SZGR2

Summary ?

GeneID	1508
Symbol	CTSB
Synonyms	APPS\|CPSB
Description	cathepsin B
Reference	MIM:116810\|HGNC:HGNC:2527\|Ensembl:ENSG00000164733\|HPRD:00287\|Vega:OTTHUMG00000090799
Gene type	protein-coding
Map location	8p22
Pascal p-value	0.007
Sherlock p-value	0.697
DMG	2 (# studies)
eGene	Caudate basal ganglia Cerebellum Nucleus accumbens basal ganglia Putamen basal ganglia Myers' cis & trans

Gene in Data Sources

Gene set name	Method of gene set	Description	Info
CV:PGCnp	Genome-wide Association Study	GWAS
DMG:Jaffe_2016	Genome-wide DNA methylation analysis	This dataset includes 2,104 probes/CpGs associated with SZ patients (n=108) compared to 136 controls at Bonferroni-adjusted P < 0.05.	2
DMG:Wockner_2014	Genome-wide DNA methylation analysis	This dataset includes 4641 differentially methylated probes corresponding to 2929 unique genes between schizophrenia patients (n=24) and controls (n=24).	2
Network	Shortest path distance of core genes in the Human protein-protein interaction network	Contribution to shortest path in PPI network: 0.1211

Section I. Genetics and epigenetics annotation

Differentially methylated gene

Probe	Chromosome	Position	Nearest gene	P (dis)	Beta (dis)	FDR (dis)	Study
cg02637136	8	11725599	CTSB	1.704E-4	-0.349	0.033	DMG:Wockner_2014
cg18787975	8	11726094	CTSB	8.74E-8	-0.012	2.01E-5	DMG:Jaffe_2016

eQTL annotation

SNP ID	Chromosome	Position	eGene	Gene Entrez ID	pvalue	qvalue	TSS distance	eQTL type
snp_a-1856993		0	CTSB	1508		0.2		trans
rs35558975	8	11584476	CTSB	ENSG00000164733.16	1.123E-6	0	142481	gtex_brain_putamen_basal
rs1736065	8	11685453	CTSB	ENSG00000164733.16	5.745E-7	0	41504	gtex_brain_putamen_basal
rs144275726	8	11685801	CTSB	ENSG00000164733.16	1.2E-6	0	41156	gtex_brain_putamen_basal
rs1293316	8	11690915	CTSB	ENSG00000164733.16	5.838E-7	0	36042	gtex_brain_putamen_basal
rs6990033	8	11693378	CTSB	ENSG00000164733.16	2.796E-7	0	33579	gtex_brain_putamen_basal
rs1293325	8	11693577	CTSB	ENSG00000164733.16	5.838E-7	0	33380	gtex_brain_putamen_basal
rs1293326	8	11694765	CTSB	ENSG00000164733.16	5.838E-7	0	32192	gtex_brain_putamen_basal
rs1293327	8	11694986	CTSB	ENSG00000164733.16	4.256E-7	0	31971	gtex_brain_putamen_basal
rs1293328	8	11695060	CTSB	ENSG00000164733.16	5.838E-7	0	31897	gtex_brain_putamen_basal
rs1296026	8	11697442	CTSB	ENSG00000164733.16	5.025E-7	0	29515	gtex_brain_putamen_basal
rs1293331	8	11698436	CTSB	ENSG00000164733.16	5.102E-7	0	28521	gtex_brain_putamen_basal
rs1296028	8	11698747	CTSB	ENSG00000164733.16	5.838E-7	0	28210	gtex_brain_putamen_basal
rs1613883	8	11699632	CTSB	ENSG00000164733.16	5.756E-7	0	27325	gtex_brain_putamen_basal
rs1692821	8	11699988	CTSB	ENSG00000164733.16	7.886E-7	0	26969	gtex_brain_putamen_basal
rs2740592	8	11701253	CTSB	ENSG00000164733.16	5.102E-7	0	25704	gtex_brain_putamen_basal
rs2645425	8	11701278	CTSB	ENSG00000164733.16	5.114E-7	0	25679	gtex_brain_putamen_basal
rs4839	8	11701933	CTSB	ENSG00000164733.16	5.102E-7	0	25024	gtex_brain_putamen_basal
rs3947	8	11702375	CTSB	ENSG00000164733.16	5.154E-7	0	24582	gtex_brain_putamen_basal
rs709821	8	11702594	CTSB	ENSG00000164733.16	5.197E-7	0	24363	gtex_brain_putamen_basal
rs1736081	8	11702840	CTSB	ENSG00000164733.16	2.995E-7	0	24117	gtex_brain_putamen_basal
rs1692811	8	11703048	CTSB	ENSG00000164733.16	5.34E-7	0	23909	gtex_brain_putamen_basal
rs1736082	8	11703420	CTSB	ENSG00000164733.16	5.102E-7	0	23537	gtex_brain_putamen_basal
rs1736083	8	11703497	CTSB	ENSG00000164733.16	5.544E-7	0	23460	gtex_brain_putamen_basal
rs1692812	8	11703523	CTSB	ENSG00000164733.16	5.554E-7	0	23434	gtex_brain_putamen_basal
rs1736084	8	11703657	CTSB	ENSG00000164733.16	5.102E-7	0	23300	gtex_brain_putamen_basal
rs1736085	8	11703659	CTSB	ENSG00000164733.16	5.102E-7	0	23298	gtex_brain_putamen_basal
rs1736086	8	11704897	CTSB	ENSG00000164733.16	1.766E-6	0	22060	gtex_brain_putamen_basal
rs1692819	8	11705448	CTSB	ENSG00000164733.16	9.144E-8	0	21509	gtex_brain_putamen_basal
rs1736089	8	11705870	CTSB	ENSG00000164733.16	6.551E-8	0	21087	gtex_brain_putamen_basal
rs2740594	8	11707174	CTSB	ENSG00000164733.16	5.048E-8	0	19783	gtex_brain_putamen_basal
rs2645417	8	11708800	CTSB	ENSG00000164733.16	9.882E-8	0	18157	gtex_brain_putamen_basal
rs2740595	8	11708830	CTSB	ENSG00000164733.16	4.785E-8	0	18127	gtex_brain_putamen_basal
rs1293289	8	11709945	CTSB	ENSG00000164733.16	2.317E-6	0	17012	gtex_brain_putamen_basal
rs1293292	8	11710369	CTSB	ENSG00000164733.16	2.241E-6	0	16588	gtex_brain_putamen_basal
rs1122182	8	11710629	CTSB	ENSG00000164733.16	2.195E-6	0	16328	gtex_brain_putamen_basal
rs34504234	8	11711113	CTSB	ENSG00000164733.16	6.443E-7	0	15844	gtex_brain_putamen_basal
rs1293296	8	11711157	CTSB	ENSG00000164733.16	6.474E-7	0	15800	gtex_brain_putamen_basal
rs1293298	8	11712443	CTSB	ENSG00000164733.16	5.409E-7	0	14514	gtex_brain_putamen_basal
rs1736103	8	11712639	CTSB	ENSG00000164733.16	3.941E-8	0	14318	gtex_brain_putamen_basal

