Gene Page: ETF1
Summary ?
GeneID | 2107 |
Symbol | ETF1 |
Synonyms | D5S1995|ERF|ERF1|RF1|SUP45L1|TB3-1 |
Description | eukaryotic translation termination factor 1 |
Reference | MIM:600285|HGNC:HGNC:3477|Ensembl:ENSG00000120705|HPRD:02616|Vega:OTTHUMG00000129199 |
Gene type | protein-coding |
Map location | 5q31.1 |
Pascal p-value | 2.412E-7 |
Sherlock p-value | 0.373 |
Fetal beta | -0.811 |
Gene in Data Sources
Gene set name | Method of gene set | Description | Info |
---|---|---|---|
CV:GWAScat | Genome-wide Association Studies | This data set includes 560 SNPs associated with schizophrenia. A total of 486 genes were mapped to these SNPs within 50kb. | |
CV:PGC128 | Genome-wide Association Study | A multi-stage schizophrenia GWAS of up to 36,989 cases and 113,075 controls. Reported by the Schizophrenia Working Group of PGC. 128 independent associations spanning 108 loci | |
CV:PGCnp | Genome-wide Association Study | GWAS | |
GSMA_I | Genome scan meta-analysis | Psr: 0.0032 | |
Expression | Meta-analysis of gene expression | P value: 1.79 | |
Network | Shortest path distance of core genes in the Human protein-protein interaction network | Contribution to shortest path in PPI network: 0.0278 |
Section I. Genetics and epigenetics annotation
CV:PGC128
SNP ID | Chromosome | Position | Allele | P | Function | Gene | Up/Down Distance |
---|---|---|---|---|---|---|---|
rs3849046 | chr5 | 137851192 | TC | 4.833E-9 | intronic | ETF1 |
Section II. Transcriptome annotation
General gene expression (GTEx)

Gene expression during devlopment (BrainCloud)
Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.
Gene expression of temporal and spatial changes (BrainSpan)
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
Top co-expressed genes in brain regions
Top 10 positively co-expressed genes | ||
Gene | Pearson's Correlation | Spearman's Correlation |
MDS1 | 1.00 | 1.00 |
FLI1 | 0.82 | 0.80 |
ITGA1 | 0.81 | 0.82 |
COBLL1 | 0.77 | 0.78 |
OCLN | 0.76 | 0.78 |
FGD5 | 0.75 | 0.78 |
ETS1 | 0.75 | 0.80 |
TEK | 0.75 | 0.77 |
TGFBR2 | 0.73 | 0.79 |
CDH5 | 0.73 | 0.73 |
Top 10 negatively co-expressed genes | ||
Gene | Pearson's Correlation | Spearman's Correlation |
RPS21 | -0.38 | -0.45 |
FAM128A | -0.37 | -0.35 |
MRPL52 | -0.37 | -0.38 |
SNHG12 | -0.36 | -0.36 |
RPL31 | -0.36 | -0.43 |
C12orf45 | -0.36 | -0.37 |
ATP5E | -0.36 | -0.41 |
BLOC1S1 | -0.36 | -0.35 |
ST20 | -0.36 | -0.36 |
AC008763.1 | -0.35 | -0.40 |
Section III. Gene Ontology annotation
Molecular function | GO term | Evidence | Neuro keywords | PubMed ID |
---|---|---|---|---|
GO:0003723 | RNA binding | TAS | 7990965 | |
