SZGR2

Summary ?

GeneID	1432
Symbol	MAPK14
Synonyms	CSBP\|CSBP1\|CSBP2\|CSPB1\|EXIP\|Mxi2\|PRKM14\|PRKM15\|RK\|SAPK2A\|p38\|p38ALPHA
Description	mitogen-activated protein kinase 14
Reference	MIM:600289\|HGNC:HGNC:6876\|Ensembl:ENSG00000112062\|HPRD:02619\|Vega:OTTHUMG00000159806
Gene type	protein-coding
Map location	6p21.3-p21.2
Pascal p-value	0.699
Fetal beta	0.459
eGene	Cortex

Gene in Data Sources

Gene set name	Method of gene set	Description	Info
CV:PGCnp	Genome-wide Association Study	GWAS
PMID:cooccur	High-throughput literature-search	Systematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
GSMA_I	Genome scan meta-analysis	Psr: 0.033
GSMA_IIE	Genome scan meta-analysis (European-ancestry samples)	Psr: 0.04433
Literature	High-throughput literature-search	Co-occurance with Schizophrenia keywords: schizophrenia,schizophrenic,schizophrenias	Click to show details
Network	Shortest path distance of core genes in the Human protein-protein interaction network	Contribution to shortest path in PPI network: 0.0305

Section I. Genetics and epigenetics annotation

Section II. Transcriptome annotation

General gene expression (GTEx)

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

No co-expressed genes in brain regions

Section III. Gene Ontology annotation

Molecular function	GO term	Evidence	Neuro keywords	PubMed ID
GO:0000166	nucleotide binding	IEA		-
GO:0004707	MAP kinase activity	IEA		-
GO:0004708	MAP kinase kinase activity	TAS		10706854
GO:0008339	MP kinase activity	IDA		7997261
GO:0005515	protein binding	IPI		9792677 \|12761180 \|16189514 \|16636664 \|16751104 \|17255097
GO:0005524	ATP binding	IEA		-
GO:0004674	protein serine/threonine kinase activity	EXP		8846784 \|9687510
GO:0004674	protein serine/threonine kinase activity	IEA		-
GO:0016740	transferase activity	IEA		-
Biological process	GO term	Evidence	Neuro keywords	PubMed ID
GO:0006468	protein amino acid phosphorylation	IEA		-
GO:0007265	Ras protein signal transduction	EXP		11520933
GO:0007243	protein kinase cascade	IDA		10838079
GO:0006950	response to stress	IDA		7997261
GO:0007166	cell surface receptor linked signal transduction	TAS		10706854
GO:0006935	chemotaxis	TAS		10706854
GO:0006928	cell motion	TAS		10912793
Cellular component	GO term	Evidence	Neuro keywords	PubMed ID
GO:0005829	cytosol	EXP		9687510
GO:0005634	nucleus	ISS		-
GO:0005654	nucleoplasm	EXP		8846784
GO:0005737	cytoplasm	ISS		-

