Summary ?
GeneID10659
SymbolCELF2
SynonymsBRUNOL3|CUGBP2|ETR-3|ETR3|NAPOR
DescriptionCUGBP, Elav-like family member 2
ReferenceMIM:602538|HGNC:HGNC:2550|Ensembl:ENSG00000048740|HPRD:03964|Vega:OTTHUMG00000017668
Gene typeprotein-coding
Map location10p13
Pascal p-value0.002
Sherlock p-value0.617
TADA p-value0.001
Fetal beta1.193
eGeneMyers' cis & trans
SupportCompositeSet

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
CV:PGCnpGenome-wide Association StudyGWAS
DNM:Xu_2012Whole Exome Sequencing analysisDe novo mutations of 4 genes were identified by exome sequencing of 795 samples in this study

Section I. Genetics and epigenetics annotation

@DNM table

GeneChromosomePositionRefAltTranscriptAA changeMutation typeSiftCG46TraitStudy
CELF2chr1011356223TNNM_001025076
NM_001025076
NM_001025077
NM_001025077
NM_001083591
NM_006561
NM_006561
.
.
.
.
p.335G>?
.
.
intronic
splice-donor-in2
intronic
splice-donor-in2
exonic-unknown
intronic
splice-donor-in2
SchizophreniaDNM:Xu_2012

@eQTL annotation

SNP IDChromosomePositioneGeneGene Entrez IDpvalueqvalueTSS distanceeQTL type
rs10508433chr1011869520CELF2106590.06cis
rs10868543chr989852686CELF2106590.15trans

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
GenePearson's Correlation Spearman's Correlation
GFOD20.870.88
DGCR140.870.90
CARM10.870.90
CTBP10.870.89
RAB11B0.870.89
RAB350.860.89
BAT30.860.89
PRCC0.860.89
G6PD0.860.89
C7orf260.860.90
Top 10 negatively co-expressed genes
GenePearson's Correlation Spearman's Correlation
MT-CO2-0.77-0.84
AF347015.31-0.77-0.83
MT-CYB-0.74-0.81
AF347015.33-0.73-0.80
AF347015.8-0.73-0.82
AF347015.27-0.72-0.81
AF347015.21-0.70-0.83
NOSTRIN-0.70-0.79
AF347015.2-0.69-0.79
AF347015.15-0.69-0.79

Section III. Gene Ontology annotation

Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0000166nucleotide bindingIEA-
GO:0003723RNA bindingTAS9887331 
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0006397mRNA processingIEA-
GO:0008016regulation of heart contractionTAS9887331 
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005634nucleusIEA-
GO:0005737cytoplasmIEA-

Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
WINTER HYPOXIA DN 5230All SZGR 2.0 genes in this pathway
LU TUMOR VASCULATURE DN 136All SZGR 2.0 genes in this pathway
ONKEN UVEAL MELANOMA UP 783507All SZGR 2.0 genes in this pathway
SCHUETZ BREAST CANCER DUCTAL INVASIVE UP 351230All SZGR 2.0 genes in this pathway
TURASHVILI BREAST NORMAL DUCTAL VS LOBULAR UP 6840All SZGR 2.0 genes in this pathway
THUM SYSTOLIC HEART FAILURE DN 244147All SZGR 2.0 genes in this pathway
OSMAN BLADDER CANCER DN 406230All SZGR 2.0 genes in this pathway
SENESE HDAC1 AND HDAC2 TARGETS DN 232139All SZGR 2.0 genes in this pathway
WAMUNYOKOLI OVARIAN CANCER LMP DN 199124All SZGR 2.0 genes in this pathway
WAMUNYOKOLI OVARIAN CANCER GRADES 1 2 DN 6743All SZGR 2.0 genes in this pathway
LINDGREN BLADDER CANCER CLUSTER 2A DN 14184All SZGR 2.0 genes in this pathway
BERENJENO TRANSFORMED BY RHOA DN 394258All SZGR 2.0 genes in this pathway
HAMAI APOPTOSIS VIA TRAIL UP 584356All SZGR 2.0 genes in this pathway
PEREZ TP53 TARGETS 1174695All SZGR 2.0 genes in this pathway
PEREZ TP63 TARGETS 355243All SZGR 2.0 genes in this pathway
PEREZ TP53 AND TP63 TARGETS 205145All SZGR 2.0 genes in this pathway
LINDGREN BLADDER CANCER CLUSTER 2B 392251All SZGR 2.0 genes in this pathway
DAIRKEE TERT TARGETS DN 12479All SZGR 2.0 genes in this pathway
GRUETZMANN PANCREATIC CANCER UP 358245All SZGR 2.0 genes in this pathway
JAZAG TGFB1 SIGNALING UP 10869All SZGR 2.0 genes in this pathway
JAZAG TGFB1 SIGNALING VIA SMAD4 UP 10866All SZGR 2.0 genes in this pathway
SHETH LIVER CANCER VS TXNIP LOSS PAM4 261153All SZGR 2.0 genes in this pathway
PASQUALUCCI LYMPHOMA BY GC STAGE DN 165104All SZGR 2.0 genes in this pathway
BENPORATH NANOG TARGETS 988594All SZGR 2.0 genes in this pathway
KENNY CTNNB1 TARGETS UP 5030All SZGR 2.0 genes in this pathway
PARK HSC VS MULTIPOTENT PROGENITORS UP 1914All SZGR 2.0 genes in this pathway
FLECHNER BIOPSY KIDNEY TRANSPLANT REJECTED VS OK UP 8758All SZGR 2.0 genes in this pathway
ASTON MAJOR DEPRESSIVE DISORDER UP 4936All SZGR 2.0 genes in this pathway
MANALO HYPOXIA UP 207145All SZGR 2.0 genes in this pathway
THEILGAARD NEUTROPHIL AT SKIN WOUND DN 225163All SZGR 2.0 genes in this pathway
REN ALVEOLAR RHABDOMYOSARCOMA UP 9864All SZGR 2.0 genes in this pathway
CUI TCF21 TARGETS 2 DN 830547All SZGR 2.0 genes in this pathway
MCCLUNG COCAINE REWARD 5D 7962All SZGR 2.0 genes in this pathway
LINDVALL IMMORTALIZED BY TERT DN 8056All SZGR 2.0 genes in this pathway
BROWNE HCMV INFECTION 48HR DN 504323All SZGR 2.0 genes in this pathway