Section II. Transcriptome annotation

General gene expression (GTEx)

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

No co-expressed genes in brain regions

Section III. Gene Ontology annotation

Molecular function	GO term	Evidence	Neuro keywords	PubMed ID
GO:0005515	protein binding	IPI		16364318
GO:0004197	cysteine-type endopeptidase activity	IEA		-
GO:0004197	cysteine-type endopeptidase activity	TAS		1645961
GO:0008233	peptidase activity	IEA		-
Biological process	GO term	Evidence	Neuro keywords	PubMed ID
GO:0006508	proteolysis	IEA		-
GO:0006508	proteolysis	TAS		3463996
GO:0042981	regulation of apoptosis	TAS		16130169
GO:0050790	regulation of catalytic activity	IEA		-
Cellular component	GO term	Evidence	Neuro keywords	PubMed ID
GO:0005622	intracellular	TAS		1645961
GO:0005739	mitochondrion	IEA		-
GO:0005764	lysosome	IEA		-
GO:0042470	melanosome	IEA		-

Section IV. Protein-protein interaction annotation

Interactors	Aliases B	Official full name B	Experimental	Source	PubMed ID
A2M	CPAMD5 \| DKFZp779B086 \| FWP007 \| S863-7	alpha-2-macroglobulin	-	HPRD	2476070
ANXA2	ANX2 \| ANX2L4 \| CAL1H \| LIP2 \| LPC2 \| LPC2D \| P36 \| PAP-IV	annexin A2	-	HPRD,BioGRID	10777578
APOE	AD2 \| LPG \| MGC1571 \| apoprotein	apolipoprotein E	-	HPRD	12057992
BAT3	BAG-6 \| BAG6 \| D6S52E \| G3	HLA-B associated transcript 3	Two-hybrid	BioGRID	16169070
CST3	ARMD11 \| MGC117328	cystatin C	Reconstituted Complex	BioGRID	14503883
CST3	ARMD11 \| MGC117328	cystatin C	-	HPRD	1996959 \|7890620
CST7	CMAP	cystatin F (leukocystatin)	-	HPRD	9632704 \|9733783
CSTA	STF1 \| STFA	cystatin A (stefin A)	Reconstituted Complex	BioGRID	9585570 \|14503883
CSTA	STF1 \| STFA	cystatin A (stefin A)	-	HPRD	9585570 \|10353845 \|14503883
CSTB	CST6 \| EPM1 \| PME \| STFB	cystatin B (stefin B)	-	HPRD,BioGRID	11514663
MARCKS	80K-L \| FLJ14368 \| FLJ90045 \| MACS \| MRACKS \| PKCSL \| PRKCSL	myristoylated alanine-rich protein kinase C substrate	-	HPRD	9295331
S100A10	42C \| ANX2L \| ANX2LG \| CAL1L \| CLP11 \| Ca[1] \| GP11 \| MGC111133 \| P11 \| p10	S100 calcium binding protein A10	-	HPRD,BioGRID	10777578
SERPINB13	HSHUR7SEQ \| HUR7 \| MGC126870 \| PI13 \| headpin	serpin peptidase inhibitor, clade B (ovalbumin), member 13	-	HPRD	10512713

