Gene Page: SLC26A2

Summary ?
GeneID1836
SymbolSLC26A2
SynonymsD5S1708|DTD|DTDST|EDM4|MST153|MSTP157
Descriptionsolute carrier family 26 member 2
ReferenceMIM:606718|HGNC:HGNC:10994|Ensembl:ENSG00000155850|HPRD:05990|Vega:OTTHUMG00000130054
Gene typeprotein-coding
Map location5q32
Pascal p-value0.244
Fetal beta0.902
DMG1 (# studies)
eGeneMyers' cis & trans

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
CV:PGCnpGenome-wide Association StudyGWAS
DMG:Jaffe_2016Genome-wide DNA methylation analysisThis dataset includes 2,104 probes/CpGs associated with SZ patients (n=108) compared to 136 controls at Bonferroni-adjusted P < 0.05. 1
GSMA_IGenome scan meta-analysisPsr: 0.0032 
GSMA_IIAGenome scan meta-analysis (All samples)Psr: 0.00459 
GSMA_IIEGenome scan meta-analysis (European-ancestry samples)Psr: 0.01718 

Section I. Genetics and epigenetics annotation

@Differentially methylated gene

ProbeChromosomePositionNearest geneP (dis)Beta (dis)FDR (dis)Study
cg205403785149340137SLC26A21.5E-8-0.0075.7E-6DMG:Jaffe_2016

@eQTL annotation

SNP IDChromosomePositioneGeneGene Entrez IDpvalueqvalueTSS distanceeQTL type
rs6874540chr5149911669SLC26A218360.13cis
rs2273232chr5149912526SLC26A218360.13cis
rs17131472chr191962966SLC26A218360.01trans
rs1473237chr1191045246SLC26A218360.11trans
rs2115055chr2119478688SLC26A218360.09trans
rs2922180chr3125280472SLC26A218367.742E-5trans
rs2976809chr3125451738SLC26A218363.095E-4trans
rs16889842chr49872012SLC26A218360.02trans
snp_a-19762280SLC26A218360.08trans
rs2732167chr488706292SLC26A218360.03trans
rs313946chr4113975904SLC26A218360trans
rs10050805chr530805352SLC26A218360.05trans
rs17056435chr5158453782SLC26A218360trans
rs17135501chr62704474SLC26A218360.01trans
rs17135521chr62707631SLC26A218360.01trans
snp_a-17879260SLC26A218360.01trans
rs6455226chr667930295SLC26A218360.05trans
rs8192621chr6132966206SLC26A218360.03trans
rs17065063chr6136207301SLC26A218360.17trans
rs2398707chr72113428SLC26A218360.16trans
rs3778951chr72125319SLC26A218360.16trans
rs3778957chr72127710SLC26A218360.16trans
rs17156987chr728704217SLC26A218360.2trans
rs2286089chr738789903SLC26A218360.09trans
rs2430483chr7104548631SLC26A218360.03trans
rs888577chr8239323SLC26A218360.17trans
rs2515434chr86374892SLC26A218360.05trans
rs2442623chr86376337SLC26A218360.05trans
rs2515437chr86377140SLC26A218360.05trans
rs1960369chr86379235SLC26A218360.01trans
rs2515463chr86384137SLC26A218360.12trans
rs2919377chr832573740SLC26A218360.11trans
rs2253777chr993467893SLC26A218360.12trans
rs6478086chr9117273020SLC26A218360.03trans
rs998410chr9117622673SLC26A218361.521E-5trans
rs9423711chr102574802SLC26A218360.17trans
rs4514358chr1043861923SLC26A218360.04trans
rs2116478chr1183362424SLC26A218360.05trans
rs2098090chr124770747SLC26A218360.09trans
rs107479720SLC26A218360.02trans
rs995817chr1267557935SLC26A218360trans
rs11112163chr12105072508SLC26A218360.02trans
rs9551590chr1329589464SLC26A218360.01trans
rs9529974chr1372821935SLC26A218360.05trans
rs11840833chr1394378306SLC26A218360.01trans
rs17381373chr13109002943SLC26A218360.18trans
rs10142086chr1435135892SLC26A218360.08trans
rs1956517chr1437738426SLC26A218360.1trans
rs10498433chr1452289530SLC26A218360trans
rs2093759chr1497171024SLC26A218360.09trans
rs17244419chr1497171074SLC26A218360trans
rs16976022chr1555454260SLC26A218360.2trans
rs16976029chr1555455268SLC26A218360.13trans
rs16977927chr1772154232SLC26A218360.06trans
rs16940550chr1813442256SLC26A218360.07trans
rs11873703chr1861448702SLC26A218360trans
rs9951107chr1874437994SLC26A218360.07trans
rs1075540chr2225254707SLC26A218360.09trans
rs6000401chr2237149335SLC26A218360.14trans
rs5991662chrX43335796SLC26A218360.06trans

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
GenePearson's Correlation Spearman's Correlation
AC024909.10.980.98
CACNB20.850.86
CNNM10.840.83
PRRT30.830.85
SLC35F30.830.84
KCNS20.830.83
CX3CL10.820.84
GPR610.820.85
EGR20.820.79
NALCN0.810.88
Top 10 negatively co-expressed genes
GenePearson's Correlation Spearman's Correlation
RBMX2-0.43-0.51
SNHG12-0.42-0.52
GTF3C6-0.42-0.42
EXOSC8-0.41-0.40
RPL38-0.41-0.56
RPL37-0.41-0.58
RPS20-0.41-0.52
RPL23A-0.41-0.49
RPS13P2-0.40-0.43
RPS27A-0.40-0.49