Section IV. Protein-protein interaction annotation

Interactors	Aliases B	Official full name B	Experimental	Source	PubMed ID
AKT1	AKT \| MGC99656 \| PKB \| PKB-ALPHA \| PRKBA \| RAC \| RAC-ALPHA	v-akt murine thymoma viral oncogene homolog 1	Affinity Capture-Western Biochemical Activity	BioGRID	11042204
ATF2	CRE-BP1 \| CREB2 \| HB16 \| MGC111558 \| TREB7	activating transcription factor 2	An unspecified isoform of p38 interacts with and phosphorylates ATF2.	BIND	9155018
ATF2	CRE-BP1 \| CREB2 \| HB16 \| MGC111558 \| TREB7	activating transcription factor 2	An unspecified isoform of p38 interacts with and phosphorylates ATF2.	BIND	9235954
ATF2	CRE-BP1 \| CREB2 \| HB16 \| MGC111558 \| TREB7	activating transcription factor 2	p38 phosphorylates ATF2. This interaction was modelled on a demonstrated interaction between human p38 and ATF2 from an unspecified species.	BIND	15692053
ATF2	CRE-BP1 \| CREB2 \| HB16 \| MGC111558 \| TREB7	activating transcription factor 2	-	HPRD,BioGRID	7535770
CDC25A	CDC25A2	cell division cycle 25 homolog A (S. pombe)	Reconstituted Complex	BioGRID	12963847
CDC25B	-	cell division cycle 25 homolog B (S. pombe)	Biochemical Activity Reconstituted Complex	BioGRID	11333986
CDC25B	-	cell division cycle 25 homolog B (S. pombe)	p38-alpha interacts with and phosphorylates CDC25B.	BIND	15629715
CDC25C	CDC25	cell division cycle 25 homolog C (S. pombe)	-	HPRD,BioGRID	11333986
CREB1	CREB \| MGC9284	cAMP responsive element binding protein 1	-	HPRD,BioGRID	11377386
CSNK2A1	CK2A1 \| CKII	casein kinase 2, alpha 1 polypeptide	Affinity Capture-Western Reconstituted Complex	BioGRID	10747897
CSNK2A2	CK2A2 \| CSNK2A1 \| FLJ43934	casein kinase 2, alpha prime polypeptide	-	HPRD	10747897
CSNK2B	CK2B \| CK2N \| CSK2B \| G5A \| MGC138222 \| MGC138224	casein kinase 2, beta polypeptide	-	HPRD	10747897
DDIT3	CEBPZ \| CHOP \| CHOP10 \| GADD153 \| MGC4154	DNA-damage-inducible transcript 3	-	HPRD,BioGRID	8650547
DUSP1	CL100 \| HVH1 \| MKP-1 \| MKP1 \| PTPN10	dual specificity phosphatase 1	-	HPRD	7535770
DUSP1	CL100 \| HVH1 \| MKP-1 \| MKP1 \| PTPN10	dual specificity phosphatase 1	Affinity Capture-Western Two-hybrid	BioGRID	11278799 \|11359773
DUSP10	MKP-5 \| MKP5	dual specificity phosphatase 10	Affinity Capture-Western Biochemical Activity Reconstituted Complex Two-hybrid	BioGRID	10391943 \|11157753 \|11359773
DUSP10	MKP-5 \| MKP5	dual specificity phosphatase 10	An unspecified isoform of MAPK14 interacts with DUSP10.	BIND	10391943
DUSP10	MKP-5 \| MKP5	dual specificity phosphatase 10	-	HPRD	10391943 \|10597297 \|11359773
DUSP16	KIAA1700 \| MGC129701 \| MGC129702 \| MKP-7 \| MKP7	dual specificity phosphatase 16	-	HPRD,BioGRID	11359773 \|11489891 \|14586399
DUSP2	PAC-1 \| PAC1	dual specificity phosphatase 2	-	HPRD	7535770
DUSP22	JKAP \| JSP1 \| MKPX \| VHX	dual specificity phosphatase 22	-	HPRD	11346645
DUSP4	HVH2 \| MKP-2 \| MKP2 \| TYP	dual specificity phosphatase 4	-	HPRD,BioGRID	11387337
DUSP6	MKP3 \| PYST1	dual specificity phosphatase 6	Affinity Capture-Western	BioGRID	11359773
DYRK1B	MIRK	dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1B	-	HPRD,BioGRID	10910078