GO:0005515 | protein binding | IPI | 9620853 |9712840 | |
GO:0016149 | translation release factor activity, codon specific | IEA | - | |
GO:0043022 | ribosome binding | TAS | 12867083 | |
Biological process | GO term | Evidence | Neuro keywords | PubMed ID |
GO:0006449 | regulation of translational termination | TAS | 7990965 | |
Cellular component | GO term | Evidence | Neuro keywords | PubMed ID |
GO:0005737 | cytoplasm | TAS | 7990965 |
Section V. Pathway annotation
Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
---|---|---|---|
REACTOME TRANSLATION | 222 | 75 | All SZGR 2.0 genes in this pathway |
REACTOME METABOLISM OF PROTEINS | 518 | 242 | All SZGR 2.0 genes in this pathway |
REACTOME METABOLISM OF MRNA | 284 | 128 | All SZGR 2.0 genes in this pathway |
REACTOME METABOLISM OF RNA | 330 | 155 | All SZGR 2.0 genes in this pathway |
REACTOME NONSENSE MEDIATED DECAY ENHANCED BY THE EXON JUNCTION COMPLEX | 176 | 57 | All SZGR 2.0 genes in this pathway |
GARY CD5 TARGETS DN | 431 | 263 | All SZGR 2.0 genes in this pathway |
DIAZ CHRONIC MEYLOGENOUS LEUKEMIA UP | 1382 | 904 | All SZGR 2.0 genes in this pathway |
CHARAFE BREAST CANCER LUMINAL VS BASAL DN | 455 | 304 | All SZGR 2.0 genes in this pathway |
TIEN INTESTINE PROBIOTICS 6HR DN | 167 | 100 | All SZGR 2.0 genes in this pathway |
TIEN INTESTINE PROBIOTICS 24HR UP | 557 | 331 | All SZGR 2.0 genes in this pathway |
KINSEY TARGETS OF EWSR1 FLII FUSION UP | 1278 | 748 | All SZGR 2.0 genes in this pathway |
ELVIDGE HYPOXIA DN | 146 | 94 | All SZGR 2.0 genes in this pathway |
GRAESSMANN APOPTOSIS BY SERUM DEPRIVATION UP | 552 | 347 | All SZGR 2.0 genes in this pathway |
GRAESSMANN APOPTOSIS BY DOXORUBICIN DN | 1781 | 1082 | All SZGR 2.0 genes in this pathway |
GRAESSMANN RESPONSE TO MC AND DOXORUBICIN DN | 770 | 415 | All SZGR 2.0 genes in this pathway |
BERENJENO TRANSFORMED BY RHOA UP | 536 | 340 | All SZGR 2.0 genes in this pathway |
SCHLOSSER MYC TARGETS REPRESSED BY SERUM | 159 | 93 | All SZGR 2.0 genes in this pathway |
DIRMEIER LMP1 RESPONSE LATE UP | 57 | 41 | All SZGR 2.0 genes in this pathway |
SPIELMAN LYMPHOBLAST EUROPEAN VS ASIAN DN | 584 | 395 | All SZGR 2.0 genes in this pathway |
PUJANA BRCA1 PCC NETWORK | 1652 | 1023 | All SZGR 2.0 genes in this pathway |
WEI MYCN TARGETS WITH E BOX | 795 | 478 | All SZGR 2.0 genes in this pathway |
SCIAN INVERSED TARGETS OF TP53 AND TP73 DN | 31 | 23 | All SZGR 2.0 genes in this pathway |
BENPORATH MYC MAX TARGETS | 775 | 494 | All SZGR 2.0 genes in this pathway |
SHEPARD CRUSH AND BURN MUTANT UP | 197 | 110 | All SZGR 2.0 genes in this pathway |