Section V. Pathway annotation

Pathway name	Pathway size	# SZGR 2.0 genes in pathway	Info
KEGG LYSOSOME	121	83	All SZGR 2.0 genes in this pathway
KEGG ANTIGEN PROCESSING AND PRESENTATION	89	65	All SZGR 2.0 genes in this pathway
REACTOME TRAFFICKING AND PROCESSING OF ENDOSOMAL TLR	14	10	All SZGR 2.0 genes in this pathway
REACTOME MHC CLASS II ANTIGEN PRESENTATION	91	61	All SZGR 2.0 genes in this pathway
REACTOME INNATE IMMUNE SYSTEM	279	178	All SZGR 2.0 genes in this pathway
REACTOME IMMUNE SYSTEM	933	616	All SZGR 2.0 genes in this pathway
REACTOME TOLL RECEPTOR CASCADES	118	84	All SZGR 2.0 genes in this pathway
REACTOME ADAPTIVE IMMUNE SYSTEM	539	350	All SZGR 2.0 genes in this pathway
LIU PROSTATE CANCER DN	481	290	All SZGR 2.0 genes in this pathway
ONKEN UVEAL MELANOMA UP	783	507	All SZGR 2.0 genes in this pathway
GAZDA DIAMOND BLACKFAN ANEMIA ERYTHROID DN	493	298	All SZGR 2.0 genes in this pathway
THUM SYSTOLIC HEART FAILURE UP	423	283	All SZGR 2.0 genes in this pathway
LAIHO COLORECTAL CANCER SERRATED UP	112	71	All SZGR 2.0 genes in this pathway
WANG CLIM2 TARGETS DN	186	114	All SZGR 2.0 genes in this pathway
VECCHI GASTRIC CANCER EARLY UP	430	232	All SZGR 2.0 genes in this pathway
SMIRNOV CIRCULATING ENDOTHELIOCYTES IN CANCER UP	158	103	All SZGR 2.0 genes in this pathway
OSMAN BLADDER CANCER UP	404	246	All SZGR 2.0 genes in this pathway
TAKEDA TARGETS OF NUP98 HOXA9 FUSION 8D DN	205	127	All SZGR 2.0 genes in this pathway
TAKEDA TARGETS OF NUP98 HOXA9 FUSION 10D DN	142	90	All SZGR 2.0 genes in this pathway
PAPASPYRIDONOS UNSTABLE ATEROSCLEROTIC PLAQUE UP	52	36	All SZGR 2.0 genes in this pathway
SENESE HDAC3 TARGETS UP	501	327	All SZGR 2.0 genes in this pathway
JAATINEN HEMATOPOIETIC STEM CELL DN	226	132	All SZGR 2.0 genes in this pathway
RODRIGUES THYROID CARCINOMA POORLY DIFFERENTIATED DN	805	505	All SZGR 2.0 genes in this pathway
RODRIGUES THYROID CARCINOMA ANAPLASTIC DN	537	339	All SZGR 2.0 genes in this pathway
PROVENZANI METASTASIS DN	136	94	All SZGR 2.0 genes in this pathway
ENK UV RESPONSE EPIDERMIS UP	293	179	All SZGR 2.0 genes in this pathway
DELYS THYROID CANCER UP	443	294	All SZGR 2.0 genes in this pathway
CHIARADONNA NEOPLASTIC TRANSFORMATION KRAS UP	126	72	All SZGR 2.0 genes in this pathway
CHIARADONNA NEOPLASTIC TRANSFORMATION CDC25 UP	120	73	All SZGR 2.0 genes in this pathway
MARKEY RB1 ACUTE LOF UP	215	137	All SZGR 2.0 genes in this pathway
CHIN BREAST CANCER COPY NUMBER DN	16	10	All SZGR 2.0 genes in this pathway
GRAESSMANN APOPTOSIS BY DOXORUBICIN UP	1142	669	All SZGR 2.0 genes in this pathway
GRAESSMANN RESPONSE TO MC AND DOXORUBICIN UP	612	367	All SZGR 2.0 genes in this pathway
MISSIAGLIA REGULATED BY METHYLATION UP	126	78	All SZGR 2.0 genes in this pathway
WANG BARRETTS ESOPHAGUS DN	25	13	All SZGR 2.0 genes in this pathway