EGFR	ERBB \| ERBB1 \| HER1 \| PIG61 \| mENA	epidermal growth factor receptor (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian)	Biochemical Activity	BioGRID	7535770
ELK1	-	ELK1, member of ETS oncogene family	Elk-1 is phosphorylated by an unspecified isoform of p38 MAPK. This interaction was modeled on a demonstrated interaction between human Elk-1 and p38 MAPK from an unspecified species.	BIND	9130707
ELK1	-	ELK1, member of ETS oncogene family	-	HPRD	8622669
ELK1	-	ELK1, member of ETS oncogene family	An unspecified isoform of p38 interacts with and phosphorylates Elk-1.	BIND	9155018
ELK4	SAP1	ELK4, ETS-domain protein (SRF accessory protein 1)	An unspecified isoform of p38 interacts with and phosphorylates Sap-1a.	BIND	9235954
ELK4	SAP1	ELK4, ETS-domain protein (SRF accessory protein 1)	Sap-1a is phosphorylated by an unspecified isoform of p38 MAPK. This interaction was modeled on a demonstrated interaction between human Sap-1a and p38 MAPK from an unspecified species.	BIND	9130707
ETV1	DKFZp781L0674 \| ER81 \| MGC104699 \| MGC120533 \| MGC120534	ets variant 1	Biochemical Activity	BioGRID	11551945
FLNA	ABP-280 \| ABPX \| DKFZp434P031 \| FLN \| FLN1 \| FMD \| MNS \| NHBP \| OPD \| OPD1 \| OPD2	filamin A, alpha (actin binding protein 280)	-	HPRD	11390380
FUBP1	FBP \| FUBP	far upstream element (FUSE) binding protein 1	Affinity Capture-Western Reconstituted Complex Two-hybrid	BioGRID	12819782
GMFB	GMF	glia maturation factor, beta	-	HPRD,BioGRID	8798479
GRB2	ASH \| EGFRBP-GRB2 \| Grb3-3 \| MST084 \| MSTP084	growth factor receptor-bound protein 2	-	HPRD	8695800
HTRA2	OMI \| PARK13 \| PRSS25	HtrA serine peptidase 2	-	HPRD,BioGRID	10644717
JUN	AP-1 \| AP1 \| c-Jun	jun oncogene	An unspecified isoform of p38 interacts with and phosphorylates c-Jun.	BIND	9155018
KARS	KARS2 \| KIAA0070 \| KRS	lysyl-tRNA synthetase	Two-hybrid	BioGRID	12819782
KRT18	CYK18 \| K18	keratin 18	-	HPRD,BioGRID	11788583
MAP2K1	MAPKK1 \| MEK1 \| MKK1 \| PRKMK1	mitogen-activated protein kinase kinase 1	-	HPRD	12697810
MAP2K3	MAPKK3 \| MEK3 \| MKK3 \| PRKMK3	mitogen-activated protein kinase kinase 3	-	HPRD	7839144\|8622669
MAP2K3	MAPKK3 \| MEK3 \| MKK3 \| PRKMK3	mitogen-activated protein kinase kinase 3	Biochemical Activity	BioGRID	11279118
MAP2K3	MAPKK3 \| MEK3 \| MKK3 \| PRKMK3	mitogen-activated protein kinase kinase 3	MKK3 phosphorylates an unspecified isoform of p38. This interaction was modeled on a demonstrated interaction between human MKK3 and p38 from an unspecified species.	BIND	8622669
MAP2K4	JNKK \| JNKK1 \| MAPKK4 \| MEK4 \| MKK4 \| PRKMK4 \| SEK1 \| SERK1	mitogen-activated protein kinase kinase 4	-	HPRD,BioGRID	7716521
MAP2K6	MAPKK6 \| MEK6 \| MKK6 \| PRKMK6 \| SAPKK3	mitogen-activated protein kinase kinase 6	-	HPRD,BioGRID	8626699
MAP2K7	Jnkk2 \| MAPKK7 \| MKK7 \| PRKMK7	mitogen-activated protein kinase kinase 7	Biochemical Activity	BioGRID	9207092
MAP3K7IP1	3'-Tab1 \| MGC57664 \| TAB1	mitogen-activated protein kinase kinase kinase 7 interacting protein 1	TAB1 interacts with an unspecified isoform of p38.	BIND	12829618
MAP3K7IP1	3'-Tab1 \| MGC57664 \| TAB1	mitogen-activated protein kinase kinase kinase 7 interacting protein 1	-	HPRD,BioGRID	11847341
MAPK1	ERK \| ERK2 \| ERT1 \| MAPK2 \| P42MAPK \| PRKM1 \| PRKM2 \| p38 \| p40 \| p41 \| p41mapk	mitogen-activated protein kinase 1	-	HPRD,BioGRID	12697810