RODWELL AGING KIDNEY UP 487303All SZGR 2.0 genes in this pathway
KRASNOSELSKAYA ILF3 TARGETS DN 4638All SZGR 2.0 genes in this pathway
ZHENG BOUND BY FOXP3 491310All SZGR 2.0 genes in this pathway
ZHENG FOXP3 TARGETS IN THYMUS UP 196137All SZGR 2.0 genes in this pathway
HELLER HDAC TARGETS DN 292189All SZGR 2.0 genes in this pathway
HELLER HDAC TARGETS SILENCED BY METHYLATION DN 281179All SZGR 2.0 genes in this pathway
MARTINEZ RB1 TARGETS UP 673430All SZGR 2.0 genes in this pathway
MARTINEZ TP53 TARGETS UP 602364All SZGR 2.0 genes in this pathway
MARTINEZ RB1 AND TP53 TARGETS UP 601369All SZGR 2.0 genes in this pathway
WALLACE PROSTATE CANCER RACE UP 299167All SZGR 2.0 genes in this pathway
SMID BREAST CANCER NORMAL LIKE UP 476285All SZGR 2.0 genes in this pathway
IZADPANAH STEM CELL ADIPOSE VS BONE DN 10868All SZGR 2.0 genes in this pathway
BOQUEST STEM CELL UP 260174All SZGR 2.0 genes in this pathway
BOQUEST STEM CELL CULTURED VS FRESH UP 425298All SZGR 2.0 genes in this pathway
WANG TUMOR INVASIVENESS DN 210128All SZGR 2.0 genes in this pathway
RUTELLA RESPONSE TO CSF2RB AND IL4 UP 338225All SZGR 2.0 genes in this pathway
RUTELLA RESPONSE TO HGF DN 235144All SZGR 2.0 genes in this pathway
RUTELLA RESPONSE TO HGF VS CSF2RB AND IL4 DN 245150All SZGR 2.0 genes in this pathway
LEE DIFFERENTIATING T LYMPHOCYTE 200115All SZGR 2.0 genes in this pathway
COLINA TARGETS OF 4EBP1 AND 4EBP2 356214All SZGR 2.0 genes in this pathway
MILI PSEUDOPODIA HAPTOTAXIS UP 518299All SZGR 2.0 genes in this pathway
BOYAULT LIVER CANCER SUBCLASS G5 DN 2717All SZGR 2.0 genes in this pathway
MARSON FOXP3 TARGETS UP 6643All SZGR 2.0 genes in this pathway
HOSHIDA LIVER CANCER SUBCLASS S1 237159All SZGR 2.0 genes in this pathway
KARLSSON TGFB1 TARGETS DN 207139All SZGR 2.0 genes in this pathway
MARTENS BOUND BY PML RARA FUSION 456287All SZGR 2.0 genes in this pathway
GREGORY SYNTHETIC LETHAL WITH IMATINIB 14583All SZGR 2.0 genes in this pathway
PANGAS TUMOR SUPPRESSION BY SMAD1 AND SMAD5 UP 13485All SZGR 2.0 genes in this pathway
CHYLA CBFA2T3 TARGETS UP 387225All SZGR 2.0 genes in this pathway
PILON KLF1 TARGETS DN 19721213All SZGR 2.0 genes in this pathway
LEE BMP2 TARGETS UP 745475All SZGR 2.0 genes in this pathway
TORCHIA TARGETS OF EWSR1 FLI1 FUSION DN 321200All SZGR 2.0 genes in this pathway
IKEDA MIR30 TARGETS UP 11687All SZGR 2.0 genes in this pathway
PLASARI TGFB1 TARGETS 10HR DN 244157All SZGR 2.0 genes in this pathway
PLASARI TGFB1 SIGNALING VIA NFIC 10HR DN 3025All SZGR 2.0 genes in this pathway
RATTENBACHER BOUND BY CELF1 467251All SZGR 2.0 genes in this pathway