AIYAR COBRA1 TARGETS UP	39	25	All SZGR 2.0 genes in this pathway
DAUER STAT3 TARGETS UP	49	35	All SZGR 2.0 genes in this pathway
TSUNODA CISPLATIN RESISTANCE DN	51	38	All SZGR 2.0 genes in this pathway
MOHANKUMAR TLX1 TARGETS UP	414	287	All SZGR 2.0 genes in this pathway
HOWLIN PUBERTAL MAMMARY GLAND	69	40	All SZGR 2.0 genes in this pathway
NUYTTEN EZH2 TARGETS UP	1037	673	All SZGR 2.0 genes in this pathway
LIU BREAST CANCER	30	19	All SZGR 2.0 genes in this pathway
WEI MIR34A TARGETS	148	97	All SZGR 2.0 genes in this pathway
SCHAEFFER PROSTATE DEVELOPMENT 48HR DN	428	306	All SZGR 2.0 genes in this pathway
MORI PLASMA CELL UP	51	29	All SZGR 2.0 genes in this pathway
JECHLINGER EPITHELIAL TO MESENCHYMAL TRANSITION UP	71	51	All SZGR 2.0 genes in this pathway
WIELAND UP BY HBV INFECTION	101	66	All SZGR 2.0 genes in this pathway
MAGRANGEAS MULTIPLE MYELOMA IGLL VS IGLK UP	42	24	All SZGR 2.0 genes in this pathway
NADLER OBESITY UP	61	34	All SZGR 2.0 genes in this pathway
LIAN NEUTROPHIL GRANULE CONSTITUENTS	25	13	All SZGR 2.0 genes in this pathway
APPEL IMATINIB RESPONSE	33	22	All SZGR 2.0 genes in this pathway
KUMAR TARGETS OF MLL AF9 FUSION	405	264	All SZGR 2.0 genes in this pathway
REN ALVEOLAR RHABDOMYOSARCOMA DN	408	274	All SZGR 2.0 genes in this pathway
IVANOVA HEMATOPOIESIS MATURE CELL	293	160	All SZGR 2.0 genes in this pathway
IVANOVA HEMATOPOIESIS LATE PROGENITOR	544	307	All SZGR 2.0 genes in this pathway
RAMALHO STEMNESS DN	74	55	All SZGR 2.0 genes in this pathway
LIAN LIPA TARGETS 6M	74	47	All SZGR 2.0 genes in this pathway
HENDRICKS SMARCA4 TARGETS UP	56	35	All SZGR 2.0 genes in this pathway
CHEN LVAD SUPPORT OF FAILING HEART DN	42	32	All SZGR 2.0 genes in this pathway
BLALOCK ALZHEIMERS DISEASE UP	1691	1088	All SZGR 2.0 genes in this pathway
LIAN LIPA TARGETS 3M	59	36	All SZGR 2.0 genes in this pathway
MCLACHLAN DENTAL CARIES DN	245	144	All SZGR 2.0 genes in this pathway
KYNG RESPONSE TO H2O2	71	42	All SZGR 2.0 genes in this pathway
MCLACHLAN DENTAL CARIES UP	253	147	All SZGR 2.0 genes in this pathway
ZHONG SECRETOME OF LUNG CANCER AND MACROPHAGE	77	50	All SZGR 2.0 genes in this pathway
ZHONG SECRETOME OF LUNG CANCER AND FIBROBLAST	132	93	All SZGR 2.0 genes in this pathway
KONDO EZH2 TARGETS	245	148	All SZGR 2.0 genes in this pathway
ZHANG GATA6 TARGETS DN	64	46	All SZGR 2.0 genes in this pathway
MARTINEZ RB1 TARGETS UP	673	430	All SZGR 2.0 genes in this pathway
MARTINEZ TP53 TARGETS DN	593	372	All SZGR 2.0 genes in this pathway
MARTINEZ RB1 AND TP53 TARGETS UP	601	369	All SZGR 2.0 genes in this pathway
IWANAGA CARCINOGENESIS BY KRAS PTEN UP	181	112	All SZGR 2.0 genes in this pathway
OUYANG PROSTATE CANCER MARKERS	19	16	All SZGR 2.0 genes in this pathway
HUANG FOXA2 TARGETS DN	36	21	All SZGR 2.0 genes in this pathway
