Gene Page: EDN1

Summary
GeneID  1906
Symbol  EDN1
Synonyms  ET1|HDLCQ7
Description  endothelin 1
See related  HGNC:3176|MIM:131240|Ensembl:ENSG00000078401|HPRD:07030|
Locus tag  -
Gene type  protein-coding
Map location  6p24.1
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
GSMA_Igenome scan meta-analysisPsr: 0.0159 
LiteratureHigh-throughput literature-searchCo-occurance with Schizophrenia keywords: [schizophrenias, schizophrenia]Click to show detail
GO_AnnotationMapping neuro-related keywords to Gene Ontology annotationsHits with neuro-related keywords: 1 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
Top 10 negatively co-expressed genes
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0005179hormone activityIDA2649896 |10770212 
GO:0031707endothelin A receptor bindingIEA-
GO:0031708endothelin B receptor bindingIDA10770212 
GO:0031708endothelin B receptor bindingIPI1713452 
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0043179rhythmic excitationIEASynap (GO term level: 9)-
GO:0001569patterning of blood vesselsIEA-
GO:0001666response to hypoxiaIEA-
GO:0001701in utero embryonic developmentIEA-
GO:0003100regulation of systemic arterial blood pressure by endothelinIDA2649896 
GO:0007205activation of protein kinase C activityIEA-
GO:0008217regulation of blood pressureIEA-
GO:0007267cell-cell signalingIDA12379507 
GO:0010595positive regulation of endothelial cell migrationTAS8999856 
GO:0009953dorsal/ventral pattern formationIEA-
GO:0030195negative regulation of blood coagulationTAS16820593 
GO:0048016inositol phosphate-mediated signalingIDA1917960 
GO:0030072peptide hormone secretionIDA10770212 
GO:0007507heart developmentIEA-
GO:0007585respiratory gaseous exchangeIEA-
GO:0014032neural crest cell developmentIEA-
GO:0015758glucose transportIEA-
GO:0010460positive regulation of heart rateIDA2649896 
GO:0006885regulation of pHIEA-
GO:0014065phosphoinositide 3-kinase cascadeIDA17078114 
GO:0019722calcium-mediated signalingIDA1917960 |10770212 
GO:0042313protein kinase C deactivationIDA16820593 
GO:0014824artery smooth muscle contractionTAS1725334 
GO:0043507positive regulation of JNK activityIDA12847114 
GO:0042474middle ear morphogenesisIEA-
GO:0051216cartilage developmentIEA-
GO:0019229regulation of vasoconstrictionIEA-
GO:0030818negative regulation of cAMP biosynthetic processIEA-
GO:0031583G-protein signaling, phospholipase D activating pathwayIEA-
GO:0030146diuresisIEA-
GO:0030147natriuresisIEA-
GO:0030185nitric oxide transportIDA16820593 
GO:0045321leukocyte activationTAS16820593 
GO:0045840positive regulation of mitosisIDA10770212 
GO:0046887positive regulation of hormone secretionIDA10770212 
GO:0045793positive regulation of cell sizeIDA12847114 
GO:0045987positive regulation of smooth muscle contractionIEA-
GO:0048514blood vessel morphogenesisIEA-
GO:0048661positive regulation of smooth muscle cell proliferationIDA10393673 
GO:0045429positive regulation of nitric oxide biosynthetic processTAS8999856 
GO:0051482elevation of cytosolic calcium ion concentration during G-protein signaling, coupled to IP3 second messenger (phospholipase C activating)IEA-
GO:0051771negative regulation of nitric-oxide synthase biosynthetic processIDA16820593 
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005576extracellular regionIEA-
GO:0005615extracellular spaceIEA-