MAPK14	CSBP1 \| CSBP2 \| CSPB1 \| EXIP \| Mxi2 \| PRKM14 \| PRKM15 \| RK \| SAPK2A \| p38 \| p38ALPHA	mitogen-activated protein kinase 14	Biochemical Activity Two-hybrid	BioGRID	11847341 \|12819782
MAPK3	ERK1 \| HS44KDAP \| HUMKER1A \| MGC20180 \| P44ERK1 \| P44MAPK \| PRKM3	mitogen-activated protein kinase 3	-	HPRD,BioGRID	12697810
MAPKAPK2	MK2	mitogen-activated protein kinase-activated protein kinase 2	-	HPRD,BioGRID	9768359 \|11042204 \|11551945
MAPKAPK3	3PK \| MAPKAP3	mitogen-activated protein kinase-activated protein kinase 3	-	HPRD,BioGRID	11157753
MARS	FLJ35667 \| METRS \| MTRNS	methionyl-tRNA synthetase	-	HPRD	9878398
MEF2A	ADCAD1 \| RSRFC4 \| RSRFC9	myocyte enhancer factor 2A	-	HPRD,BioGRID	10330143
MEF2C	-	myocyte enhancer factor 2C	-	HPRD	9753748 \|10330143
MKNK1	MNK1	MAP kinase interacting serine/threonine kinase 1	-	HPRD	9155018
MKNK1	MNK1	MAP kinase interacting serine/threonine kinase 1	Affinity Capture-Western	BioGRID	11157753
MKNK1	MNK1	MAP kinase interacting serine/threonine kinase 1	An unspecified isoform of p38 interacts with and phosphorylates MNK1.	BIND	9155018
MKNK2	GPRK7 \| MNK2	MAP kinase interacting serine/threonine kinase 2	-	HPRD	12897141
NCF1C	SH3PXD1C	neutrophil cytosolic factor 1C pseudogene	p38-alpha interacts with and phosphorylates p47phox.	BIND	15629715
PLCB2	FLJ38135	phospholipase C, beta 2	Affinity Capture-Western	BioGRID	12054652
PML	MYL \| PP8675 \| RNF71 \| TRIM19	promyelocytic leukemia	-	HPRD	15273249
PTPN7	BPTP-4 \| HEPTP \| LC-PTP \| LPTP \| PTPNI	protein tyrosine phosphatase, non-receptor type 7	-	HPRD	10559944
RPS6KA3	CLS \| HU-3 \| ISPK-1 \| MAPKAPK1B \| MRX19 \| RSK \| RSK2 \| S6K-alpha3 \| p90-RSK2 \| pp90RSK2	ribosomal protein S6 kinase, 90kDa, polypeptide 3	Affinity Capture-Western	BioGRID	11157753
RPS6KA4	MSK2 \| RSK-B	ribosomal protein S6 kinase, 90kDa, polypeptide 4	-	HPRD,BioGRID	9792677
RPS6KA5	MGC1911 \| MSK1 \| MSPK1 \| RLPK	ribosomal protein S6 kinase, 90kDa, polypeptide 5	Affinity Capture-Western	BioGRID	11157753
SCYE1	AIMP1 \| EMAP-2 \| EMAP-II \| EMAP2 \| EMAPII \| p43	small inducible cytokine subfamily E, member 1 (endothelial monocyte-activating)	-	HPRD	9878398
SLC12A2	BSC \| BSC2 \| MGC104233 \| NKCC1	solute carrier family 12 (sodium/potassium/chloride transporters), member 2	Affinity Capture-Western	BioGRID	14563843
SLC44A1	CD92 \| CDW92 \| CHTL1 \| CTL1 \| RP11-287A8.1	solute carrier family 44, member 1	-	HPRD	9707433
SMAD7	CRCS3 \| FLJ16482 \| MADH7 \| MADH8	SMAD family member 7	-	HPRD,BioGRID	12589052
SPAG9	FLJ13450 \| FLJ14006 \| FLJ26141 \| FLJ34602 \| HLC4 \| JLP \| KIAA0516 \| MGC117291 \| MGC14967 \| MGC74461 \| PHET \| PIG6	sperm associated antigen 9	-	HPRD,BioGRID	12391307
STK39	DCHT \| DKFZp686K05124 \| PASK \| SPAK	serine threonine kinase 39 (STE20/SPS1 homolog, yeast)	-	HPRD	10980603
STK39	DCHT \| DKFZp686K05124 \| PASK \| SPAK	serine threonine kinase 39 (STE20/SPS1 homolog, yeast)	Affinity Capture-Western	BioGRID	14563843
ZFP36L1	BRF1 \| Berg36 \| ERF-1 \| ERF1 \| RNF162B \| TIS11B \| cMG1	zinc finger protein 36, C3H type-like 1	Affinity Capture-Western Two-hybrid	BioGRID	16189514