ACEVEDO NORMAL TISSUE ADJACENT TO LIVER TUMOR DN	354	216	All SZGR 2.0 genes in this pathway
ACEVEDO LIVER CANCER DN	540	340	All SZGR 2.0 genes in this pathway
MITSIADES RESPONSE TO APLIDIN UP	439	257	All SZGR 2.0 genes in this pathway
CHUNG BLISTER CYTOTOXICITY UP	134	84	All SZGR 2.0 genes in this pathway
GRADE COLON CANCER UP	871	505	All SZGR 2.0 genes in this pathway
GRADE COLON AND RECTAL CANCER UP	285	167	All SZGR 2.0 genes in this pathway
ALONSO METASTASIS EMT UP	36	24	All SZGR 2.0 genes in this pathway
ALONSO METASTASIS UP	198	128	All SZGR 2.0 genes in this pathway
HELLEBREKERS SILENCED DURING TUMOR ANGIOGENESIS	80	56	All SZGR 2.0 genes in this pathway
TOOKER GEMCITABINE RESISTANCE DN	122	84	All SZGR 2.0 genes in this pathway
RUTELLA RESPONSE TO CSF2RB AND IL4 DN	315	201	All SZGR 2.0 genes in this pathway
RUTELLA RESPONSE TO HGF UP	418	282	All SZGR 2.0 genes in this pathway
RUTELLA RESPONSE TO HGF VS CSF2RB AND IL4 UP	408	276	All SZGR 2.0 genes in this pathway
SWEET LUNG CANCER KRAS UP	491	316	All SZGR 2.0 genes in this pathway
HAN SATB1 TARGETS UP	395	249	All SZGR 2.0 genes in this pathway
CHEN METABOLIC SYNDROM NETWORK	1210	725	All SZGR 2.0 genes in this pathway
MILI PSEUDOPODIA CHEMOTAXIS DN	457	302	All SZGR 2.0 genes in this pathway
BOYAULT LIVER CANCER SUBCLASS G1 DN	40	26	All SZGR 2.0 genes in this pathway
DANG REGULATED BY MYC DN	253	192	All SZGR 2.0 genes in this pathway
KARLSSON TGFB1 TARGETS DN	207	139	All SZGR 2.0 genes in this pathway
VERHAAK GLIOBLASTOMA MESENCHYMAL	216	130	All SZGR 2.0 genes in this pathway
HIRSCH CELLULAR TRANSFORMATION SIGNATURE UP	242	159	All SZGR 2.0 genes in this pathway
WANG RESPONSE TO GSK3 INHIBITOR SB216763 UP	397	206	All SZGR 2.0 genes in this pathway
GREGORY SYNTHETIC LETHAL WITH IMATINIB	145	83	All SZGR 2.0 genes in this pathway
JOHNSTONE PARVB TARGETS 1 DN	63	39	All SZGR 2.0 genes in this pathway
JOHNSTONE PARVB TARGETS 3 UP	430	288	All SZGR 2.0 genes in this pathway
DELPUECH FOXO3 TARGETS UP	68	49	All SZGR 2.0 genes in this pathway
LEE BMP2 TARGETS UP	745	475	All SZGR 2.0 genes in this pathway
FEVR CTNNB1 TARGETS UP	682	433	All SZGR 2.0 genes in this pathway
PURBEY TARGETS OF CTBP1 NOT SATB1 DN	448	282	All SZGR 2.0 genes in this pathway
DELACROIX RARG BOUND MEF	367	231	All SZGR 2.0 genes in this pathway
NABA ECM REGULATORS	238	125	All SZGR 2.0 genes in this pathway
NABA MATRISOME ASSOCIATED	753	411	All SZGR 2.0 genes in this pathway
NABA MATRISOME	1028	559	All SZGR 2.0 genes in this pathway

Section VI. microRNA annotation

miRNA family	Target position			miRNA ID	miRNA seq
miRNA family	UTR start	UTR end	Match method	miRNA ID	miRNA seq
miR-186	59	66	1A,m8	hsa-miR-186	CAAAGAAUUCUCCUUUUGGGCUU

SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.

Gene Page: CTSB