PENG LEUCINE DEPRIVATION DN | 187 | 122 | All SZGR 2.0 genes in this pathway |
BYSTROEM CORRELATED WITH IL5 UP | 51 | 30 | All SZGR 2.0 genes in this pathway |
TARTE PLASMA CELL VS PLASMABLAST DN | 309 | 206 | All SZGR 2.0 genes in this pathway |
BYSTRYKH HEMATOPOIESIS STEM CELL QTL TRANS | 882 | 572 | All SZGR 2.0 genes in this pathway |
PENG RAPAMYCIN RESPONSE DN | 245 | 154 | All SZGR 2.0 genes in this pathway |
FLECHNER BIOPSY KIDNEY TRANSPLANT OK VS DONOR UP | 555 | 346 | All SZGR 2.0 genes in this pathway |
NEMETH INFLAMMATORY RESPONSE LPS UP | 88 | 64 | All SZGR 2.0 genes in this pathway |
IVANOVA HEMATOPOIESIS LATE PROGENITOR | 544 | 307 | All SZGR 2.0 genes in this pathway |
SESTO RESPONSE TO UV C1 | 72 | 45 | All SZGR 2.0 genes in this pathway |
MONNIER POSTRADIATION TUMOR ESCAPE UP | 393 | 244 | All SZGR 2.0 genes in this pathway |
HOWLIN CITED1 TARGETS 2 DN | 17 | 11 | All SZGR 2.0 genes in this pathway |
MARSON BOUND BY FOXP3 STIMULATED | 1022 | 619 | All SZGR 2.0 genes in this pathway |
FOSTER TOLERANT MACROPHAGE UP | 156 | 92 | All SZGR 2.0 genes in this pathway |
ACEVEDO LIVER TUMOR VS NORMAL ADJACENT TISSUE UP | 863 | 514 | All SZGR 2.0 genes in this pathway |
YAGI AML WITH INV 16 TRANSLOCATION | 422 | 277 | All SZGR 2.0 genes in this pathway |
MARSON FOXP3 TARGETS DN | 54 | 38 | All SZGR 2.0 genes in this pathway |
GUTIERREZ MULTIPLE MYELOMA UP | 35 | 24 | All SZGR 2.0 genes in this pathway |
DANG BOUND BY MYC | 1103 | 714 | All SZGR 2.0 genes in this pathway |
YAO TEMPORAL RESPONSE TO PROGESTERONE CLUSTER 7 | 76 | 46 | All SZGR 2.0 genes in this pathway |
THILLAINADESAN ZNF217 TARGETS UP | 44 | 22 | All SZGR 2.0 genes in this pathway |
BRUINS UVC RESPONSE VIA TP53 GROUP C | 92 | 60 | All SZGR 2.0 genes in this pathway |
LEE BMP2 TARGETS DN | 882 | 538 | All SZGR 2.0 genes in this pathway |
HUANG GATA2 TARGETS DN | 72 | 52 | All SZGR 2.0 genes in this pathway |
RAO BOUND BY SALL4 ISOFORM B | 517 | 302 | All SZGR 2.0 genes in this pathway |
Section VI. microRNA annotation
miRNA family | Target position | miRNA ID | miRNA seq | ||
---|---|---|---|---|---|
UTR start | UTR end | Match method | |||
miR-124.1 | 88 | 94 | m8 | hsa-miR-124a | UUAAGGCACGCGGUGAAUGCCA |
miR-124/506 | 88 | 94 | 1A | hsa-miR-506 | UAAGGCACCCUUCUGAGUAGA |
hsa-miR-124brain | UAAGGCACGCGGUGAAUGCC | ||||
miR-134 | 1481 | 1487 | m8 | hsa-miR-134brain | UGUGACUGGUUGACCAGAGGG |
miR-136 | 2177 | 2184 | 1A,m8 | hsa-miR-136 | ACUCCAUUUGUUUUGAUGAUGGA |
miR-150 | 832 | 839 | 1A,m8 | hsa-miR-150 | UCUCCCAACCCUUGUACCAGUG |