GO:0005737cytoplasmIDA12379507 
 
InteractionsShown by Network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
ADMAMadrenomedullin-HPRD11410113 
BAT3BAG-6 | BAG6 | D6S52E | G3HLA-B associated transcript 3Two-hybridBioGRID16169070 
COPS6CSN6 | MOV34-34KDCOP9 constitutive photomorphogenic homolog subunit 6 (Arabidopsis)Two-hybridBioGRID16169070 
EDNRAETA | ETRAendothelin receptor type A-HPRD10770212 
EDNRBABCDS | ETB | ETBR | ETRB | HSCR | HSCR2endothelin receptor type B-HPRD12972292 
NPPCCNPnatriuretic peptide precursor C-HPRD12379507 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
KEGG_MELANOGENESIS 10280All SZGR genes in this pathway
BIOCARTA_HIF_PATHWAY 1512All SZGR genes in this pathway
BIOCARTA_NFAT_PATHWAY 5645All SZGR genes in this pathway
BIOCARTA_CARDIACEGF_PATHWAY 1816All SZGR genes in this pathway
PID_ENDOTHELIN_PATHWAY 6352All SZGR genes in this pathway
PID_AP1_PATHWAY 7060All SZGR genes in this pathway
PID_HIF1_TFPATHWAY 6652All SZGR genes in this pathway
REACTOME_GASTRIN_CREB_SIGNALLING_PATHWAY_VIA_PKC_AND_MAPK 205136All SZGR genes in this pathway
REACTOME_SIGNALING_BY_GPCR 920449All SZGR genes in this pathway
REACTOME_PEPTIDE_LIGAND_BINDING_RECEPTORS 188108All SZGR genes in this pathway
REACTOME_CLASS_A1_RHODOPSIN_LIKE_RECEPTORS 305177All SZGR genes in this pathway
REACTOME_G_ALPHA_Q_SIGNALLING_EVENTS 184116All SZGR genes in this pathway
REACTOME_GPCR_DOWNSTREAM_SIGNALING 805368All SZGR genes in this pathway
REACTOME_GPCR_LIGAND_BINDING 408246All SZGR genes in this pathway
FULCHER_INFLAMMATORY_RESPONSE_LECTIN_VS_LPS_UP 579346All SZGR genes in this pathway
ZHOU_INFLAMMATORY_RESPONSE_LIVE_UP 485293All SZGR genes in this pathway
THUM_SYSTOLIC_HEART_FAILURE_UP 423283All SZGR genes in this pathway
DOANE_RESPONSE_TO_ANDROGEN_DN 241146All SZGR genes in this pathway
TAKEDA_TARGETS_OF_NUP98_HOXA9_FUSION_6HR_UP 8554All SZGR genes in this pathway
SENESE_HDAC1_TARGETS_DN 260143All SZGR genes in this pathway
SENESE_HDAC2_TARGETS_DN 13377All SZGR genes in this pathway
SENESE_HDAC3_TARGETS_DN 536332All SZGR genes in this pathway
ZHOU_INFLAMMATORY_RESPONSE_FIMA_UP 544308All SZGR genes in this pathway
ZHOU_INFLAMMATORY_RESPONSE_LPS_UP 431237All SZGR genes in this pathway
NAGASHIMA_NRG1_SIGNALING_UP 176123All SZGR genes in this pathway
NAGASHIMA_EGF_SIGNALING_UP 5840All SZGR genes in this pathway
GOZGIT_ESR1_TARGETS_DN 781465All SZGR genes in this pathway
MARKEY_RB1_CHRONIC_LOF_DN 11878All SZGR genes in this pathway
OLSSON_E2F3_TARGETS_DN 4933All SZGR genes in this pathway
DEBOSSCHER_NFKB_TARGETS_REPRESSED_BY_GLUCOCORTICOIDS 2418All SZGR genes in this pathway
RASHI_RESPONSE_TO_IONIZING_RADIATION_2 12792All SZGR genes in this pathway
SASAI_RESISTANCE_TO_NEOPLASTIC_TRANSFROMATION 5031All SZGR genes in this pathway
WILLIAMS_ESR2_TARGETS_DN 116All SZGR genes in this pathway
GROSS_ELK3_TARGETS_UP 2716All SZGR genes in this pathway
GROSS_HYPOXIA_VIA_ELK3_DN 156106All SZGR genes in this pathway
GROSS_HYPOXIA_VIA_HIF1A_DN 11078All SZGR genes in this pathway
GROSS_HYPOXIA_VIA_ELK3_AND_HIF1A_UP 142104All SZGR genes in this pathway
NUYTTEN_EZH2_TARGETS_UP 1037673All SZGR genes in this pathway
BUYTAERT_PHOTODYNAMIC_THERAPY_STRESS_DN 637377All SZGR genes in this pathway
SCHAEFFER_PROSTATE_DEVELOPMENT_48HR_UP 487286All SZGR genes in this pathway