Section VI. microRNA annotation

miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-10717723m8hsa-miR-10aUACCCUGUAGAUCCGAAUUUGUG
hsa-miR-10bUACCCUGUAGAACCGAAUUUGU
miR-101212121271Ahsa-miR-101UACAGUACUGUGAUAACUGAAG
miR-103/107161216181Ahsa-miR-103brainAGCAGCAUUGUACAGGGCUAUGA
hsa-miR-107brainAGCAGCAUUGUACAGGGCUAUCA
miR-129-5p225022561Ahsa-miR-129brainCUUUUUGCGGUCUGGGCUUGC
hsa-miR-129-5pCUUUUUGCGGUCUGGGCUUGCU
hsa-miR-129brainCUUUUUGCGGUCUGGGCUUGC
hsa-miR-129-5pCUUUUUGCGGUCUGGGCUUGCU
hsa-miR-129brainCUUUUUGCGGUCUGGGCUUGC
hsa-miR-129-5pCUUUUUGCGGUCUGGGCUUGCU
miR-132/21272067212m8hsa-miR-212SZUAACAGUCUCCAGUCACGGCC
hsa-miR-132brainUAACAGUCUACAGCCAUGGUCG
miR-13451025108m8hsa-miR-134brainUGUGACUGGUUGACCAGAGGG
miR-137176917751Ahsa-miR-137UAUUGCUUAAGAAUACGCGUAG
miR-142-3p5505561Ahsa-miR-142-3pUGUAGUGUUUCCUACUUUAUGGA
miR-144212121271Ahsa-miR-144UACAGUAUAGAUGAUGUACUAG
hsa-miR-144UACAGUAUAGAUGAUGUACUAG
miR-14511471153m8hsa-miR-145GUCCAGUUUUCCCAGGAAUCCCUU
miR-146942948m8hsa-miR-146aUGAGAACUGAAUUCCAUGGGUU
hsa-miR-146bbrainUGAGAACUGAAUUCCAUAGGCU
miR-15373707376m8hsa-miR-153UUGCAUAGUCACAAAAGUGA
miR-15550065012m8hsa-miR-155UUAAUGCUAAUCGUGAUAGGGG
miR-17-5p/20/93.mr/106/519.d510651121Ahsa-miR-17-5pCAAAGUGCUUACAGUGCAGGUAGU
hsa-miR-20abrainUAAAGUGCUUAUAGUGCAGGUAG
hsa-miR-106aAAAAGUGCUUACAGUGCAGGUAGC
hsa-miR-106bSZUAAAGUGCUGACAGUGCAGAU
hsa-miR-20bSZCAAAGUGCUCAUAGUGCAGGUAG
hsa-miR-519dCAAAGUGCCUCCCUUUAGAGUGU
miR-182244224481Ahsa-miR-182UUUGGCAAUGGUAGAACUCACA
miR-183348034871A,m8hsa-miR-183UAUGGCACUGGUAGAAUUCACUG
miR-196201420201Ahsa-miR-196aUAGGUAGUUUCAUGUUGUUGG
hsa-miR-196bUAGGUAGUUUCCUGUUGUUGG
miR-199628634m8hsa-miR-199aCCCAGUGUUCAGACUACCUGUUC
hsa-miR-199bCCCAGUGUUUAGACUAUCUGUUC
miR-200bc/429172417301Ahsa-miR-200bUAAUACUGCCUGGUAAUGAUGAC
hsa-miR-200cUAAUACUGCCGGGUAAUGAUGG
hsa-miR-429UAAUACUGUCUGGUAAAACCGU
miR-208502050261Ahsa-miR-208AUAAGACGAGCAAAAAGCUUGU
hsa-miR-208AUAAGACGAGCAAAAAGCUUGU
miR-21434613467m8hsa-miR-214brainACAGCAGGCACAGACAGGCAG
miR-216483248381Ahsa-miR-216UAAUCUCAGCUGGCAACUGUG
miR-219717771831Ahsa-miR-219brainUGAUUGUCCAAACGCAAUUCU
hsa-miR-219brainUGAUUGUCCAAACGCAAUUCU
miR-23159816051A,m8hsa-miR-23abrainAUCACAUUGCCAGGGAUUUCC
hsa-miR-23bbrainAUCACAUUGCCAGGGAUUACC
hsa-miR-23abrainAUCACAUUGCCAGGGAUUUCC
hsa-miR-23bbrainAUCACAUUGCCAGGGAUUACC
hsa-miR-23abrainAUCACAUUGCCAGGGAUUUCC
hsa-miR-23bbrainAUCACAUUGCCAGGGAUUACC
miR-24474647521Ahsa-miR-24SZUGGCUCAGUUCAGCAGGAACAG
miR-26171717231Ahsa-miR-26abrainUUCAAGUAAUCCAGGAUAGGC
hsa-miR-26bSZUUCAAGUAAUUCAGGAUAGGUU
hsa-miR-26abrainUUCAAGUAAUCCAGGAUAGGC
hsa-miR-26bSZUUCAAGUAAUUCAGGAUAGGUU
miR-299-5p528852941Ahsa-miR-299-5pUGGUUUACCGUCCCACAUACAU
miR-30-3p16291635m8hsa-miR-30a-3pCUUUCAGUCGGAUGUUUGCAGC
hsa-miR-30e-3pCUUUCAGUCGGAUGUUUACAGC
miR-30-5p37763782m8hsa-miR-30a-5pUGUAAACAUCCUCGACUGGAAG
