUU
miR-452	359	365	1A	hsa-miR-452	UGUUUGCAGAGGAAACUGAGAC
miR-486	2106	2113	1A,m8	hsa-miR-486	UCCUGUACUGAGCUGCCCCGAG
miR-493-5p	2104	2110	m8	hsa-miR-493-5p	UUGUACAUGGUAGGCUUUCAUU
miR-494	754	760	m8	hsa-miR-494^brain	UGAAACAUACACGGGAAACCUCUU
miR-495	643	649	1A	hsa-miR-495^brain	AAACAAACAUGGUGCACUUCUUU
miR-495	643	649	1A	hsa-miR-495^brain	AAACAAACAUGGUGCACUUCUUU
miR-499	5020	5026	1A	hsa-miR-499	UUAAGACUUGCAGUGAUGUUUAA
miR-499	5020	5026	1A	hsa-miR-499	UUAAGACUUGCAGUGAUGUUUAA
miR-539	1934	1940	1A	hsa-miR-539	GGAGAAAUUAUCCUUGGUGUGU
miR-539	1934	1940	1A	hsa-miR-539	GGAGAAAUUAUCCUUGGUGUGU
miR-543	1792	1798	m8	hsa-miR-543	AAACAUUCGCGGUGCACUUCU
miR-93.hd/291-3p/294/295/302/372/373/520	523	530	1A,m8	hsa-miR-93^brain	AAAGUGCUGUUCGUGCAGGUAG
				hsa-miR-302a	UAAGUGCUUCCAUGUUUUGGUGA
				hsa-miR-302b	UAAGUGCUUCCAUGUUUUAGUAG
				hsa-miR-302c	UAAGUGCUUCCAUGUUUCAGUGG
				hsa-miR-302d	UAAGUGCUUCCAUGUUUGAGUGU
				hsa-miR-372	AAAGUGCUGCGACAUUUGAGCGU
				hsa-miR-373	GAAGUGCUUCGAUUUUGGGGUGU
				hsa-miR-520e	AAAGUGCUUCCUUUUUGAGGG
				hsa-miR-520a	AAAGUGCUUCCCUUUGGACUGU
				hsa-miR-520b	AAAGUGCUUCCUUUUAGAGGG
				hsa-miR-520c	AAAGUGCUUCCUUUUAGAGGGUU
				hsa-miR-520d	AAAGUGCUUCUCUUUGGUGGGUU
miR-96	2441	2448	1A,m8	hsa-miR-96^brain	UUUGGCACUAGCACAUUUUUGC

SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.

Gene Page: CELF2