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| GeneID |
1815
|
| Symbol |
DRD4
|
| Synonyms |
D4DR
|
| Description |
dopamine receptor D4 |
| See related |
HGNC:3025|MIM:126452|Ensembl:ENSG00000069696|HPRD:00541| |
| Locus tag |
- |
| Gene type |
protein-coding |
| Map location |
11p15.5 |
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| Gene set name |
Method of gene set |
Evidence |
Info |
| Association | A combined odds ratio method (Sun et al. 2008), association studies | 3 | Link to SZGene | | Literature | High-throughput literature-search | Co-occurance with Schizophrenia keywords: [schizophrenias, schizophrenia] | Click to show detail | | GO_Annotation | Mapping neuro-related keywords to Gene Ontology annotations | Hits with neuro-related keywords: 9 | | | Network | Shortest path distance of core genes in the Human protein-protein interaction network | Contribution to shortest path in PPI network: 31 | |
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| General Gene Expression (microarray) ? |
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| Gene Expression in Brain Regions (new) |
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| Top co-expressed genes in Brain Regions (new) |
|
| Gene | Pearson's Correlation | Spearman's Correlation | | |
| Top 10 positively co-expressed genes |
| TBR1 | 0.92 | 0.79 | | |
| FAM59A | 0.92 | 0.90 | | |
| SLC35F2 | 0.91 | 0.81 | | |
| PBX1 | 0.90 | 0.88 | | |
| OSBPL10 | 0.90 | 0.85 | | |
| STT3B | 0.89 | 0.90 | | |
| GPD1L | 0.88 | 0.89 | | |
| DAP | 0.88 | 0.69 | | |
| TOX | 0.88 | 0.81 | | |
| LIMCH1 | 0.88 | 0.84 | | |
Top 10 negatively co-expressed genes | | SERPINB6 | -0.56 | -0.66 | | |
| C5orf53 | -0.53 | -0.69 | | |
| TNFSF12 | -0.53 | -0.58 | | |
| HSD17B14 | -0.53 | -0.73 | | |
| IFI27 | -0.52 | -0.80 | | |
| FXYD1 | -0.52 | -0.82 | | |
| AC018755.7 | -0.51 | -0.65 | | |
| AC007405.8 | -0.51 | -0.60 | | |
| PTH1R | -0.51 | -0.68 | | |
| AIFM3 | -0.51 | -0.70 | | |
|
| Molecular function | GO term | Evidence | Neuro keywords | PubMed ID |
|---|
| GO:0004952 | dopamine receptor activity | IEA | Neurotransmitter, dopamine (GO term level: 8) | - |
| GO:0004952 | dopamine receptor activity | NAS | Neurotransmitter, dopamine (GO term level: 8) | 8746407 |
| GO:0001593 | dopamine D4 receptor activity | IEA | dopamine (GO term level: 10) | - |
| GO:0001591 | dopamine receptor coupled via Gi/Go | TAS | Neurotransmitter, dopamine (GO term level: 9) | 9457173 |
| GO:0004872 | receptor activity | IEA | | - |
| GO:0008144 | drug binding | IDA | | 1840645 |
| Biological process | GO term | Evidence | Neuro keywords | PubMed ID |
|---|
| GO:0060080 | regulation of inhibitory postsynaptic membrane potential | IEA | neuron, Synap (GO term level: 10) | - |
| GO:0007268 | synaptic transmission | TAS | neuron, Synap, Neurotransmitter (GO term level: 6) | 8413587 |
| GO:0007195 | dopamine receptor, adenylate cyclase inhibiting pathway | IEA | dopamine (GO term level: 12) | - |
| GO:0007195 | dopamine receptor, adenylate cyclase inhibiting pathway | TAS | dopamine (GO term level: 12) | 9457173 |
| GO:0042053 | regulation of dopamine metabolic process | IEA | dopamine (GO term level: 9) | - |
| GO:0001975 | response to amphetamine | IEA | | - |
| GO:0007186 | G-protein coupled receptor protein signaling pathway | IEA | | - |
| GO:0007194 | negative regulation of adenylate cyclase activity | TAS | | 9457173 |
| GO:0008344 | adult locomotory behavior | IEA | | - |
| GO:0006874 | cellular calcium ion homeostasis | IC | | 7921596 |
| GO:0014075 | response to amine stimulus | IDA | | 16839358 |
| GO:0042596 | fear response | IEA | | - |
| GO:0048148 | behavioral response to cocaine | IEA | | - |
| GO:0050709 | negative regulation of protein secretion | IDA | | 16839358 |
| GO:0051927 | negative regulation of calcium ion transport via voltage-gated calcium channel | IDA | | 7921596 |
| Cellular component | GO term | Evidence | Neuro keywords | PubMed ID |
|---|
| GO:0016020 | membrane | NAS | | 8746407 |
| GO:0016021 | integral to membrane | IEA | | - |
| GO:0005886 | plasma membrane | TAS | | 1319557 |
| GO:0005887 | integral to plasma membrane | TAS | | 1319557 |
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