Section V. Pathway annotation

Pathway name	Pathway size	# SZGR 2.0 genes in pathway	Info
KEGG MAPK SIGNALING PATHWAY	267	205	All SZGR 2.0 genes in this pathway
KEGG VEGF SIGNALING PATHWAY	76	53	All SZGR 2.0 genes in this pathway
KEGG TOLL LIKE RECEPTOR SIGNALING PATHWAY	102	88	All SZGR 2.0 genes in this pathway
KEGG NOD LIKE RECEPTOR SIGNALING PATHWAY	62	47	All SZGR 2.0 genes in this pathway
KEGG RIG I LIKE RECEPTOR SIGNALING PATHWAY	71	51	All SZGR 2.0 genes in this pathway
KEGG T CELL RECEPTOR SIGNALING PATHWAY	108	89	All SZGR 2.0 genes in this pathway
KEGG FC EPSILON RI SIGNALING PATHWAY	79	58	All SZGR 2.0 genes in this pathway
KEGG LEUKOCYTE TRANSENDOTHELIAL MIGRATION	118	78	All SZGR 2.0 genes in this pathway
KEGG NEUROTROPHIN SIGNALING PATHWAY	126	103	All SZGR 2.0 genes in this pathway
KEGG GNRH SIGNALING PATHWAY	101	77	All SZGR 2.0 genes in this pathway
KEGG PROGESTERONE MEDIATED OOCYTE MATURATION	86	59	All SZGR 2.0 genes in this pathway
KEGG AMYOTROPHIC LATERAL SCLEROSIS ALS	53	43	All SZGR 2.0 genes in this pathway
KEGG EPITHELIAL CELL SIGNALING IN HELICOBACTER PYLORI INFECTION	68	44	All SZGR 2.0 genes in this pathway
KEGG LEISHMANIA INFECTION	72	56	All SZGR 2.0 genes in this pathway
BIOCARTA BCR PATHWAY	37	28	All SZGR 2.0 genes in this pathway
BIOCARTA BIOPEPTIDES PATHWAY	45	35	All SZGR 2.0 genes in this pathway
BIOCARTA HDAC PATHWAY	32	25	All SZGR 2.0 genes in this pathway
BIOCARTA FMLP PATHWAY	39	29	All SZGR 2.0 genes in this pathway
BIOCARTA GATA3 PATHWAY	16	15	All SZGR 2.0 genes in this pathway
BIOCARTA HCMV PATHWAY	17	16	All SZGR 2.0 genes in this pathway
BIOCARTA IL12 PATHWAY	23	17	All SZGR 2.0 genes in this pathway
BIOCARTA KERATINOCYTE PATHWAY	46	38	All SZGR 2.0 genes in this pathway
BIOCARTA PYK2 PATHWAY	31	24	All SZGR 2.0 genes in this pathway
BIOCARTA EGFR SMRTE PATHWAY	11	11	All SZGR 2.0 genes in this pathway
BIOCARTA MAPK PATHWAY	87	68	All SZGR 2.0 genes in this pathway
BIOCARTA NFAT PATHWAY	56	45	All SZGR 2.0 genes in this pathway
BIOCARTA NTHI PATHWAY	24	20	All SZGR 2.0 genes in this pathway
BIOCARTA ARENRF2 PATHWAY	13	9	All SZGR 2.0 genes in this pathway
BIOCARTA P38MAPK PATHWAY	40	31	All SZGR 2.0 genes in this pathway
BIOCARTA CCR5 PATHWAY	20	16	All SZGR 2.0 genes in this pathway
BIOCARTA RB PATHWAY	13	11	All SZGR 2.0 genes in this pathway
BIOCARTA EIF4 PATHWAY	24	19	All SZGR 2.0 genes in this pathway
BIOCARTA IL1R PATHWAY	33	29	All SZGR 2.0 genes in this pathway
BIOCARTA TALL1 PATHWAY	15	15	All SZGR 2.0 genes in this pathway
BIOCARTA 41BB PATHWAY	17	15	All SZGR 2.0 genes in this pathway
BIOCARTA SARS PATHWAY	10	5	All SZGR 2.0 genes in this pathway
BIOCARTA STRESS PATHWAY	25	18	All SZGR 2.0 genes in this pathway
BIOCARTA TOLL PATHWAY	37	31	All SZGR 2.0 genes in this pathway
BIOCARTA CREB PATHWAY	27	25	All SZGR 2.0 genes in this pathway
SIG CD40PATHWAYMAP	34	28	All SZGR 2.0 genes in this pathway
ST P38 MAPK PATHWAY	37	28	All SZGR 2.0 genes in this pathway
ST ADRENERGIC	36	29	All SZGR 2.0 genes in this pathway
PID ENDOTHELIN PATHWAY	63	52	All SZGR 2.0 genes in this pathway
PID BCR 5PATHWAY	65	50	All SZGR 2.0 genes in this pathway
PID P73PATHWAY	79	59	All SZGR 2.0 genes in this pathway
PID P38 MKK3 6PATHWAY	26	21	All SZGR 2.0 genes in this pathway
PID NFKAPPAB ATYPICAL PATHWAY	17	15	All SZGR 2.0 genes in this pathway
PID IL4 2PATHWAY	65	43	All SZGR 2.0 genes in this pathway
PID CD40 PATHWAY	31	26	All SZGR 2.0 genes in this pathway
PID IL12 2PATHWAY	63	54	All SZGR 2.0 genes in this pathway
PID P38 ALPHA BETA PATHWAY	31	25	All SZGR 2.0 genes in this pathway
PID CDC42 PATHWAY	70	51	All SZGR 2.0 genes in this pathway
PID ANGIOPOIETIN RECEPTOR PATHWAY	50	41	All SZGR 2.0 genes in this pathway
PID FAS PATHWAY	38	29	All SZGR 2.0 genes in this pathway
