Gene Page: DRD4

Summary ?
GeneID1815
SymbolDRD4
SynonymsD4DR
Descriptiondopamine receptor D4
ReferenceMIM:126452|HGNC:HGNC:3025|Ensembl:ENSG00000069696|HPRD:00541|Vega:OTTHUMG00000133312
Gene typeprotein-coding
Map location11p15.5
Pascal p-value0.357
Sherlock p-value0.764
Fetal beta0.027
eGeneMyers' cis & trans

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
ADT:Sun_2012Systematic Investigation of Antipsychotic Drugs and Their TargetsA total of 382 drug-target associations involving 43 antipsychotic drugs and 49 target genes.
CV:PGCnpGenome-wide Association StudyGWAS
PMID:cooccurHigh-throughput literature-searchSystematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
AssociationA combined odds ratio method (Sun et al. 2008), association studies3Link to SZGene
LiteratureHigh-throughput literature-searchCo-occurance with Schizophrenia keywords: schizophrenia,schizophrenic,schizophrenics,schizotypy,schizophrenias,schizotypalClick to show details
GO_AnnotationMapping neuro-related keywords to Gene Ontology annotationsHits with neuro-related keywords: 9 
NetworkShortest path distance of core genes in the Human protein-protein interaction networkContribution to shortest path in PPI network: 31 

Section I. Genetics and epigenetics annotation

@eQTL annotation

SNP IDChromosomePositioneGeneGene Entrez IDpvalueqvalueTSS distanceeQTL type
rs16903386chr588159284DRD418150.11trans
rs7503446chr1737246066DRD418150.01trans

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
GenePearson's Correlation Spearman's Correlation
TBR10.920.79
FAM59A0.920.90
SLC35F20.910.81
PBX10.900.88
OSBPL100.900.85
STT3B0.890.90
GPD1L0.880.89
DAP0.880.69
TOX0.880.81
LIMCH10.880.84
Top 10 negatively co-expressed genes
GenePearson's Correlation Spearman's Correlation
SERPINB6-0.56-0.66
C5orf53-0.53-0.69
TNFSF12-0.53-0.58
HSD17B14-0.53-0.73
IFI27-0.52-0.80
FXYD1-0.52-0.82
AC018755.7-0.51-0.65
AC007405.8-0.51-0.60
PTH1R-0.51-0.68
AIFM3-0.51-0.70

Section III. Gene Ontology annotation

Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0004952dopamine receptor activityIEANeurotransmitter, dopamine (GO term level: 8)-
GO:0004952dopamine receptor activityNASNeurotransmitter, dopamine (GO term level: 8)8746407 
GO:0001593dopamine D4 receptor activityIEAdopamine (GO term level: 10)-
GO:0001591dopamine receptor coupled via Gi/GoTASNeurotransmitter, dopamine (GO term level: 9)9457173 
GO:0004872receptor activityIEA-
GO:0008144drug bindingIDA1840645 
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0060080regulation of inhibitory postsynaptic membrane potentialIEAneuron, Synap (GO term level: 10)-
GO:0007268synaptic transmissionTASneuron, Synap, Neurotransmitter (GO term level: 6)8413587 
GO:0007195dopamine receptor, adenylate cyclase inhibiting pathwayIEAdopamine (GO term level: 12)-
GO:0007195dopamine receptor, adenylate cyclase inhibiting pathwayTASdopamine (GO term level: 12)9457173 
GO:0042053regulation of dopamine metabolic processIEAdopamine (GO term level: 9)-
GO:0001975response to amphetamineIEA-
GO:0007186G-protein coupled receptor protein signaling pathwayIEA-
GO:0007194negative regulation of adenylate cyclase activityTAS9457173 
GO:0008344adult locomotory behaviorIEA-
GO:0006874cellular calcium ion homeostasisIC7921596 
GO:0014075response to amine stimulusIDA16839358 
GO:0042596fear responseIEA-
GO:0048148behavioral response to cocaineIEA-
GO:0050709negative regulation of protein secretionIDA16839358 
GO:0051927negative regulation of calcium ion transport via voltage-gated calcium channelIDA7921596 
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0016020membraneNAS8746407 
GO:0016021integral to membraneIEA-
GO:0005886plasma membraneTAS1319557 
GO:0005887integral to plasma membraneTAS1319557 

Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
KEGG NEUROACTIVE LIGAND RECEPTOR INTERACTION 272195All SZGR 2.0 genes in this pathway
HATADA METHYLATED IN LUNG CANCER UP 390236All SZGR 2.0 genes in this pathway
BENPORATH EED TARGETS 1062725All SZGR 2.0 genes in this pathway
BENPORATH ES WITH H3K27ME3 1118744All SZGR 2.0 genes in this pathway
AFFAR YY1 TARGETS UP 214133All SZGR 2.0 genes in this pathway
LEE CALORIE RESTRICTION NEOCORTEX UP 8366All SZGR 2.0 genes in this pathway
HOQUE METHYLATED IN CANCER 5645All SZGR 2.0 genes in this pathway
MUELLER COMMON TARGETS OF AML FUSIONS DN 3121All SZGR 2.0 genes in this pathway
SHEDDEN LUNG CANCER GOOD SURVIVAL A12 317177All SZGR 2.0 genes in this pathway
MEISSNER BRAIN HCP WITH H3K27ME3 269159All SZGR 2.0 genes in this pathway
MEISSNER NPC HCP WITH H3K4ME2 491319All SZGR 2.0 genes in this pathway
MIKKELSEN MCV6 HCP WITH H3K27ME3 435318All SZGR 2.0 genes in this pathway
YAO TEMPORAL RESPONSE TO PROGESTERONE CLUSTER 4 1511All SZGR 2.0 genes in this pathway
PANGAS TUMOR SUPPRESSION BY SMAD1 AND SMAD5 DN 157106All SZGR 2.0 genes in this pathway
LEE BMP2 TARGETS DN 882538All SZGR 2.0 genes in this pathway
ZWANG TRANSIENTLY UP BY 2ND EGF PULSE ONLY 1725838All SZGR 2.0 genes in this pathway