Gene Page: CBX1

Summary ?
GeneID10951
SymbolCBX1
SynonymsCBX|HP1-BETA|HP1Hs-beta|HP1Hsbeta|M31|MOD1|p25beta
Descriptionchromobox 1
ReferenceMIM:604511|HGNC:HGNC:1551|Ensembl:ENSG00000108468|HPRD:05149|Vega:OTTHUMG00000150417
Gene typeprotein-coding
Map location17q21.32
Pascal p-value0.002
Sherlock p-value0.515
eGeneMyers' cis & trans

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
CV:PGCnpGenome-wide Association StudyGWAS

Section I. Genetics and epigenetics annotation

@eQTL annotation

SNP IDChromosomePositioneGeneGene Entrez IDpvalueqvalueTSS distanceeQTL type
rs17073502chr4183431488CBX1109510.05trans
rs16900783chr531245333CBX1109510.15trans
rs17141097chr719338527CBX1109510.11trans
rs7135241chr1295163565CBX1109510.03trans
rs12591303chr1556761869CBX1109510.09trans
snp_a-22791900CBX1109510.03trans

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

No co-expressed genes in brain regions


Section IV. Protein-protein interaction annotation

InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
ARL5AARFLP5 | ARL5ADP-ribosylation factor-like 5ATwo-hybridBioGRID12414990 
C11orf30EMSY | FLJ90741 | GL002chromosome 11 open reading frame 30-HPRD,BioGRID14651845 
C1orf103FLJ11269 | RIF1 | RP11-96K19.1chromosome 1 open reading frame 103Two-hybridBioGRID16169070 
CBX1CBX | HP1-BETA | HP1Hs-beta | HP1Hsbeta | M31 | MOD1 | p25betachromobox homolog 1 (HP1 beta homolog Drosophila )-HPRD,BioGRID10747027 |11336697 
CBX3HECH | HP1-GAMMA | HP1Hs-gammachromobox homolog 3 (HP1 gamma homolog, Drosophila)-HPRD,BioGRID11336697 
CBX5HP1 | HP1Achromobox homolog 5 (HP1 alpha homolog, Drosophila)-HPRD,BioGRID11336697 
CHAF1ACAF-1 | CAF1 | CAF1B | CAF1P150 | MGC71229 | P150chromatin assembly factor 1, subunit A (p150)-HPRD10549285 
DNMT1AIM | CXXC9 | DNMT | FLJ16293 | MCMT | MGC104992DNA (cytosine-5-)-methyltransferase 1-HPRD,BioGRID12711675 
DNMT3ADNMT3A2 | M.HsaIIIADNA (cytosine-5-)-methyltransferase 3 alpha-HPRD,BioGRID12711675 
DNMT3BICF | M.HsaIIIBDNA (cytosine-5-)-methyltransferase 3 betaDNMT3B interacts with HP1-beta. This interaction was modeled on a demonstrated interaction between mouse Dnmt3b1 and human HP1-beta.BIND15120635 
DNMT3BICF | M.HsaIIIBDNA (cytosine-5-)-methyltransferase 3 beta-HPRD,BioGRID12867029 
HIST1H3CH3.1 | H3/c | H3FChistone cluster 1, H3c-HPRD11882902 
MKI67KIA | Ki-67antigen identified by monoclonal antibody Ki-67pKi-67 interacts with the CS domain of HP1 protein via its C-terminus. This interaction was modeled on a demonstrated interaction between pKi-67 from human and HP1-beta from mouse.BIND11793364 
PIM1PIMpim-1 oncogene-HPRD,BioGRID12111331 
RB1OSRC | RB | p105-Rb | pRb | pp110retinoblastoma 1Reconstituted ComplexBioGRID12711675 
RPL12-ribosomal protein L12Two-hybridBioGRID16169070 
SUV39H1KMT1A | MG44 | SUV39Hsuppressor of variegation 3-9 homolog 1 (Drosophila)-HPRD,BioGRID10202156 
TRIM24PTC6 | RNF82 | TF1A | TIF1 | TIF1A | TIF1ALPHA | hTIF1tripartite motif-containing 24-HPRD,BioGRID10562550 
TRIM28FLJ29029 | KAP1 | RNF96 | TF1B | TIF1Btripartite motif-containing 28-HPRD,BioGRID10562550 |11336697 
UCHL1PARK5 | PGP9.5 | Uch-L1ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)Two-hybridBioGRID16169070 


Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
IGARASHI ATF4 TARGETS DN 9065All SZGR 2.0 genes in this pathway
DIAZ CHRONIC MEYLOGENOUS LEUKEMIA UP 1382904All SZGR 2.0 genes in this pathway
AKL HTLV1 INFECTION UP 2716All SZGR 2.0 genes in this pathway
DODD NASOPHARYNGEAL CARCINOMA DN 1375806All SZGR 2.0 genes in this pathway
ENK UV RESPONSE KERATINOCYTE DN 485334All SZGR 2.0 genes in this pathway
BERENJENO TRANSFORMED BY RHOA REVERSIBLY DN 2921All SZGR 2.0 genes in this pathway
GRAESSMANN APOPTOSIS BY DOXORUBICIN UP 1142669All SZGR 2.0 genes in this pathway
GRAESSMANN APOPTOSIS BY DOXORUBICIN DN 17811082All SZGR 2.0 genes in this pathway
GRAESSMANN RESPONSE TO MC AND DOXORUBICIN UP 612367All SZGR 2.0 genes in this pathway
GRAESSMANN RESPONSE TO MC AND DOXORUBICIN DN 770415All SZGR 2.0 genes in this pathway
OUELLET OVARIAN CANCER INVASIVE VS LMP UP 11785All SZGR 2.0 genes in this pathway
BERENJENO TRANSFORMED BY RHOA UP 536340All SZGR 2.0 genes in this pathway
OUELLET CULTURED OVARIAN CANCER INVASIVE VS LMP UP 6940All SZGR 2.0 genes in this pathway
SCHLOSSER SERUM RESPONSE DN 712443All SZGR 2.0 genes in this pathway
PATIL LIVER CANCER 747453All SZGR 2.0 genes in this pathway
PUJANA BRCA2 PCC NETWORK 423265All SZGR 2.0 genes in this pathway
GOTZMANN EPITHELIAL TO MESENCHYMAL TRANSITION DN 206136All SZGR 2.0 genes in this pathway
SHEN SMARCA2 TARGETS UP 424268All SZGR 2.0 genes in this pathway
MORI LARGE PRE BII LYMPHOCYTE UP 8649All SZGR 2.0 genes in this pathway
MORI IMMATURE B LYMPHOCYTE DN 9055All SZGR 2.0 genes in this pathway
MORI EMU MYC LYMPHOMA BY ONSET TIME UP 11069All SZGR 2.0 genes in this pathway
NIKOLSKY BREAST CANCER 17Q21 Q25 AMPLICON 335181All SZGR 2.0 genes in this pathway
GOLUB ALL VS AML UP 2420All SZGR 2.0 genes in this pathway
FLECHNER PBL KIDNEY TRANSPLANT REJECTED VS OK UP 6348All SZGR 2.0 genes in this pathway
THEILGAARD NEUTROPHIL AT SKIN WOUND DN 225163All SZGR 2.0 genes in this pathway
LY AGING PREMATURE DN 3017All SZGR 2.0 genes in this pathway
IVANOVA HEMATOPOIESIS STEM CELL AND PROGENITOR 681420All SZGR 2.0 genes in this pathway
XU GH1 AUTOCRINE TARGETS UP 268157All SZGR 2.0 genes in this pathway
XU GH1 EXOGENOUS TARGETS DN 12069All SZGR 2.0 genes in this pathway
MARSON BOUND BY E2F4 UNSTIMULATED 728415All SZGR 2.0 genes in this pathway
FUJII YBX1 TARGETS DN 202132All SZGR 2.0 genes in this pathway
BLUM RESPONSE TO SALIRASIB DN 342220All SZGR 2.0 genes in this pathway
CHANG CORE SERUM RESPONSE UP 212128All SZGR 2.0 genes in this pathway
AGUIRRE PANCREATIC CANCER COPY NUMBER UP 298174All SZGR 2.0 genes in this pathway
HOFFMANN LARGE TO SMALL PRE BII LYMPHOCYTE UP 163102All SZGR 2.0 genes in this pathway
BOYAULT LIVER CANCER SUBCLASS G123 UP 4521All SZGR 2.0 genes in this pathway
YAGI AML WITH 11Q23 REARRANGED 351238All SZGR 2.0 genes in this pathway
CAIRO HEPATOBLASTOMA UP 207143All SZGR 2.0 genes in this pathway
DANG BOUND BY MYC 1103714All SZGR 2.0 genes in this pathway
VERHAAK GLIOBLASTOMA PRONEURAL 177132All SZGR 2.0 genes in this pathway
JOHNSTONE PARVB TARGETS 3 DN 918550All SZGR 2.0 genes in this pathway
FEVR CTNNB1 TARGETS DN 553343All SZGR 2.0 genes in this pathway
RAO BOUND BY SALL4 ISOFORM B 517302All SZGR 2.0 genes in this pathway