Gene Page: WWP2

Summary ?
GeneID11060
SymbolWWP2
SynonymsAIP2|WWp2-like
DescriptionWW domain containing E3 ubiquitin protein ligase 2
ReferenceMIM:602308|HGNC:HGNC:16804|Ensembl:ENSG00000198373|HPRD:03812|Vega:OTTHUMG00000137573
Gene typeprotein-coding
Map location16q22.1
Pascal p-value0.241
Sherlock p-value0.599
Fetal beta-0.297
DMG1 (# studies)
eGeneCerebellar Hemisphere
Cerebellum

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
CV:PGCnpGenome-wide Association StudyGWAS
DMG:Wockner_2014Genome-wide DNA methylation analysisThis dataset includes 4641 differentially methylated probes corresponding to 2929 unique genes between schizophrenia patients (n=24) and controls (n=24). 2

Section I. Genetics and epigenetics annotation

@Differentially methylated gene

ProbeChromosomePositionNearest geneP (dis)Beta (dis)FDR (dis)Study
cg165162481669958626WWP23.795E-40.4250.043DMG:Wockner_2014
cg027125461669969166WWP24.41E-40.4240.045DMG:Wockner_2014


Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

No co-expressed genes in brain regions


Section IV. Protein-protein interaction annotation

InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
ATN1B37 | D12S755E | DRPLA | NODatrophin 1Atrophin-1 interacts with AIP2.BIND9647693 
ATN1B37 | D12S755E | DRPLA | NODatrophin 1-HPRD,BioGRID9647693 
CLCN5CLC5 | CLCK2 | DENTS | NPHL1 | NPHL2 | XLRH | XRN | hCIC-K2 | hClC-K2chloride channel 5-HPRD9169421 
CPSF6CFIM | CFIM68 | HPBRII-4 | HPBRII-7cleavage and polyadenylation specific factor 6, 68kDaTwo-hybridBioGRID16189514 
DAG1156DAG | A3a | AGRNR | DAGdystroglycan 1 (dystrophin-associated glycoprotein 1)-HPRD9169421 
DIDO1BYE1 | C20orf158 | DATF1 | DIDO2 | DIDO3 | DIO-1 | DIO1 | DKFZp434P1115 | FLJ11265 | KIAA0333 | MGC16140 | dJ885L7.8death inducer-obliterator 1Two-hybridBioGRID16189514 
EWSR1EWSEwing sarcoma breakpoint region 1Two-hybridBioGRID16189514 
IL2RGCD132 | IMD4 | SCIDX | SCIDX1interleukin 2 receptor, gamma (severe combined immunodeficiency)-HPRD9169421 
IL6RCD126 | IL-6R-1 | IL-6R-alpha | IL6RA | MGC104991interleukin 6 receptor-HPRD9169421 
NDFIP2FLJ25842 | KIAA1165 | N4wbp5aNedd4 family interacting protein 2-HPRD15252135 
PDLIM7LMP1PDZ and LIM domain 7 (enigma)Two-hybridBioGRID16189514 
RASA1CM-AVM | CMAVM | DKFZp434N071 | GAP | PKWS | RASA | RASGAP | p120GAP | p120RASGAPRAS p21 protein activator (GTPase activating protein) 1-HPRD9169421 
SCNN1AENaCa | ENaCalpha | FLJ21883 | SCNEA | SCNN1sodium channel, nonvoltage-gated 1 alpha-HPRD,BioGRID12167593 
SCNN1BENaCb | ENaCbeta | SCNEBsodium channel, nonvoltage-gated 1, beta-HPRD,BioGRID12167593 
SCNN1GENaCg | ENaCgamma | PHA1 | SCNEGsodium channel, nonvoltage-gated 1, gamma-HPRD,BioGRID12167593 
SF1D11S636 | ZFM1 | ZNF162splicing factor 1Two-hybridBioGRID16189514 
TFAP2AAP-2 | AP-2alpha | AP2TF | BOFS | TFAP2transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)-HPRD9169421 
TP53BP253BP2 | ASPP2 | BBP | PPP1R13A | p53BP2tumor protein p53 binding protein, 2-HPRD9169421 
VASP-vasodilator-stimulated phosphoproteinTwo-hybridBioGRID16189514 
WBP1MGC15305 | WBP-1WW domain binding protein 1-HPRD,BioGRID9169421 
WBP2MGC18269 | WBP-2WW domain binding protein 2Protein-peptideBioGRID9169421 


Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
KEGG UBIQUITIN MEDIATED PROTEOLYSIS 13898All SZGR 2.0 genes in this pathway
ONKEN UVEAL MELANOMA DN 526357All SZGR 2.0 genes in this pathway
WANG LMO4 TARGETS UP 372227All SZGR 2.0 genes in this pathway
DODD NASOPHARYNGEAL CARCINOMA UP 1821933All SZGR 2.0 genes in this pathway
CHIARADONNA NEOPLASTIC TRANSFORMATION KRAS DN 14295All SZGR 2.0 genes in this pathway
CHIARADONNA NEOPLASTIC TRANSFORMATION CDC25 DN 153100All SZGR 2.0 genes in this pathway
HUMMERICH SKIN CANCER PROGRESSION DN 10064All SZGR 2.0 genes in this pathway
RASHI RESPONSE TO IONIZING RADIATION 1 4527All SZGR 2.0 genes in this pathway
SILIGAN BOUND BY EWS FLT1 FUSION 4734All SZGR 2.0 genes in this pathway
GRUETZMANN PANCREATIC CANCER DN 203134All SZGR 2.0 genes in this pathway
SPIELMAN LYMPHOBLAST EUROPEAN VS ASIAN UP 479299All SZGR 2.0 genes in this pathway
WOTTON RUNX TARGETS UP 2114All SZGR 2.0 genes in this pathway
NING CHRONIC OBSTRUCTIVE PULMONARY DISEASE UP 157105All SZGR 2.0 genes in this pathway
BLALOCK ALZHEIMERS DISEASE INCIPIENT UP 390242All SZGR 2.0 genes in this pathway
BROWNE HCMV INFECTION 14HR DN 298200All SZGR 2.0 genes in this pathway
BLALOCK ALZHEIMERS DISEASE UP 16911088All SZGR 2.0 genes in this pathway
BROWNE HCMV INFECTION 18HR DN 178121All SZGR 2.0 genes in this pathway
IWANAGA CARCINOGENESIS BY KRAS PTEN UP 181112All SZGR 2.0 genes in this pathway
TOYOTA TARGETS OF MIR34B AND MIR34C 463262All SZGR 2.0 genes in this pathway
WEST ADRENOCORTICAL TUMOR DN 546362All SZGR 2.0 genes in this pathway
FIRESTEIN PROLIFERATION 175125All SZGR 2.0 genes in this pathway
WANG TUMOR INVASIVENESS UP 374247All SZGR 2.0 genes in this pathway
MILI PSEUDOPODIA CHEMOTAXIS DN 457302All SZGR 2.0 genes in this pathway
NIELSEN GIST 9866All SZGR 2.0 genes in this pathway
GOBERT OLIGODENDROCYTE DIFFERENTIATION DN 1080713All SZGR 2.0 genes in this pathway
WAKABAYASHI ADIPOGENESIS PPARG BOUND 8D 658397All SZGR 2.0 genes in this pathway
VANOEVELEN MYOGENESIS SIN3A TARGETS 220133All SZGR 2.0 genes in this pathway