PID TXA2PATHWAY	57	43	All SZGR 2.0 genes in this pathway
PID NFAT 3PATHWAY	54	47	All SZGR 2.0 genes in this pathway
PID REG GR PATHWAY	82	60	All SZGR 2.0 genes in this pathway
PID IL2 1PATHWAY	55	43	All SZGR 2.0 genes in this pathway
PID AR TF PATHWAY	53	38	All SZGR 2.0 genes in this pathway
PID ATF2 PATHWAY	59	43	All SZGR 2.0 genes in this pathway
PID IL6 7 PATHWAY	47	40	All SZGR 2.0 genes in this pathway
PID P38 MK2 PATHWAY	21	19	All SZGR 2.0 genes in this pathway
PID RETINOIC ACID PATHWAY	30	23	All SZGR 2.0 genes in this pathway
PID CXCR3 PATHWAY	43	34	All SZGR 2.0 genes in this pathway
PID P38 ALPHA BETA DOWNSTREAM PATHWAY	38	29	All SZGR 2.0 genes in this pathway
PID EPO PATHWAY	34	29	All SZGR 2.0 genes in this pathway
PID VEGFR1 2 PATHWAY	69	57	All SZGR 2.0 genes in this pathway
PID P53 REGULATION PATHWAY	59	50	All SZGR 2.0 genes in this pathway
PID S1P S1P2 PATHWAY	24	19	All SZGR 2.0 genes in this pathway
PID MAPK TRK PATHWAY	34	31	All SZGR 2.0 genes in this pathway
PID LYMPH ANGIOGENESIS PATHWAY	25	16	All SZGR 2.0 genes in this pathway
PID RAC1 PATHWAY	54	37	All SZGR 2.0 genes in this pathway
PID RB 1PATHWAY	65	46	All SZGR 2.0 genes in this pathway
REACTOME SIGNALLING BY NGF	217	167	All SZGR 2.0 genes in this pathway
REACTOME DEVELOPMENTAL BIOLOGY	396	292	All SZGR 2.0 genes in this pathway
REACTOME TRIF MEDIATED TLR3 SIGNALING	74	54	All SZGR 2.0 genes in this pathway
REACTOME CELL CELL COMMUNICATION	120	77	All SZGR 2.0 genes in this pathway
REACTOME SIGNALLING TO RAS	27	23	All SZGR 2.0 genes in this pathway
REACTOME NGF SIGNALLING VIA TRKA FROM THE PLASMA MEMBRANE	137	105	All SZGR 2.0 genes in this pathway
REACTOME SIGNALLING TO ERKS	36	30	All SZGR 2.0 genes in this pathway
REACTOME P38MAPK EVENTS	13	12	All SZGR 2.0 genes in this pathway
REACTOME NUCLEAR EVENTS KINASE AND TRANSCRIPTION FACTOR ACTIVATION	24	20	All SZGR 2.0 genes in this pathway
REACTOME ERK MAPK TARGETS	21	17	All SZGR 2.0 genes in this pathway
REACTOME ADP SIGNALLING THROUGH P2RY1	25	16	All SZGR 2.0 genes in this pathway
REACTOME SIGNAL AMPLIFICATION	31	19	All SZGR 2.0 genes in this pathway
REACTOME METABOLISM OF MRNA	284	128	All SZGR 2.0 genes in this pathway
REACTOME METABOLISM OF RNA	330	155	All SZGR 2.0 genes in this pathway
REACTOME MYOGENESIS	28	20	All SZGR 2.0 genes in this pathway
REACTOME MAP KINASE ACTIVATION IN TLR CASCADE	50	37	All SZGR 2.0 genes in this pathway
REACTOME ACTIVATION OF THE AP1 FAMILY OF TRANSCRIPTION FACTORS	10	8	All SZGR 2.0 genes in this pathway
REACTOME MAPK TARGETS NUCLEAR EVENTS MEDIATED BY MAP KINASES	30	24	All SZGR 2.0 genes in this pathway
REACTOME ACTIVATED TAK1 MEDIATES P38 MAPK ACTIVATION	18	12	All SZGR 2.0 genes in this pathway
REACTOME PLATELET HOMEOSTASIS	78	49	All SZGR 2.0 genes in this pathway
REACTOME PLATELET SENSITIZATION BY LDL	16	9	All SZGR 2.0 genes in this pathway
REACTOME REGULATION OF MRNA STABILITY BY PROTEINS THAT BIND AU RICH ELEMENTS	84	50	All SZGR 2.0 genes in this pathway
REACTOME TRAF6 MEDIATED INDUCTION OF NFKB AND MAP KINASES UPON TLR7 8 OR 9 ACTIVATION	77	57	All SZGR 2.0 genes in this pathway
REACTOME DESTABILIZATION OF MRNA BY KSRP	17	9	All SZGR 2.0 genes in this pathway
REACTOME NFKB AND MAP KINASES ACTIVATION MEDIATED BY TLR4 SIGNALING REPERTOIRE	72	53	All SZGR 2.0 genes in this pathway
REACTOME DSCAM INTERACTIONS	11	10	All SZGR 2.0 genes in this pathway
REACTOME HEMOSTASIS	466	331	All SZGR 2.0 genes in this pathway
REACTOME MYD88 MAL CASCADE INITIATED ON PLASMA MEMBRANE	83	63	All SZGR 2.0 genes in this pathway
REACTOME INNATE IMMUNE SYSTEM	279	178	All SZGR 2.0 genes in this pathway
REACTOME ACTIVATED TLR4 SIGNALLING	93	69	All SZGR 2.0 genes in this pathway
REACTOME IMMUNE SYSTEM	933	616	All SZGR 2.0 genes in this pathway
REACTOME TOLL RECEPTOR CASCADES	118	84	All SZGR 2.0 genes in this pathway