miR-17-5p/20/93.mr/106/519.d | 1442 | 1448 | 1A | hsa-miR-17-5p | CAAAGUGCUUACAGUGCAGGUAGU |
hsa-miR-20abrain | UAAAGUGCUUAUAGUGCAGGUAG | ||||
hsa-miR-106a | AAAAGUGCUUACAGUGCAGGUAGC | ||||
hsa-miR-106bSZ | UAAAGUGCUGACAGUGCAGAU | ||||
hsa-miR-20bSZ | CAAAGUGCUCAUAGUGCAGGUAG | ||||
hsa-miR-519d | CAAAGUGCCUCCCUUUAGAGUGU | ||||
miR-181 | 962 | 968 | m8 | hsa-miR-181abrain | AACAUUCAACGCUGUCGGUGAGU |
hsa-miR-181bSZ | AACAUUCAUUGCUGUCGGUGGG | ||||
hsa-miR-181cbrain | AACAUUCAACCUGUCGGUGAGU | ||||
hsa-miR-181dbrain | AACAUUCAUUGUUGUCGGUGGGUU | ||||
miR-182 | 1966 | 1972 | 1A | hsa-miR-182 | UUUGGCAAUGGUAGAACUCACA |
miR-186 | 1982 | 1988 | 1A | hsa-miR-186 | CAAAGAAUUCUCCUUUUGGGCUU |
miR-200bc/429 | 2187 | 2193 | 1A | hsa-miR-200b | UAAUACUGCCUGGUAAUGAUGAC |
hsa-miR-200c | UAAUACUGCCGGGUAAUGAUGG | ||||
hsa-miR-429 | UAAUACUGUCUGGUAAAACCGU | ||||
miR-205 | 1349 | 1355 | 1A | hsa-miR-205 | UCCUUCAUUCCACCGGAGUCUG |
hsa-miR-205 | UCCUUCAUUCCACCGGAGUCUG | ||||
miR-216 | 952 | 959 | 1A,m8 | hsa-miR-216 | UAAUCUCAGCUGGCAACUGUG |
miR-23 | 959 | 965 | 1A | hsa-miR-23abrain | AUCACAUUGCCAGGGAUUUCC |
hsa-miR-23bbrain | AUCACAUUGCCAGGGAUUACC | ||||
miR-26 | 1564 | 1570 | 1A | hsa-miR-26abrain | UUCAAGUAAUCCAGGAUAGGC |
hsa-miR-26bSZ | UUCAAGUAAUUCAGGAUAGGUU | ||||
miR-299-5p | 2192 | 2198 | 1A | hsa-miR-299-5p | UGGUUUACCGUCCCACAUACAU |
hsa-miR-299-5p | UGGUUUACCGUCCCACAUACAU | ||||
miR-320 | 1492 | 1498 | 1A | hsa-miR-320 | AAAAGCUGGGUUGAGAGGGCGAA |
miR-324-3p | 447 | 453 | 1A | hsa-miR-324-3p | CCACUGCCCCAGGUGCUGCUGG |
miR-326 | 1849 | 1855 | 1A | hsa-miR-326 | CCUCUGGGCCCUUCCUCCAG |
miR-329 | 2034 | 2040 | 1A | hsa-miR-329brain | AACACACCUGGUUAACCUCUUU |
miR-330 | 1733 | 1739 | m8 | hsa-miR-330brain | GCAAAGCACACGGCCUGCAGAGA |
miR-335 | 292 | 298 | m8 | hsa-miR-335brain | UCAAGAGCAAUAACGAAAAAUGU |
miR-34b | 1536 | 1542 | 1A | hsa-miR-34b | UAGGCAGUGUCAUUAGCUGAUUG |
miR-381 | 295 | 301 | m8 | hsa-miR-381 | UAUACAAGGGCAAGCUCUCUGU |
miR-410 | 2022 | 2028 | 1A | hsa-miR-410 | AAUAUAACACAGAUGGCCUGU |
miR-490 | 1523 | 1530 | 1A,m8 | hsa-miR-490 | CAACCUGGAGGACUCCAUGCUG |
miR-493-5p | 2168 | 2174 | m8 | hsa-miR-493-5p | UUGUACAUGGUAGGCUUUCAUU |
miR-496 | 1590 | 1596 | 1A | hsa-miR-496 | AUUACAUGGCCAAUCUC |
hsa-miR-496 | AUUACAUGGCCAAUCUC | ||||
miR-505 | 545 | 551 | 1A | hsa-miR-505 | GUCAACACUUGCUGGUUUCCUC |
miR-543 | 963 | 969 | m8 | hsa-miR-543 | AAACAUUCGCGGUGCACUUCU |
miR-544 | 1756 | 1762 | m8 | hsa-miR-544 | AUUCUGCAUUUUUAGCAAGU |
miR-96 | 1966 | 1972 | 1A | hsa-miR-96brain | UUUGGCACUAGCACAUUUUUGC |
- SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
- Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.