hsa-miR-30cbrainUGUAAACAUCCUACACUCUCAGC
hsa-miR-30dSZUGUAAACAUCCCCGACUGGAAG
hsa-miR-30bSZUGUAAACAUCCUACACUCAGCU
hsa-miR-30e-5pUGUAAACAUCCUUGACUGGA
miR-323159816041Ahsa-miR-323brainGCACAUUACACGGUCGACCUCU
hsa-miR-323brainGCACAUUACACGGUCGACCUCU
hsa-miR-323brainGCACAUUACACGGUCGACCUCU
miR-324-3p18911897m8hsa-miR-324-3pCCACUGCCCCAGGUGCUGCUGG
miR-32628022808m8hsa-miR-326CCUCUGGGCCCUUCCUCCAG
miR-33126212681Ahsa-miR-33GUGCAUUGUAGUUGCAUUG
hsa-miR-33bGUGCAUUGCUGUUGCAUUGCA
hsa-miR-33GUGCAUUGUAGUUGCAUUG
hsa-miR-33bGUGCAUUGCUGUUGCAUUGCA
miR-339430043061Ahsa-miR-339UCCCUGUCCUCCAGGAGCUCA
hsa-miR-339UCCCUGUCCUCCAGGAGCUCA
miR-34/449417423m8hsa-miR-34abrainUGGCAGUGUCUUAGCUGGUUGUU
hsa-miR-34cAGGCAGUGUAGUUAGCUGAUUGC
hsa-miR-449UGGCAGUGUAUUGUUAGCUGGU
hsa-miR-449bAGGCAGUGUAUUGUUAGCUGGC
miR-340116122m8hsa-miR-340UCCGUCUCAGUUACUUUAUAGCC
miR-342248924951Ahsa-miR-342brainUCUCACACAGAAAUCGCACCCGUC
miR-34b878884m8hsa-miR-34bUAGGCAGUGUCAUUAGCUGAUUG
hsa-miR-34bUAGGCAGUGUCAUUAGCUGAUUG
miR-361714871541Ahsa-miR-361brainUUAUCAGAAUCUCCAGGGGUAC
miR-376157915851Ahsa-miR-376aAUCAUAGAGGAAAAUCCACGU
hsa-miR-376bAUCAUAGAGGAAAAUCCAUGUU
miR-37752535259m8hsa-miR-377AUCACACAAAGGCAACUUUUGU
miR-378719772031Ahsa-miR-378CUCCUGACUCCAGGUCCUGUGU
hsa-miR-378CUCCUGACUCCAGGUCCUGUGU
miR-381253125371Ahsa-miR-381UAUACAAGGGCAAGCUCUCUGU
hsa-miR-381UAUACAAGGGCAAGCUCUCUGU
miR-384992998m8hsa-miR-384AUUCCUAGAAAUUGUUCAUA
miR-410740974151Ahsa-miR-410AAUAUAACACAGAUGGCCUGU
miR-411520752141A,m8hsa-miR-411AACACGGUCCACUAACCCUCAGU
miR-43116241630m8hsa-miR-431UGUCUUGCAGGCCGUCAUGCA
miR-433-5p10101016m8hsa-miR-433-5pUACGGUGAGCCUGUCAUUAUUC
miR-450368936951Ahsa-miR-450UUUUUGCGAUGUGUUCCUAAUA
miR-4511191251Ahsa-miR-451brainAAACCGUUACCAUUACUGAGUUU
miR-4523593651Ahsa-miR-452UGUUUGCAGAGGAAACUGAGAC
miR-486210621131A,m8hsa-miR-486UCCUGUACUGAGCUGCCCCGAG
miR-493-5p21042110m8hsa-miR-493-5pUUGUACAUGGUAGGCUUUCAUU
miR-494754760m8hsa-miR-494brainUGAAACAUACACGGGAAACCUCUU
miR-4956436491Ahsa-miR-495brainAAACAAACAUGGUGCACUUCUUU
hsa-miR-495brainAAACAAACAUGGUGCACUUCUUU
miR-499502050261Ahsa-miR-499UUAAGACUUGCAGUGAUGUUUAA
hsa-miR-499UUAAGACUUGCAGUGAUGUUUAA
miR-539193419401Ahsa-miR-539GGAGAAAUUAUCCUUGGUGUGU
hsa-miR-539GGAGAAAUUAUCCUUGGUGUGU
miR-54317921798m8hsa-miR-543AAACAUUCGCGGUGCACUUCU
miR-93.hd/291-3p/294/295/302/372/373/5205235301A,m8hsa-miR-93brainAAAGUGCUGUUCGUGCAGGUAG
hsa-miR-302aUAAGUGCUUCCAUGUUUUGGUGA
hsa-miR-302bUAAGUGCUUCCAUGUUUUAGUAG
hsa-miR-302cUAAGUGCUUCCAUGUUUCAGUGG
hsa-miR-302dUAAGUGCUUCCAUGUUUGAGUGU
hsa-miR-372AAAGUGCUGCGACAUUUGAGCGU
hsa-miR-373GAAGUGCUUCGAUUUUGGGGUGU
hsa-miR-520eAAAGUGCUUCCUUUUUGAGGG
hsa-miR-520aAAAGUGCUUCCCUUUGGACUGU
hsa-miR-520bAAAGUGCUUCCUUUUAGAGGG
hsa-miR-520cAAAGUGCUUCCUUUUAGAGGGUU
hsa-miR-520dAAAGUGCUUCUCUUUGGUGGGUU
miR-96244124481A,m8hsa-miR-96brainUUUGGCACUAGCACAUUUUUGC