SCHAEFFER_SOX9_TARGETS_IN_PROSTATE_DEVELOPMENT_UP 2119All SZGR genes in this pathway
GOTZMANN_EPITHELIAL_TO_MESENCHYMAL_TRANSITION_UP 6955All SZGR genes in this pathway
AMIT_SERUM_RESPONSE_120_MCF10A 6544All SZGR genes in this pathway
ZHANG_RESPONSE_TO_IKK_INHIBITOR_AND_TNF_UP 223140All SZGR genes in this pathway
ONDER_CDH1_TARGETS_2_DN 464276All SZGR genes in this pathway
ONDER_CDH1_TARGETS_1_DN 169102All SZGR genes in this pathway
ONDER_CDH1_TARGETS_3_DN 5932All SZGR genes in this pathway
CERVERA_SDHB_TARGETS_1_UP 11866All SZGR genes in this pathway
LEE_LIVER_CANCER_ACOX1_UP 6440All SZGR genes in this pathway
BYSTRYKH_HEMATOPOIESIS_STEM_CELL_QTL_TRANS 882572All SZGR genes in this pathway
MANALO_HYPOXIA_UP 207145All SZGR genes in this pathway
ZHAN_MULTIPLE_MYELOMA_LB_UP 4828All SZGR genes in this pathway
HARRIS_HYPOXIA 8164All SZGR genes in this pathway
CHUANG_OXIDATIVE_STRESS_RESPONSE_UP 2818All SZGR genes in this pathway
LEE_CALORIE_RESTRICTION_NEOCORTEX_DN 8858All SZGR genes in this pathway
SEMENZA_HIF1_TARGETS 3632All SZGR genes in this pathway
CLASPER_LYMPHATIC_VESSELS_DURING_METASTASIS_UP 2012All SZGR genes in this pathway
SANSOM_APC_TARGETS 212121All SZGR genes in this pathway
SANSOM_WNT_PATHWAY_REQUIRE_MYC 5843All SZGR genes in this pathway
FOSTER_TOLERANT_MACROPHAGE_DN 409268All SZGR genes in this pathway
MASSARWEH_TAMOXIFEN_RESISTANCE_UP 578341All SZGR genes in this pathway
SMID_BREAST_CANCER_RELAPSE_IN_BONE_DN 315197All SZGR genes in this pathway
SMID_BREAST_CANCER_LUMINAL_B_DN 564326All SZGR genes in this pathway
SMID_BREAST_CANCER_BASAL_UP 648398All SZGR genes in this pathway
LU_TUMOR_ANGIOGENESIS_UP 2522All SZGR genes in this pathway
WINTER_HYPOXIA_METAGENE 242168All SZGR genes in this pathway
YOSHIMURA_MAPK8_TARGETS_DN 366257All SZGR genes in this pathway
SWEET_LUNG_CANCER_KRAS_DN 435289All SZGR genes in this pathway
SCHOEN_NFKB_SIGNALING 3426All SZGR genes in this pathway
DANG_REGULATED_BY_MYC_DN 253192All SZGR genes in this pathway
DUTERTRE_ESTRADIOL_RESPONSE_24HR_DN 505328All SZGR genes in this pathway
DELPUECH_FOXO3_TARGETS_UP 6849All SZGR genes in this pathway
WIEDERSCHAIN_TARGETS_OF_BMI1_AND_PCGF2 5739All SZGR genes in this pathway
WINZEN_DEGRADED_VIA_KHSRP 10070All SZGR genes in this pathway
KOINUMA_TARGETS_OF_SMAD2_OR_SMAD3 824528All SZGR genes in this pathway
IKEDA_MIR1_TARGETS_UP 5339All SZGR genes in this pathway
YANG_BCL3_TARGETS_UP 364236All SZGR genes in this pathway
KRIEG_HYPOXIA_VIA_KDM3A 5334All SZGR genes in this pathway
FORTSCHEGGER_PHF8_TARGETS_DN 784464All SZGR genes in this pathway
ACEVEDO_FGFR1_TARGETS_IN_PROSTATE_CANCER_MODEL_UP 289184All SZGR genes in this pathway
ZWANG_CLASS_3_TRANSIENTLY_INDUCED_BY_EGF 222159All SZGR genes in this pathway
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-1/2061431501A,m8hsa-miR-1UGGAAUGUAAAGAAGUAUGUA
hsa-miR-206SZUGGAAUGUAAGGAAGUGUGUGG
hsa-miR-613AGGAAUGUUCCUUCUUUGCC
miR-125/3513883941Ahsa-miR-125bbrainUCCCUGAGACCCUAACUUGUGA
hsa-miR-125abrainUCCCUGAGACCCUUUAACCUGUG
miR-203.13833901A,m8hsa-miR-203UGAAAUGUUUAGGACCACUAG
miR-378*404410m8hsa-miR-422bCUGGACUUGGAGUCAGAAGGCC
hsa-miR-422aCUGGACUUAGGGUCAGAAGGCC
miR-409-3p142148m8hsa-miR-409-3pCGAAUGUUGCUCGGUGAACCCCU
miR-455380386m8hsa-miR-455UAUGUGCCUUUGGACUACAUCG
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


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