REACTOME NOD1 2 SIGNALING PATHWAY	30	22	All SZGR 2.0 genes in this pathway
REACTOME NUCLEOTIDE BINDING DOMAIN LEUCINE RICH REPEAT CONTAINING RECEPTOR NLR SIGNALING PATHWAYS	46	33	All SZGR 2.0 genes in this pathway
REACTOME PLATELET ACTIVATION SIGNALING AND AGGREGATION	208	138	All SZGR 2.0 genes in this pathway
LIU SOX4 TARGETS DN	309	191	All SZGR 2.0 genes in this pathway
ZHOU INFLAMMATORY RESPONSE LIVE DN	384	220	All SZGR 2.0 genes in this pathway
CASORELLI ACUTE PROMYELOCYTIC LEUKEMIA DN	663	425	All SZGR 2.0 genes in this pathway
SENESE HDAC3 TARGETS UP	501	327	All SZGR 2.0 genes in this pathway
KIM WT1 TARGETS DN	459	276	All SZGR 2.0 genes in this pathway
RODRIGUES THYROID CARCINOMA ANAPLASTIC UP	722	443	All SZGR 2.0 genes in this pathway
HAHTOLA MYCOSIS FUNGOIDES CD4 UP	64	46	All SZGR 2.0 genes in this pathway
KOKKINAKIS METHIONINE DEPRIVATION 48HR DN	64	39	All SZGR 2.0 genes in this pathway
KOKKINAKIS METHIONINE DEPRIVATION 96HR DN	75	50	All SZGR 2.0 genes in this pathway
MCBRYAN PUBERTAL BREAST 5 6WK DN	137	97	All SZGR 2.0 genes in this pathway
MCBRYAN PUBERTAL BREAST 6 7WK UP	197	135	All SZGR 2.0 genes in this pathway
MCBRYAN PUBERTAL TGFB1 TARGETS UP	169	127	All SZGR 2.0 genes in this pathway
GALLUZZI PREVENT MITOCHONDIAL PERMEABILIZATION	22	16	All SZGR 2.0 genes in this pathway
DACOSTA UV RESPONSE VIA ERCC3 DN	855	609	All SZGR 2.0 genes in this pathway
WANG RESPONSE TO BEXAROTENE DN	29	19	All SZGR 2.0 genes in this pathway
GROSS HYPOXIA VIA ELK3 UP	209	139	All SZGR 2.0 genes in this pathway
GROSS HYPOXIA VIA ELK3 ONLY DN	44	30	All SZGR 2.0 genes in this pathway
BUYTAERT PHOTODYNAMIC THERAPY STRESS DN	637	377	All SZGR 2.0 genes in this pathway
RANKIN ANGIOGENIC TARGETS OF VHL HIF2A UP	5	5	All SZGR 2.0 genes in this pathway
GOTZMANN EPITHELIAL TO MESENCHYMAL TRANSITION DN	206	136	All SZGR 2.0 genes in this pathway
BENPORATH NANOG TARGETS	988	594	All SZGR 2.0 genes in this pathway
FLECHNER PBL KIDNEY TRANSPLANT OK VS DONOR DN	41	30	All SZGR 2.0 genes in this pathway
UEDA PERIFERAL CLOCK	169	111	All SZGR 2.0 genes in this pathway
TENEDINI MEGAKARYOCYTE MARKERS	66	48	All SZGR 2.0 genes in this pathway
FLECHNER PBL KIDNEY TRANSPLANT REJECTED VS OK DN	51	35	All SZGR 2.0 genes in this pathway
PARK HSC AND MULTIPOTENT PROGENITORS	50	33	All SZGR 2.0 genes in this pathway
MOREAUX MULTIPLE MYELOMA BY TACI UP	412	249	All SZGR 2.0 genes in this pathway
HOEGERKORP CD44 TARGETS DIRECT UP	27	21	All SZGR 2.0 genes in this pathway
BLALOCK ALZHEIMERS DISEASE DN	1237	837	All SZGR 2.0 genes in this pathway
MURAKAMI UV RESPONSE 6HR UP	37	31	All SZGR 2.0 genes in this pathway
KAYO AGING MUSCLE DN	123	76	All SZGR 2.0 genes in this pathway
BROWNE HCMV INFECTION 48HR DN	504	323	All SZGR 2.0 genes in this pathway
ZHU CMV 8 HR DN	53	40	All SZGR 2.0 genes in this pathway
ZHU CMV ALL DN	128	93	All SZGR 2.0 genes in this pathway
GENTILE UV RESPONSE CLUSTER D8	40	29	All SZGR 2.0 genes in this pathway
MARTINEZ RESPONSE TO TRABECTEDIN DN	271	175	All SZGR 2.0 genes in this pathway
MONNIER POSTRADIATION TUMOR ESCAPE UP	393	244	All SZGR 2.0 genes in this pathway
YOSHIMURA MAPK8 TARGETS UP	1305	895	All SZGR 2.0 genes in this pathway
YOSHIMURA MAPK8 TARGETS DN	366	257	All SZGR 2.0 genes in this pathway
MILI PSEUDOPODIA CHEMOTAXIS DN	457	302	All SZGR 2.0 genes in this pathway
SASSON RESPONSE TO GONADOTROPHINS DN	87	66	All SZGR 2.0 genes in this pathway
SASSON RESPONSE TO FORSKOLIN UP	90	58	All SZGR 2.0 genes in this pathway
HIRSCH CELLULAR TRANSFORMATION SIGNATURE UP	242	159	All SZGR 2.0 genes in this pathway
PILON KLF1 TARGETS UP	504	321	All SZGR 2.0 genes in this pathway
PILON KLF1 TARGETS DN	1972	1213	All SZGR 2.0 genes in this pathway
JOHNSTONE PARVB TARGETS 2 DN	336	211	All SZGR 2.0 genes in this pathway