Section III. Gene Ontology annotation

Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0005215transporter activityIEA-
GO:0008271secondary active sulfate transmembrane transporter activityIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0008272sulfate transportTAS7923357 
GO:0006810transportIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005624membrane fractionTAS8528239 
GO:0016020membraneIEA-
GO:0005887integral to plasma membraneTAS8528239 

Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
REACTOME TRANSMEMBRANE TRANSPORT OF SMALL MOLECULES 413270All SZGR 2.0 genes in this pathway
REACTOME SLC MEDIATED TRANSMEMBRANE TRANSPORT 241157All SZGR 2.0 genes in this pathway
REACTOME TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES 9465All SZGR 2.0 genes in this pathway
WATANABE COLON CANCER MSI VS MSS DN 8142All SZGR 2.0 genes in this pathway
WANG CLIM2 TARGETS UP 269146All SZGR 2.0 genes in this pathway
OSMAN BLADDER CANCER UP 404246All SZGR 2.0 genes in this pathway
SENESE HDAC1 AND HDAC2 TARGETS DN 232139All SZGR 2.0 genes in this pathway
SABATES COLORECTAL ADENOMA DN 291176All SZGR 2.0 genes in this pathway
KIM WT1 TARGETS DN 459276All SZGR 2.0 genes in this pathway
DODD NASOPHARYNGEAL CARCINOMA UP 1821933All SZGR 2.0 genes in this pathway
GAUSSMANN MLL AF4 FUSION TARGETS G UP 238135All SZGR 2.0 genes in this pathway
WANG ESOPHAGUS CANCER VS NORMAL DN 10166All SZGR 2.0 genes in this pathway
PATIL LIVER CANCER 747453All SZGR 2.0 genes in this pathway
WILLIAMS ESR1 TARGETS UP 2616All SZGR 2.0 genes in this pathway
NUYTTEN EZH2 TARGETS DN 1024594All SZGR 2.0 genes in this pathway
BUYTAERT PHOTODYNAMIC THERAPY STRESS DN 637377All SZGR 2.0 genes in this pathway
AMIT SERUM RESPONSE 480 MCF10A 3920All SZGR 2.0 genes in this pathway
GEORGES TARGETS OF MIR192 AND MIR215 893528All SZGR 2.0 genes in this pathway
CERVERA SDHB TARGETS 2 11476All SZGR 2.0 genes in this pathway
CHEOK RESPONSE TO MERCAPTOPURINE UP 1310All SZGR 2.0 genes in this pathway
NELSON RESPONSE TO ANDROGEN UP 8661All SZGR 2.0 genes in this pathway
TRAYNOR RETT SYNDROM DN 1914All SZGR 2.0 genes in this pathway
BLALOCK ALZHEIMERS DISEASE UP 16911088All SZGR 2.0 genes in this pathway
NIELSEN SCHWANNOMA UP 1816All SZGR 2.0 genes in this pathway
XU GH1 AUTOCRINE TARGETS UP 268157All SZGR 2.0 genes in this pathway
CREIGHTON ENDOCRINE THERAPY RESISTANCE 4 307185All SZGR 2.0 genes in this pathway
MASSARWEH TAMOXIFEN RESISTANCE DN 258160All SZGR 2.0 genes in this pathway
MASSARWEH RESPONSE TO ESTRADIOL 6147All SZGR 2.0 genes in this pathway
FUJII YBX1 TARGETS DN 202132All SZGR 2.0 genes in this pathway
RIGGI EWING SARCOMA PROGENITOR UP 430288All SZGR 2.0 genes in this pathway
ACEVEDO LIVER CANCER WITH H3K9ME3 DN 12071All SZGR 2.0 genes in this pathway
SMID BREAST CANCER BASAL UP 648398All SZGR 2.0 genes in this pathway
ZHENG GLIOBLASTOMA PLASTICITY DN 5839All SZGR 2.0 genes in this pathway
BOYAULT LIVER CANCER SUBCLASS G23 UP 5235All SZGR 2.0 genes in this pathway
CAIRO HEPATOBLASTOMA UP 207143All SZGR 2.0 genes in this pathway
KYNG RESPONSE TO H2O2 VIA ERCC6 UP 4030All SZGR 2.0 genes in this pathway
STAMBOLSKY RESPONSE TO VITAMIN D3 UP 8448All SZGR 2.0 genes in this pathway
DUTERTRE ESTRADIOL RESPONSE 6HR UP 229149All SZGR 2.0 genes in this pathway
DUTERTRE ESTRADIOL RESPONSE 24HR UP 324193All SZGR 2.0 genes in this pathway
GABRIELY MIR21 TARGETS 289187All SZGR 2.0 genes in this pathway
MIYAGAWA TARGETS OF EWSR1 ETS FUSIONS UP 259159All SZGR 2.0 genes in this pathway
GOBERT OLIGODENDROCYTE DIFFERENTIATION DN 1080713All SZGR 2.0 genes in this pathway
ZWANG CLASS 1 TRANSIENTLY INDUCED BY EGF 516308All SZGR 2.0 genes in this pathway