Section VI. microRNA annotation

miRNA family	Target position			miRNA ID	miRNA seq
miRNA family	UTR start	UTR end	Match method	miRNA ID	miRNA seq
miR-124.1	605	612	1A,m8	hsa-miR-124a	UUAAGGCACGCGGUGAAUGCCA
miR-124/506	604	611	1A,m8	hsa-miR-506	UAAGGCACCCUUCUGAGUAGA
miR-124/506	604	611	1A,m8	hsa-miR-124^brain	UAAGGCACGCGGUGAAUGCC
miR-125/351	1610	1616	m8	hsa-miR-125b^brain	UCCCUGAGACCCUAACUUGUGA
miR-125/351	1610	1616	m8	hsa-miR-125a^brain	UCCCUGAGACCCUUUAACCUGUG
miR-128	32	39	1A,m8	hsa-miR-128a	UCACAGUGAACCGGUCUCUUUU
miR-128	32	39	1A,m8	hsa-miR-128b	UCACAGUGAACCGGUCUCUUUC
miR-142-5p	1589	1596	1A,m8	hsa-miR-142-5p	CAUAAAGUAGAAAGCACUAC
miR-185	62	68	1A	hsa-miR-185^brain	UGGAGAGAAAGGCAGUUC
miR-19	2057	2064	1A,m8	hsa-miR-19a	UGUGCAAAUCUAUGCAAAACUGA
miR-19	2057	2064	1A,m8	hsa-miR-19b	UGUGCAAAUCCAUGCAAAACUGA
miR-22	1451	1457	m8	hsa-miR-22^brain	AAGCUGCCAGUUGAAGAACUGU
miR-224	213	219	m8	hsa-miR-224	CAAGUCACUAGUGGUUCCGUUUA
miR-27	33	39	m8	hsa-miR-27a^brain	UUCACAGUGGCUAAGUUCCGC
miR-27	33	39	m8	hsa-miR-27b^brain	UUCACAGUGGCUAAGUUCUGC
miR-505	1105	1112	1A,m8	hsa-miR-505	GUCAACACUUGCUGGUUUCCUC

SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.

Gene Page: MAPK14